This document discusses the evaluation and differential diagnosis of hip pain in children. It outlines the key steps as obtaining a thorough history, conducting a physical exam, ordering relevant lab tests and imaging studies, and providing follow up care. The differential diagnosis for hip pain in children can include traumatic injuries, infections like septic arthritis, inflammatory conditions such as Legg-Calve-Perthes disease, and vascular causes like osteonecrosis. Joint aspiration is an important diagnostic tool to differentiate between potential infectious and non-infectious causes.
Madelung deformity is an abnormality of the palmar ulnar part of the distal radial physis in which progressive ulnar and volar tilt develops at the distal radial articular surface, with dorsal subluxation of the distal ulna.
Madelung deformity is an abnormality of the palmar ulnar part of the distal radial physis in which progressive ulnar and volar tilt develops at the distal radial articular surface, with dorsal subluxation of the distal ulna.
Approach to child with leg pain-Septic arthritisAtheer Al-zubedi
Septic arthritis is a "diagnosis not to miss" in the evaluation of a child with hip pain, given the potential for rapid joint destruction and long-term morbidity that can accompany delay in diagnosis and treatment.
29-2-40
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. Case Presentation
• 8y/F.
• 2d worsening hip & thigh pain, 1st time.
• No trauma.
• Stopped playing e friends.
• Walks few steps then sits down.
4. Case Presentation
• No fever now.
• 10d ago streptococcal pharyngitis e fever.
• No insect bite or rashes.
• No other joint C/O.
• Normal milestones & immunizations.
17. Physical Examination
Ability to bear weight through the knees proximally
when crawling can localize the problem to the legs
or feet.
Inability to sit comfortably may point to spinal pathology,
What about the child who refuses to bear weight ??
18. Physical Examination
what is the Resting Position of the hip ?
• Flexion, abduction, and outward rotation
• Febrile infant holding the hip in this position at rest
likely needs an aspiration and arthrogram to rule out
pyarthrosis.
19. How can you differentiate between Acute and Chronic
Pathology….!!
• Thigh atrophy (measured at a standard distance above
the patella)
20. Laboratory studies
• Most frequently ordered are
(CBC) with differential,
(ESR),
(CRP),
Rheumatoid Panel (RF, ANA).
Blood culture
Synovial fluid analysis
21. The ESR and CRP …
• are acute phase reactants, and either infectious, inflammatory,
or neoplastic causes can result in elevation above normal
levels.
• The CRP will increase and decrease faster than the ESR
ESR and CRP are better negative predictors
24. Slipped capital femoral epiphysis
• SCFE is a disorder of the physis of the proximal femur.
• Age 10 -16 years old
• Boys > Girls
• It is bilateral in 20% of patients at the time of initial presentation,and another 20%
to 30% will develop a contralateral slip within 12 to 18 months of the initial slip.
25. • Acute slip
• Sudden onset of pain,
severe enough to prevent
weight bearing
• Normal WBC, CRP, and
ESR
Chronic slip;
• Most common presentation
• Pain referred to hip, distal
medial thigh, or knee
• Loss of internal rotation and
abduction
• May have limped for months
26. the goal of evaluation of ambulatory patients who have SCFE??
• Treat them (better life)
• Prevent progression of stable to an unstable SCFE.
• Prevent developing osteoarthrosis.
30. Transient synovitis
Hip pain, muscle spasm, restriction of
motion, refusal to walk
• Onset acute or insidious
• Usually appear healthy
• Diagnosis of exclusion
• Age 2-8 years
• septic Arthritis ;
exaggerated clinical picture of
Transient Synovitis
31.
32. Pyomyositis
Similar clinical presentation for septic arthritis !!
Typically ESR and CRP are elevated.
Keep it in mind if hip aspiration or arthrogram is negative and
the patient continues to manifest signs of infection (fever, positive
blood cultures).
MRI is the best imaging study to assess for both of them
33. Joint Aspiration
Should be sent for;
Cytology (in regular tubes)
Microbiology (in blood culture tubes)
Biochemistry (in green tubes)
Histology (in Formaline saline)
34. Joint aspiration is essential for the diagnosis.
WBC >50,000 with 75% nuetrophils.
Gram stains of the aspirate are positive in 30% to 50% of cases
cultures are positive in 50% to 80%.
Synovial protein levels that are 40 mg/dL and are less than the
serum protein levels
Lactate levels are typically elevated and the glucose level in the
aspirate is lower than the level in the serum.
35. Vascular causes
Idiopathic osteonecrosis of the proximal femoral epiphysis.
Age 4 - 8 years old
Boys > Girls
Develop pain, typically in concert with femoral head collapse.
36. • History of pain in the hip, thigh, or knee.
• On Examination pain at the end range of motion, especially
abduction and internal rotation, with less painful mid range
motion.
• Symptoms and limp severity are usually
• worse at the end of the day.
39. Summery
• High index of suspicion
• Clinical presentation in infantile is not classical.
• Never let the sun set on pus under pressure.
• Aspirated samples ?? what we want to know?
• Knee pain equals hip pain
• Hilton’s low
• Heamoglobinopathies might be the cause.
40. transient synovitis or septic arthritis?
History of trauma and through history of pain is
important.
Never start antibiotics before sending for cultures.