Infratemporal fossa a systematic approachAugustine raj
infratemporal fossa is a irregular space with numerous neurovascular structures. an attempt has been made by me to decode all the boundaries and structures in a systematic way. sincere thanks to Dr. Viren Karia for his awesome video.
orthognathic surgery is very intresting and well knowing branch in oral surgery ....this presentation is dealing with jaw correction surgery in upper jaw.
INFRATEMPORAL FOSSA AND PTERYGOPALATINE FOSSA NEW.pptxSudin Kayastha
INFRA TEMPORAL FOSSA
Irregularly shaped space deep & inferior to zygomatic arch, deep to ramus of mandible & posterior to maxilla
Communicates with temporal fossa through interval between (deep to) zygomatic arch & (superficial to) cranial bones
Temporal fossa is superior to zygomatic arch In
an overview of muscle pain disorder which regularly create some discomfort for patient to live a normal life as well as to the doctor regarding diagnosis of the problem.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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3. General information
Temporal region & its contents
Infra-temporal region & its contents
Clinical importance of this region
4. A knowledge of the anatomy of the
infratemporal andTemporal region and their
contents is essential for understanding
regarding oro-facial region.
Many of the nerves and blood vessels supplying
the structures of the maxillofacial region run
through or close to these fossae.
In addition, the infratemporal fossa contains the
pterygoid muscles which play an important part
in movements of the mandible.
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10. The bone of calvarium is thinnest in the temporal fossa. Strong
blows to the side of the head may cause a depressed fracture, in
which a fragment of bone is depressed inward to compress or
injure the brain.
At the pterion, the middle meningeal artery is easily ruptured
following such an injury CAUSING EXTRA DURAL HEMATOMA.
The resulting hematoma will compress the brain and could be
fatal if untreated.
TREATMENT
According to the "Guidelines for the Management ofTraumatic Brain Injury, EDH with
volume greater than 30 mL should undergo surgical evacuation
This criterion becomes especially important when the EDH exhibits thickness of 15 mm or
more, and a midline shift beyond 5 mm
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12.
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14. ORIGIN: floor of temporal
fossa & deep surface of
temporal fasica
INSERTION: the tendon
passes deep to zygomatic
arch to be inserted to all
coronoid process NERVE
SUPPLY: temporal branch
from anterior division of
mandibular nerve
BLOOD SUPPLY:DEEP
TEMPORALARTERY
ACTION:
Elevation of mandible, Its posterior
fibers retract the mandible
15. Temporalis Muscle as a flap
reconstruction
This type of flap was first described
by Golovine in 1898.
The approach to harvest is through a
temporal rhytidectomy incision and
subperiosteal dissection.
Indications
orbital reconstructions
sling for the lower eyelid and lip in facial
paralysis
Reconstruction of oral cavity and
oropharynx defect
16. REHABILITATION of facial paralysis is one of the greatest
challenges faced by reconstructive surgeons today.
The available options for facial reanimation are determined by
the duration and cause of the paralysis.
Dynamic muscle transfer remains an excellent option for facial
reanimation in patients for whom the options of primary nerve
repair, grafting, and nerve transfer are not possible.
The mainstay of this technique is temporalis muscle transfer.
Temporalis tendon transfer provides for improved function
and elimination of the telltale signs of temporalis transfer
produced by the classic technique.
Orthodromic temporalis insertion transfer involves release and
mobilization oftemporalis at the insertion into the coronoid.
The temporalis is then transferred to the oral commissure,
effectively eliminating the depression in the temple and any
tissue protrusion around the zygomatic arch.
17. ORIGIN:
1. Upper head: infratemporal
surface of greater wing of
sphenoid
2. Lower head: lateral surface of
lateral pterygoid plate
INSERTION: pterygoid fovea (in
front of neck of mandible) +
capsule & articular disc ofTMJ
NERVE SUPPLY: from anterior
division of mandibular nerve
ACTION:
1. Pulls the condylar process
forward to depress the mandible
2. Side-to-side movement
18. Superficial: temporalis, masseter, ramus of
mandible, maxillary artery, buccal nerve
Deep: medial pterygoid, mandibular nerve,
middle meningeal artery, otic ganglion
Emerging through its upper border: deep
temporal & masseteric nerves
Emerging through its lower border: lingual &
inferior alveolar nerves + maxillary artery
Emerging between its 2 heads: buccal nerve,
maxillary artery
19. ORIGIN:
1. Superficial head: tuberosity of
maxilla
2. Deep head: medial surface of
lateral pterygoid plate
INSERTION: medial surface of
ramus & angle of mandible
NERVE SUPPLY: from trunk of
mandibular nerve
ACTION:
1. Elevation of mandible
2. Protrusion of mandible (when
muscles on both sides act
together)
3. Side-to-side movement
(when muscles on both sides
act alternatively)
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23.
