What is blood..
Its composition??
Plasma
Blood Cells (RBC, WBC, Platelets)
Its types
Its functions
FACTS AND FIGURES
Disorders of blood
Sequential Arrangement
Function of blood
Disorders of blood??
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
What is blood..
Its composition??
Plasma
Blood Cells (RBC, WBC, Platelets)
Its types
Its functions
FACTS AND FIGURES
Disorders of blood
Sequential Arrangement
Function of blood
Disorders of blood??
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
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This lecture was the opening lecture on the ‘Physiology of Coagulation’ at the Continuing Medical Education (CME) Grand Rounds, 2011. Organised by Kuwait Anesthesia Council, Kuwait
Coagulation cascade PowerPoint templates designed by skilled, experienced and professional graphic designers that are intended to solve the big issue of time consumption. These are fully editable slides and organized in a way to simplify the most complex topics and present it in an attractive manner. You can easily incorporate charts, diagrams and animations along with the content to these layouts in order to explore new technologies and trends of businesses in a unique way. All editable slides are digitally created to pinpoint and clarify the message, and summarize information regarding topic.
Hemoglubin is are carrier protein for oxygen and CO2. it a pigmented and globular protein present within the red blood cell, its structure, synthesis, and how it function in the transportation of oxygen and CO2 are given in this presentation
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Platelets
Disc-shape cell fragment with no nucleus
Platelets are the cell fragments pinched off from megakaryocytes in red bone marrow
Platelets are important in preventing blood loss
Platelet plugs
Promoting formation and contraction of clots
Platelets--Life History
Platelets form in bone marrow by following steps:
myeloid stem cells eventually become megakaryocytes whose cell fragments form platelets.
Short life span (5 to 9 days in bloodstream)
They are formed in bone marrow.
They remain few days in circulating blood.
Aged ones are removed by fixed macrophages in liver and spleen.
Normal count: 2-4 lacs per mm3 of blood.
Hemostasis and coagulation of blood For M.Sc & Basic Medical Students by Pand...Pandian M
Blood coagulation
Mechanism of coagulation
STAGES OF HEMOSTASIS
Coagulation of blood
Factors involved in blood clotting
Enzyme cascade theory
Mechanisms for formation of prothrombin activator
Fibrinolysis
Anticlotting mechanism in the body
Applied physiology
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
section 2, chapter 14: blood plasma
1. Plasma
Overview
1. Plasma is the liquid portion of blood
2. Makes up 55% of blood volume
3. Straw colored
4. Components include Plasma proteins, Dissolved gasses, Wastes, Electrolytes,
Nutrients, Hormones
Chapter 14, Section 2 of 2.
2. Plasma proteins
1. Albumin
• 60% of plasma proteins
• Synthesized in liver
• Creates an osmotic that helps
maintain blood pressure
2. Globulins
• 36% of plasma proteins
• Alpha & Beta globulins
o Are produced by liver
o Transports lipids
• Gamma globulins
o Are produced by
lymphatic tissues
o function as antibodies
3. Fibrinogen
• 4% of plasma proteins
• Primary role in blood coagulation
4. Plasma Gasses & Nutrients
• Blood Gasses:
• Oxygen
•Most is bound to hemoglobin. Less than 2% of
oxygen is dissolved in plasma
• Carbon dioxide
•Most CO2 is transported as bicarbonate (HCO3-)
• About 7% is dissolved in plasma
• Nutrients:
• Amino acids
• Simple sugars
• Nucleotides
• Lipids
• Hydrophobic lipids are bound to plasma proteins
within the plasma
5. Nonprotein Nitrogenous Substances
• These are molecules containing nitrogen but are not proteins
• In plasma they include:
• Urea – product of protein catabolism; about 50% of nonprotein
nitrogenous substances
• Uric acid – product of nucleic acid catabolism
• Amino acids – product of protein catabolism
• Creatine – biproduct of creatine phosphate metabolism
• Creatinine – product of creatine metabolism
Common tests that evaluate kidney functions:
•Creatinine test – measures creatinine
•BUN – blood urea nitrogen; indicates health of kidney
6. Plasma Electrolytes
• Plasma contains a variety of these ions called electrolytes
• They are absorbed from the intestine or released as by-products of
cellular metabolism
• They include:
• Sodium (most abundant with chloride)
• Potassium
• Calcium
• Magnesium
• Chloride (most abundant with sodium)
• Bicarbonate
• Phosphate
• Sulfate
7. Hemostasis
• Hemostasis refers to the stoppage of bleeding
• Actions that limit or prevent blood loss include:
1. Blood vessel spasm (vasospasm)
2. Platelet plug formation
3. Blood coagulation
8. hemostasis, step 1: vasospasm
• Blood vessel spasm (vasospasm)
• Cutting or breaking a vessel wall stimulates the smooth
muscles in its walls to contract.
•Vasospasm reduces blood loss almost immediately, and may
close small blood vessels completely.
9. hemostasis, step 2: platelet plug formation
1. Platelet adhesion – platelets
adhere to collagen fibers that
become exposed due to the
damage in a vascular walls
2. Platelets undergo a shape
change, producing several
processes to which additional
platelets bind.
3. In addition, platelets secrete
thromboxanes, which attract
additional platelets to the site of
injury.
4. A platelet plug may control blood
loss from a small break.
