The wrist joint, also called the radiocarpal joint, is a synovial ellipsoid joint formed by the proximal row of carpal bones and the distal end of the radius. Scaphoid fracture is the most common carpal bone injury, often resulting from a fall on an outstretched hand which puts the wrist in hyperextension. Clinical evaluation looks for tenderness and deformity while radiological evaluation with x-rays, CT, MRI, and arthrography can diagnose fractures and ligament injuries. Common fractures include Colles' fracture of the distal radius and fractures of the scaphoid and lunate bones.
elbow joint , type of joint, articular surface of elbow joint, joint capsule of elbow joint, articulating bones of elbow joint, cubital articulation, ligaments of the elbow joint, medial collateral ligament, lateral collateral ligament, relation of elbow joint, action of elbow joint, blood supply and nerve supply of elbow joint, dislocation of elbow joint, carrying angle, cubital varus, cubital vulgus, subluxation of head of radius, tennis elbow, students or minors elbow,
The upper limb consists of various joints that enable movement and provide flexibility. These joints can be classified into different types based on their structure and function.
Understanding the anatomy and function of these joints is crucial for assessing and managing conditions related to the upper limb, as well as for rehabilitation and therapeutic interventions. Joint injuries, arthritis, and other disorders may affect the functionality of these joints, and appropriate medical care may be necessary for optimal outcomes.
Assessent and radiology of distal end radius fractureSusanta85
distal end radius is a common fracture in elderly groups and also in young by high velocity trauma its assessment and radiology should know for its management
elbow joint , type of joint, articular surface of elbow joint, joint capsule of elbow joint, articulating bones of elbow joint, cubital articulation, ligaments of the elbow joint, medial collateral ligament, lateral collateral ligament, relation of elbow joint, action of elbow joint, blood supply and nerve supply of elbow joint, dislocation of elbow joint, carrying angle, cubital varus, cubital vulgus, subluxation of head of radius, tennis elbow, students or minors elbow,
The upper limb consists of various joints that enable movement and provide flexibility. These joints can be classified into different types based on their structure and function.
Understanding the anatomy and function of these joints is crucial for assessing and managing conditions related to the upper limb, as well as for rehabilitation and therapeutic interventions. Joint injuries, arthritis, and other disorders may affect the functionality of these joints, and appropriate medical care may be necessary for optimal outcomes.
Assessent and radiology of distal end radius fractureSusanta85
distal end radius is a common fracture in elderly groups and also in young by high velocity trauma its assessment and radiology should know for its management
With the pandemic overclouding the whole world it has effected every strato of people including the Orthopaedic groups. This is to highlight the impact of COVID 19 on the orthopaedic in general.
Conservative management in 3 and 4 part proximal humerus fractureBipulBorthakur
Proximal humerus fracture is common in both young as well as elderly people with most of the elderly patients unable to undergo operative management. This study is to see the aspect of conservative management in proximal humerus fracture.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
3. WRIST JOINT
• Wrist joint is a synovial joint of ellipsoid type.
• Also called radio carpal joint
• Carpal fracture accounts for 18% all wrist fracture
• Carpal fracture associated with 7% of distal radius
fracture
4. Normal anatomic relationship
Radial inclination: ranges from 13
to 30 %
Radial length: ranges from 8 to 18
mm
Palmar tilt: ranges from 0 to 28
degree
5. ARTICULAR SURFACES
WRIST JOINT IS FORMED BY:
DISTALLY:
•The proximal row of the carpel
bone(except pisiform)
PROXIMALLY:
•The distal end of radius and
articular disc
CARPAL BONES:
•Proximal row: scaphoid, lunate,
triquetrum and pisiform (lateral
to medial)
•Distal row: trapezium, trapezoid,
capitate and hamate (lateral to
medial)
6. SURFACE MARKINGS OF WRIST JOINT
•The position of wrist joint can
be indicated by drawing a curve
line, with its convexity upward ,
between the styloid process of
radius and ulna
•The summit of convexity is
about 1 cm , above the centre
of straight line joining the two
processes
7. LIGAMENTS
• There are four ligaments in the wrist joint:
• Palmar radiocarpal: it is found on the palmar( anterior)
surface of hand. It provides stability of joint. Besides it
ensure that the hand follows the forearm during pronation
• Dorsal radiocarpal: it is found on posterior surfaces of hand .
