The posterior belly of the digastric muscle originates from the mastoid notch of the temporal bone and inserts on the intermediate tendon which connects to the hyoid bone. It has relationships superiorly with the external carotid artery branches and inferiorly with the internal carotid artery, internal jugular vein and cranial nerves IX, X, XI, XII. The posterior belly is supplied by the posterior auricular and occipital arteries and innervated by the facial nerve.
VENOUS DRAINAGE OF HEAD, FACE, NECK AND BRAINDrVishal2
THIS SEMINAR ON VENOUS DRAINAGE OF HEAD, FACE, NECK AND BRAIN ENCOMPASSES ALL THE POSSIBLE DETAILED EXPLANATION ALONG WITH DIAGRAMMATIC ILLUSTRATIONS OF THE SAME. APPLIED AND SURGICAL ANATOMY ALONG WITH RECENT MODALITIES HAS BEEN ADDED HEREIN..
VENOUS DRAINAGE OF HEAD, FACE, NECK AND BRAINDrVishal2
THIS SEMINAR ON VENOUS DRAINAGE OF HEAD, FACE, NECK AND BRAIN ENCOMPASSES ALL THE POSSIBLE DETAILED EXPLANATION ALONG WITH DIAGRAMMATIC ILLUSTRATIONS OF THE SAME. APPLIED AND SURGICAL ANATOMY ALONG WITH RECENT MODALITIES HAS BEEN ADDED HEREIN..
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
3. •Contains the superficial lobe of the
submandibular (submaxillary) salivary gland.
•Its floor is formed by
•The mylohyoid,
•The hyoglossus and
•The middle constrictor muscles
The digastric triangle
4.
5. Digastric (Submandibular) Triangle
• A digastric triangle is bounded by
– (1) The posterior belly and intermediate tendon of
the digastric,
– (2) The anterior belly of the digastric, and
– (3) The lower border of the mandible.
Since the posterior belly of the digastric is
coincident with a line between the angle of the
mandible and the mastoid process.
– The digastric triangle does not exist posterior to the mandible.
– Thus, for all practical purposes, the posterior border of the digastric
triangle is formed solely by the intermediate tendon of the digastric.
6. The submandibular region
• It is the region between the body of the
mandible & the hyoid bone.
• It is almost totally hidden from view by the
submandibular gland.
• Superficial part includes submental &
digastric triangles.
7. Submandibular fossa
• The Submandibular Gland occupies the
submandibular fossa on the inner
aspect of the mandible & extends into
• The mental foramen-----in front
• The angle of mandible---behind
• The mylohyoid line -------above
• May overlap two bellies of digastric
muscles
8.
9. Muscle Origin Insertion Innervation Main Action(s)
Digastric Anterior
belly:
digastric
fossa of
mandible
Posterior
belly:
mastoid
notch of
temporal
bone
Intermediate
tendon to body
and greater horn
of hyoid
Anterior belly:
Nerve to
mylohyoid, a branch
of inferior alveolar
nerve
Posterior belly:
Digastric branch of
(preparotid) facial
nerve (CN VII)
Working with
infrahyoid muscles,
depresses mandible
against resistance;
elevates and steadies
hyoid during
swallowing and
speaking
10.
11. Digastric muscle
• Each digastric muscle has two bellies, joined by an
intermediate tendon, that descends toward the hyoid.
A fibrous sling derived from the pretracheal layer of deep cervical fascia allows the
tendon to slide anteriorly and posteriorly as it connects this tendon to the body and
greater horn of the hyoid.
• The difference in nerve supply between the anterior
and posterior bellies of the digastric muscles results
from their different embryological origin from the 1st
and 2nd pharyngeal arches, respectively. CN V
supplies derivatives of the 1st arch, and CN VII
supplies those of the 2nd arch.
12. Digastric muscle
• Digastric has two bellies and lies below the mandible,
extending from the mastoid process to the chin.
• The posterior belly, which is longer than the anterior,
is attached in the mastoid notch of the temporal bone,
and passes downwards and forwards.
• The anterior belly is attached to the digastric fossa on
the base of the mandible near the midline, and slopes
downwards and backwards.
• The two bellies meet in an intermediate tendon which
runs in a fibrous sling attached to the body and greater
cornu of the hyoid bone and is sometimes lined by a
synovial sheath. The tendon perforates stylohyoid.
13. The posterior belly of the digastric
• Comes from the medial surface of the mastoid process,
• Attaches to the anterior belly of digastric by the
intermediate tendon which is tied down by a fascial sling
to the body of the hyoid.
• Arises from the 2nd branchial arch and is innervated by
cranial nerve VII, while the anterior belly is derived from
the 1st arch and receives its nerve supply from V3 (the
mandibular division of the trigeminal nerve).
• Is associated with the stylohyoid muscle which is also
innervated by cranial nerveVII.
