Shigella is a bacterium that causes shigellosis, which was first discovered in the late 19th century by Japanese scientist Kiyoshi Shiga. It is transmitted via the fecal-oral route and infects the intestines. There are four subgroups of Shigella, with Shigella dysenteriae type 1 often causing epidemics. Symptoms include diarrhea, fever, and stomach cramps. Prevention focuses on handwashing and improving sanitation.
Clostridium is a genus of anaerobic, Gram-positive bacteria. Species of Clostridium inhabit soils and the intestinal tract of animals, including humans. This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
Clostridium are anerobic gram positive rod shaped spore forming organisms responsible to cause various life threatening diseases in humans like Gas gangrene, Tetanus, Botulism, etc
Neisseria is a large genus of bacteria that colonize the mucosal surfaces of many animals. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae.
Clostridium is a genus of anaerobic, Gram-positive bacteria. Species of Clostridium inhabit soils and the intestinal tract of animals, including humans. This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
Clostridium are anerobic gram positive rod shaped spore forming organisms responsible to cause various life threatening diseases in humans like Gas gangrene, Tetanus, Botulism, etc
Neisseria is a large genus of bacteria that colonize the mucosal surfaces of many animals. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae.
Season Plan for Ebola Virus Disease and Shigella BacteriaAbdullah Madir
this is my last presentation on this year but there is a lot presentation.. insyaallah later and when i have a time i'll upload all of them..
i hope u enjoy the slideshow and can solve your problem for your assignment..
tq..gudluck
The genus Shigella exclusively infects human intestine.
Shigella dysenteriae is the causative agent of bacillary dysentery or shigellosis in humans.
It is a diarrheal illness which is characterized by frequent passage of blood stained mucopurulent stools.
The four important species of the genus Shigella are:
Shigella dysenteriae
Shigella flexneri
Shigella sonnei
Shigella boydii.
shigellosis presentation , communicable diseases lecture, community medicine master , university of Khartoum
contains basic information about the disease, its clinical features and treatment
1. The laboratory findings and symptoms described are suggestive of .pdfarasanlethers
1. The laboratory findings and symptoms described are suggestive of Shigellosis. Shigella sp. are
facultative anaerobic, non-motile, non-spore forming, Gram negative bacilli belonging to the
family Enterobacteriaceae. The incubation period, although variable from 12 hours to a week, is
typically 1-3 days. Hemorrhagic colitis (causing bloody diarrhea) and severe abdominal cramps
are characteristic findings.
2. Secondary outbreaks of hemorrhagic colitis (bloody diarrhea) are quite common in
Shigellosis; food-borne transmission from improper hygiene being the most common cause.
3. The pathogen, being a facultative anaerobe, survives well in foods like salads, dips, shredded
vegetables, etc. It is most commonly transmitted from an infected individual by ingestion
through contaminated food and water, or direct contact.
4. The primary outbreak could have been stopped by securing the source of the infection;
Shigella do not survive for long outside the host and infections are usually from a concentrated,
point source.
Proper hygiene is the easiest way to prevent Shigellosis; any individual suspected of infection
must not be allowed to handle food preparation. Water used for washing ingredients and utensils
must meet microbial standards. People who handle food preparation must follow strict hygienic
measures.
Solution
1. The laboratory findings and symptoms described are suggestive of Shigellosis. Shigella sp. are
facultative anaerobic, non-motile, non-spore forming, Gram negative bacilli belonging to the
family Enterobacteriaceae. The incubation period, although variable from 12 hours to a week, is
typically 1-3 days. Hemorrhagic colitis (causing bloody diarrhea) and severe abdominal cramps
are characteristic findings.
2. Secondary outbreaks of hemorrhagic colitis (bloody diarrhea) are quite common in
Shigellosis; food-borne transmission from improper hygiene being the most common cause.
3. The pathogen, being a facultative anaerobe, survives well in foods like salads, dips, shredded
vegetables, etc. It is most commonly transmitted from an infected individual by ingestion
through contaminated food and water, or direct contact.
4. The primary outbreak could have been stopped by securing the source of the infection;
Shigella do not survive for long outside the host and infections are usually from a concentrated,
point source.
Proper hygiene is the easiest way to prevent Shigellosis; any individual suspected of infection
must not be allowed to handle food preparation. Water used for washing ingredients and utensils
must meet microbial standards. People who handle food preparation must follow strict hygienic
measures..