It also provides joint stability
8. Ulnar collateral:
•Runs from the ulnar styloid proces to the triquetrum and
pisiform. It prevent excessive lateral joint displacement
Radial collateral:
•Runs from radial styloid process to the scaphoid and
trapezium. It also prevent excessive lateral displacement
9. Movements of the wrist joint
All the movements are performed by the musles of forearm
i. Flexion:
Produced by flexor carpi ulnaris , flexor carpi radialis,
and flexor digitorium superficialis
ii. Extension:
Produced by extensor carpi radialis longus and brevis
and extensor carpi ulnaris
iii. Adduction:
Extensor carpi ulnaris and flexor carpi ulnaris
iv. abduction:
Produced by the abductor pollicis longus flexor carpi
radialis and extensor carpi radialis longus and brevis
10.
11. Blood supply of wrist joint
•The wrist received blood from branches of
the deep and superficial palmar arches, which
are derived from the ulnar and radial arteries
12. Nerve supply of wrist joint
Wrist is innervated by:
i. Anterior interosseous branch:
Branch of median nerve
ii. Posterior interosseus branch:
Branch of radial nerve
iii. Deep & dorsal branches:
Branch of ulnar nerve
13. MECHANISM OF INJURY
• The most common mechanism of carpal
bones injury in hand is fall onto
outstretched, due to axial compressive force
with the wrist in hyperextension
• The volar ligaments are placed under tension
with compression and shear forces applied
dorsally ,especially when the wrist is
extended beyond the physiological limits
• Excessive ulnar deviation and intercarpal
supination result in a predictable pattern of
perilunate injury
• Direct injuries like crush injuries
14. CLINICAL EVALUATION
• The clinical evaluation of individual carpal
bones are variable , but in general most
consistent sign of carpel injury are well
localized tenderness
• Gross deformity may be present , ranging from
displacement of carpus to prominance of
individual carpal bones
15. RADIOLOGICAL EVALUATION
• Radiography:
– Posteroanterior, oblique and lateral x rays are each taken
with the wrist in the neutral position. Gilula lines (3 smooth
radiographic arc) are distorted in ligamentous instability
• Arthrography &arthroscopy:
– Can assist in the diagnosis of carpal ligament injuries.
• Computed tomography (CT):
– Helps in evaluating carpel fractures, malunion , nonunion
and bone loss
• Magnetic resonance imaging(MRI):
– It is sensitive to occult fractures and osteonecrosis of bones
and soft tissue injury and ligament injury
16. SOME SPECIFIC RADIOLOGICAL VIEWS
WRIST INJURY
•Scaphoid view:
It is anteroposterior x-ray with wrist supinated 30
degree and ulnar deviation
•Pronated oblique view:
To look for schaphoid fracture
•Clenched fist AP view:
To look for widening of scapholunate interval
•Maximal ulnar & radial deviation:
To look for carpal instability
19. BLOOD SUPPLY OF SCAPHOID
•The scaphoid is at
particular risk of avascular
necrosis after fracture
because of its retrograde
blood supply
20. CLINICAL CONDITION AFFECTING WRIST JOINT
Fracture of distal radius Fracture of carpel bone
Adults:
•Colles fracture
•Smith fracture
•Barton’fracture
•Radial styloid fracture
Children
•Fracture of distal radial
epiphysis
•Fracture of distal radial
metaphysis
•scaphoid fracture
•Lunate fracture
•Perilunate dislocation
•Dorsal chip fracture
21. SUMMARY
• Wrist joint is also known as radio carpal joint which
is a synovial joint of ellipsoid type
• Colles fracture is the fracture of distal end of radius
in a skeletally mature person produced by a fall on
outstreched hand
• The most common mechanism of carpal bones injury
in hand is fall onto outstretched, due to axial
compressive force with the wrist in hyperextension
• Scaphoid fracture is the commonest injury of carpus
• Carpal tunnel syndrome is due to compression of
median nerve causing numbness and tingling or
weakness in hand