A 13-year-old male presents to clinic with knee pain. Slipped capital femoral epiphysis (SCFE) is discussed, which is a hip disorder where the femoral head remains in the acetabulum but the neck is displaced anteriorly and rotates externally. Risk factors include males ages 12-14, obesity, heredity, and hormonal abnormalities during puberty. Presenting symptoms can include hip, groin, or knee pain. Imaging including x-rays of both hips are needed for diagnosis. Surgical treatment options are discussed depending on stability and degree of slippage.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
Tendoachilles rupture and its managementRohan Vakta
Achilles tendon is the strongest tendon of body. There are many causes of its rupture. It can be acute or chronic rupture. Management of chronic rupture by semitendinosus tendon is mentioned here.
Prof. Anisuddin Bhatti Paediatric Orthopaedic Surgeon Dr. Ziauddin University Hospital, Clifton, Karachi delivered lecture on DZU Webinar series Lecture 2 on Legg Calve Perthes. Declared few pics and material taken from google.
The presentation I have made and uploaded provides you with an in-depth insight into the patterns the strabismus may take following anomalies of extraocular muscles, deformities of the orbital structures,innnervational disturbances.
The author does not assume responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
No copyright infringement, or plagiarism intended.
Amrit Pokharel
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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7.
What is SCFE
O Misnomer
O A hip disorder, the proximal femoral
metaphysis displaces in relation to the capital
femoral epiphysis.
O The femoral head remains in the acetabulum,
and the neck is displaced anteriorly and rotates
externally
9.
Epidemiology
O Males : females (2:1)
O 12 ± 1.5 years for girls and 13.5 ± 1.7 years
for boys (associated with puberty)
O Left hip is more commonly
O African American or Polynesian
O Obese children
O Unilateral is more common but bilateral
involvement varies 10% to 60%.
10.
11.
Etiology
O Heredity:
O 2nd family Member 7.1 % & close relative 14.1
% (Rennie 1974)
O Mechanical:
O Obesity.
O Minor Trauma
O Femoral retroversion
O Increased physeal obliquity
O Previous radiaotherapy to the femoral head
region
12.
Etiology
O Hormonal
O Puberty: estrogen ↑ & GH ↓ growth plate.
O Endocrinopathies: hypothyroidism,
hypogonadism, panhypopituitarism, growth
hormone abnormalities, systemic diseases such
as renal osteodystropy.
O Younger than 10 years
O Wight < 50th percentile.
13.
History
O Hip, groin, or knee pain, or limping
O 23 - 46% of patients: knee or distal thigh pain
as initial presentation (Carney 1991)
O The diagnosis is missed most often because
patients present with knee pain.
O Weight Bearing
O Younger Patient or < 50th percentile.
14.
Physical Examination
O General
O Gait
O Antalgic or Trendelenburg
O Foot Progression angle External rotated
O Local
O Look: Position, thigh
O ↓ Internal rotation & flexion
O Obligatory external rotation during passive
flexion of hip
15.
Imaging
O X-ray
O U/S
O Acute
O Chronic
O CT:
O Three-dimensional visualization of femoral
head displacement
O MRI:
O Pre-slip.
O Growth plate widening
25.
Temporal Classification
O Based on duration of the symptoms
O Acute < 3 weeks
O 10 -15 % of SCFE
O Chronic > 3 weeks
O 85 % of SCFE
O Acute exacerbation of long-standing symptoms
26.
Loder Classification
O 1993, based on SCFE stability:
O Stable: Able to bear weight with or without
crutches
O Un-stable: Unable to ambulate
O Predict osteonecrosis
O Single study, 47 % vs. 0 %
27.
Grading System
O Percentage of epiphyseal displacement relative
to metaphyseal width of femoral neck
O Mild (0% to 33%)
O Moderate (33% to 50%)
O Severe (>50%)
29.
Southwick Angle Classification
O Subtraction of the angle on the normal side
from the angle of the affected hip
O Mild Slip: < 30° difference
O Moderate Slip: 30° - 60° difference
O Severe Slip: > 60° difference
33.
Non-Surgical
O No longer recommended
O Complications:
O Chondrolysis: up to 67%
O Recurrent slip after cast removal: 18%
O Full-thickness pressure ulcers: 16%
O Osteonecrosis: 7%
34.
Surgical
O Considerations:
O Is the slip stable or unstable ?
O Is the slip acute, chronic, or acute-on-chronic ?
O What is the degree of slippage ?
O Is the age of the patient outside of the expected
range (10 to 16 years) ?
O Does the patient have a systemic disorder ?
35.
Surgical Option
O Treatment to prevent further slippage
O Percutaneous in situ fixation
O Open bone bone-peg epiphysiodesis
O Treatment to reduce the degree of slippage
O Corrective osteotomies
O Salvage Procedures
36.
Percutaneous In-situ Fixation
O Reduction of epiphysis ?
O One Vs. Two cannulated screw
O Prophylactic Pinning of Contralateral Hip
O Risk Factors
39.
Percutaneous In-situ Fixation
O Procedure:
O Position:
O Angio vs. Fracture table.
O Proper x-ray
O Skin Markers for the entry point
O The Aim is center-center position of the screws
must be at least 5 mm from subchondral bone
in all views & perpendicular to the physis.