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
1. Sharq Elneil College
School of Medical Laboratory Sciences
Department of Microbiology
Medical Bacteriology course
shigella
U.Mahadi Hassan Mahmoud
mahadi2010sd@yahoo.com
Bsc, Msc, MIBMS Microbiology
3. Historical information
Discovered over 100 years ago by a
Japanese scientist named Kiyoshi Shiga,
Since its discovery, there have been several
epidemics of shigellosis (caused by the S.
dysenteriae bacterium
Outbreak in the Mexican-Guatemalan
border caused the deaths of 20,000 people
4. Reservoirs:
Human intestines are the
natural habitat and reservoir for
Shigella ,
thus the bacteria are present in
the stools of an infected person
up to a week or two after the
alleviation of symptoms
5. Morphology
Shigellae are Gram negative, rods.
Unlike salmonellae and many other
enterobacteria, shigellae are non-motile.
Non-sporing
Noncapsulate
6.
7.
8. Medically Important spp
Subgroup A: Shigella dysenteriae
Contains 12 distinct serotypes
Serotype 1 was formerly called S. shiga
Serotype 2 was formerly called S. schmitzii
Subgroup B: Shigella flexneri
Contains 6 related serotypes and 4 serotypes
divided into subserotypes.
Subgroup C: Shigella boydii
Contains 18 distinct serotypes
Subgroup D: Shigella sonnei
Contains one serotype
9. Culture &chaacteristics:
Shigellae are aerobes and facultative
anaerobes.
They grow between 10–45 ºC with an
optimum temperature of 37 ºC.
Specimens must be cultured with the
minimum of delay.
A selective medium is required to
isolate Shigella species from faeces.
10. XLD agar: Shigellae produce red-
pink
colonies, 2–4 mm in diameter,
without black centres
DCA and MacConkey agar:
Shigellae
produce non-lactose fermenting pale
coloured 1–2 mm diameter colonies.
On prolonged incubation, S. sonnei
forms pink colonies
11. .
Salmonella-Shigella (SS) agar:
Despite its name, this medium is
not suitable for isolating shigellae as
it is inhibitory to most strains
12.
13.
14.
15. Routes of transmission
Faecal-oral route with poor sanitation,
unhygienic conditions, overcrowding,
facilitating the rapid spread of infection.
Only a few organisms are required to
cause disease.
Houseflies help to transfer shigellae
from faeces to food. The
16. Reactions of shigellae
● Lactose negative (S. sonnei is a late lactose and
sucrose fermenter)
● H2S negative
● Urease negative
● Oxidase negative
● Citrate negative
● Lysine decarboxylase (LDC) negative
● Ornithine decarboxylase (ODC) negative except
S. sonnei which is ODC positive
● Beta-galactosidase (ONPG) negative. S. sonnei
and up to 15% of Sd 1 strains and minority of
S. boydii strains are ONPG positive
17. Colicins typing
Colicins are bactericidal macromolecules
which have narrow spectrum activity and they
are produced by Sh.sonneii (16)
colicins kill sensitive bacteria in 3 defined
steps :
1. Adsorption onto a specific receptor at the
surface of the bacterium.
2. Translocation across the outer membrane.
3. Killing activity.
18. Virulence factors
several toxins (endotoxin, enterotoxin, and
cytotoxin)
its ability to induce endocytosis into host cells, and
intracellular growth.
Each variation of the bacteria is able to penetrate
large intestine epithelial cells and multiply within.
S. dysenteriae, however, causes more severe
symptoms due to the production of the Shiga toxin.
This enables it to kill host cells by inhibiting protein
synthesis
19. Pathology: Shigellosis
Developing countries:
Sh. flexneri is endemic (always present) in most
communities
Sh. dysenteriae type 1 often occurs in an epidemic pattern
These two species of Shigella generally produce the most
severe illness.
Developed countries:
Sh. sonnei is the most common and is the least virulent
Sh. boydii causes disease of intermediate severity is least
common, except in the Indian sub-continent.
20. Fecal-oral transmission
person-to-person, fomites, food, water,
Waterborne and water-washed
Infectious dose: low; as few as 10 cells to
infect
Incubation period: 1 to 7 days; typically,
1-3 days
Duration of illness:
untreated: severe symptoms for about two
weeks
Antibiotic treatment shortens illness and
prevent spread to others
21. Shigellosis - Complications
severe anorexia (loss of appetite)
hypoproteinaemia (a low concentration of blood
protein)
hyponatraemia (a low concentration of blood
sodium)
dilation of the large intestine
seizures
anaemia
kidney damage
persistent diarrhoea
24. Prevention and Control:
Handwashing, especially after
defacation
Improved sanitation and hygiene
Improve water, waste
treatment/disposal and food sanitation
Reduce overcrowding, etc.
No effective vaccine