24. Anastomoses of the pterygoid venous plexus with the
facial vein and cavernous sinus represent an important
potential pathway for the spread of infection.
Normally, blood from the medial angle of the eye, nose
and lips drains down through the facial vein.
Veins in the head, including those of the pterygoid
venous plexus, do not have valves, however.
Infections may therefore reverse the flow of blood into
the cavernous sinus, resulting ultimately in meningeal
infections.
25.
26.
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28.
29.
30.
31.
32. CLINICAL CORRELATION OF INFRATEMPORAL FOSSA AND
MANDIBULAR NERVE BLOCK
The pathways are significant clinically because they help
describe the consequences of interrupted nerve function,
due either to anesthesia or injury.
To numb the mandibular teeth for a dental procedure,
anesthetic is injected at the lingula of the mandible to
block the inferior alveolar nerve. If the needle passes too
far posteriorly, it may anesthetize branches of CN VII
coursing through the parotid gland.
33. • CLINICAL CORRELATON-AURICULOTEMPORAL Nerve
• Frey’s syndrome produces flushing and
sweating instead of salivation in
response to taste of food after injury of
the auriculotemporal nerve, which
carries parasympathetic secretomotor
fibers to the parotid gland and
sympathetic fibers to the sweat
glands.
• When the nerve is damaged, the fibers
can regenerate along each other’s
pathways and innervate the wrong
gland.
• It can occur after parotid surgery and
may be treated by cutting the
tympanic plexus in the middle ear.
34. The posterior superior alveolar artery runs with the
nerve(s), but is no more likely to be damaged than
arteries in other neurovascular bundles.
The pterygoid venous plexus lies within and around
the lateral pterygoid muscle, and should not be
damaged unless the needle is inserted too deeply or
laterally.
If a positive (venous) aspiration is observed during this
procedure, withdrawal will disengage the needle with
minimal bleeding resulting—injecting into the friable
plexus causes disruption which can lead to
haematoma formation and postoperative trismus.
35. Cervicofacial celulitis
Infratemporal fossa space infection
Submasseteric space infection
Pharyngeal space infection
Cavernous sinus thrombosis
36. Several surgical approaches to the infratemporal fossa have been described over the years and
some of them have been improved and modified. Basically the various approaches can be
grouped under the following categories, which are
Transoral,
Transantral,
Transpharyngeal,
Transmaxillary,
Extended maxillotomy,
Maxillary swing,
Transmandibular,
Transzygomatic ,
Facial translocation,
Transcranial,
Combined
37. The superior gingivolabial sulcus posteriorly is close to the tuberosity of
the maxilla and provides access to the lower part of the infratemporal
fossa.
An approach through this area does not provide enough exposure for
removal of tumours,
the view is obstructed by fatty tissue and there is no vascular control.
However, the recess provides access for biopsy purposes especially if the
lesion is located low in the infratemporal fossa.
Occasionally a benign tumour may be removed through this approach.
38. The antral cavity is entered through a
sublabial incision, extending from the
level of the canine to the first molar
tooth and the mucoperiosteal flap is
elevated until the infraorbital foramen,
so as to preserve the infraorbital vessels and
A window is made into the anterolateral wall of the antrum large enough to provide
good exposure of the complete posterior wall of the maxillary sinus.
The roots of the canine and premolars are preserved.
The antral mucosa on the posterior wall is incised at its junction with the medial,
lateral and superior walls, and the mucoperiosteal flap is reflected down.
39. • The periosteum on the outer surface of the
posterior wall is incised along its medial,
lateral and superior border and reflected
downwards.
• At the end of the procedure the bony
posterior wall and the mucoperiosteal flap are
replaced.
• This approach is not suitable for tumour
excision by itself, but may be combined with
other approaches. It is invariably employed for
the purpose of obtaining a biopsy.
40. The authors Kornfehl et al. have basically described a transpharyngeal approach via the
palate.
The nasopharynx is reached via an ‘S'-shaped incision running vertically on the soft
palate and on to the anterior pharyngeal arch towards the side of the lesion.
The mucosa of the lateral wall of the nasopharynx is incised vertically, the superior
constrictor muscle of the pharynx is split to enter the most medial part of the
infratemporal fossa.
Kornfehl et al. employed this approach to extirpate a cavernous haemangioma close to
the lateral pterygoid muscle which had been shown not to have any feeding vessels.
This is not a safe approach for tumour excision.
The internal carotid artery is close to the pharyngeal wall and it is not possible to obtain
any control on the vessel.The exposure obtained is limited.
