g protein coupled receptors, ion channels, types of receptors, wnt signalling, cell signalling, tranduction pathway, disorders regarding the signalling
here is some information about autophagy, how it happend, when it happend and it's mechanism.
and some information about it's effect on cancer and some disorders.
G Proteins - Dr. P. Saranraj, Assistant Professor, Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Vellore District, Tamil Nadu, India.
GENERAL IDEA OF SIGNAL TRANSDUCTION
DEFINATION
WHAT DOES THE TERM SIGNAL TRANSDUCTION MEANS
HISTORY
BASIC ELEMENTS IN SIGNAL TRANSDUCTION
TYPES OF SIGNAL TRANSDUCTION
SIGNALLING MOLECULE
RECEPTOR MOLECULE
MODES OF CELL CELL SIGNALING
SECOND MESSENGER
SIGNAL TRANSDUCTION PATHWAY
SOME SIGNALING PATHWAYS
SIGNIFICANCE
CONCLUSION
REFERENCE
here is some information about autophagy, how it happend, when it happend and it's mechanism.
and some information about it's effect on cancer and some disorders.
G Proteins - Dr. P. Saranraj, Assistant Professor, Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Vellore District, Tamil Nadu, India.
GENERAL IDEA OF SIGNAL TRANSDUCTION
DEFINATION
WHAT DOES THE TERM SIGNAL TRANSDUCTION MEANS
HISTORY
BASIC ELEMENTS IN SIGNAL TRANSDUCTION
TYPES OF SIGNAL TRANSDUCTION
SIGNALLING MOLECULE
RECEPTOR MOLECULE
MODES OF CELL CELL SIGNALING
SECOND MESSENGER
SIGNAL TRANSDUCTION PATHWAY
SOME SIGNALING PATHWAYS
SIGNIFICANCE
CONCLUSION
REFERENCE
Signal transducing machinery as targets for potential drugs.
Drugs:-
a). Diclofenac- for treating cholera toxin
b). Fasentin- for treating insulin signalling
1.Receptors Link to other Enzymatic Activity.
2.Pathway of Intracellular Signal Transduction.
3.The Cyclic AMP pathway4.Cyclic GMP pathway
5.Phospholipids and Ca2+
6.The PI3-Kinase /Akt and mTOR pathways.
7.MAP Kinase Pathway.
Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis
In biology, cell signaling is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis.
Respiratory stimulants: types, complete discussion on indications, contraindications, assessment, patient notes and examples of stimulants both central and respiratory
Expectorants and Antitussives: types, complete discussion on indications, contraindications, assessment, patient notes and examples of expectorants and antitussives
Complete pharmacology of Non steroidal Anti inflammatory Drugs, classification, Mechanism of action, Pharmacological actions, Indications, Contraindications, Adverse effects
Pharmacology laboratory experiment, both invivo and invitro includes interpolation, matching , bracketing, three point, four point bioassays with a note on hypoglycemic activity, acute skin irritation, acute eye irritaiton, pyrogen test, gastrointestinal motility test, physiological salt solutions
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
signal transduction
1. Signal Transduction andSignal Transduction and
the Related Disordersthe Related Disorders
RVS Chaitanya KoppalaRVS Chaitanya Koppala
Assistant professorAssistant professor
Lovely Professional University, PunjabLovely Professional University, Punjab
2. General Introduction of Cell SignalGeneral Introduction of Cell Signal
TransductionTransduction
3. Concept of Cell Signaling
The process in which cells sense the extracellular stimuli
through membranous or intracellular receptors, transduce the
signals via intracellular molecules, and thus regulate the
biological function of the cells
4. Signal molecules
Physical signals
Light, electronic, mechanic, UV, heat, volume or osmotic, etc
Chemical signals
Hormones, neurotransmitters, Growthe factors, cytokines,
odor molecules, ATP, active oxygen, drugs, toxins, etc
5. Endocrine: Act on a far away organ via blood circulation
Paracrine: Act on a nearby target
Autocrine: Act on itself after secreted
Synaptic: Presynaptic to postsynaptic,
Autocrine
Endocrine Paracrine
Synaptic
Modes for the function of endogenous signals
7. G-protein-mediated pathway
High moleular weight G-protein
(trimeric GTP-binding regulatory protein )
Low moleular weight G-protein
Ras
Classification of G-protein
G-proteins, coupled with members of the seven transmembrane
domain of the receptor superfamily, are regulatory proteins that
act as molecular switches. They control a wide range of
biological processes
8. Regulation of G-Protein Activity
G protein-coupled receptors exhibit a common structural motif consisting of
seven membrane spanning regions. Receptor occupation promotes interaction
between the receptor and the G protein on the interior surface of the
membrane. This induces an exchange of GDP for GTP on the G protein α
subunit and dissociation of the α subunit from the βγ heterodimer. Depending
on its isoform, the GTP-α subunit complex mediates intracellular signaling
either indirectly by acting on effector molecules such as adenylyl cyclase (AC)
or phospholipase C (PLC), or directly by regulating ion channel or kinase
function.
