Scientists have discovered the first new antibiotic in nearly 30 years called Teixobactin. It is effective against many common bacterial infections like tuberculosis and C. difficile. Teixobactin works via a novel dual mechanism attacking the building blocks of bacterial cell walls. Testing on mice showed it cleared infections without side effects. This discovery is significant because Teixobactin does not encounter any detectable resistance, which could lead to a new generation of antibiotics. It may be available for human use within 5 years.

1. Scientists create 1st new
antibiotic in nearly 30 years
May Hold Key To Beating Superbug
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2. Contd..
In a massive breakthrough, scientists have created
the first new antibiotic in nearly three decades.
Teixobactin can treat many common bacterial
infections such as tuberculosis, septicemia and C
Diff or clostridium difficile colitis. It eliminates
pathogens without encountering any detectable
resistance.
The discovery comes at a time when World Health
Organization (WHO) has sent out warnings that
the world is staring at a post-antibiotic era when
common infections will no longer have a cure. The
first antibiotic, Penicillin, was discovered by
Alexander Fleming in 1928.More than 100
compounds have been found since then, but no
new class has been found since 1987.
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3. Contd..
Antibiotics have been magic bullets for human health
for decades but irrational use has made most bugs
resistant to these. Northeastern University's professor
Kim Lewis announced on Thursday the discovery of the
antibiotic. Lewis and Northeastern biology professor
Slava Epstein co-authored the finding with colleagues
from University of Bonn in Germany , Novo Biotic
Pharmaceuticals in Cambridge, Massachusetts, and
Selcia Ltd in the UK.
Most antibiotics target bacterial proteins, but bugs can
become resistant by evolving new kinds of proteins.
What's unique about Teixobactin is that it launches a
double attack on the building blocks of bacterial cell
walls. Experts say this will pave the way for a new
generation of antibiotics because of the way it was
discovered.
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4. Contd..
Teixobactin could be available in the next five
years. Its testing on mice has shown it clears
infections without side-effects. The NU team led
by Prof Lewis is now concentrating on upscaling
production of Teixobactin to test it on humans.
Northeastern researchers' pioneering work to
develop a novel method for growing uncultured
bacteria led to the discovery of the antibiotic,
and Lewis's lab played a key role in analyzing
and testing the compound for resistance from
pathogens.
Lewis said this marks the first discovery of an
antibiotic to which resistance by mutations of
pathogens have not been identified.
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5. Contd..
“So far, the strategy has been based on developing
new antibiotics faster than the pathogens acquire
resistance. Teixobactin presents a new opportunity
to develop compounds that are essentially free of
resistance,“ Lewis said. The screening of soil micro-
organisms has produced most antibiotics, but only
1% of these will grow in the lab, Lewis explained. He
and Epstein spent years seeking to address this
problem by tapping into a new source of antibiotics
beyond those created by synthetic means:
uncultured bacteria, which make up 99% of all
species in external environments.
Britain's CMO, Dame Sally Davies, said antibiotic
resistant was “as big a risk as terrorism“, and warned
that Britain faced returning to 19th century scourges
when the smallest infection or operations could kill.
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