The appendicular skeleton consists of the
shoulder girdle with the upper limbs and the
pelvic girdle with the lower limbs
Shoulder girdle and upper limb:
Each shoulder girdle consists of:
•1 clavicle
•1 scapula.
Each upper limb consists of the following bones:
1 humerus, 1 radius, 1 ulna, 8 carpal bones, 5 metacarpal bones and 14 phalanges.
Bones of lower limb (Human Anatomy)
by DR RAI M. AMMAR
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Bones of lower limb (Human Anatomy)
by DR RAI M. AMMAR
www.facebook.com/drraiammar
www.twitter.com/drraiammar
www.instagram.com/drraiammar
www.linkedin.com/in/drraiammar
www.themedicall.com/blog/auther/drraiammar/
For Any Book or Notes Visit Our Website:
www.allmedicaldata.wordpress.com
www.drraiammar.blogspot.com
YOUTUBE CHANNEL :
https://www.youtube.com/channel/UCu-oR9V3OdFNTJW5yqXWXxA
ANY QUESTION ??
Get in touch with us at Any of the Above Social Media or Email at
drraiammar@gmail.com
allmedicaldata@gmail.com
A joint is an articulation between two bones in the body and are broadly classified by the tissue which connects the bones. The three main types of joints are: synovial, cartilaginous and fibrous.
Slideshow: Carpus andf Hand Bones
View The Fuinky Professor videos here
http://publishing.rcseng.ac.uk/journal/video?doi=10.1308%2Fvideo.2016.1.10&videoTaxonomy=FUNK
A joint is an articulation between two bones in the body and are broadly classified by the tissue which connects the bones. The three main types of joints are: synovial, cartilaginous and fibrous.
Slideshow: Carpus andf Hand Bones
View The Fuinky Professor videos here
http://publishing.rcseng.ac.uk/journal/video?doi=10.1308%2Fvideo.2016.1.10&videoTaxonomy=FUNK
Osseous system II , is the appendicular skeletal system , it representing about the bone of pectoral girdle , pelvic girdle and upper limbs and lower limbs. structure and function of humerus , radius ulna and structure and function of femur , tibia fibula.
Definition of pelvis, pelvis of structure, gynaecoid pelvis, types of pelvic bones, pelvic joints, pelvic ligaments, diameters, land marks, types of pelvis, functions of pelvis, deformities of pelvis all includes the detailed content of female pelvis.
Skeleton system- bones and their number with detailed description.bhartisharma175
this ppt consist of skeleton system and its types. it consist of every individual bone and their number in adult human being. easy to understand for students as well as for teachers.
Genetic polymorphisms are variations in gene sequences that occur in at least 1% of the general population, resulting in multiple alleles or variants of a gene sequence.
The most commonly occurring form of genetic variability is the single nucleotide polymorphism (SNP, often called “snip”)
Population pharmacokinetics is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest
Clinical pharmacokinetics is the discipline that applies pharmacokinetic concepts and principles in humans in order to design individualized dosage regimens which optimize the therapeutic response of a medication while minimizing the chance of an adverse drug reaction.
Cardiac cycle is defined as the succession of coordinated events taking place in the heart during each beat. Each heart beat consists of two major periods called systole and diastole.
Although some lymphocytes have a lifetime measured in years, most formed elements of the blood last only hours, days, or weeks, and must be replaced continually.
Negative feedback systems regulate the total number of RBCs and platelets in circulation, and their numbers normally remain steady.
The abundance of the different types of WBCs, however, varies in response to challenges by invading pathogens and other foreign antigens.
The heart has four chambers. The two superior receiving chambers are the atria (= entry halls or chambers), and the two inferior pumping chambers are the ventricles (= little bellies).
On the anterior surface of each atrium is a wrinkled pouchlike structure called an auricle
Desmopressin
Lypressin
Terlipressin
Felypressin
Argipressin
ornipressin
Desmopressin: It is a selective V2-receptor agonist and is more potent than vasopressin as an antidiuretic. It has negligible vasoconstrictor action. It is administered by oral, nasal and parenteral routes. Lypressin: It acts on both V1- and V2-receptors. It is less potent but longer acting than vasopressin. It is administered parenterally. Terlipressin: It is a prodrug of vasopressin with selective V1 action. It is administered intravenously. Felypressin: It is a synthetic analogue of vasopressin. It is mainly used for its vasoconstrictor (V1 ) action along with local anaesthetics to prolong the duration of action. Felypressin should be avoided in pregnancy because of its oxytocic (uterine stimulant) activity.
