The document summarizes key aspects of the structure and function of the nervous system. It describes the central nervous system (CNS), which includes the brain and spinal cord, and the peripheral nervous system (PNS). The CNS is responsible for integrating sensory information and coordinating motor responses through neuronal signaling. Within the nervous system, neurons communicate with each other via synapses to transmit electrochemical signals. Supporting glial cells aid neuronal function and regeneration.
This document provides an overview of the physiology of pain. It discusses:
1. The definition of pain according to the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
2. The dual nature of pain as either fast, acute pain transmitted by thin myelinated nerve fibers or slow, chronic pain transmitted by unmyelinated nerve fibers.
3. The pathways that carry pain signals from nociceptors to the brain, including nerve fibers entering the spinal cord and traveling via the lateral spinothalamic tract to the thalamus and sensory cortex.
4. Descending pain modulatory pathways from the brainstem that can inhibit pain
The document discusses pain transduction, transmission, and modulation. It begins by describing sensory receptors including nociceptors, which detect potentially harmful stimuli and transduce them into neural signals. Nociceptive fibers called Aδ and C fibers transmit these signals to the spinal cord. Transduction involves converting stimuli into neural signals, transmission moves these signals through the nervous system, and modulation regulates signal strength. The spinothalamic tract then relays nociceptive information from the spinal cord to the thalamus and cortex, allowing the perception of pain.
Mediators of inflammation include cell-derived and plasma protein-derived substances that initiate and regulate inflammatory reactions. Key mediators include vasoactive amines like histamine, lipid products like prostaglandins and leukotrienes derived from arachidonic acid, cytokines, chemokines, and products of complement activation. Mediators are locally produced at sites of inflammation or derived from circulating precursors activated at sites. They stimulate vascular changes, recruit immune cells, and regulate the inflammatory response in a complex network of interactions.
- Glutamate-based theories of schizophrenia focus on dysfunction of brain glutamate systems, particularly NMDA receptors. These theories originated over 20 years ago and have led to new conceptualizations of schizophrenia and potential assessment and treatment approaches.
- Dopamine dysfunction in schizophrenia may be caused by genetically determined abnormalities or by NMDA receptor dysfunction impairing dopamine system regulation. Disturbances in both glutamate and dopamine systems likely contribute to positive symptoms.
- Glutamate and NMDA receptors are widely distributed in the brain, suggesting schizophrenia involves dysfunction beyond prefrontal and limbic regions, including sensory cortices. Deficits in auditory and visual processing correlate with impaired functioning.
- While past drug trials targeting glut
Synapses are neuro-neuronal junctions that transmit information from one neuron to another. Key properties of synapses include forward conduction of impulses from presynaptic to postsynaptic terminals. Intense stimulation can cause synaptic fatigue due to depletion of neurotransmitters. Synaptic delay of ~0.5 ms helps determine the number of synapses in a pathway. Convergence allows many inputs to influence a cell while divergence allows one input to affect multiple neurons. Synaptic plasticity, including long-term potentiation and depression, underlies learning and memory formation.
Pain definition, pathway,analgesic pathway, types of painekta dwivedi
This document provides an overview of pain physiology, including definitions of pain, pain receptors and pathways, and theories of pain modulation. It discusses fast and slow pain fibers, pain transmission through the spinal cord and brain, and endogenous analgesic pathways. The gate control theory of pain is explained in detail. Different types of pain and assessment methods are outlined. Both pharmacological and non-pharmacological pain management approaches are summarized.
This document discusses the physiology of pain, including:
- Types of pain receptors and the pathways for fast and slow pain transmission.
- Pain is transmitted via A-delta fibers for fast pain and C fibers for slow pain to the spinal cord.
- From the spinal cord, pain travels via the spinothalamic tracts to the thalamus and brain for perception. Modulatory pathways can inhibit pain transmission.
This document provides an overview of the physiology of pain. It discusses:
1. The definition of pain according to the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
2. The dual nature of pain as either fast, acute pain transmitted by thin myelinated nerve fibers or slow, chronic pain transmitted by unmyelinated nerve fibers.
3. The pathways that carry pain signals from nociceptors to the brain, including nerve fibers entering the spinal cord and traveling via the lateral spinothalamic tract to the thalamus and sensory cortex.
4. Descending pain modulatory pathways from the brainstem that can inhibit pain
The document discusses pain transduction, transmission, and modulation. It begins by describing sensory receptors including nociceptors, which detect potentially harmful stimuli and transduce them into neural signals. Nociceptive fibers called Aδ and C fibers transmit these signals to the spinal cord. Transduction involves converting stimuli into neural signals, transmission moves these signals through the nervous system, and modulation regulates signal strength. The spinothalamic tract then relays nociceptive information from the spinal cord to the thalamus and cortex, allowing the perception of pain.
Mediators of inflammation include cell-derived and plasma protein-derived substances that initiate and regulate inflammatory reactions. Key mediators include vasoactive amines like histamine, lipid products like prostaglandins and leukotrienes derived from arachidonic acid, cytokines, chemokines, and products of complement activation. Mediators are locally produced at sites of inflammation or derived from circulating precursors activated at sites. They stimulate vascular changes, recruit immune cells, and regulate the inflammatory response in a complex network of interactions.
- Glutamate-based theories of schizophrenia focus on dysfunction of brain glutamate systems, particularly NMDA receptors. These theories originated over 20 years ago and have led to new conceptualizations of schizophrenia and potential assessment and treatment approaches.
- Dopamine dysfunction in schizophrenia may be caused by genetically determined abnormalities or by NMDA receptor dysfunction impairing dopamine system regulation. Disturbances in both glutamate and dopamine systems likely contribute to positive symptoms.
- Glutamate and NMDA receptors are widely distributed in the brain, suggesting schizophrenia involves dysfunction beyond prefrontal and limbic regions, including sensory cortices. Deficits in auditory and visual processing correlate with impaired functioning.
- While past drug trials targeting glut
Synapses are neuro-neuronal junctions that transmit information from one neuron to another. Key properties of synapses include forward conduction of impulses from presynaptic to postsynaptic terminals. Intense stimulation can cause synaptic fatigue due to depletion of neurotransmitters. Synaptic delay of ~0.5 ms helps determine the number of synapses in a pathway. Convergence allows many inputs to influence a cell while divergence allows one input to affect multiple neurons. Synaptic plasticity, including long-term potentiation and depression, underlies learning and memory formation.
Pain definition, pathway,analgesic pathway, types of painekta dwivedi
This document provides an overview of pain physiology, including definitions of pain, pain receptors and pathways, and theories of pain modulation. It discusses fast and slow pain fibers, pain transmission through the spinal cord and brain, and endogenous analgesic pathways. The gate control theory of pain is explained in detail. Different types of pain and assessment methods are outlined. Both pharmacological and non-pharmacological pain management approaches are summarized.
This document discusses the physiology of pain, including:
- Types of pain receptors and the pathways for fast and slow pain transmission.
- Pain is transmitted via A-delta fibers for fast pain and C fibers for slow pain to the spinal cord.
- From the spinal cord, pain travels via the spinothalamic tracts to the thalamus and brain for perception. Modulatory pathways can inhibit pain transmission.
Stress can influence the immune system both positively and negatively. Certain psychiatric disorders like schizophrenia and major depressive disorder have also been linked to immunological dysfunction. The document discusses the theoretical integration of stress, emotions, immunological responses, and the relationship between the mind and body in developing both physical and mental diseases.
The document discusses the role of biogenic monoamine neurotransmitters in psychiatry. It describes the key neurotransmitters dopamine, serotonin, histamine, acetylcholine, and epinephrine/norepinephrine. For each neurotransmitter, it covers synthesis and degradation pathways, receptor types and locations, and clinical implications for conditions like schizophrenia, depression, addiction, and others. Histamine is highlighted as originating from the hypothalamus and projecting widely, influencing arousal, pituitary function, eating, and cognition.
This document provides an overview of pain physiology. It begins with objectives to classify types of pain, describe pain pathways and mechanisms of referred pain, explain the analgesia system, and list examples of referred pain. It then outlines topics to be covered including definition of pain, types of pain, pain receptors, stimuli for pain receptors, pain pathways, and clinical abnormalities of pain. It provides descriptions of fast and slow pain, nociception, pain receptors, stimuli for pain receptors, and the peripheral and central pain pathways involving three neurons and dual tracts for fast-sharp and slow-chronic pain signaling.
The brain has an endogenous analgesia system that can suppress pain signals entering the nervous system. This system includes the periaqueductal gray area of the midbrain, the raphe magnus nucleus of the pons, and a pain inhibitory complex in the spinal cord dorsal horn. Signals from these areas inhibit the transmission of pain impulses through the release of enkephalins and serotonin before pain signals reach the brain. Activation of this system by stimuli in certain brain areas or by opioids can dramatically reduce pain perception.
General introduction of neuotransmitters, difference from neuromodulatorsJithin Mampatta
Neurotransmitters are chemicals that transmit signals between neurons. They are synthesized and stored in vesicles in the presynaptic neuron and released into the synaptic cleft upon neuronal stimulation. Neurotransmitters then bind to and activate receptors on the postsynaptic neuron, eliciting an electrical or biochemical response. In contrast, neuromodulators have a broader range of influence, altering signal transmission between many neurons through metabotropic receptors and volume transmission. Some key neurotransmitters include dopamine, GABA, norepinephrine, and serotonin.
