Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It presents in stages, beginning with a painless sore and progressing to a rash and lesions on mucous membranes if left untreated. Without treatment, it can spread throughout the body and cause damage to internal organs, nerves, and blood vessels. Syphilis is treated with antibiotics, most commonly penicillin, with the treatment depending on which stage the infection is in. Congenital syphilis can occur if an infected mother transmits the bacterium to her fetus during pregnancy.
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary).
To tell about the sexually transmitted disease like syphilis and treatment of disease stages of the syphilis. symptoms and introduction of the bacteria and causative agents. drug dose and usage of the medications
syphilis, pathophysiology of syphilis, symptoms of syphilis, mode of transmission of syphilis, complications of syphilis, stages of syphilis, diagnosis of syphilis, pathology of syphilis, syphilis symptoms, syphilis diagnosis, cause of syphilis
Meningococci are a type of bacteria that cause serious infections. The most common infection is meningitis, which is an inflammation of the thin tissue that surrounds the brain and spinal cord. Meningococci can also cause other problems, including a serious bloodstream infection called sepsis. In its early stages, you may have flu-like symptoms and a stiff neck. But the disease can progress quickly and can be fatal. Early diagnosis and treatment are extremely important. Lab tests on your blood and cerebrospinal fluid can tell if you have it. Treatment is with antibiotics. Since the infection spreads from person to person, family members may also need to be treated.
A vaccine can prevent meningococcal infections.
Syphilis and gonorrhea - Its etiology, pathophysiology, signs and symptoms,di...Aiswarya Thomas
Discussed about Syphilis and gonorrhea - Its etiology, pathophysiology, signs and symptoms,diagnosis and prevention. Also dicussed about the classifications of both STDs and its diagnostic tests
Non-Gonococcal urethritis. main causative organisms are Chlamydiae, Mycoplasma, Ureaplasma. various other bacteria and viruses can cause this. this powerpoint is made in systemic manner and will be helpful for Postgraduate students.
a double-stranded DNA virus : human herpesvirus-3 subfamily Alphaherpersvirinae
only one serotype is known
humans are the only reservoir
VZV enters the host through the nasopharyngeal mucosa, and almost invariably produces clinical disease in susceptible individuals
Following varicella, the virus persists in sensory nerve ganglia, from where it may later be reactivated to cause herpes zoster (Shingles)
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary).
To tell about the sexually transmitted disease like syphilis and treatment of disease stages of the syphilis. symptoms and introduction of the bacteria and causative agents. drug dose and usage of the medications
syphilis, pathophysiology of syphilis, symptoms of syphilis, mode of transmission of syphilis, complications of syphilis, stages of syphilis, diagnosis of syphilis, pathology of syphilis, syphilis symptoms, syphilis diagnosis, cause of syphilis
Meningococci are a type of bacteria that cause serious infections. The most common infection is meningitis, which is an inflammation of the thin tissue that surrounds the brain and spinal cord. Meningococci can also cause other problems, including a serious bloodstream infection called sepsis. In its early stages, you may have flu-like symptoms and a stiff neck. But the disease can progress quickly and can be fatal. Early diagnosis and treatment are extremely important. Lab tests on your blood and cerebrospinal fluid can tell if you have it. Treatment is with antibiotics. Since the infection spreads from person to person, family members may also need to be treated.
A vaccine can prevent meningococcal infections.
Syphilis and gonorrhea - Its etiology, pathophysiology, signs and symptoms,di...Aiswarya Thomas
Discussed about Syphilis and gonorrhea - Its etiology, pathophysiology, signs and symptoms,diagnosis and prevention. Also dicussed about the classifications of both STDs and its diagnostic tests
Non-Gonococcal urethritis. main causative organisms are Chlamydiae, Mycoplasma, Ureaplasma. various other bacteria and viruses can cause this. this powerpoint is made in systemic manner and will be helpful for Postgraduate students.
a double-stranded DNA virus : human herpesvirus-3 subfamily Alphaherpersvirinae
only one serotype is known
humans are the only reservoir
VZV enters the host through the nasopharyngeal mucosa, and almost invariably produces clinical disease in susceptible individuals
Following varicella, the virus persists in sensory nerve ganglia, from where it may later be reactivated to cause herpes zoster (Shingles)
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Reportsemualkaira
In recent years, syphilis has grown again with alarming numbers,
not only in Brazil, but worldwide. In October 2016, the Ministry
of Health recognized that the situation was getting out of hand and
declared an epidemic.
Most cases are in the Southeast region (56%), the most urbanized
and developed in the country. The disease that previously affected
the poorest population, today affects all social classes
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Reportsemualkaira
In recent years, syphilis has grown again with alarming numbers, not only in Brazil, but worldwide. In October 2016, the Ministry of Health recognized that the situation was getting out of hand and declared an epidemic.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. SYPHILIS
Syphilis - infectious treponematoses caused by
Treponema pallidum transmitted usually by sexual
intercourse
Discovered by Schaudinn and Hoffmann(1905)
Affects most of the organs
Marked by florid manifestations on the one hand
And years of asymptomatic latency on the other hand
Affects both man & women in age group of 20-40
years
6. Pathogenesis
Mode of transmission
1. Sexual intercourse
2. Blood transfusion
3. Contaminated needles
4. Vertical transmission
5. To hospital personnel by indiscriminate
handling of infected lesions
7. 1.ATTACHMENT, INVASION AND DISSEMINATION
2. INNATE HOST RESPONSE – TLR2
3. ACQUIRED IMMUNITY - clinical manifestations caused
by inflammatory and immune responses rather than by
any direct cytotoxic effect of T. pallidum
4. BACTERIAL CLEARANCE- phagocytosis of treponemes
by macrophages
Predominant cytokine –Th1
Predominant mediator- IFN-γ
5. ANTIBODIES IN SYPHILIS
6. INVASION OF HOST IMMUNITY AND
ESTABLISHMENT OF LATENT INFECTION
7. PROTECTIVE AND LONG-LASTING IMMUNITY
Pathogenesis
8. Classification of Syphilis
Clinical course of acquired syphilis is divided in to
early &late syphilis.