Management of Peripheral Neuropathy and Cardiovascular Effects in Vitamin B1...PARUL UNIVERSITY
Peripheral nerves are susceptible to damage by a wide array of toxins, medications, and vitamin
deficiencies. Vitamin B12 (VB12) deficiency neuropathy is a rare debilitating disease that affects
mostly the elderly. It is important to consider these etiologies when approaching patients with a variety
of neuropathic presentations in this review were have included most relevant and latest information on
mechanisms causing Peripheral neuropathy in VB12 deficiency. We also have included cardiovascular
disorders and their management. Hyperhomocysteinemia has been implicated in endothelial
dysfunction and cardiovascular disease. The association of homocysteine (Hcy) and VB12 with
cardiovascular risk factors in patients with coronary artery disease (CAD) has also been studied
Moyamoya disease (MMD) is a rare and unique cerebrovascular disease. The term “moyamoya” is Japanese and refers to a hazy puff of smoke or cloud. In people with moyamoya disease, this is how the blood vessels appear in the angiogram. MMD is characterized by the progressive stenosis of the distal internal carotid artery (ICA) resulting in a hazy network of basal collaterals called moyamoya vessels. This may be a consequence of Mutations in a few genes. In addition, MMD is also associated with many genetically transmitted disorders, including neurofibromatosis, Down syndrome, Sickle cell anemia, and Collagen vascular disease. It follows bimodal age distribution. Younger populations present with ischaemic symptoms, whereas adults show hemorrhagic symptoms The exact cause remains unknown. Immune, genetic and other factors contribute to this disease. It follows complex pathophysiology resulting in neovascularization as a compensatory mechanism. Diagnosis is based on cerebral angiography using the DSA scale. Treatment involves managing symptoms with medicine or surgery, improving blood flow to the brain, and controlling seizures. Revascularization helps to rebuild the blood supply to the underside of the brain.
A case report on Rheumatoid Arthritis with sickle cell traitPARUL UNIVERSITY
A female patient aged 6 years, a suspected case of sickle cell trait (SCT) having symptoms of Rheumatoid arthritis (RA),
while evaluating joint complaints in adult sickle cell disease (SCD) patients, a number of sickle cell-based entities come
to mind such as avascular necrosis, osteomyelitis, bone infarcts, and septic arthritis. RA is a chronic systemic
inflammatory disease, many reports highlighted the occurrence of RA in SCD presenting as diagnostic challenges for
cases with chronic inflammatory arthritis, SCT also have appeared to persist in some populations at a perplexingly high
rate given the degree of early mortality of homozygosity of SCD, our case report showed that not only SCD but if a patient
has SCT they can develop RA as complication. Our case report concludes that during the evaluation of a SCT patient who
presents with chronic synovitis, one should strongly consider the possibility of coexistence of RA and SCT.
Histamine is a biogenic amine present in many animal and plant tissues that function as neurotransmitters and are also found in non-neural tissues, have complex physiologic and pathologic effects through multiple receptor subtypes, and are often released locally.
It is also present in venoms and stinging secretions. It is synthesized by decarboxylation of the amino acid, histidine. Histamine is mainly present in storage granules of mast cells in tissues like skin, lungs, liver, gastric mucosa, placenta, etc. It is one of the mediators involved in inflammatory and hypersensitivity reactions.
Anabolic steroids promote protein synthesis and increase muscle mass, resulting in weight gain.
Testosterone is secreted by the testis and is the main androgen in the plasma of men. In women, testosterone (in small amounts) is secreted by the ovary and adrenal glands. Many of the androgens are modified forms of testosterone
Kinetics: Absorbed orally and from of injection site and undergoes rapid first pass metabolism and quick metabolism respectively. In order to retard the rate of absorption, testosterone esters in oil are used which are less polar than the free steroid.