Physiology of Pain (PPT) Nervous System PhysiologyShaista Jabeen
https://www.youtube.com/channel/UCrrAABI7QDRCJ1yMrQCip_w/videos
https://www.facebook.com/ShaistaJabeeen/
https://www.facebook.com/Human-Physiology-Lectures-100702741804409/
Physiology of Pain (PPT)
Nervous System Physiology
INTRODUCTION
BENEFITS OF PAIN SENSATION
COMPONENTS OF PAIN SENSATION
PATHWAYS OF PAIN SENSATION
FROM SKIN AND DEEPER STRUCTURES
FROM FACE
FROM VISCERA
FROM PELVIC REGION
VISCERAL PAIN
CAUSES OF VISCERAL PAIN
REFERRED PAIN
DEFINITION
EXAMPLES OF REFERRED PAIN
MECHANISM OF REFERRED PAIN
NEUROTRANSMITTERS INVOLVED IN PAIN SENSATION
ANALGESIA SYSTEM
ANALGESIC PATHWAY
GATE CONTROL THEORY
APPLIED PHYSIOLOGY
Short Notes
pdf ppt
The document discusses different types of pain including acute pain, chronic pain, and cancer pain. It defines acute pain as sudden onset lasting less than 6 months, while chronic pain lasts over 6 months. Cancer pain includes both acute cancer-related pain and chronic pain from tumor progression or therapy. Pain is also classified as nociceptive (from tissue damage), neuropathic (from nerve damage), or psychogenic (of emotional origin). A thorough pain assessment considers location, quality, intensity, timing, and impact on daily activities. Cultural beliefs and expressions of pain can vary between individuals and cultures. Non-pharmacological interventions for pain include positioning, education, touch therapies, heat/cold, relaxation, and acupuncture.
This interesting ppt deals with the Pharmacology of Antiepileptic drugs and the treatment of different types of seizures with beautiful illustrations....
The document provides an overview of the autonomic nervous system (ANS). It discusses that the ANS controls involuntary functions and is divided into the sympathetic and parasympathetic nervous systems. The sympathetic system is activated during fight or flight responses and controls functions like increased heart rate and blood pressure. The parasympathetic system activates rest and digest functions like increased gastrointestinal and salivary gland activity. Key topics covered include the anatomy and pathways of the sympathetic and parasympathetic systems, the receptors they act on, examples of their excitatory and inhibitory effects, and clinical tests of the ANS.
An Overview of Aute and Transient Psychiosis / Brief Psychotic DisorderGaurav Sharma
Introduction: ATPD as a diagnostic entity is of particular History and present-day relevance; however, the concept of ATPD, and its management and prognosis remain contentious.
History: Description given by Kraeplin (1856-1926), Bleuler (1857-1939), Freud (1856-1939), different names in different part of world, types as Amentia, Cycloid psychosis, Bouffée délirante, Psychogenic or reactive psychosis, Schizophreniform psychosis or disorder etc. and description according to DSM-III, DSM-III R, DSM IV and IV-R, DSM 5-R.
Evidence Based Studies: 1. IPSS 2. DOSMeD (Determinants of Outcome of Severe MentalHealth Disorders) (1978-1980) 3. CAP (Cross-cultural study of Acute Psychosis) (1980- 1982)
Relationship Of ATPs With Schizophrenia And Affective Disorders: The risk for affective disorders among FDRs (First degree relatives) of schizophrenics was 6-8%; and the risk for schizophrenia among relatives of affective disorders was 0.5-3.5% and both these risks were much higher than the risk in the general population for the respective disorders.
ATP Validation Studies: Chandigarh Acute Psychosis Study, Chandigarh CAP study, ICMR Acute Psychosis Study and their results discussed.
Recurrence in ATP: Malhotra et al. reported a recurrence rate of 46.6% on 8-year follow-up; whereas Rozario et al. found recurrence in 35% cases of ATP on 5-year follow-up.
Antecedent Factors In ATP: Female preponderance, Low socio-economic status and rural population, Stress preceding the onset, febrile illness etc.
Epidemiology: More often among younger patients (20s and 30s) than among older patients.
More common in women than in men. Results of studies conducted in Nottingham, England, and in developing countries.
Etiology: Role of Febrile Illness, Infectious diseases Hypothalamic–pituitary axis abnormalities.
Management: Role of Second-generation antipsychotics and First generation Antipsychotic and Sociotherapy.
1) There are two main types of cholinergic receptors: muscarinic and nicotinic. Muscarinic receptors have subtypes M1-M5 and recognize muscarine, while nicotinic receptors are ligand-gated ion channels composed of five subunits.
2) Muscarinic receptors are located in the peripheral and central nervous systems and on effector organs like the heart and glands. M1/M3 activation leads to phosphatidylinositol hydrolysis and calcium increases, while M2 inhibits adenylate cyclase.
3) Nicotinic receptors are located in the CNS, adrenal medulla, autonomic ganglia, and neuromus
This document summarizes the neurotensin system. It describes neurotensin as a peptide hormone and neurotransmitter synthesized from a precursor and stored in dense granules. It acts through three receptor subtypes, NTSR1-3, with NTSR1 having the highest affinity. Neurotensin is involved in various functions like hypothermia, analgesia, and modulation of acute pain. It is distributed in both the central nervous system and gastrointestinal tract. Neurotensin has roles in diseases like Parkinson's and schizophrenia, and may be involved in eating disorders and cancer. Studies examine neurotensin agonists and antagonists that could have therapeutic applications.
Delusions are defined as fixed beliefs that are firmly held despite clear proof to the contrary. They are categorized as bizarre, non-bizarre, mood-congruent, or mood-neutral. Common delusional themes include control, jealousy, guilt, reference, and grandeur. Biological, psychological, and cognitive theories attempt to explain delusion formation, with factors including brain abnormalities, emotions, perception, and biases in attention and reasoning. Delusions may arise from errors in reasoning about the mental states of others.
Causes of Leukocytosis, Leokopenia, Lymphocytosis and Leukemoid reactions..pptxUtkarsh Sharma
This document summarizes various disorders of white blood cells, including leukocytosis, leukopenia, lymphocytosis, and leukemoid reactions. It describes the causes and characteristics of these conditions. Proliferative disorders can be reactive or neoplastic. Leukopenia is usually caused by neutropenia and results from reduced bone marrow production or increased destruction of neutrophils. Agranulocytosis is a severe form of neutropenia caused by drugs or idiosyncratic reactions. Leukocytosis can result from infections, inflammation, burns, or metastatic cancer stimulating bone marrow. Leukemoid reactions involve markedly elevated white counts with immature cells resembling leukemia but occurring in non-leukemic disorders.
1. Nociceptive fibers that detect painful stimuli are distinct from other sensory fibers, and can be classified as myelinated A-delta fibers or unmyelinated C fibers.
2. Pain signals travel through two main pathways in the spinal cord - the anterolateral pathway and dorsal column pathway.
3. Pain processing involves peripheral sensitization at the site of injury, and central sensitization in the spinal cord which can amplify pain signaling.
Neurons in the central nervous system have very limited regenerative abilities after injury. While it was once thought that neuronal injury always led to cell death, it is now known that neurons can remodel their projections and synaptic connections. The severity of injury can range from reversible myelin sheath damage (neuropraxia) to complete axon severing (neurotmesis). After injury, neurons undergo chromatolysis and may experience transneuronal degeneration. The distal stumps of severed axons undergo Wallerian degeneration over time. Growth cones allow limited axon regrowth, but glial scars and myelin inhibitors in the CNS make full recovery difficult.
This document discusses the human sensory systems. It describes four types of sensations - superficial, deep, visceral, and special. It then provides details on the receptors, pathways, and neural connections involved in touch, pain, temperature, proprioception, and other senses. Specifically, it outlines the locations and functions of mechanoreceptors like Meissner's corpuscles and Merkel endings, as well as nociceptors that detect pain. It also compares the dorsal column-medial lemniscus pathway and spinothalamic tract, noting their roles in transmitting different sensory signals to the cortex.
The document discusses the physiology of pain. It defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. It describes the dual nature of fast and slow pain mediated by different nerve fiber types. Stimuli that can cause pain and the receptors involved are discussed. The pathways that carry pain signals from receptors to the brain through the spinal cord and thalamus are summarized. Finally, it outlines the gate control theory of pain modulation by interactions between pain and touch fibers at the spinal cord.
This document summarizes factors that influence blood pressure, including cardiac output and peripheral resistance. It discusses how blood pressure is regulated through control of stroke volume, heart rate, and peripheral resistance. Stroke volume depends on preload and the contractile strength of the ventricles. Other factors like blood volume, viscosity, and vasoconstriction also impact blood pressure. The document outlines the anatomy of arteries branching from the aorta and how venous return relies on skeletal muscle contraction and respiratory movements.
The document summarizes section 1 of chapter 11 from an anatomy textbook. It describes the meninges, which are the three layers of membrane that surround and protect the brain and spinal cord. It also describes the ventricles in the brain and spinal cord that produce and circulate cerebrospinal fluid. Spinal taps are usually performed below the 4th lumbar vertebra to access cerebrospinal fluid without puncturing the spinal cord.
Stress can influence the immune system both positively and negatively. Certain psychiatric disorders like schizophrenia and major depressive disorder have also been linked to immunological dysfunction. The document discusses the theoretical integration of stress, emotions, immunological responses, and the relationship between the mind and body in developing both physical and mental diseases.
