Scientists have developed proteins that can target and deliver chemotherapy drugs directly to cancer cells, avoiding healthy cells. These "guided missile" proteins bind to tumors and transport chemotherapy, potentially allowing higher doses that fully infiltrate hard-to-reach tumors without subjecting the whole body to toxic side effects. The proteins may also be able to cross the blood-brain barrier to treat brain cancers. This approach builds on antibody-based therapies by using engineered proteins rather than antibodies to selectively guide anti-cancer drugs.

1. Now, `guided chemo missiles'
that target only cancer cells
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2. Contd…
Scientists have engineered novel proteins that work like `guided
missiles' which seek out cancer cells and deliver chemotherapy drugs
to treat hard-to-reach tumours without harming healthy cells.
Although chemotherapy drugs do often effectively kill cancer cells, they
also damage other quickly dividing cells in the body , cau sing side
effects ranging from cosmetic, like hair loss, to disabling.
Sometimes, the drug dose needed to kill a tumour may be more than
what a person's body can handle. This might happen if the tumour
does not have much of a blood supply and very little of the drug, which
is delivered through the bloodstream, can get in.
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3. Contd…
A dose high enough to infiltrate the tumour could be deadly to other cells in
the body. Some recently approved therapies get around this problem using
antibodies to deliver a drug directly to tumours, bypassing healthy cells and
possibly overcoming some of the uglier aspects of cancer chemotherapy .
Jennifer Cochran, associate professor at Stanford University in the US, has
built on this antibody approach using an engineered protein rat her than an
antibody to direct the drug to the tumour.
Although the two techniques are conceptually similar, the specialised protein
has the potential advantage of being able to pass through the barrier that
protects the bra in, thereby being able to treat brain tumours.
It is also smaller than the antibody and might be able to reach dense
tumours with little blood supply.
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