DKA
HHS
CASE DISCUSSION
DIABETES COMPLICATION
Hyperglycaemia is the main cause leading to dehydration due to osmotic diuresis which, if severe, results in hyperosmolarity. In HHS, unlike diabetic ketoacidosis, there is no significant ketone production and therefore no severe acidosis.
Hyperosmolarity may increase blood viscosity and the risk of thromboembolism. Factors precipitating HHS are infection, myocardial infarction, poor adherence with medication regimens or medicines which cause diuresis or impair glucose tolerance, for example, glucocorticoids.
A study on the pharmacological management of mineral bone disease in chronick...PARUL UNIVERSITY
In patients with chronic kidney disease (CKD), along with progression of CKD,
abnormalities of mineral and bone metabolism develop, which result in altered serum levels of minerals
such as calcium and phosphorus, as well as abnormalities in parathyroid hormone (PTH) or vitamin D
metabolism. Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) is a serious burden because of
increased cardiovascular mortality thus making therapeutic improvements essential in CKD-MBD. The
present study was aimed at evaluation of pharmacological management of CKD-MBD.
Methods:A retrospective study including 180 patients divided into two groups of 90 each (diabetes
mellitus and non-Diabetes) was performed in the Department of Nephrology, SVIMS, Tirupati. Patients
who were on follow up for at least 3 years (2015-2017) were considered, serum parameters were measured at every six months with a total of 6 visits. First visit was taken as baseline and sixth visit as
conclusion.
Results:The disease incidence of CKD-MBD is more common in male patients i.e. 67.8%. Serum calcium
levels were significantly increased and eGFR was significantly decreased in all patients with CKD at
conclusion compared to baseline.Further, Serum calcium levels were significantly increased at conclusion
in CKD patients without DM and eGFR was significantly decreased at conclusion compared to baseline
in CKD patients with DM. The proportion of untreated patients is high for all the drugs except vitamin D
analogues in both subgroups of CKD patients.
Conclusion:Pharmacological intervention in CKD patients helps in the effective management of mineral
bone disease by maintaining serum calcium, phosphate and calcium phosphorous product status.
A Retrospective Study of Clinical and Biochemical Profile in Geriatric Patien...PARUL UNIVERSITY
The aim of the study was to evaluate the clinical and
biochemical characteristics of geriatric patients with type 2
diabetes mellitus (DM) attending tertiary care teaching hospital,
SVIMS, Tirupati. OBJECTIVES: To document clinical
features, biochemical parameters and anti-diabetic medications
received as per records. METHODOLOGY: This
retrospective study was performed in Department of
Endocrinology in SVIMS, Tirupati, over a period of 6 months.
Demograghic details, laboratory parameters and
pharmacotherapy details were collected in the pre-designed
annexure form. RESULTS: A total of 100 diabetic elderly
patients were included in the study. Out of which 57 were men,
43 were women. Most of them were under the age group of
60-64 years followed by other age groups. 28 patients were
having the diabetes duration of 11-15 years. Some of them were
having diabetic complications (such as diabetic retinopathy,
diabetic neuropathy, diabetic nephropathy). Among 100
patients, 32 patients were normal weight, 22 patients were
overweight, 28 patients were obese-I, 18 patients were obese-II.