The document discusses the role of biogenic monoamine neurotransmitters in psychiatry. It describes the key neurotransmitters dopamine, serotonin, histamine, acetylcholine, and epinephrine/norepinephrine. For each neurotransmitter, it covers synthesis and degradation pathways, receptor types and locations, and clinical implications for conditions like schizophrenia, depression, addiction, and others. Histamine is highlighted as originating from the hypothalamus and projecting widely, influencing arousal, pituitary function, eating, and cognition.
This document provides an overview of pain physiology. It begins with objectives to classify types of pain, describe pain pathways and mechanisms of referred pain, explain the analgesia system, and list examples of referred pain. It then outlines topics to be covered including definition of pain, types of pain, pain receptors, stimuli for pain receptors, pain pathways, and clinical abnormalities of pain. It provides descriptions of fast and slow pain, nociception, pain receptors, stimuli for pain receptors, and the peripheral and central pain pathways involving three neurons and dual tracts for fast-sharp and slow-chronic pain signaling.
The brain has an endogenous analgesia system that can suppress pain signals entering the nervous system. This system includes the periaqueductal gray area of the midbrain, the raphe magnus nucleus of the pons, and a pain inhibitory complex in the spinal cord dorsal horn. Signals from these areas inhibit the transmission of pain impulses through the release of enkephalins and serotonin before pain signals reach the brain. Activation of this system by stimuli in certain brain areas or by opioids can dramatically reduce pain perception.
General introduction of neuotransmitters, difference from neuromodulatorsJithin Mampatta
Neurotransmitters are chemicals that transmit signals between neurons. They are synthesized and stored in vesicles in the presynaptic neuron and released into the synaptic cleft upon neuronal stimulation. Neurotransmitters then bind to and activate receptors on the postsynaptic neuron, eliciting an electrical or biochemical response. In contrast, neuromodulators have a broader range of influence, altering signal transmission between many neurons through metabotropic receptors and volume transmission. Some key neurotransmitters include dopamine, GABA, norepinephrine, and serotonin.
Physiology of Pain (PPT) Nervous System PhysiologyShaista Jabeen
https://www.youtube.com/channel/UCrrAABI7QDRCJ1yMrQCip_w/videos
https://www.facebook.com/ShaistaJabeeen/
https://www.facebook.com/Human-Physiology-Lectures-100702741804409/
Physiology of Pain (PPT)
Nervous System Physiology
INTRODUCTION
BENEFITS OF PAIN SENSATION
COMPONENTS OF PAIN SENSATION
PATHWAYS OF PAIN SENSATION
FROM SKIN AND DEEPER STRUCTURES
FROM FACE
FROM VISCERA
FROM PELVIC REGION
VISCERAL PAIN
CAUSES OF VISCERAL PAIN
REFERRED PAIN
DEFINITION
EXAMPLES OF REFERRED PAIN
MECHANISM OF REFERRED PAIN
NEUROTRANSMITTERS INVOLVED IN PAIN SENSATION
ANALGESIA SYSTEM
ANALGESIC PATHWAY
GATE CONTROL THEORY
APPLIED PHYSIOLOGY
Short Notes
pdf ppt
The document discusses different types of pain including acute pain, chronic pain, and cancer pain. It defines acute pain as sudden onset lasting less than 6 months, while chronic pain lasts over 6 months. Cancer pain includes both acute cancer-related pain and chronic pain from tumor progression or therapy. Pain is also classified as nociceptive (from tissue damage), neuropathic (from nerve damage), or psychogenic (of emotional origin). A thorough pain assessment considers location, quality, intensity, timing, and impact on daily activities. Cultural beliefs and expressions of pain can vary between individuals and cultures. Non-pharmacological interventions for pain include positioning, education, touch therapies, heat/cold, relaxation, and acupuncture.
This interesting ppt deals with the Pharmacology of Antiepileptic drugs and the treatment of different types of seizures with beautiful illustrations....
The document provides an overview of the autonomic nervous system (ANS). It discusses that the ANS controls involuntary functions and is divided into the sympathetic and parasympathetic nervous systems. The sympathetic system is activated during fight or flight responses and controls functions like increased heart rate and blood pressure. The parasympathetic system activates rest and digest functions like increased gastrointestinal and salivary gland activity. Key topics covered include the anatomy and pathways of the sympathetic and parasympathetic systems, the receptors they act on, examples of their excitatory and inhibitory effects, and clinical tests of the ANS.
An Overview of Aute and Transient Psychiosis / Brief Psychotic DisorderGaurav Sharma
Introduction: ATPD as a diagnostic entity is of particular History and present-day relevance; however, the concept of ATPD, and its management and prognosis remain contentious.
History: Description given by Kraeplin (1856-1926), Bleuler (1857-1939), Freud (1856-1939), different names in different part of world, types as Amentia, Cycloid psychosis, Bouffée délirante, Psychogenic or reactive psychosis, Schizophreniform psychosis or disorder etc. and description according to DSM-III, DSM-III R, DSM IV and IV-R, DSM 5-R.
Evidence Based Studies: 1. IPSS 2. DOSMeD (Determinants of Outcome of Severe MentalHealth Disorders) (1978-1980) 3. CAP (Cross-cultural study of Acute Psychosis) (1980- 1982)
Relationship Of ATPs With Schizophrenia And Affective Disorders: The risk for affective disorders among FDRs (First degree relatives) of schizophrenics was 6-8%; and the risk for schizophrenia among relatives of affective disorders was 0.5-3.5% and both these risks were much higher than the risk in the general population for the respective disorders.
ATP Validation Studies: Chandigarh Acute Psychosis Study, Chandigarh CAP study, ICMR Acute Psychosis Study and their results discussed.
Recurrence in ATP: Malhotra et al. reported a recurrence rate of 46.6% on 8-year follow-up; whereas Rozario et al. found recurrence in 35% cases of ATP on 5-year follow-up.
Antecedent Factors In ATP: Female preponderance, Low socio-economic status and rural population, Stress preceding the onset, febrile illness etc.
Epidemiology: More often among younger patients (20s and 30s) than among older patients.
More common in women than in men. Results of studies conducted in Nottingham, England, and in developing countries.
Etiology: Role of Febrile Illness, Infectious diseases Hypothalamic–pituitary axis abnormalities.
Management: Role of Second-generation antipsychotics and First generation Antipsychotic and Sociotherapy.
1) There are two main types of cholinergic receptors: muscarinic and nicotinic. Muscarinic receptors have subtypes M1-M5 and recognize muscarine, while nicotinic receptors are ligand-gated ion channels composed of five subunits.
2) Muscarinic receptors are located in the peripheral and central nervous systems and on effector organs like the heart and glands. M1/M3 activation leads to phosphatidylinositol hydrolysis and calcium increases, while M2 inhibits adenylate cyclase.
3) Nicotinic receptors are located in the CNS, adrenal medulla, autonomic ganglia, and neuromus
This document summarizes the neurotensin system. It describes neurotensin as a peptide hormone and neurotransmitter synthesized from a precursor and stored in dense granules. It acts through three receptor subtypes, NTSR1-3, with NTSR1 having the highest affinity. Neurotensin is involved in various functions like hypothermia, analgesia, and modulation of acute pain. It is distributed in both the central nervous system and gastrointestinal tract. Neurotensin has roles in diseases like Parkinson's and schizophrenia, and may be involved in eating disorders and cancer. Studies examine neurotensin agonists and antagonists that could have therapeutic applications.
Delusions are defined as fixed beliefs that are firmly held despite clear proof to the contrary. They are categorized as bizarre, non-bizarre, mood-congruent, or mood-neutral. Common delusional themes include control, jealousy, guilt, reference, and grandeur. Biological, psychological, and cognitive theories attempt to explain delusion formation, with factors including brain abnormalities, emotions, perception, and biases in attention and reasoning. Delusions may arise from errors in reasoning about the mental states of others.
Causes of Leukocytosis, Leokopenia, Lymphocytosis and Leukemoid reactions..pptxUtkarsh Sharma
This document summarizes various disorders of white blood cells, including leukocytosis, leukopenia, lymphocytosis, and leukemoid reactions. It describes the causes and characteristics of these conditions. Proliferative disorders can be reactive or neoplastic. Leukopenia is usually caused by neutropenia and results from reduced bone marrow production or increased destruction of neutrophils. Agranulocytosis is a severe form of neutropenia caused by drugs or idiosyncratic reactions. Leukocytosis can result from infections, inflammation, burns, or metastatic cancer stimulating bone marrow. Leukemoid reactions involve markedly elevated white counts with immature cells resembling leukemia but occurring in non-leukemic disorders.
1. Nociceptive fibers that detect painful stimuli are distinct from other sensory fibers, and can be classified as myelinated A-delta fibers or unmyelinated C fibers.
2. Pain signals travel through two main pathways in the spinal cord - the anterolateral pathway and dorsal column pathway.
3. Pain processing involves peripheral sensitization at the site of injury, and central sensitization in the spinal cord which can amplify pain signaling.
Neurons in the central nervous system have very limited regenerative abilities after injury. While it was once thought that neuronal injury always led to cell death, it is now known that neurons can remodel their projections and synaptic connections. The severity of injury can range from reversible myelin sheath damage (neuropraxia) to complete axon severing (neurotmesis). After injury, neurons undergo chromatolysis and may experience transneuronal degeneration. The distal stumps of severed axons undergo Wallerian degeneration over time. Growth cones allow limited axon regrowth, but glial scars and myelin inhibitors in the CNS make full recovery difficult.