10. hemostasis, step 3: coagulation
• Blood coagulation
• Is triggered by cellular damage and blood contact with foreign surfaces
• Coagulation is a cascade reaction involving several biochemicals (clotting factors)
• The major event is formation of a blood clot when fibrin (a thread-like protein)
forms a mesh surrounding the damaged vessel.
•
The
1.
2.
3.
cascade is divided into three events
Extrinsic mechanism
Intrinsic mechanism
Common pathway
11. Coagulation
• Extrinsic clotting mechanism
• A chemical released from tissue outside the blood
vessels trigger the extrinsic pathway
•Damaged tissues releases thromboplastin
(also called factor III)
•Factor III initiates a cascade reaction that, in the
presence of Calcium, activates factor X.
•Activation of factor X initiates the common
pathway
12. Coagulation
• Intrinsic clotting mechanism
• An inactive clotting factor within the
blood (Hageman, or factor XII) is
activated when foreign tissue, such as
collagen enters the bloodstream.
•Factor XII proceeds through a cascade
of reactions in the presence of Calcium
to activate factor X.
•Activation of factor X initiates the
common pathway.
13. Coagulation
•Common Pathway
•Is the point at which intrinsic & extrinsic pathways converge
•Activated factor X (with help of Calcium & factor V) leads to the
release of prothrombin activator from platelets.
•Prothrombin activator converts prothrombin into thrombin.
•Thrombin, in turn converts fibrinogen into long threads of fibrin.
•Fibrin forms an insoluble clot at the site of injury.
14. Coagulation
Figure 14.19c. Schematic of the common pathway in the
blood clotting mechanism
Figure 14.18 A scanning electron micrograph of fibrin
threads. The insoluble fibers trap blood cells and
platelets, which contribute to the blood clot formation.
16. Blood Clot Dissolution
• After a blood clot forms it retracts and pulls the edges of a broken
blood vessel together while squeezing the fluid serum from the clot
• Platelet-derived growth factor stimulates smooth muscle cells and
fibroblasts to repair damaged blood vessel walls
• Plasmin digests the blood clots
17. Blood Clot Disorders
•A thrombus is an abnormal blood clot
•Deep vein thrombosis – prolonged immobility causes blood to pool, especially
in the deep veins of the legs or pelvis.
• An embolus is a blood clot moving through the blood vessels
•Pulmonary embolism – may occur when part of a thrombus breaks away from
the clot and lodges in a pulmonary artery. Rapidly fatal.
•Atherosclerosis – accumulation of fatty deposits along arterial lining
•May cause inappropriate clotting
•Most common cause of thrombosis in medium-sized arteries
•Arteriosclerosis – hardening of an artery.
•Stenosis – abnormal narrowing of a passage in a body
•Atherosclerosis of an artery narrows the passage through which blood flows in
an artery, and increases the likelihood of an embolism at that site.
18. Blood Clot Disorders
Figure 14.20 Artery cross sections.
(a) light micrograph of a normal
artery.
(b) The inner wall of an artery
changed as a result of atheroclerosis.
Ultrasound image of stenosis within the internal carotid artery.
19. Blood Typing
Blood typing is the process of identifying an individual’s blood group.
(eg. Type A, B, AB or O)
• Terms to become familiar with:
•Antigen – a chemical (or membrane protein) that stimulates cells to
produce antibodies
• Foreign antigens in the body stimulate the immune response.
• Antibodies – a plasma protein that reacts against a specific antigen
• Agglutination – clumping of red blood cells in response to a
reaction between an antibody and an antigen
20. ABO Blood Group
• This blood group is based on the presence (or absence) of two
antigens on red blood cell membranes: Antigen A & Antigen B
antigens
Type A blood contains A-antigens on the surface
of its RBCs.
Type B blood contains B-antigens on the
surface of its RBCs. and anti-A antibodies in its
plasma.
Type AB blood contains A-antigens and Bantigens on the surface of its RBCs. and has
neither antibody
Type O blood contains neither A or B antigen
on the surface of its RBCs
21. Blood Typing
antibodies
Type A blood plasma contains anti-B antibodies.
Type B blood plasma contains anti-A antibodies.
Type AB blood plasma contains neither antibody
Type O blood plasma contains both anti-A and anti-B antibodies.
23. Rh Blood Group
• The Rh blood group was named for the rhesus monkey
•Rh positive (Rh+) indicates the presence of D-antigen (or other Rh
antigen) on the red blood cell membranes
• Rh negative (Rh-) lacks the D-antigen
• When Rh- blood is exposed to the D antigen, it becomes sensitized
and develops anti-D antibodies
• Anti-D antibodies are formed only after a person is exposed to Dantigen (Rh sensitization).
24. erythroblastosis fetalis
•The seriousness of the Rh blood group is evident in a fetus that develops the
condition erythroblastosis fetalis or hemolytic disease of the newborn.
• If the mother is Rh- and has been sensitized to the D-antigen, her own
antibodies may attack the red blood cells of a fetus that is Rh+.
25. erythroblastosis fetalis
•Erythroblastosis fetalis can be prevented for women at high risk by administering a
serum that contains anti-D antibodies into the mother during the pregnancy and after
birth (before she becomes sensitized to D-antigen).
•The injected antibodies quickly agglutinate any fetal red blood cells, thereby preventing
her from becoming sensitized to the D-antigen.
End of Section 2 of 2.