About 85% of patients were having high lipid levels. Some
patients were on Oral Hypoglycemic Agents (OHAS), some
patients were using both Insulin & OHAS.CONCLUSION:
The present study comprised of 100 elderly type 2 diabetic
patients in which males were higher in number when compared
to females, most of the patients were in the age of group of
60-64 years. Hypertension was the most common co-morbidity
associated with DM followed by Coronary Artery Disease
(CAD). Diabetic neuropathy was the most prevalent
complication followed by Diabetic retinopathy and diabetic
nephropathy. In this study 46% of the patients were obese. Most
of the patients were on OHAS alone, some were on OHAS and
Insulin combination therapy while very few were on insulin
therapy alone. Dyslipidemia was present in 85% of the patients
and the most common form of dyslipidemia was low HDL and
high LD
Hypoxic ischemic encephalopathy and sepsis: A case studyPARUL UNIVERSITY
Hypoxic ischemic encephalopathy(HIE) is a rare neonatal cerebral hypoxic condition that occurs when entire brain is deprived of an adequate oxygen supply which can occur due to birth asphyxia. 40-60% of affected infants die by 2 years of age or have severe disabilities. The incidence of hypoxic ischemic encephalopathy is estimated to be 1.5 per 1000 live births. The decreased ability of the neonatal brain to eliminate free radicals and the increased susceptibility to the free radials leads to damage of neuronal tissue Case report: We found a rare HIE case of 1 day old child who was bought to the hospital with the complaints of difficulty in breathing and looks dull with a body weight of 2.5kg. The baby delayed crying after birth, on examination the baby has bluish appearance with irregular respiration and had two episodes of seizures. The partial pressure of oxygen (spo2) found was 86-98% and heart rate was 126 beats per minute, Then immediately started treatment was Oxygen inhalation 2litres/min, Intra Venous 10% dextrose and Normal saline. Brain CT scan was done and in the report focal cephalo hematoma was noted and the patient is treated with oxygen inhalation, Penicillin injection, Vitamin k, IV fluids, Netilmicin, Phenobarbeton, Ranitidine, vancomycin and hydrocortisone. The patient was completely stabilized and escorted him back to his house. Conclusion: The patient was diagnosed by HIE with sepsis as per clinical presentations. The baby was kept in ICU for five days and managed with anti-epileptics, Vitamin K, Antibiotics and Corticosteroids. The child was performed with whole body cooling followed by rewarming over 4 hours to maintain desired rectal temperature. After 5day therapy the child was succesfully stabilized and discharged.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
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Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
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In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
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Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
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Appendicular skeleton
1. APPENDICULAR SKELETON
Dr. S P SRINIVAS NAYAK,
PharmD, RPh, (MSc), (PGDND) (PhD)
ASSISTANT PROFESSOR, DEPT. OF PHARMACY PRACTICE, PU.
2. APPENDICULAR SKELETON
● The appendicular skeleton consists of the
shoulder girdle with the upper limbs and the
pelvic girdle with the lower limbs
1. Shoulder girdle and upper limb:
Each shoulder girdle consists of:
•1 clavicle
•1 scapula.
Each upper limb consists of the following bones:
1 humerus, 1 radius, 1 ulna, 8 carpal bones, 5 metacarpal bones and 14
phalanges.
3. CLAVICLE OR COLLAR BONE
● The clavicle is a long bone which has a double curve. It articulates
with the manubrium of the sternum at the sternoclavicular joint and
forms the acromioclavicular joint with the acromion process of the
scapula. The clavicle provides the only bony link between the upper
limb and the axial skeleton.
5. SCAPULA OR SHOULDER BLADE
The scapula is a flat triangular-shaped bone, lying on the posterior chest
wall superficial to the ribs and separated from them by muscles.
● At the lateral angle there is a shallow articular surface, the glenoid
cavity which, with the head of the humerus, forms the shoulder joint.
● On the posterior surface there is a spinous process that projects
beyond the lateral angle of the bone that overhangs the shoulder joint,
called the acromion process. It articulates with the clavicle at the
acromioclavicular joint.
● The coracoid process, a projection from the upper border of the bone,
gives attachment to muscles that move the shoulder joint.
7. This is the bone of the upper arm. The head
articulates with the glenoid cavity of the
scapula, forming the shoulder joint.
Distal to the head there are two roughened
projections of bone, the greater and lesser
tubercles, and between them there is a deep
groove, the bicipital groove or intertubercular
sulcus, occupied by one of the tendons of the
biceps muscle.
The distal end of the bone presents two
surfaces that articulate with the radius and
ulna to form the elbow joint.
PIPR, PARUL UNIVERSITY
HUMERUS
8. These are the two bones of the
forearm. The ulna is longer than
and medial to the radius and when
the arm is in the anatomical
position, i.e. with the palm of the
hand facing forward, the two bones
are parallel.
They articulate with the humerus at
the elbow joint, the carpal bones at
the wrist joint and with each other
at the proximal and distal
radioulnar joints.