This document discusses the human sensory systems. It describes four types of sensations - superficial, deep, visceral, and special. It then provides details on the receptors, pathways, and neural connections involved in touch, pain, temperature, proprioception, and other senses. Specifically, it outlines the locations and functions of mechanoreceptors like Meissner's corpuscles and Merkel endings, as well as nociceptors that detect pain. It also compares the dorsal column-medial lemniscus pathway and spinothalamic tract, noting their roles in transmitting different sensory signals to the cortex.
The document discusses the physiology of pain. It defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. It describes the dual nature of fast and slow pain mediated by different nerve fiber types. Stimuli that can cause pain and the receptors involved are discussed. The pathways that carry pain signals from receptors to the brain through the spinal cord and thalamus are summarized. Finally, it outlines the gate control theory of pain modulation by interactions between pain and touch fibers at the spinal cord.
This document summarizes factors that influence blood pressure, including cardiac output and peripheral resistance. It discusses how blood pressure is regulated through control of stroke volume, heart rate, and peripheral resistance. Stroke volume depends on preload and the contractile strength of the ventricles. Other factors like blood volume, viscosity, and vasoconstriction also impact blood pressure. The document outlines the anatomy of arteries branching from the aorta and how venous return relies on skeletal muscle contraction and respiratory movements.
The document summarizes section 1 of chapter 11 from an anatomy textbook. It describes the meninges, which are the three layers of membrane that surround and protect the brain and spinal cord. It also describes the ventricles in the brain and spinal cord that produce and circulate cerebrospinal fluid. Spinal taps are usually performed below the 4th lumbar vertebra to access cerebrospinal fluid without puncturing the spinal cord.
This chapter discusses water, electrolyte, and acid-base balance in the human body. It describes how the body maintains balance through various mechanisms that regulate intake and output of water and electrolytes like sodium, potassium, and chloride. The body contains two main fluid compartments - intracellular and extracellular fluid. Acid-base balance involves regulating hydrogen ion concentrations through buffer systems, respiratory excretion of carbon dioxide, and renal excretion of hydrogen ions. Imbalances can occur in the form of acidosis or alkalosis due to accumulation or loss of acids and bases.
This document summarizes key aspects of impulse conduction and neurotransmitters discussed in Chapter 10. It describes how myelinated axons conduct impulses faster than unmyelinated axons via saltatory conduction between nodes of Ranvier. It also explains how neurotransmitters are released at synapses and can either excite or inhibit postsynaptic neurons through EPSPs and IPSPs. Summation of these synaptic potentials determines whether an action potential is triggered in the postsynaptic cell. Examples of different neurotransmitters like acetylcholine, monoamines, amino acids, and gases are provided, along with how neuronal pools process nerve impulses through convergence and divergence.
This document introduces an 8th grade social studies class, discussing why social studies is important, class objectives, and how social studies can be applied to daily life. It gives the example of the heavy metal band Iron Maiden, whose songs are inspired by historical events like World War II and the Crimean War. One song is analyzed, "The Trooper", which is based on the Charge of the Light Brigade battle and Tennyson's poem of the same name.
1) The document describes the major arteries of the systemic circulation, including branches off the aorta such as the coronary, carotid, and brachial arteries.
2) It also details important veins that drain blood from the head, neck, arms and abdomen, including the internal and external jugular veins, brachial veins, and hepatic portal vein.
3) The hepatic portal system is summarized as carrying nutrient-rich blood from the abdominal viscera to the liver through the hepatic portal vein and its tributaries, before the blood continues to the inferior vena cava and heart.
This document summarizes the structure and function of the three main types of muscles - skeletal, smooth, and cardiac muscle. It describes their characteristics, locations in the body, and cellular structures. The key functions of muscles include body movement, maintaining posture, producing heat, and propelling substances through the body. Muscle contraction occurs through a sliding filament mechanism where actin and myosin filaments interact through cross-bridge cycling, powered by ATP hydrolysis. Calcium ions play a crucial role in initiating contraction by allowing the myosin heads to bind actin.
This document summarizes the key points from Chapter 12 of the textbook. It begins by distinguishing between general senses, which have receptors distributed throughout the body to detect touch, pain, temperature and pressure, and special senses like vision, taste and smell that have specialized receptors in the head. It then describes how sensory receptors detect stimuli and transmit sensory impulses to the brain to produce sensations and perceptions. The different types of receptors are identified, including those for chemicals, pain, temperature, mechanics, light, touch and pressure. The pathways and processing of pain signals in the nervous system are outlined. Proprioception receptors that provide information on body position and muscle tension are also defined.
The document summarizes key aspects of the urinary system as described in Chapter 20 of Hole's Human Anatomy and Physiology. It discusses the main functions of the urinary system which include maintaining homeostasis by removing wastes and regulating fluid volume and composition. The major components are the kidneys, ureters, urinary bladder and urethra. Nephrons in the kidneys filter blood to form urine through glomerular filtration, tubular reabsorption and secretion. Hormones help regulate urine concentration and volume by controlling water reabsorption in the kidneys.
DNA contains the genetic instructions for making proteins. It exists as a double-stranded helix structure, with the two strands running in opposite directions. DNA replication is the process where the DNA double helix unwinds and each strand serves as a template to produce a new complementary strand, resulting in two identical DNA molecules each with one original and one new strand. This semi-conservative method of replication occurs during S-phase and is catalyzed by the DNA polymerase enzyme.
The respiratory system consists of passages that filter air and transport it into the body and lungs where gas exchange occurs. Respiration involves ventilation, gas exchange in the lungs, transport of gases, and cellular respiration. The organs of the respiratory system include the nose, pharynx, larynx, trachea, bronchi, and lungs. Breathing is controlled by respiratory centers in the brain and is affected by factors like oxygen and carbon dioxide levels.
The document discusses the anatomy and classification of joints in the human body. There are three main types of joints - fibrous, cartilaginous, and synovial joints. Synovial joints are the most common and complex, containing articular cartilage, a synovial membrane, joint cavity, joint capsule, and often ligaments and menisci. The major synovial joints include ball-and-socket, hinge, pivot, saddle, gliding, and condylar joints. The knee is a prominent condylar joint between the femur and tibia, strengthened by ligaments and menisci.
Section 3, chapter 17: liver and intestinesMichael Walls
The liver is the largest internal organ located in the upper right abdominal quadrant. It has two major lobes and two minor lobes. The liver contains hepatic lobules which are the functional units, each containing hepatocytes, sinusoids, and triads. The liver performs many metabolic functions including glycogen storage, protein synthesis, and detoxification. Bile produced by the liver aids in fat digestion. The gallbladder stores and concentrates bile between meals. The small intestine completes digestion and absorbs nutrients through villi and microvilli before contents pass to the large intestine where water is absorbed and feces is formed.
Section 2, chapter 17: stomach and pancreasMichael Walls
The digestive system chapter discusses the anatomy and functions of the pharynx, esophagus, stomach, pancreas, and their roles in digestion. It describes 3 key points:
1) The pharynx connects the mouth to the esophagus. It has muscles that contract during swallowing to push food into the esophagus.
2) The stomach mixes food with gastric juices and empties slowly into the small intestine. Glands in its lining secrete enzymes and acid to break down proteins.
3) The pancreas secretes enzymes and bicarbonate into the small intestine to further break down food. Hormones regulate pancreatic secretions in response to food in the duodenum
This document summarizes the structure and function of the nervous system. It describes how the nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS includes the brain and spinal cord and integrates sensory input. The PNS includes nerves and carries signals between the CNS and sensory receptors and muscles/glands. Neurons transmit signals and neuroglia provide support. The document also details the anatomy and classifications of neurons, as well as the roles of myelin sheaths and different types of glial cells.
The nervous system is a highly organized network of billions of nerve cells that functions as the body's control center by integrating sensory information, processing signals, and initiating motor responses through the central and peripheral nervous systems. It is composed of neurons, which communicate through electrical and chemical signals, and neuroglia, which provide support and insulation. The peripheral nervous system connects the central nervous system to the rest of the body and is divided into sensory and motor divisions that receive input and initiate output, respectively.
The document summarizes the basic concepts of the human nervous system. It describes that the nervous system consists of two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS contains the brain and spinal cord. The PNS contains nerves that connect to the CNS and spread throughout the body. Both systems are composed of neurons, which are specialized cells that transmit electrical signals and allow communication within the nervous system and between it and other body systems.
The document summarizes the structure and function of the nervous system. It describes how the nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS includes the brain and spinal cord and integrates sensory input. The PNS includes nerves and carries signals between the CNS and sensory receptors and muscles/glands. Neurons are the basic functional units that transmit signals as electrical impulses. Glial cells provide support and insulation to neurons.
Nervous system PPT for grade 10 (basic concepts regarding human nervous system)AzkaSamreen
Human nervous system is highly complex, while reading in higher classes, we often mix up concepts. In this SlideShare I've tried to simplify the material for grade 10 students to better understand the concept.
The document discusses the structure and function of the human nervous system. It describes that the nervous system consists of the central nervous system (CNS), which includes the brain and spinal cord, and the peripheral nervous system (PNS), which carries information into and out of the CNS. Neurons are the basic functional units of the nervous system that communicate via electrical and chemical signals to integrate sensory input and coordinate motor output.