15. G-protein-mediated pathway
cAMP can activate protein kinase A(PKA), which can phosphorylate
CREB ( binding protein of cAMP-respones element ) and initiate gene
transcription.
Adenylate cyclase mediated
pathway
17. Non-G-protein-mediated pathway
Receptor tyrosine kinase mediated pathway
Receptor tyrosine kinases transmit signals across the plasma membrane,
from the cell exterior to the cytoplasm.
The interaction of the external domain of a receptor tyrosine kinase with
the ligand, often a growth factor, up-regulates the enzymatic activity of the
intracellular catalytic domain, which causes tyrosine phosphorylation of
cytoplasmic signaling molecules.
Receptor tyrosine kinase mediated pathway
Receptor serine/threonine kinase mediated pathway
Receptor guanilate cyclase mediated pathway
Intracellular (unclear) receptor mediated pathway
18. Receptor tyrosine kinases transmit signals across the plasma membrane,
from the cell exterior to the cytoplasm.
The interaction of the external domain of a receptor tyrosine kinase with
the ligand, often a growth factor, up-regulates the enzymatic activity of the
intracellular catalytic domain, which causes tyrosine phosphorylation of
cytoplasmic signaling molecules.
Receptor tyrosine kinase mediated pathway
19. Mechanism of Tyrosine Kinase Receptors
When hormone binds to the extracellular domain the receptors aggregate
20. When the receptors aggregate, the tyrosine kinase domains phosphorylate
the C terminal tyrosine residues
Mechanism of Tyrosine Kinase Receptors
21. This phosphorylation produces binding sites for proteins with SH2 domains.
GRB2 is one of these proteins. GRB2, with SOS bound to it, then binds to
the receptor complex. This causes the activation of SOS.
Mechanism of Tyrosine Kinase Receptors
22. SOS is a guanyl nucleotide-release protein (GNRP). When this is
activated, it causes certain G proteins to release GDP and exchange it for
GTP. Ras is one of these proteins. When ras has GTP bound to it, it
becomes active.
Mechanism of Tyrosine Kinase Receptors
23. Activated ras then causes the activation of a cellular kinase called raf-1
Mechanism of Tyrosine Kinase Receptors
24. Raf-1 kinase then phosphorylates another cellular kinase called
MEK. This cause the activation of MEK
Mechanism of Tyrosine Kinase Receptors
25. Activated MEK then phosphorylates another protein kinase called MAPK
causing its activation. This series of phosphylating activations is called a
kinase cascade. It results in amplification of the signal
Mechanism of Tyrosine Kinase Receptors
26. Among the final targets of the kinase cascade are transcriptions factors
(fos and jun showed here). Phosphorylation of these proteins causes them
to become active and bind to the DNA, causing changes in gene
transcription
Mechanism of Tyrosine Kinase Receptors
28. (1) Type I and type II
receptors for TGF(beta) in
a cell prior to binding of the
growth factor.
(2) Binding of growth factor
results in clustering of type
I and type II receptors, and
phosphorylation of type I
receptors by type II
receptors.
(3) The activated type I
receptors then
phosphorylate particular
receptor-mediated Smads.
(4) These Smads then bind to
other Smads (co-Smads),
and together they enter the
nucleus.
Receptor serine/threonine kinase mediated pathway
32. Networks of Signal Transduction
600 G protein-coupled receptors
Multiple gene families and combinations
of G protein subunits
20Gα isoforms
6 Gβ isoforms
12 Gγ isoforms
Multiple gene families for selected effector proteins
Adenylyl cyclases
Phospholipases
Ion channels
+
+
33. The magnitude of amplification within this cellular cascade structure often
exceeds 10+4. That is, the binding of one molecule of ligand to a cell-surface
receptor leads a change of 10,000-fold in the intracellular concentration of a
metabolic product.