O “APPROACH-WITHDRAW” Technique
50.
Percutaneous In-situ Fixation
O Post OP care
O Educate for contralateral hip
O Follow up every 3 - 4 months until physis
closure, x-rays both hips
O Do not remove screw unless complications
O Rehabilitation Protocol
51.
Percutaneous In-situ Fixation
O Rehabilitation
O stable slip
O weight as tolerated with crutches.
O Return to athletic activity is patient-dependent
and is typically allowed 3 to 6 months
postoperatively
O unstable slip
O 4 - 6 weeks of non-weight bearing
O In the absence of osteonecrosis, the
recommendation to wait 6 months or until
physeal closure before returning to impact
activities.
52.
Open bone bone-peg
epiphysiodesis
O Complication:
O Extensive surgical approach
O Longer OR time
O Increased blood loss
O Potential continued slippage
O Need for hip spica immobilization
54.
Corrective Osteotomies
O Indications
O Severe Chronic slips (> 60°)
O Types:
O Subcapital, Femoral Neck, Intertrochanteric, or
Subtrochanteric
O Subcapital and femoral neck levels provide the
most correction but should be avoided because
the osteonecrosis (37% of cases) and future
osteoarthritis (37%)
O Correction consists of flexion, valgus and
derotation
57.
Surgical Hip Dislocation
O First described by Ganz
O Epiphyseal reorientation
O No randomized trials with long-term follow-
up are available
58. O The mean pre-operative slip angle was 40.2
degrees on the AP view and 50.65 degrees on
the lateral view. Post-operatively, the mean
values were 7,20 degrees on the AP view and
9,45 degrees on the lateral view
O The small number of technical complications
appears favourable considering the surgical
complexity of the procedure, and our
technique offers clear advantages in treating
these complex deformities.
62.
Complication
O Osteonecrosis
O Risk factor
O Stability of the slip
O Placement of screw in the posterior and superior
O Severe SCFE
O Most symptoms within 2 12 mo (up to 18)
64.
Complication
O Chondrolysis
O Definition: joint space reduction of more than
50% compared with the uninvolved side or,
with bilateral disease, a total joint space less
than 3mm
O Risk Factor:
O Unrecognized pin penetration esp. antrosuperior
O Hip spica cast treatment
O Autoimmune destruction
O 5% to 7% of patients with SCFE
65.
Complication
O Recurrent slip
O 1-3 % of cases
O poor pin placement,
O growth of the epiphysis off the implant,
O removal of the implant prior to growth plate
closure
72.
Q 1
An 12-year-old girl presents with groin pain six months
after treatment of a slipped capital femoral epiphysis.
Preoperative radiographs are seen in Figure A, radiographs
six months after in situ fixation are seen in Figure B.
Which of the following is associated with the radiographic
abnormality seen in Figure B?
O 1. Lack of reduction prior to fixation
O 2. Single screw fixation
O 3. Female sex
O 4. Inability to bear weight preoperatively
O 5. Obesity
74.
Q 1
An 12-year-old girl presents with groin pain six months
after treatment of a slipped capital femoral epiphysis.
Preoperative radiographs are seen in Figure A, radiographs
six months after in situ fixation are seen in Figure B.
Which of the following is associated with the radiographic
abnormality seen in Figure B?
O 1. Lack of reduction prior to fixation
O 2. Single screw fixation
O 3. Female sex
O 4. Inability to bear weight preoperatively
O 5. Obesity
75.
Q 2
O Southwick angle (epiphyseal-shaft angle)
serves what purpose in the evaluation of a
slipped capital femoral epiphysis (SCFE)?
O 1. Determine prognosis for AVN
O 2. Determine the severity of the slip
O 3. Determine the presence or absence of a slip
O 4. Determine the etiology of a slip
O 5. Determine the chronicity of the slip
76.
Q 3
O An 11-year-old boy with hypothyroidism
presents with groin pain and the inability to
ambulate. His radiograph is shown in Figure
A. What is the most appropriate treatment?
O 1. Toe-touch weigh tbearing for 3 weeks
O 2. Hip spica cast and non-weight bearing for 4
weeks
O 3. In situ pinning of the right hip
O 4. Open reduction and pinning of the right hip
O 5. In situ pinning of both hips
78.
Q 3
O An 11-year-old boy with hypothyroidism
presents with groin pain and the inability to
ambulate. His radiograph is shown in Figure
A. What is the most appropriate treatment?
O 1. Toe-touch weight bearing for 3 weeks
O 2. Hip spica cast and non-weight bearing for 4
weeks
O 3. In situ pinning of the right hip
O 4. Open reduction and pinning of the right hip
O 5. In situ pinning of both hips
79.
Q 4
O A 14-year-old overweight boy complains of vague left knee
pain which worsens with activity. He has an antalgic gait and
increased external rotation of his foot progression angle
compared to the contralateral side. Knee radiographs,
including stress views, are negative. What is the next step in
management?
O 1. Knee MRI
O 2. Knee CT
O 3. AP pelvis and frog-lateral views
O 4. Diagnostic knee arthroscopy
O 5. Hip MRI