Scientists in the UK have developed a new technique called "mito-priming" that gets cancer cells addicted to drugs that kill them within minutes. Mito-priming works by producing equal amounts of toxic and protective proteins in cells, leaving them highly sensitive to drugs that inhibit the protective proteins. This allows rapid screening of potential anti-cancer drugs and improves ways to kill cancer cells.

1. New way to kill cancer cells:
Get them addicted to drugs
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2. Contd…
Scientists in the UK have found a new way to combat cancer by getting
tumour cells addicted to drugs that will kill them in minutes. The
technique called “mitopriming“ was developed as a research tool while
trying to understand how cancer cells die. Mito-priming can be applied
to identify new anti-cancer drugs to screen their effectiveness.
According to the research paper, BH3-mimetics are a promising new
class of cancer drugs developed to specifically kill tumour cells. They
target a family of proteins called BCL-2 proteins, which function to keep
cancer cells alive. While not yet in use in clinical practice, BH3-mimetic
anticancer drugs are showing promise in late-stage clinical trials,
particularly in the treatment of chronic lymphocytic leukaemia.
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3. Contd…
Stephen Tait, the lead author of the paper, said, “Mito-priming can be used
to rapidly screen for new BH3-mimetics and other anti-cancer drugs, and
should improve ways to kill cancer cells. It can also be used to rapidly define
the potency and specificity of BH3-mimetics.“ Finally , the technique will
allow us to under stand how drug resistance occurs thereby allowing us to
prevent this from happening in the first place, he added.
“There is currently a lot of interest in targeting BCL2 proteins in the fight
against cancer and there will be new therapies emerging in the future,“ Tait
said. The scientists developed mito-priming by producing equal amounts of
toxic and protective BCL-2 proteins in cells.
“Cells in this state are very sensitive to inhibition of protective BCL-2 function
by BH3-mimetics, such that they die within a few minutes of drug addiction,“
Tait said.
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