There is also the quoricity about the human brain, here is the solution. This presentation give you the knowledge about the nervous system. The introduction about the neurons, neurolgia, synapse,etc.
The nervous system controls and coordinates functions throughout the body using electrical signals called nerve impulses. It has three main parts - the central nervous system (brain and spinal cord), and the peripheral nervous system which includes sensory neurons, motor neurons, and interneurons. Sensory neurons detect stimuli and send signals to the central nervous system. Motor neurons carry signals from the central nervous system to muscles and glands. Interneurons connect neurons within the central nervous system. Neurons communicate via neurotransmitters released at synapses between neurons.
Powerpoint presentation about peripheral nerveavivrin18
The nervous system is comprised of the central nervous system (CNS) and peripheral nervous system (PNS). The CNS consists of the brain and spinal cord, and processes sensory information and coordinates motor responses. The PNS connects the CNS to the limbs and organs, and consists of nerves and ganglia. The nervous system contains two main cell types - neurons, which transmit signals, and neuroglia including oligodendrocytes and astrocytes, which support neuron function. The autonomic nervous system controls involuntary functions and contains sympathetic and parasympathetic divisions.
The nervous system is divided into the central nervous system (brain and spinal cord) and peripheral nervous system. It coordinates the body's activities and transmits signals via neurons, which are composed of a cell body, dendrites, and an axon. Neuroglia provide support and protection to the neurons. The nervous system consists of sensory neurons that receive information, interneurons that communicate within the central nervous system, and motor neurons that activate muscles and glands. A nerve impulse is transmitted through neurons via changes in electrical charges across the cell membrane.
The nervous system is composed of nerve cells and neurons that collect sensory information, integrate it, and coordinate responses. The basic functional unit is the neuron, which transmits electrochemical signals. There are three main types: sensory, motor, and interneurons. The nervous system is divided into the central nervous system (brain and spinal cord) and peripheral nervous system (nerves). The peripheral system connects the central system to the rest of the body. Sensory input is processed and motor responses are generated to coordinate organismal functions.
The nervous system presentation dawn part 1DAWN V TOMY
The document discusses the structure and function of the nervous system. It describes how the nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS consists of the brain and spinal cord, while the PNS contains nerves that branch throughout the body. The PNS can be further divided into the somatic, autonomic, and enteric nervous systems. Neurons are the basic functional units and come in three types - bipolar, unipolar, and multipolar. Neuroglial cells provide support and insulation for neurons. The nervous system has three main functions - receiving sensory input, integrating information, and initiating motor responses.
Nervous system - Arun Kumar Beborta, Tutor, SON, Christian Hospital Mungeli ruhiarun
This presentation was prepared for the GNM 1st year students with objectives: they will be able to:
1. define nervous system
2. describe neurones
3. explain different parts of brain and their function
4. list down types of nerves and their functions
5. differentiate between sympathetic and parasympathetic nervous system.
Here are the key features of synaptic transmission:
- EPSP/IPSP - Excitatory postsynaptic potential caused by sodium influx, inhibitory caused by chloride influx
- Summation - Spatial from multiple synapses, temporal from repeated firing overcomes threshold
- Synaptic delay - Time for neurotransmitter release, binding and opening of channels
- Fatigue - Repeated firing causes depletion of neurotransmitters, reducing response
- Role in information processing - Synapses allow complex neural circuits and computations
- Drugs - Can enhance or block neurotransmitters, altering synaptic transmission and neural function
- Acidosis/alkalosis - Can affect binding of neurotransmitters or opening of ion channels
- Hypoxia - Reduces
The nervous system consists of two main parts - the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS contains the brain and spinal cord, while the PNS contains nerves that connect the CNS to the rest of the body. The structures that make up the nervous system include neurons, neuroglia, the brain, spinal cord, cranial and spinal nerves. Neurons are specialized to conduct electrical signals, while neuroglia provide support and insulation to the neurons. The spinal cord is protected within the bony vertebral column and surrounded by three layers of meninges.
The document summarizes the structure and function of the nervous system. It begins by stating that the nervous system controls all body activities and is divided into the central and peripheral nervous systems. The central nervous system comprises the brain and spinal cord, while the peripheral nervous system includes cranial and spinal nerves. It then provides details on the anatomy and cellular components of the nervous system, including neurons, neuroglia, the myelin sheath and different classifications of nerve fibers.
The nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS contains the brain and spinal cord, which receive sensory input, integrate information, and respond through motor output. The PNS includes the somatic and autonomic nervous systems. The somatic system connects the CNS to skeletal muscles and senses, while the autonomic system regulates involuntary functions through its sympathetic and parasympathetic divisions. Neurons are the basic functional units that conduct electrical signals, while neuroglia provide support and insulation to neurons.
Nervous system
Master controller and communicating system in the body
Every thought, action and emotion reflects its activity.
It signals the body through electrical impulses that communicate with the body cells.
Its signaling and responding abilities are highly specific and rapid.
The reticular formation is a region in the brainstem that contains a network of neurons and fibers. It receives sensory information from ascending and descending tracts and has connections with other brain regions. It contains four important neuronal systems - the gigantocellular nuclei, substantia nigra, locus ceruleus, and raphe nuclei. The reticular formation plays roles in consciousness, sleep, sensory regulation, motor control, and autonomic functions through these neuronal systems.
The skin is the largest organ of the integumentary system and has three main layers - the epidermis, dermis and subcutaneous layer. The epidermis is made of stratified squamous epithelium and provides protection, while the dermis contains connective tissue, hair follicles, and glands. The skin regulates body temperature through vasodilation, sweating, and insulation from fat in the subcutaneous layer. When injured, the skin initiates an inflammatory response and repairs through processes like epithelial cell regeneration, collagen deposition, and scar formation.
This document summarizes key concepts about metabolism, including:
1) Metabolism involves both anabolic and catabolic reactions that synthesize and break down molecules. ATP is the main energy currency molecule in cells.
2) Glycolysis, the citric acid cycle, and electron transport chain are the main catabolic pathways that break down glucose and other fuels to generate ATP through cellular respiration.
3) Dehydration synthesis and hydrolysis are important reaction types in metabolism. Enzymes catalyze metabolic reactions and are essential for metabolic pathways and cellular function.
There are approximately 75 trillion cells in the human body that are derived from a single fertilized egg. The cell membrane maintains the integrity of the cell and is selectively permeable, controlling what moves in and out. It consists of a phospholipid bilayer, membrane proteins, and cholesterol. Transport across the membrane can occur through passive diffusion, facilitated diffusion, osmosis, and filtration. Active transport uses cellular energy and includes processes like endocytosis, exocytosis, and transcytosis. The basic stages of the cell cycle are interphase, mitosis, and cytokinesis.
This document provides an overview of basic chemistry concepts important for understanding physiology. It defines key terms like elements, compounds, molecules, and atoms. It describes atomic structure including protons, neutrons, electrons and isotopes. It explains different types of chemical bonds and reactions. It also summarizes important macromolecules and inorganic chemicals in the body like carbohydrates, lipids, proteins, nucleic acids, water, and salts. Understanding chemistry is essential for studying how organ systems and cellular functions rely on chemical reactions in the body.
This document discusses key concepts in anatomy and physiology including:
- Anatomy refers to the study of structures while physiology refers to the study of functions.
- Form follows function - the anatomy of an organ is based on its intended physiology.
- Homeostasis is the maintenance of stable internal conditions through feedback loops like negative feedback which returns conditions to normal ranges.
- Positive feedback drives conditions further from the set point and is not involved in homeostasis, like the contractions during childbirth.
This document summarizes the structure and function of blood vessels. It describes the three main types of blood vessels - arteries, which carry blood away from the heart; veins, which carry blood back towards the heart; and capillaries, which allow for the exchange of gases, nutrients, and waste between blood and tissues. Each vessel type has distinct layers in its walls to facilitate blood flow and transport. Arterioles branch from arteries and connect to capillaries, while venules branch from capillaries and merge to form veins. The document highlights key differences between arteries and veins like wall composition and the presence of valves in veins.
An electrocardiogram (ECG or EKG) records the electrical activity of the heart during each cardiac cycle. It detects the P wave, QRS complex, and T wave which represent atrial depolarization, ventricular depolarization, and ventricular repolarization, respectively. The ECG can also detect abnormal heart rhythms such as bradycardia, tachycardia, atrial flutter, atrial fibrillation, and ventricular fibrillation. The heart rate is controlled by the sinoatrial node but can be influenced by the cardioinhibitor and cardioaccelerator centers in the medulla which increase or decrease heart rate through the release of acetylcholine or norepinephrine acting on the SA and AV
section 2, chapter 15: conduction of the heartMichael Walls
The cardiac cycle involves the coordinated contraction and relaxation of the left and right sides of the heart. During ventricular systole, the ventricles contract to expel blood while the atria relax and fill with blood. During ventricular diastole, the ventricles relax and fill with blood while the atria contract to push the remaining blood into the ventricles.
The heart produces distinct lub-dubb sounds as the atrioventricular and semilunar valves close, which can be auscultated through specific areas on the chest. Abnormal valve closure sounds are called murmurs.
The heart's conduction system initiates and coordinates contractions. The sinoatrial node initiates atrial contractions
Section 1, chapter 15: anatomy of the heartMichael Walls
The cardiovascular system consists of the heart and blood vessels. The heart pumps around 7000L of blood daily through two circuits - the pulmonary circuit carries blood to the lungs, while the systemic circuit carries blood to the body. The heart has four chambers and is surrounded by membranes. It contains valves that ensure one-way blood flow, preventing backflow into chambers. Blood flows through the right side of the heart to the lungs, then the left side to the body.
