Bill Gates believes that genetically modified mosquitoes could help reduce malaria deaths within the next 5 years. Researchers are developing a "gene drive" technique to alter mosquitoes so they pass on malaria resistance to nearly all offspring. This could quickly alter entire mosquito populations. While the technology may help reduce malaria, some researchers have raised concerns about potential unintended consequences if the GM mosquitoes crossbreed with other species or develop unexpected mutations. Gates remains optimistic this approach can be made safe with further testing and regulation.

1. GM mosquitoes to
fight malaria
Gene-editing tech to create genetically altered
mosquitoes may be out there in five years,
says Bill Gates
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2. Contd…
Bring on the genetically modified mosquitoes, Bill Gates says. In recent years,
biolo gists armed with a new gene editing technology have proposed altering
mosquitoes so they're more resistant to diseases like malaria and dengue.
Using a mechanism known as a `gene drive', researchers say they can quickly
push an alteration through an entire species. “In less than five years, I think
there's a good chance it will be out there,“ Gates said in an interview before
speaking at a conference of the American Society for Microbiology in
Boston.In normal reproduction, a mosquito carrying one copy of an altered
gene passes it on to 50% of its offspring. In a gene drive, an engineered
segment of DNA is inserted in the mosquito that causes nearly 100% of the
offspring to inherit the altered gene, dramatically increasing the rate of
spread.
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3. Contd…
“Gene drives, over the next three to five years will be developed in a
form that will be extremely beneficial for knocking down“ mosquito
populations, Gates said. “Of course, that makes it a key tool to reduce
malaria deaths.“
Controversial Approach
Scientists have said they've successfully created malaria-resistant
mosquitoes in a lab that passed on the trait to 99.5% of their progeny .
While the technology may work, it's controversial. Some researchers
have warned that gene drives may not be safe -what if the targeted
species cross-breed with another organism?
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4. Contd…
What if released mosquitoes develop spontaneous, unintended
mutations? -and have called for more regulation. “My basic belief is
that children dying of malaria is a bad thing, and that we should be
able to meet these objections,“ Gates said. “But there's still a fair bit of
work to be done.“
Through the Bill and Melinda Gates Foundation, the Microsoft
cofounder has waged a lengthy battle against malaria, committing
almost $2 billion in grants since 2000. There were about 214 million
malaria cases and 438,000 deaths from the disease in 2015, according
to the World Health Organization.
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