1. Early-duration is 1 yrs.
Includes primary and secondary stage and early latent syphilis
2. Late-after 1 yrs.
Include late latent & tertiary syphilis
Congenital Syphilis
COLLES’S LAW(1837)
Syphilitic infants could transmit the disease to previously healthy wet
nurses but never to their own mother
KASSOWITZ’S LAW(1876)
Untreated syphilitic mother tends to improve on her past performance
9. Primary Syphilis
It’s the first stage after infection
Painless & localized ulcer with rolled edge
(chancres).
Single or multiple.
Appear 2-3 weeks after contact.
Most common site are cervix , vagina , vulva
, anus and mouth.
Regional L.N become enlarged.
11. SECONDARY SYPHILIS
The skin rash:
Diffuse
often with a superficial scale (papulosquamous).
May leave residual pigmentation or depigmentation.
Condylomata Lata:
Formed by coalescence of large, pale, flat-topped papules.
Occur in warm, moist areas such as the perineum.
Highly infectious.
Mucosal lesions:
~ 30% of secondary syphilis patients develop mucous patch
(slightly raised, oval area covered by a grayish white
membrane, with a pink base that does not bleed).
Highly infectious
12. Systemic
1-6 months after contact
Fever, malaise, general adenopathy and
nonitchy maculopapular skin rash “money
spot” .
Involve the palms of the hands and the soles
of the feet.
Mucous patches and linear (snail track)
ulcers are seen on the mucosal surfaces.
SECONDARY SYPHILIS
17. LATENT SYPHILIS
Positive syphilis serology without clinical signs of syphilis
(& has normal CSF).
It begins with the end of secondary syphilis and may last
for a lifetime.
Pt may or may not have a h/o primary or secondary
syphilis.
Diseases known to cause occasional false-positive
nontreponemal test reactions for syphilis, such as
systemic lupus erythematosus (SLE), and congenital
syphilis must be excluded before the diagnosis of latent
syphilis can be made.
Is divided into early and late latency.
18. Early latent:
The first year after the resolution of primary or
secondary lesions, or
A reactive serologic test for syphilis in an
asymptomatic individual who has had a negative
serologic test within the preceding year.
Infectious.
Late latent:
Usually not infectious, except for the pregnant
woman, who may transmit infection to her fetus.
LATENT SYPHILIS
20. TERTIARY SYPHILIS
Morbidity and mortality of syphilis in adults in
past years were due to late manifestations of illness
There may be an interval of 1 - 20 yrs from acute
infection to clinical onset of late or tertiary stages
of disease
Tertiary syphilis conveniently divided into three
main groups
Late benign syphilis
Cardiovascular syphilis
Neurosyphilis
26. Congenital Syphilis
Mode of transmission:
Trans placental passage from infected mother
At birth
Congenital infection is associated with several
adverse outcomes including:
Low birth wt
Congenital anomalies
Premature birth
Miscarriages or death of baby
27. Lab diagnosis of syphilis
Tests are divided in four categories :
Direct microscopic exam - used when
lesions are present
Non treponemal tests - used for screening
Treponemal tests - are confirmatory
Direct antigen detection tests - used in
research settings and as gold standards for
test evaluation
28. TREATMENT
Early infections
The first-line treatment for uncomplicated syphilis remains
a single dose of intramuscular benzathine benzylpenicillin.
Doxycycline and tetracycline are alternative choices for
those allergic to penicillin; due to the risk of birth defects,
these are not recommended for pregnant women.
Resistance to macrolides, rifampicin, and clindamycin is
often present.
Ceftriaxone, a third-generation cephalosporin antibiotic,
may be as effective as penicillin-based treatment.
It is recommended that a treated person avoid sex until the
sores are healed.
29. Late infections
For neurosyphilis, due to the poor penetration of
benzathine penicillin into the central nervous system, those
affected are given large doses of intravenous penicillin for a
minimum of 10 days.
If a person is allergic to penicillin, ceftriaxone may be used
or penicillin desensitization attempted.
Other late presentations may be treated with once-weekly
intramuscular benzathine penicillin for three weeks.
Treatment at this stage solely limits further progression of
the disease and has a limited effect on damage which has
already occurred.
TREATMENT
30. Jarisch-Herxheimer reaction
One of the potential side effects of treatment is
the Jarisch-Herxheimer reaction.
It frequently starts within one hour and lasts for 24
hours, with symptoms of fever, muscle pains,
headache, and a fast heart rate.
It is caused by cytokines released by the immune
system in response to lipoproteins released from
rupturing syphilis bacteria.
TREATMENT
31. Pregnancy
Penicillin is an effective treatment
for syphilis in pregnancy but there
is no agreement on which dose or
route of delivery is most effective.
TREATMENT