The digestive system breaks down food into smaller molecules that can be absorbed by cells. It consists of the alimentary canal (mouth to anus) and accessory glands. The alimentary canal wall has four layers - mucosa, submucosa, muscular layer, and serosa. Muscles in the walls provide segmentation to mix foods and peristalsis to propel foods through the canal. Accessory glands like the salivary glands secrete chemicals to aid digestion. The mouth is the beginning of the alimentary canal and contains the teeth, tongue, and palate to mechanically break down foods. Saliva from the parotid, submandibular, and sublingual
Section 2, chapter 16: defense and immunityMichael Walls
The lymphatic system and innate/adaptive defenses work together to protect the body from infection. Innate defenses provide general protection and include mechanical, chemical, cellular barriers and inflammation. Adaptive defenses provide targeted protection through lymphocytes and antibodies. When pathogens evade innate defenses, lymphocytes mount a response by cloning into memory and effector cells to recognize and eliminate the pathogen upon future exposures. T cells activate other immune cells and destroy infected cells while B cells produce antibodies to neutralize pathogens. Together these coordinated defenses provide robust protection against a wide range of infectious threats.
section 2, chapter 16: defense against pathogensMichael Walls
The lymphatic system and innate/adaptive defenses work together to protect the body from infection. Innate defenses provide general protection and include mechanical/chemical barriers that prevent pathogen entry. Adaptive defenses provide targeted protection through lymphocytes like T and B cells. T cells lead cellular immunity responses, while B cells produce antibodies for humoral immunity. When pathogens breach innate defenses, lymphocytes are activated through processes like antigen presentation and cytokine signaling to mount tailored immune responses through memory cells and targeted destruction of infected cells.
The lymphatic system filters and returns interstitial fluid to the blood circulation through a network of vessels and organs. It begins with lymphatic capillaries that collect fluid from tissues and convey it through lymphatic vessels to lymph nodes, where the fluid is filtered and monitored for pathogens. The lymph then passes through larger lymphatic vessels and trunks before the two main collecting ducts, the thoracic duct and right lymphatic duct, return the lymph to venous circulation. Lymph nodes throughout the body help fight infection by filtering lymph and producing immune cells.
The document summarizes key aspects of several endocrine glands and their hormones. It describes the location and functions of the thyroid gland, parathyroid glands, adrenal glands, pancreas, pineal gland, thymus gland and reproductive organs. It discusses how thyroid hormones, calcitonin, parathyroid hormone, adrenal hormones, insulin, glucagon and reproductive hormones regulate processes like metabolism, calcium levels, stress response and reproduction. It also summarizes thyroid disorders like hypothyroidism and hyperthyroidism as well as diabetes mellitus types I and II.
The pituitary gland, located at the base of the brain, has two lobes - the anterior and posterior pituitary. The anterior pituitary is controlled by releasing hormones from the hypothalamus and secretes tropic hormones that target other endocrine glands. The posterior pituitary stores and releases two hormones - antidiuretic hormone and oxytocin - that are produced in the hypothalamus. The pituitary gland plays a key role in regulating growth, metabolism, fluid balance, and reproduction through its control of other endocrine glands.
The endocrine system works with the nervous system to communicate and control the body. The endocrine system uses hormones to regulate distant target cells. Hormones are secreted into the bloodstream by endocrine glands and only target cells with receptors for that hormone. Hormone secretion is controlled through negative feedback loops, hormone deactivation, and up/down regulation of receptors on target cells.
1. Plasma is the liquid portion of blood and makes up 55% of the blood volume. It contains proteins, dissolved gases, wastes, electrolytes, nutrients, and hormones.
2. The major plasma proteins are albumin, globulins, and fibrinogen. Albumin helps maintain blood pressure while globulins transport lipids and act as antibodies. Fibrinogen functions in blood coagulation.
3. Hemostasis is the process of stopping bleeding and occurs through vasospasm, platelet plug formation, and blood coagulation. A blood clot forms that traps blood cells and platelets.
This document provides an overview of blood and its components. It discusses the functions of blood which include transporting gases, nutrients, wastes, and hormones. Blood is a connective tissue composed of formed elements (red blood cells, white blood cells, and platelets) suspended in plasma. Red blood cells transport oxygen and carbon dioxide, white blood cells provide immunity, and platelets aid in blood clotting. Hematopoiesis is the formation of blood cells from stem cells in bone marrow. The document describes the different types of blood cells and their characteristics and functions.
The document summarizes key aspects of vision and eye anatomy. It describes the eyelids, lacrimal apparatus, and extrinsic eye muscles that support vision. It then details the internal structures of the eye, including the three tunics (fibrous, vascular, nervous), aqueous humor, lens, iris, retina, and visual receptors (rods and cones). It explains light refraction by the cornea and lens, accommodation of the lens, and the pathways for visual signals in the retina and brain. Common refractive disorders like myopia and hyperopia are also summarized.
The document summarizes the key sensory organs and processes of smell, taste, hearing, and balance. It describes the main sensory receptors for each sense, including olfactory receptors in the nose, taste buds on the tongue, hair cells in the inner ear, and balance-related structures in the inner ear. It also outlines the main neural pathways that carry sensory signals from these receptors to the brain structures involved in perception and processing.
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
Physiology and chemistry of skin and pigmentation, hairs, scalp, lips and nail, Cleansing cream, Lotions, Face powders, Face packs, Lipsticks, Bath products, soaps and baby product,
Preparation and standardization of the following : Tonic, Bleaches, Dentifrices and Mouth washes & Tooth Pastes, Cosmetics for Nails.
2. Sensory Function:
• Sensory receptors detect changes in the environment (stimuli)
• Information is carried to the CNS on sensory (afferent) neurons
Motor Function:
• Nerve impulses are transmitted from the CNS to PNS on motor
(efferent) neurons
• effectors (muscles or glands) within the PNS cause a change
(effect)
Integrative Function:
• Nervous system maintains homeostasis – detects and responds to
changes in blood pressure, body temp, heart rate, etc.
• Higher intellect: problem solving, thoughts, memory, judgment
3. The Central Nervous System (CNS)
• brain and spinal cord.
The Peripheral Nervous System (PNS)
• 12 pairs of cranial nerves and
• 31 pairs of spinal nerves
• Nerves may be motor (efferent), sensory
(afferent), or both (mixed)
The Central Nervous System is Red, while
the Peripheral Nervous System is Blue.
4. Sensory (Afferent) Division
• Transmits impulses from receptors in the PNS to CNS
Motor (Efferent) Division
• Transmits impulses from CNS to effectors in the PNS
5. Somatic Sensory
• Senses you’re consciously aware of
• Vision, taste, olfaction, smell, hearing
• Touch, vibration, pain
Somatic Motor
• Controls voluntary (skeletal) activities
• Skeletal muscles – voluntary control
Somatic Division is associated with voluntary (skeletal) activities and senses that
detect shapes, textures, sounds, and other external and internal forces acting on
the body.
6. Autonomic Sensory
• Senses that monitor vital conditions within the body
• O2/CO2 levels, pH, Blood Pressure, Body Temp
Autonomic Motor – involuntary control
• Smooth muscles
• Cardiac muscles
• glands
Autonomic Nervous System regulates functions of the internal organs
Heart rate, digestion, sexual arousal, urination
7. Sympathetic Division
• Fight-or-Flight Response
• Prepares body for emergency
Parasympathetic Divsion
• Rest-and-Digest
• Maintains body activities at rest
The Autonomic Nervous System (ANS) is divided into two branches
8.
9. Neurons
• Integrate, regulate, and coordinate body functions
• Transmit nerve impulses (action potentials)
Neuroglia (glia = “glue”)
• Neuroglia provide neurons with nutritional,
structural, and functional support
Neural Tissue contains two Cell Types:
10. Neurons vary in shape and size
Dendrite
Cell Body (soma)
Nucleus
axon
axon terminal
Myelin sheath
Schwann Cell
3 Parts of a Neuron
• Dendrites – receive inputs from other
neurons or other stimuli
• Cell Body (Soma)
• Axon – transmit nerve impulses
away from the cell body towards
other neurons, muscles, or
glands
11. Dendrites
• Dendrites transmit information towards the cell body
• A cell may have many dendrites, few dendrites, or no dendrites
• Dendritic spines – additional contact points on dendrites
• A neuron may add more spines, increasing its sensitivity to incoming
stimuli, or It may remove spines to decrease its sensitivity to stimuli.
Segment of a dendrite (green) with dendritic spines (yellow)
12. Cell Body (Soma)
• Contains organelles such as nucleus, mitochondria, Golgi Apparatus,
neurofilaments, and Rough ER
• Chromatophilic Substances (Nissl Bodies) – mostly Rough ER, protein
synthesis
• Cell body produces proteins for the cell
13. Axon
• Transmits electrical impulses (action potentials)
away from the neuron
• Each neuron has only 1 axon, but it may divide
into several branches, called collaterals.
• Axon Hillock (trigger zone) – specialized site
connected to the cell body, where electrical
impulses (action potentials) are initiated
• Axon terminal – end of the axon.
• Contains enlarged synaptic knob (bouton)
• Neurotransmitters are stored within secretory
vesicles within the synaptic knob.
