The document presents a comprehensive exploration of bionanoimaging, focusing on quantum dots (QDs) and their applications in medical imaging, particularly for cancer detection. It discusses the properties, classifications, and emerging technologies associated with QDs and ultrasound contrast agents. Future trends and innovative approaches in medical nanotechnology are also highlighted, emphasizing the ongoing advancements in imaging techniques.

1. An unexpected journey to a wonderful world
Presented By: Mehdi Soleymani
Goloujeh
Medical Nanotechnology Department
Tabriz University of Medical Sciences
Supervisor: Dr. A. Barzegar

2. Presentation Layout:
 Introduction
 Classifications
New approaches
Future trends
Conclusions
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
2

3. Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 Introduction to Bionanoimaging
 Introduction
3

4. 4
Bionanoimaging
An unexpected journey to a wonderful world
Nowadays we use in cancer detection,
molecular imaging, MRI & US
Some facilities and materials are
prerequisite to reach our goals
So we should classify Mehdi Soleymani these Goloujeh
materials to
Medical Nanotechnology Department
 Introduction to Bionanoimaging

5. QDs
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 Classifications
Bionanoimaging
MNPs UICA
5

6. Quantum Dots
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
6

7. QUANTUM DOTS
• Emission of photons under excitation, which are visible
• Emission depends on size not on the material
“Size Matters”
• Smaller the dot –
• Larger the dot – red end of spectrum
• They can also be tuned
beyond visible light to
IR or UV
7
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

8. Quantum dots (QDs) are incredibly small particles. They range between 2
to 10 nanometers in diameter, which is equivalent to 50 atoms
A quantum dot as this: tiny pieces of matter with unique properties,
including the ability to emit light at very specific wavelengths. Sort of like
microscopic pieces of glitter that glow green, red, or blue depending on their
size.
The colour light that a quantum dot emits is directly related to its size;
smaller dots appear blue, larger ones more red.
Quantum dots are a "semiconductor nano-crystal
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
8

9. The smaller the nanoparticle, the higher the energy difference between the valence band
and conduction band, which results in a deeper blue color. For a larger nanoparticle, the
energy difference between the valence band and the conduction band is lower, which shifts
the glow toward red.
Quantum dots are very, very tiny particules on the order of a nanometer in size. They are
composed of a hundred to a thousand atoms. These semiconductor materials can be made
from an element, such as silicon or germanium, or a compound, such as CdS or CdSe.
These tiny particles can differ in color depending on their size. Below is a collection of CdSe
quantum dot nanoparticles that different in size as a result of how long they were allowed to
form in the synthersis reaction
9
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

10. MEDICAL IMAGING
The quantum dots (QD) can be injected to a
subject, and then be detected by exciting them
to emit light
CdSe nanoparticle (QD) structure
Source: Laurence Livermore Laboratories
Solutions of CdSe QD’s of different diameter
Source: Department of immunology, University of Toronto
Imaging of QD’s targeted on cellular structures
Nano Letters 2008., Vol. 8, pp3887-3892
10
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

11. QD LOCALIZATION OF A TUMOR
A. It is possible to overlap X-ray images with infrared images to localize a tumor. The X-ray
images give the images an anatomical context, while the infrared images detect the QD’s
emission, which correlates to the tumor location (see B.)
B. C. 560-QD-Streptadivin targets and images In-vitro
breast cancer cells having the IgG factor characteristic
of chemotherapy responsive cells
Annu. Rev. Biomed. Eng. 2007. Vol. 9, pp. 257–288
Nature Biotechnology 2003. Vol. 9, pp. 41-46
11

12. 12
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

13. Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
13

14. 14
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

15. 15
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

16. ULTRASOUND CONTRAST AGENTS
 Ultrasound is currently a well-established technology enabling real-time imaging of the
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
human body
 Traditional ultrasound, however, has its own limitation including increase in
attenuation with increasing insonating frequency, yielding low resolution of thicker
structures, and thus prohibiting deeper scans
 A possible solution to overcoming the issues of deep scans and achieving improved
resolution is the use of contrast agents (CA) for ultrasound imaging [25, 26]. The
ultrasound imaging contrast agents (UICA) can be classified into liposomes, polymeric
nanosomes, and these are further classified according to the type of ultrasound agent
encapsulated in them.
16

17. 17
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

18. 18
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

19. 19
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

20. 20
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

21. 21
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

22. 22
MAGNETIC NANOPARTICLES
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 Paramagnetic
 Super-paramagnetic Iron Oxide(SPIO)

23. 23
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

24. 24
Applications:
 Passive Targeting
 Active Targeting
 Cell Tracking
 Magnetic Relaxation Switching(MRS)
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

25. 25
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department

26. Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 New approaches
26
 New Developments

27. 27
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 New approaches

28. Experiences
Insights Documents
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
 Future trends
28
Science-fiction
Jules Verne Stories
Imaginations
Thoughts

29. C O O H
C O O H
H O O C
O H
C O O H
C O O H
C O O H
H O O C
O H
H O O C
H O O C
C O O H
H O
C O O H
H O O C
C O O
50 μm
Fe3O4 NPs
H
H O
C O O H
H O O
H O O C
O H
O H
C O O H
H O O C
H O O C
H O O C
C O O H
C O O H
H O O C
O H
H O O C
H O O C
O H
H O O C O H
C O O H
i
 Conclusions
29
Mehdi Soleymani Goloujeh
 Conclusions
Medical Nanotechnology Department

30. 30