Shock is a clinical syndrome characterized by a systemic imbalance between oxygen supply and demand. It progresses through three stages: compensatory shock, progressive shock, and irreversible shock. Types of shock include hypovolemic, cardiogenic, septic, neurogenic, and anaphylactic shock. Treatment focuses on identifying and treating the underlying cause, restoring intravascular volume through fluid resuscitation, and providing supportive care and organ function support. Nursing care involves careful monitoring for signs of deteriorating condition and interventions to increase patient comfort.
Cardiogenic shock is a condition of diminished cardiac output that severely impairs cardiac perfusion. In this condition in which the heart suddenly can't pump enough blood to meet the body's needs.
Shock is a life threatening situation due to poor tissue perfusion with impaired cellular metabolism, manifested in turn by serious pathophysiology abnormalities.
Cardiogenic shock is a condition of diminished cardiac output that severely impairs cardiac perfusion. In this condition in which the heart suddenly can't pump enough blood to meet the body's needs.
Shock is a life threatening situation due to poor tissue perfusion with impaired cellular metabolism, manifested in turn by serious pathophysiology abnormalities.
this presentation includes all the parts of shock. its definition classisfication, types of shock, pathophysiology, and additiionaly also includes clinical emergencies such as anaphylactic shock and syncope. hope this helps everyone.
Dr satyaki Verma
Dept of perio
shock is the state of insufficient blood flow to the tissues of the body .it contains introduction, definition, stages of shock, types of shock, diagnostic evaluation, prognosis ,prevention, care for each stage.
this presentation includes all the parts of shock. its definition classisfication, types of shock, pathophysiology, and additiionaly also includes clinical emergencies such as anaphylactic shock and syncope. hope this helps everyone.
Dr satyaki Verma
Dept of perio
shock is the state of insufficient blood flow to the tissues of the body .it contains introduction, definition, stages of shock, types of shock, diagnostic evaluation, prognosis ,prevention, care for each stage.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
4. STAGE I: COMPENSATORY SHOCK
Pressure changes detected by the baroceptors in the aorta.
Activation of compensatory mechanism by
1- activation of sympathetic nervous system to cause
vasoconstriction.
2- secretion of adrenaline and nor adrenaline from adrenal to cause
vasoconstriction
3-activation of renin angiotensin aldosterone system to cause
vasoconstriction and promote reabsorption of water from kidneys.
4- secretion of Anti di uretic hormone for reabsorption of water from
kidneys
To increase the blood pressure.
5. STAGE II: PROGRESSIVE SHOCK
•Sustained drop in blood pressure
•The cell does not get enough oxygen to produce energy, they
shift to anaerobic respiration.
•Production of lactic acid as bi product.
•Lactic acid causes acidosis
6. STAGE III: IRREVERSIBLE SHOCK
•Irreversible stage the tissue anoxia becomes generalized and
wide spread cell death happens.
•Death of vital organs contributes to subsequent death of the
body.
9. 1- HYPOVOLEMIC SHOCK
Hypovolemic shock, the most common type of shock, is characterized by a
decreased intravascular volume.
Hypovolemic shock is caused by a decrease in intravascular volume of 15%
or more
Etiology
Trauma
Surgery
Vomiting
Diarrhea
Diuresis
Hemorrhage
Burns
Ascites
Peritonitis
Dehydration
10. MANAGEMENT
TREATMENT OF THE UNDERLYING CAUSE
If the patient is hemorrhaging, efforts are made to stop the bleeding.
This may involve applying pressure to the bleeding site or surgery to
stop internal bleeding.
FLUID AND BLOOD REPLACEMENT
At least two large-gauge intravenous lines are inserted to establish
access for fluid administration.
administration of fluid(isotonic, colloids), medications, and blood
component therapy if required.
the goal of the fluid replacement is to restore intravascular volume
11. 2-CARDIOGENIC SHOCK
Cardiogenic shock occurs when the heart’s ability to contract and to
pump blood is impaired.
Cardiogenic shock is defined as a condition when the heart’s
pumping ability is compromised to the point that it cannot maintain
cardiac output and adequate tissue perfusion.
Etiology
•Myocardial infarction
•Cardiomyopathies
•Valvular damage
•Dysrhythmias
•CCF
12. MANAGEMENT
The treatment include
CORRECTION OF UNDERLYING CAUSES
In coronary cardiogenic shock, the patient may require thrombolytic
therapy, angioplasty, or coronary artery bypass graft surgery.