14. Axon
• Neurofibrils – microtubules that support long axons
• Neurofibrils aid in axonal transport – transports
proteins from the cell body through the axon
• Axoplasm – cytoplasm of the axon
• Axolemma – cell membrane of the axon
15. Myelin Sheath
• Thick fatty coating of insulation surrounding some axons
• Myelin sheath greatly enhances the speed of nerve
impulses
• Schwann Cells form the myelin sheath in the PNS
• Oligodendrocytes form the myelin sheath in the CNS
Schwann cell forming the myelin sheath around an axon within the PNS
16. Schwann Cells
• Schwann Cells myelinate neurons in the PNS
• Schwann Cells wrap around the axon in a jelly-roll
fashion, forming a thick layer of lipid insulation, called
the Myelin Sheath
• Neurilemma – The cytoplasm and nucleus of the
Schwann Cell are pushed outwards, forming an outer
layer, called the neurilemma
• Nodes of Ranvier – gaps of exposed axon between
adjacent Schwann Cells
Myelin sheathNeurilemma (at the nucleus)
Mitochondrion within axon
axon
17. ◊ Not all axons are myelinated
◊ Myelinated axons in the PNS
have a series of Schwann cells
lined up along the axon, each
having a wrapped coating of
myelin insulating the axon
◊ Unmyelinated axons in the PNS
are encased by Schwann cell
cytoplasm, but there is no
wrapped coating of myelin
surrounding the axons
Schwann Cell
axon
axon
Schwann Cell
Myelin sheath
18. Oligodendrocytes
• Oligodendrocytes myelinate
axons in the PNS
• Each oligodendrocyte myelinates
multiple axons
• White Matter – mass of
myelinated axons within the CNS
• Gray Matter – unmyelinated
nervous tissue in the CNS
Oligodendrocyte myelinating several axons.
19. Gray Matter of the Cerebral Cortex
- unmyelinated tissue
White Matter of the Cerebrum
- myelinated tissue
20. Multipolar Neuron
• Many dendrites and 1 axon
• Includes most neurons in the
CNS and motor neurons
dendrites
axon
21. Bipolar Neuron
• 1 dendrite and 1 axon
• Includes some special sensory neurons,
such as photoreceptors and olfactory
neurons.
dendrite
axon
22. Psuedounipolar Neuron
• Contains a single process that acts
as an axon
• Peripheral process – conducts
information from the PNS
• Central process – conducts
information toward the CNS
• Example includes sensory neurons
within the Dorsal Root Ganglia
(DRG)
peripheral process
central process
23. Sensory (afferent) neuron
• Transmit impulses from the PNS towards the CNS
• Most afferent neurons are unipolar. Some are Bipolar.
Motor (efferent) neuron
• Transmit impulses from the CNS towards effectors in the CNS
• Somatic Motor Neurons – voluntary control
• Autonomic Motor Neurons – involuntary control.
Interneuron (association)
• Completely within the CNS
• Interneurons link together in the CNS
• Interneurons connect sensory neurons to motor neurons
24. Peripheral Nervous System Central Nervous System
Sensory receptor Sensory neuron
interneuron
interneuronMotor neuronEffector
(muscle or gland)
25. General Functions of Neuroglia:
• Provide structural and metabolic support for neurons
• Guide developing neurons into position
• Remove excess ions and neurotransmitters
• Strengthen synapses
• Neuroglia outnumber neurons 10 to 1
Neuroglia in the CNS vs. PNS
• Neuroglia of the CNS include: astrocytes, ependymal cells,
microglia, and oligodendrocytes
• Neuroglia of the PNS include: satellite cells and Schwann
Cells
26. Astrocytes:
• Star-shaped cell
• Attaches neuron to blood vessels
• Astrocytes aid in metabolism, strengthen synapses,
and participate in the Blood-Brain-Barrier
Ependymal Cells
• Simple cuboidal epithelium with cilia
• Lines ventricles of the brain and central canal of spinal
cord
• Cover choroid plexuses (capillary networks within CNS)
• Regulate the composition of cerebrospinal fluid (CSF)
27. Microglia:
• Normally small cells until activated
• Enlarge into macrophages with infection
• Phagocytize foreign material
Microglia (green) surrounding nerve processes (red)
Oligodendrocytes:
• Form the myelin sheath within the CNS
• Provide structural support
Oligodendrocyte myelinating several axons within the CNS
28. Schwann Cells:
• Form the myelin sheath in the PNS
• Greatly increase nerve impulse speed
Satellite Cells:
• Surround and support clusters of cell
bodies (ganglia) within the PNS
29. • Mature neurons do not divide
• If cell body is injured, the neuron usually dies
Neuron Regeneration in the PNS:
• If a peripheral axon is injured, it may regenerate
• Axon separated from cell body and its myelin sheath will degenerate
• Schwann cells and neurilemma remain
• Remaining Schwann cells provide guiding sheath for growing axon
• If growing axon establishes former connection, function will return; if not,
function may be lost
Neuron Regeneration in the CNS:
• CNS axons lack neurilemma to act as guiding sheath
• Oligodendrocytes do not proliferate after injury
• Regeneration is unlikely
30. Multiple Sclerosis:
• Autoimmune disease that destroys the
myelin sheath of motor neurons.
• The damaged myelin sheath is replaced
with connective tissue, leaving behind
scars (scleroses)
• The scars block transmission of underlying
neurons, so muscles no longer receive
stimuli
• Muscles atrophy and wither over time
White matter lesions (scleroses) of Multiple Sclerosis
31. Neurons communicate with each other at synapses.
• A synapse is a site at which a neuron
transmits a nerve impulse to another neuron
• Presynaptic neuron sends
impulse (usually) by releasing neurotransmitters
into the synaptic cleft
• Postsynaptic neuron
receives impulse
• Synaptic cleft separates the
2 neurons
32. 1. A nerve impulse (action potential) travels
down the axon to the axon terminal.
2. The action potential opens calcium channels
causing calcium to diffuse into the synaptic
knob.
3. The calcium influx triggers the exocytosis
of neurotransmitters from synaptic
vesicles into the synapse.
4. The neurotransmitters diffuse across the
synapse and bind to receptors on the post-
synaptic cell
5. Neurotransmitter either exerts an excitatory
or inhibitory effect, depending on the
neurotransmitter and the receptor.
33. The cell membrane is usually polarized (charged)
• Inside the membrane is negatively charged relative to outside the membrane
• Polarization is due to unequal distribution of ions across the membrane
•Polarization is maintained by a series of ion pumps and ion channels
•All Cells have a membrane potential.
Cell membrane
34. • Potassium (K+) ions: major intracellular positive ions (cations).
• Sodium (Na+) ions: major extracellular positive ions (cations).
• This distribution is largely created by the Sodium/Potassium Pump
(Na+/K+ pump) but also by ion channels in the cell membrane.
• Na+/K+ Pump transports Na+ ions out of cell and K+ ions into cell
• Ion channels, formed by membrane proteins, help regulate passage of
specific ions into or out of the cell
• Many chemical & electrical factors affect opening & closing of gated
channels
35. Non-Gated (Leak) Ion channels,
• Channels are always open, allowing specific
ions to “leak” down their concentration gradient.
• Cells have abundant K+ leak channels, making
them permeable to K+.
38. Voltage-Gated Ion channels,
• Open and close due to small changes in the
membrane potential (millivolts = mV)
• Voltage-gated Na+ channels open when
membrane potential reaches -55mV.
• Voltage-gated K+ channels open as the
membrane potential approaches +35mV
openclosed
-70mV -55mV
40. 3 Factors Establish the Membrane Potential
1. Na+/K+ ATPase
2. Non-gated K+ channels
3. Negatively charged proteins and DNA within the cell
Sodium-Potassium ATPase (Pump)
• Pumps 3 Na+ out of the cell, but only 2 K+
into the cell.
• Net positive charges leaving the cell, making
inside negatively charged.
• The Na+/K+ pump only contributes a small
amount (-5mV) to the membrane potential
41. 3 Factors Help Maintain the Cell Membrane Potential
Non-gated Potassium Channels
• Cell has many K+ leak channels, making
it permeable to potassium.
• K+ continually leaks out of the cell,
making the inside of the cell more
negative.
Na+/K+ PumpK+ leak channel
K+
K+ Na+
ATP
ADP + P
42. Resting Membrane Potential (RMP)
• RMP = membrane potential of excitable
cells (neurons and muscles) while at rest.
• For a neuron at rest, the RMP is -70mV
inside the cell.
43. Opening/Closing gated-Ion channels cause changes in local membrane potential
Hyperpolarization
• membrane potential becomes more negative.
• e.g. -100 mV
Depolarization
• membrane potential becomes less negative.
• e.g. -60 mV
Resting Membrane Potential (RMP) of neuron = -70mV
-70mv (RMP)
-70mv (RMP)
Time (ms)
44. • Local potential changes are graded—the greater
the stimulus intensity, the greater the potential
change
• If degree of depolarization reaches threshold
potential of -55 mV, an action potential results
• If degree of depolarization does not reach threshold
potential, an action potential will not occur
subhreshold potential
Graded (Local) Potentials
45. Summation – Graded potentials may add together (summate)
• Spatial summation – stimuli from multiple neurons
• Temporal summation – high frequency stimulation from a presynaptic neuron
• Combination – stimuli from multiple neurons at a high frequency
• If summation reaches threshold potential (-55mV), it initiates an action potential
Example of Spatial Summation Example of Temporal Summation
48. Depolarization
• Voltage-Gated Na+ channels open at -55mV (threshold)
• Na+ diffuses into the cell
Repolarization
• Voltage-Gated K+ channels open as cell
depolarizes towards +30mV
• K+ diffuses out of the cell
• Na+ channels close
Hyperpolarization
• K+ channels remain open, causing an overshoot
• Na+/K+ pumps reestablish the RMP.
