The sciatic nerve is the largest nerve in the body, originating from the sacral plexus (L4-S3). It begins in the pelvis and passes through the gluteal region before terminating in the popliteal fossa by dividing into the tibial and common peroneal nerves. It provides motor and sensory innervation to the hamstring muscles and skin of the lower limb. Common sites of sciatic nerve injury include intramuscular injections into the gluteal region.