This document defines syphilis as a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. It describes the epidemiology, clinical features, laboratory diagnosis, complications, treatment, and prevention of syphilis. Syphilis presents initially as a chancre sore and progresses through primary, secondary, latent, and tertiary stages if left untreated. Penicillin is the most common treatment, though antibiotics like doxycycline may be used for those allergic to penicillin. Safe sex practices and regular STI screening are important for prevention.