PIPR, PARUL UNIVERSITY
ULNA AND RADIUS
9. Carpal or wrist bones There are eight carpal
bones arranged in two rows of four. From outside
inwards they are:
proximal row: scaphoid, lunate, triquetral, pisiform
distal row: trapezium, trapezoid, capitate, hamate.
Metacarpal bones or the bones of the hand
These five bones form the palm of the hand. They
are numbered from the thumb side inwards.
Phalanges or finger bones
There are 14 phalanges, three in each finger and
two in the thumb. They articulate with the
metacarpal bones and with each other.
PIPR, PARUL UNIVERSITY
THE BONES OF THE WRIST, HAND AND FINGERS
10. PELVIC GIRDLE AND LOWER LIMB
The bones of the pelvic girdle are:
2 innominate bones
1 sacrum.
The bones of the lower limb are:
1 femur • 1 tibia • 1 fibula
7 tarsal bones
5 metatarsals
14 phalanges.
1 patella
12. The pelvis is formed by the two
innominate bones which articulate
anteriorly at the symphysis pubis
and posteriorly with the sacrum at
the sacroiliac joints which are
synovial joints.
It is divided into two parts by the
brim of the pelvis, consisting of the
promontory of the sacrum and the
iliopectineal lines of the innominate
bones.
The greater or false pelvis is above
the brim and the lesser or true
pelvis is below.
PIPR, PARUL UNIVERSITY
THE PELVIS
13. Differences between male and
female pelves
The shape of the female
pelvis allows for the
passage of the baby
during childbirth. In
comparison with the male
pelvis, the female pelvis
has lighter bones, is more
shallow and rounded and
is generally more roomy.
PIPR, PARUL UNIVERSITY
14. FEMUR OR THIGH BONE
● The femur is the longest and strongest bone of the
body. The head is almost spherical and fits into the
acetabulum of the hip bone to form the hip joint.
In the centre of the head there is a small depression
for the attachment of the ligament of the head of the
femur. This extends from the acetabulum to the femur
and contains a blood vessel that supplies blood to an
area of the head of the bone. The neck extends outwards
and slightly downwards from the head to the shaft and
most of it is within the capsule of the hip joint.
The posterior surface of the lower third forms a flat triangular area
called the popliteal surface. The distal extremity has two articular
condyles which, with the tibia and patella, form the knee joint.
15. The tibia is the medial of the two bones of the
lower leg.
The proximal extremity is broad and flat and
presents two condoles for articulation with the
femur at the knee joint. The head of the fibula
articulates with the inferior aspect of the lateral
condyle, forming the proximal tibiofibular joint.
The distal extremity of the tibia forms the ankle
joint. with the talus and the fibula. The medial
malleolus is a downward projection of bone
medial to the ankle joint.
PIPR, PARUL UNIVERSITY
TIBIA OR SHIN BONE
16. The fibula is the long slender
lateral bone in the leg. The
head or upper extremity
articulates with the lateral
condyle of the tibia forming the
proximal tibiofibular joint and
the lower extremity articulates
with the tibia then projects
beyond it to form the lateral
malleolus.
PIPR, PARUL UNIVERSITY
FIBULA
18. PATELLA OR KNEE CAP
● This is a roughly triangular-shaped sesamoid bone associated with
the knee joint. Its posterior surface articulates with the patellar surface
of the femur in the knee joint and its anterior surface is in the patellar
tendon, i.e. the tendon of the quadriceps femoris muscle.
19. TARSAL OR ANKLE BONES
● There are seven tarsal bones which form the posterior part of the
foot. They are:
1 talus
3 cuneiform
1 calcaneus
1 cuboid.
1 navicular
20. Metatarsal bones of the foot
These are five bones, numbered from within outwards, which form the
greater part of the dorsum of the foot. At their proximal ends they
articulate with the tarsal bones and at their distal ends, with the
phalanges. The enlarged distal head of the 1st metatarsal bone forms
the 'ball' of the foot.
Phalanges of the toes
There are 14 phalanges arranged in a similar manner to those in the
fingers, i.e. two in the great toe (the halux) and three in each of the other
toes.