In the case of noncoronary cardiogenic shock, the patient may require
a cardiac valve replacement or correction of a dysrhythmia.
13. INITIATION OF FIRST-LINE
TREATMENT
• Supplying supplemental oxygen
• Controlling chest pain
• Providing selected fluid support
• Administering vasoactive medications(eg. Nitroglycerin, Dopamine,
adrenaline)
• Controlling heart rate with medication or by implementation of a
transthoracic or intravenous pacemaker
• Implementing mechanical cardiac support (intra-aortic balloon
therapy, ventricular assist systems, or cardiopulmonary bypass)
• Hemodynamic monitoring
14. 3- SEPTIC SHOCK
Septic shock is a serious medical condition that occurs when sepsis,
leads to dangerously low blood pressure and abnormalities in cellular
metabolism due to vasodilation.
Risk Factors
•Immunosuppression
•Extremes of age (<1 yr and >65 yr)
•Malnourishment
•Chronic illness
•Invasive procedures
15. MANAGEMENT
Current treatment of septic shock involves identifying and
eliminating the cause of infection.
Specimens of blood, sputum, urine, wound drainage, and invasive
catheter tips are collected for culture using aseptic technique.
If the infecting organism is unknown, broad-spectrum antibiotic
agents are started until culture and sensitivity reports are
received.(Eg. Ceftriaxone, Cefotaxime,meropenem )
After the reports the antibiotic sensitive for the organism is started
16. 4- NEUROGENIC SHOCK
Neurogenic shock is a condition in which massive vasodilation occurs
as a result of a loss of sympathetic tone. This can be caused by spinal
cord injury, spinal anesthesia, or nervous system damage.
17. MANAGEMENT
•Dopamine is often used either alone or in combination with
other inotropic agents.
•Certain vasopressors (ephedrine, norepinephrine).
•Phenylephrine may be used as a first line treatment, or secondarily in
people who do not respond adequately to dopamine.
18. 5- ANAPHYLACTIC SHOCK
Anaphylactic shock is the result of a widespread humorally mediated
hypersensitivity reaction (anaphylaxis) resulting in vasodilatation,
pooling of blood in the periphery.
Etiology
•Penicillin (Drug) sensitivity
•Transfusion reaction
•Bee sting allergy
•Latex sensitivity
19. MANAGEMENT
•Treatment of anaphylactic shock requires removing the
causative antigen (eg, discontinuing an antibiotic agent).
•Epinephrine is given for its vasoconstrictive action.
Diphenhydramine (Benadryl) is administered to reverse the
effects of histamine, thereby reducing capillary permeability.
20. EMERGENCY MANAGEMENT OF
SHOCKAssess & Maintain patent airway (suction and intubation) and assess
breathing.
Put the patient on High flow oxygen
Stabilize cervical spine
Start 2 Large IV bore and administer crystalloids
Control and manage the underlying cause
Insert Catheter and Ng tube
Monitor vitals, consciousness, ECG saturation and urinary output
21. NURSING MANAGEMENT
1- Decreased Cardiac Output
•Assess and monitor cardiovascular function via the following:
■ Blood pressure
■ Heart rate and rhythm
■ Pulse oximetry
■ Peripheral pulses
■ Hemodynamic monitoring
•Measure and record intake and output
•Monitor bowel sounds, abdominal distention, and abdominal pain.
•Monitor for sudden sharp chest pain, dyspnea, cyanosis, anxiety,and
restlessness.
22. 2- Altered Tissue Perfusion
■ Monitor skin color, temperature, turgor, and moisture.
■ Monitor cardiopulmonary function
■ Monitor body temperature.
■ Monitor urinary output per Foley catheter hourly, using a urimeter.
■ Assess mental status and level of consciousness.
23. 3- Anxiety
1. Assess the cause(s) of the anxiety
2. Administer prescribed pain medications on a regular basis
3. Provide interventions to increase comfort and reduce restlessness:
■ Maintain a clean environment.
■ Provide skin and oral care.
■ Monitor the effectiveness of ventilation or oxygen therapy.
■ Eliminate all nonessential activities.
■ Remain with the patient during procedures.
■ Speak slowly and calmly, using short sentences.
■ Use touch to provide support.