Cascade structure of cellular signal pathways
34. Dysfunction of cellular signal
transduction in diseases
Aberrant Signal in cell signaling
Aberrant Receptor in cell signaling
Aberrant G-protein in cell signaling
Aberrant Intracellular Signaling
Multiple Abnormalities in cell signaling
35. Aberrant Signal in cell signaling
ischemia, epilepsy, neurodegenerative diseases
extracellular glutamate/aspartic acid
NMDAR activation
Ca2+
influx
[Ca2+
]i , activation of enzymes
excitatory intoxication
36. Receptor-based diseases
Alterations in number, structure or function of receptors
will lead to disorder in cellular signal transdution
Up-regulation/hypersensitivity
Down-regulation/desensitization
Receptor Gene Mutation
Aberrant Receptor in cell signaling
37. Myasthenia Gravis is an autoimmune receptor disorder in
which antibodies form against acetylcholine(Ach) nicotinic
postsynaptic receptors at the neuromuscular junction
Myasthenia Gravis
39. manifestations
Drooping of the eyelids
Double vision
Difficulty smiling, speaking, swallowing
Difficulty raising the arms
Difficulty walking
Difficulty breathing if chest muscle are affected
44. Receptor Gene Mutation--
Genetic insulin-resistant diabetes
NIDDM is a chronic metabolic syndrome defined by resistance to
the hormone insulin. This leads to inappropriate hyperglycaemia
(increased blood sugar levels) and deranged metabolism of
carbohydrate, fats and proteins.
Diabetes Mellitus Type 1
Diabetes Mellitus Type 2
Non-Insulin dependent diabetes mellitus, NIDDM
45. The cause of Diabetes Mellitus Type 2 is not known, but it may involve a defect
or change in the insulin receptor (IR).
mechanism
46. Disturbances in
synthesis
transfer to the membrane
affinity to insulin
RPTK activation
proteolysis
Genetic insulin-resistant diabetes
IR gene mutations
Diabetes Mellitus Type 2
48. mechanism
Gsα gene mutation
GTPase activity
Persistent activation of Gsα
Persistent activation of AC
cAMP
Acromegaly or Gigantism
Pituitary proliferation and secretion
52. Aberrant Intracellular Signaling
The intracellular signaling involves various messengers,
transducers and transcription factors. Disorders can occur in
any of these settings.
54. Wnt-1 was found as an oncogene activated by the Mouse Mammary Tumor Virus in murine breast cancer.
APC was first isolated as a tumor suppressor gene in human colon cancer. After establishing that APC and
beta-catenin bind to each other activating mutations in the human beta-catenin gene were found in human
colon cancer and melanomas .These mutations alter specific beta-catenin residues important for GSK3
phosphorylation and stability .The role for Frat/GBP in cancer is illustrated by its activation by proviral
insertion in mouse lymphomas. Interestingly, mutations in the human AXIN1 gene were reported in human
hepatocellular carcinomas. TCF1 can also act as a tumor suppressor gene , as Tcf1 mutant mice develop
adenomas in the gut and mammary glands
Cancer
55. Multiple Abnormalities in Signaling Pathway
In the development of diseases, the aberrant cellular signal
transduction usually involves multiple molecules or pathways.
Such diseases include type-2 diabetes mellitus, cancers,
hypertension, and so on
56. Multifactor Aberrancies and Cancer
(Enhancement of proliferating signals)
Ligands (GFs)
Receptors (overexpression, activation of TPK)
Intracellular transducers :
Ras mutation Ras-GTPase Ras activation Raf
MEK ERK Proliferation
Cancer
57. Multifactor Aberrancies and Cancer
(Deficits in proliferation-inhibiting signal)
Smad2 SARA
Smad2
Smad2Smad4
Smad4
P300
Fast2P300
Smad4 Smad2
Fast2
-P
-P
-P
P15、P21
Smad6,7
Cell memberane
Cytosal
Nuclear membrane
Ⅱ Ⅰ Ⅱ Ⅰ
GS
(TGF-β )2
(—)
58. Principles for Treatment
To regulate the level of extracellular molecules
To regulate the structure and the function of receptors
To regulate the level and modifications of intracellular
messenger molecules and transducers
To regulate the level of nuclear transcription factors
Target Therapy