shigellosis presentation , communicable diseases lecture, community medicine master , university of Khartoum
contains basic information about the disease, its clinical features and treatment
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
This is a series of lectures on microbiology, useful for both undergraduate and post graduate medical and paramedical students... This lecture covers cholera, typhoid, diarrhoea and dysentry
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
This is a series of lectures on microbiology, useful for both undergraduate and post graduate medical and paramedical students... This lecture covers cholera, typhoid, diarrhoea and dysentry
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
These educational posters are displayed in various OPDs and wards in the hospital & at various health centres in Mumbai and the state. various NGOs working in health have been using the posters & other materials developed by PEC for their outreach health camps in the community.
Shigellosis outbreaks associated with sexual transmission among men who have sex with men (MSM) have been reported in recent years from the United Kingdom, Germany and Spain, with severe infections among HIV-positive MSM.
Poster at ESCAIDE conference 2016, Stockholm.
Is defined as diarrhea with visible blood in
stools.
The most important and frequent cause of
acute dysentery is Shigella. Other causes
include Campylobacter jujeni, Salmonella,
and enteroinvasive E. coli.
Entameba histolytica causes dysentery in
older children but rarely in children under 5
years of age
Dysentery is specially sever in :-
1. Malnourished infants and children.
2.Those who develop clinically evident
dehydration during their illness. 3. Those who
are not breast fed. 4. Children with measles
or had measles in the preceding month.
5. Those who present with convulsion or
develop coma.
Typhoid fever is the bacterial disease caused by the ingestion of food or water
contaminated with bacterium, Salmonella typhi. The typhoid fever is also called
typhoid. Typhoid fever is diagnosed by detection of Salmonella typhi in the stool
sample. Typhoid responds to anti-biotic treatment. Approximately (3-5) % of the
people becomes carrier after acute illness. Typhoid fever is gastric fever,
abdominal typhus, infantile remittent fever, slow fever, nervous fever and
pathogenic fever.
Cholera, typhoid fever and dysentery are some communicable diseases that are mainly caused due to ingestion of food which are contaminated with pathogenic micro-organisms.
about air pollution , definition, types . effects and measures to be taken
environmental & occupational health course, master of community medicine university of Khartoum , batch 2
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Table of content :
Introduction
Epidmiology
Causative agent
Clinical feature
Diagnosis
Treatment
Prevention and control
3. Introduction
Bacillary dysentery is an acute bacterial disease
involving the large and small intestine
It is caused by bacteria of the genus Shigella, of which
S. dysenteriae type 1 causes the most severe disease
and the largest outbreaks (other species
include S. flexneri, S. sonnei and S. boydii).
It is the most important cause of acute bloody diarrhoea.
4. epidmiology
Shigellosis causes an estimated 150 million illnesses
and 14,000 deathes worldwide
Its endemic in both tropical & temprate climate
S. dysenteriae type 1 is of particular concern in
developing countries and complex emergency situations
where huge outbreaks can occur.
S. sonnei is most common in industrialized countries,
where the disease is generally less severe
5. Causative agent
Shigella strains are gram negative , faculatively
anaerobic,non motile rods classified in the family
enterobacteriacae.
Shigella strains cause dysentry by invading and
destroying the cells that line the large intestine
There are 4 subgroups of shigella
• Group A: S.dysenteriae (most severe infection due to shig toxin
type 1)
• Group B: S.flexneri
• Group C: S.bodyii
• Group D: s.sonni
Group A<B<C are further subdivided into 15,8,19
serotype respectively. While group D consist of a single
serotype
6. Mood of transmission
The only significant reservoir is human
Mainly by direct or indirect fecal-oral transmission from a
symptomatic patient or a short-term asymptomatic carrier
Infection may occur after the ingestion of contaminated food or
water as well as from person to person.
The infective dose can be as low as 10–100 organisms.
Water and milk transmission may occur as the result of direct fecal
contamination;
flies can transfer organisms from latrines to uncovered food items.
8. Clinical feature
acute
loose stools of small volume accompanied by fever,
nausea and sometimes toxaemia, vomiting, cramps and
tenesmus
In typical cases, the stools contain blood and mucus
(dysentery)resulting from mucosal ulcerations and
confluent colonic crypt micro abscesses caused by the
invasive organisms; many cases present with a watery
diarrhea.
9. Mild and asymptomatic infections occur.
illness is usually self-limited, lasting on average 4–7
days.
Case fatality rate can be up to 20% even with
hospitalization
10. Differential diagnosis
Other causes of dysentry include ::
• Campylobacter jejuni,
• entero-invasive Escherichia coli,
• Salmonella
• , Entamoeba histolytica (less frequently )
11. Complications
High risk pateints include
• Children under 5 years
• Severly malnourished patiens
• Eldelrly over 50 years
Complications include :
• Sepsis
• Rectal prolapse
• Haemolytic uremic syndrome
• Convulsions (especially among young children)
Shiga bacillus is associated with
• Toxic megacolon
• Intestinal peroration
• HUS
12. Period of communicability
During acute infection and until the infectious agent is no
longer present in feces, usually within 4 weeks after
illness.
Asymptomatic carriers may transmit infection; rarely,
the carrier state may persist for months or longer.
Appropriate antimicrobial treatment usually reduces
duration of carriage to a few days.
13. Diagnosis
Isolation of shigella from feces or rectal swabs provide
bacteriological diagnosi
Blood is observed in a fresh stool specimen
Stool speciment should be processed rapidly because
Shigella remains viable only for a short
period outside human body
Infection is usually associated with large numbers of
fecal leukocytes detected through microscopical
examination of stool mucus stained with methylene blue
or Gram.
14. Isolated specimen should be tested for antimicrobial
suseptiablity
No rapid diagnostic test or antigen assays are avaliable
yet
15. Case mangment
Refer seriously ill or severely malnourished patients to
hospital immediately.
Check the results of antimicrobial sensitivity tests with
the laboratory.
Give an antimicrobial effective against local S.
dysenteriae type 1 (Sd1)strains promptly to all patients,
preferably as inpatients
Treat dehydration with oral rehydration salts or
intravenous fluids if severe.
If the antimicrobials used are effective, clinical
improvement should be noted within 48 hours.
16. Children < 6 mo. Less likely to get
infected as breast feeding is protective
17. Azithromycin and ceftrixone may also be considered for
treatment of shigellosis especially in children
The use of antimotility agents is discourged as they
prolong the duration of illness
18. Mangment of contacts
Whenever feasible ill contacts should be discouraged
from handling food ,caring of children and patients ..
Until diareah stop and stool culutre is negative in one or
more succesive test taken 24 hours apart and 48 hours
after discontinuation of antibiotics
Thourogh hand washing after defecation, before food
handling and caring of children patients is essential
Investigate water and food sources and recreational
water sources using general sanitation measures
19. Prevention and control
Health education regarding hand washing and sanitary
measures
No prophylaxis
No vaccination
20. Specail considerations
Reporting : case report to health authoraties is obligatory
Common source water and foood borne outbreak
require prompt investigaiton & intervention whaterever
the infecting species
Shiga bacillus is a potential problem is disaster situation
where personal hygeine and enviromental sanitaion is
defiecient
21.
22. Refences
Who manual
Control of communicable diseases manual 18th edition
Control of communicable diseases manual 20th edition
Communicable disease control manula 2012 ,ministry of
health,newzeland