14. Variations
• Digastric may lack the intermediate tendon
and is then attached midway along the
body of the mandible. The posterior belly
may be augmented by a slip from the
styloid process or arise wholly from it. The
anterior belly may cross the midline and it
is not uncommon for it to fuse with
mylohyoid.
15. Relations
• Superficial to digastric are
– Platysma ,
– *sternocleidomastoid, splenius capitis, longissimus capitis and stylohyoid,
– Passes deep to angle of mandible
– The mastoid process(most posteriorly)
– Between mastoid process & angle of mandible it is covered by parotid.
– In anterior triangle it is overlapped by submandibular salivary gland.
– It is crossed by the retromandibular vein.
Medial to the anterior belly.
-Mylohyoid is medial to the anterior belly.
Medial to the posterior belly.
-3 main vessels:
-Internal jugular vein,
-Internal carotid and
-External carotid arteries,
-3 cranial nerves:
-The accessory nerve, vagus and hypoglossal nerve,
-Two arteries(branches of external carotid) pass backwards & upwards &
medially deep to upper & lower bordes of posterior belly are
-Posterior auricular artery deep to upper border
-Occipital artery deep to lower border.
-Others: Hyoglossus ,superior oblique and rectus capitis lateralis, &
-The transverse process of the atlas vertebra,
.
16.
17.
18.
19. 3 cranial nerves in relation to
posterior belly of digastric
• The vagus nerve runs vertically
downwards between internal jugular vein
& internal carotid artery
• The accessory nerve passes downwards
& backwards between posterior belly of
digastric & internal jugular vein
• The hypoglossal nerve passes between
posterior belly of digastric & internal
carotid artery
20.
21. Vascular supply
• The posterior belly is supplied by the
posterior auricular and occipital arteries.
• The anterior belly of digastric receives its
blood supply chiefly from the submental
branch of the facial artery.
22. Innervation
• The anterior belly of digastric is supplied
by the mylohyoid branch of the inferior
alveolar nerve, and the posterior belly is
supplied by the facial nerve.
• The different innervation of the two parts
reflects their separate derivations from the
mesenchyme of the first and second
branchial arches.
23. Actions
• Digastric depresses the mandible and can
elevate the hyoid bone.
• The posterior bellies are especially active
during swallowing and chewing.
24.
25. Relationships of the posterior belly of the digastric muscle
• 1) between the posterior belly of the digastric muscle
and the skin of the neck:
– The external jugular vein
– The cutaneous branches of great auricular nerve
– The cervical branch of VII
• 2) deep to the posterior belly of digastric
– The internal jugular vein
– The internal and external carotid arteries
– Cranial nerves X, XI, XII
• Deeper, cranial nerve IX and the sympathetic trunk
– The cranial nerve IX or glossopharyngeal nerve runs deep
to the internal carotid artery and penetrates the lateral
pharyngeal wall with the stylopharyngeus muscle. It is motor
to this muscle and sensory to the mucosa of posterior 1/3 of
tongue, mucosa of pharynx, palatine tonsil and soft palate.
26.
27. Relations of the Internal Carotid Artery in the Neck
• Anterolaterally:
– Below the digastric lie the skin, the fascia, the anterior
border of the sternocleidomastoid, and the hypoglossal
nerve.
– Above the digastric lie the stylohyoid muscle, the
stylopharyngeus muscle, the glossopharyngeal nerve, the
pharyngeal branch of the vagus, the parotid gland, and the
external carotid artery.
• Posteriorly: The sympathetic trunk, the longus capitis
muscle, and the transverse processes of the upper
three cervical vertebrae
• Medially: The pharyngeal wall and the superior
laryngeal nerve
• Laterally: The internal jugular vein and the vagus
nerve
28. External carotid branches
• External carotid branches lie inferior to, deep to or superior to the
posterior belly of the digastric.
• Inferior to the posterior belly of the digastric:
1) The superior thyroid artery runs to the superior pole of the thyroid
gland, anastomoses with its opposite counterpart and the inferior thyroid
artery. Its branches are:
– The superior laryngeal artery running with the internal laryngeal nerve to
become internal laryngeal artery and nerve .
– The cricothyroid branch running with the external laryngeal nerve.
– The muscular branch to the sternocleidomastoid muscle.
2) The lingual artery supplies the tongue
3) The ascending pharyngeal artery (at the bifurcation of the common
carotid artery) supplies the lateral wall of the pharynx and the nasopharynx.
• Deep to the posterior belly of the digastric:
– The facial artery
– The occipital artery (lying superior to cranial nerve XII)
• Superior to the posterior belly of the digastric:
– The posterior auricular branch with its stylomastoid branch supplying cranial
nerve VII. Neuritis compresses the artery and leads to Bell's palsy.
– The maxillary artery
– The superficial temporal artery