49. Na+
K+
At rest, the membrane is polarized
(RMP = -70mV). Sodium is mostly outside the
cell and potassium is within the cell.
Resting Membrane Potential
50. Na+
Na+
When a stimulus reaches threshold stimulus (-55mV),
voltage-gated Na+ channels open. Sodium rapidly diffuses
into the cell, depolarizing the membrane up to +30mV.
Depolarization
51. K+Na+
K+
Na+
Repolarization
As the membrane potential approaches +30mV, voltage-
gated K+ channels open and quickly repolarize the
membrane. Sodium channels also close at this point.
52. Na+
K+
Hyperpolarization
K+ channels remain open, causing an overshoot past RMP.
Following an action potential, Na+/K+ pumps actively
reestablish the Na+ and K+ concentration gradients.
53. High K+
High Na+
-70mV -70mV -70mV
Once an action potential is initiated it is propagated along the
entire axon at full strength. It does not weaken.
At rest, Na+/K+ pumps maintain a high
extracellular Na+ concentration and a high
intracellular K+ concentration.
54. • Action Potential begins when Axon Hillock
depolarizes to threshold potential (-55mV)
• Voltage-Gated Na+ channels open, Na+ diffuses
into the cell, depolarizing the region to +30mV
-70mV
+30mV
High Na+
55. High Na+
-55mV -70mV
• Sodium now within the cell diffuses to its
adjacent region, depolarizing it to threshold.
56. • Voltage-Gated Na+ channels in adjacent region
open. Na+ diffuses into the cell, causing another
action potential in the adjacent region.
Na+
K+
• Voltage-Gated K+ channels quickly repolarize the
axon, following the depolarization.
57. High Na+
-55mV -70mV
• Again Sodium diffuses to adjacent region,
depolarizing it to threshold. Another Action
potential follows.
• The action potential continues sequentially along
the entire axon, to the axon terminal.
58. 1. Resting Membrane Potential 1. Na+/K+ pumps, K+ leak channels, and negatively charged
proteins maintain RMP = -70mV
2. Graded Potential - Stimulus 2. Neuron receives stimulus initiating graded potentials
3. Threshold Potential 3. Graded potentials reach threshold, triggering an action
potential
4. Action Potential - Depolarization 4. Voltage-gated, Na+ channels open, sodium diffuses into cell.
5. Action Potential - Repolarization 5. Voltage-gated K+ channels open, potassium diffuses out of
the cell.
6. Action Potential - Hyperpolarization 6. Na+/K+ pumps re-establish RMP at region
7. Action Potential Propagation 7. Sodium diffusing into the cell generates an electrical current
that stimulates adjacent regions of the membrane.
Action potentials occur sequentially along the length of the
axon.
Action Potential propagated along the axon
is often called a nerve impulse.
59. All-or-None Response
• Action Potentials occur completely or they do not occur at all.
• A stronger stimulation does not produce a stronger impulse.
• Instead, a stronger stimulation produces a higher frequency
of nerve impulses (more impulses per second)
weaker stimulus stronger stimulus
60. Refractory Period: For a brief period following an action potential,
a threshold stimulus will not trigger another action potential.
Absolute Refractory Period
• no new action potentials can be produced
• Occurs while the membrane is changing in sodium permeability
• Between the depolarization and repolarization phases
Relative Refractory Period
• Action potential can be generated with a high intensity stimulus
• Occurs while membrane is reestablishing its resting membrane potential
• Lasts from the hyperpolarization phase, until RMP is reestablished
61. Speed of a Nerve Impulse Depends on
• Diameter of the axon: larger diameter = higher velocity
• Myelinated vs Unmyelinated: myelinated neurons are much
faster than unmyelinated neurons.
Unmeylinated Axons must generate action potentials across the entire
axon.
The impulse is slow (travels at 1 mile/hour)
62. Myelinated axons conduct impulses differently than unmyelinated axons.
Unmyelinated Axons
Generate a series of action potentials along the entire axon.
Nerve impulses are slow: travel around 1 mile/hour (0.4 meters/second)
Myelinated Axons
• Myelin is an electrical insulator
• Action potentials of myelinated axons are only generated
at the nodes of Ranvier.
• Nerve impulse through the myelinated portion travels by
electrical conduction
• This is called, salutatory conduction
• Saltatory conduction increases conduction velocity to
around 285 miles/hour (127 meters/second)
63. Unmeylinated Axons must generate action potentials across the entire
axon. The impulse is slow (travels at 1 mile/hour)
Meylinated axons conduct nerve impulses via salutatory conduction:
Electrical conduction through myelin sheath, action potentials only at nodes
of Ranvier. Appears as if nerve impulse “jumps” from node-to-node.
electrical conduction
Node of Ranvier
meyelin sheath
64. 1. A nerve impulse (action potential) travels
down the axon to the axon terminal.
2. The action potential opens calcium channels
causing calcium to diffuse into the synaptic
knob.
3. The calcium influx triggers the exocytosis
of neurotransmitters from synaptic
vesicles into the synapse.
4. The neurotransmitters diffuse across the
synapse and bind to receptors on the post-
synaptic cell
5. Neurotransmitter either exerts an excitatory
or inhibitory effect, depending on the
neurotransmitter and the receptor.
65. Synaptic Transmission
Most neuron communication occurs when a presynaptic neuron releases
neurotransmitters into the synaptic cleft, where the neurotransmitters
subsequently bind to receptors on a postsynaptic cell
Local potentials resulting from changes in
chemically gated ion channels are called synaptic
potentials
66. Excitatory postsynaptic potential (EPSP):
• Membrane change in which neurotransmitter opens Na+ channels (or
Ca2+) channels
• Depolarizes membrane of postsynaptic neuron, as Na+ enters axon
• Action potential in postsynaptic neuron becomes more likely
Inhibitory postsynaptic potential (IPSP):
• Membrane change in which neurotransmitter opens K+ channels (or Cl-
channels)
• Hyperpolarizes membrane of postsynaptic neuron, as K+ leaves axon
• Action potential of postsynaptic neuron becomes less likely
67. EPSPs and IPSPs are added together in a
process called summation
Summation occurs at axon hillock
(trigger zone)
The integrated sum of EPSPs and IPSPs
determines if an action potential occurs
If threshold stimulus is reached an action
potential is triggered.
68. Neurotransmitters
The nervous system produces at least thirty different types of neurotransmitters.
Examples:
1. Acetylcholine – skeletal muscle contractions
2. Monoamines
• Norepinephrine
- in CNS it creates a sense of well-being
- in PNS it may stimulate or inhibit autonomic nervous system
• Dopamine
- in CNS it creates a sense of well-being
- Amphetamines increase the levels of norepinephrine and dopamine
3. Amino Acids
• GABA – inhibitory neurotransmitter of the CNS
• Many sedatives and anesthesia enhances GABA secretions
• Schizophrenia is associated with a deficiency of GABA
4. Gases
• Nitric Oxide
• Vasodilation in PNS
69. Neurotransmitters
Examples:
5. Glutamate – primary excitatory neurotransmitter in the CNS
6. Serotonin – primarily inhibitory. Leads to sleepiness.
7. Substance P – pain perception
8. Endorphins & Enkaphalins – reduce pain by inhibiting substance P release
70. Enzymatic Degridation
• Acetylcholinesterase – decomposes Acetylcholine in the synaptic cleft.
• Monoamine Oxidase – decomposes Epinephrine and Norepinephrine.
• Limits the duration of your sympathetic (fight-or-flight) response.
Reuptake
• Neuroglia and enzymes transport neurotransmitters within the synaptic
cleft back to the synaptic knob of the presynaptic neuron.
• Neurotransmitters are repackaged into new secretory vesicles and used
again.
71. Cocaine
• Cocaine binds to Dopamine transporters, preventing the reuptake of
Dopamine.
• This results in excess dopamine in the synaptic cleft.
Nicotine
• Nicotine binds to Nicotinic receptors on dopaminergic neurons, causing
them to release dopamine.
72. Nerve impulses are processed by the CNS in a way that reflects
the organization of neurons in the brain and spinal cord.
Neuronal Pool
• Organized groups of interneurons within the CNS
• Pools are organized as neuronal circuits that
perform a common function, even though they
may be in different parts of the CNS.
• May have either excitatory or inhibitory effects on
effectors, or other neuronal pools.
73. Neuronal Pools
Convergence
• Several neurons synapse onto one post-synaptic
neuron
• Funnels impulses from several areas onto a
single neuron
• Information from various sensory receptors may
converge onto a single processing center.
Divergence
• Impulses spread from one axon to several post-
synaptic neurons
• May amplify a stimulus
• May send a one signal to multiple parts of the CNS.
74. • Neuron in tissue culture By GerryShaw (Own work) [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via
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• Neural Tissue Illustration By Blausen.com staff. "Blausen gallery 2014". Wikiversity Journal of Medicine.
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75. • TEM of myelinated neuron Roadnottaken at the English language Wikipedia [GFDL (http://www.gnu.org/copyleft/fdl.html) or CC-
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