The sciatic nerve is the largest nerve in the human body, originating from the sacral plexus formed by the lumbosacral trunk and sacral spinal nerves. It provides motor and sensory innervation to the muscles and skin of the lower limb. Sciatica refers to pain along the sciatic nerve distribution, often caused by a herniated disc pressing on the nerve roots in the lower back. The sciatic nerve divides into the tibial and common peroneal nerves in the popliteal fossa, each having distinct motor and sensory functions in the leg and foot.