41. It was originally described by Langenbeek in 1859
as an osteoplastic technique for tumours of the
pterygopalatine fossa.
An incision is placed in the buccal sulcus above the
attached gingivae between the maxillary second
premolars.
the incision is placed half a centimetre above the
apices of tooth to ensure the viability of the teeth.
A mucoperiosteal flap is raised.The nasal septum
is separated from the anterior nasal spine and the
maxillary crest and the facial soft tissue are
retracted cranially.
42. • An osteotomy incision is placed, using an electric burr from one maxillary
tuberosity to the other.
• The incision passes just under the zygomatic buttress and divides the anterior nasal
aperture.
• An osteotomy of the medial wall of the maxilla is performed through the inferior
meatus to the palatine canal. At this stage the palate and the inferior portion of the
maxilla remain attached by the pterygomaxillary suture, the thin posterior wall of
the maxillary sinus and the bone forming the canal of the palatine vessels.
• Using a curved osteotome the maxilla is separated and disimpacted downwards.
• The buttress of bone anterolaterally and at the piriform nasal aperture are preserved
so that they can be approximated at closure.
43. This is essentially a transantral approach with an
extended sublabial incision taken from the midline
to the maxillary tuberosity and carried down to the
periosteum.
The posterior wall of the maxillary sinus is widely
excised allowing access to the pterygomaxillary
portion of the tumour.
The medial wall of the maxillary sinus and the
nasopharynx is removed. Lateral extension of the
tumour can be exposed by removing the lateral
wall of the antrum.
It can also be combined with a transpalatal
approach. It was described by Krause and Baker
who used it mainly for surgical treatment of
nasopharyngeal angiofibroma.
44. The concept of approaching the retromaxillary area
through a mandibulotomy is not new and has been
advocated by Conley and Barbosa. The infratemporal
fossa communicates inferiorly with the neck.
If the mandible is laterally retracted and the medial
pterygoid muscle is detached from its mandibular
attachment the infratemporal space can be reached.
This approach provides good control of the vessels
and nerves and en bloc resection of nasopharynx,
posterior maxilla, infratemporal fossa structures,
mandibular ramus and parotid gland can be
performed.
The procedure has been modified by Attia et al. to
obtain wide field exposure without sacrifice of either
mandibular function or the sensory supply of the face
and oral cavity.
45. • The mandibular osteotomies are arranged
to spare the inferior alveolar nerve and
vessels and are positioned under the
intercondylar notch above the opening of
the mandibular canal and just medial to the
mental foramen.
• Detachment of the medial and lateral
pterygoid muscles and the
sphenomandibular ligament allows the
mandibular segment to be reflected
superiorly .
• This provides direct access to the
infratemporal fossa; osteosynthesis of the
mandible and intermaxillary fixation is
performed. The procedure preserves
function, exposure is good and is
cosmetically acceptable.
46. Incision – Weber Ferguson incision without gingivolabial
component
Bilateral tarsorraphy should be performed
Inverted “U” shaped incision is marked out on the hard
palate
After deepening the facial incision the lacrimal sac
should be skeletonized and sectioned at its lower end.
Infra orbital nerve should be sectioned as it comes out of
infraorbital foramen.
Periosteum of the inferior orbital wall should be
elevated.
Osteotomies should be performed on the frontal
process of maxilla and at the maxillo zygomatic suture.
The maxillo ethmoidal junction should be separated
using a straight osteotome.
47. • The mucoperiosteum over the hard palate should be
elevated based on the contralateral greater palatine
vessels. The ipsilateral greater palatine vessels were
cauterized and sectioned.
• A straight osteotome should be placed between the arms
of a v shaped notch located on the anterior nasal spine
and hammered in order to separate the maxilla down the
middle.
• Now the whole maxilla with its attached cheek tissue can
be swung like a door laterally exposing the whole of
nasopharynx.
• Mass in the naso pharynx can now be removed under
direct vision.
• Maxilla can be repositioned after surgery and secured in
position by using miniplate and screws.
48. Radical excision of tumours and the relatively
limited access obtained by any single
approach have made combined approaches
necessary.
It offers the patients the maximum benefit of
the technical ‘know-how’ of the surgical team
and the best opportunity for surgical excision.
49. - HOLLINSHED- BOOK OF ANATOMY
- GRAYS ANATOMY
- LAST ANATOMY
- ATLAS OF HUMAN BODY- NETTERS
- B.D.CHAURASIA-TEXT BOOK OF ANATOMY
- JOHN D LANGDON- SURGICAL ANATOMY
OF INFRATEMPORAL FOSSA
- JATIN SHAH- HEAD AND NECK CANCER