The ulnar nerve originates from the medial cord of the brachial plexus. It runs down the arm and enters the forearm between the two heads of the flexor carpi ulnaris muscle. In the hand, it passes through the ulnar tunnel, dividing into superficial and deep branches that provide sensory and motor innervation to portions of the fourth and fifth fingers. Lesions of the ulnar nerve can occur at different locations, with varying effects depending on whether the nerve is damaged proximally in the arm, at the elbow, in the forearm, or distally in the hand or wrist.
Radial Nerve is very important topic for first year MBBS Students and as well as for day today clinical practice. This slide gives you full course & relations with clear diagrams as well as applied anatomy with clinical Co-relation.
Claw Hand,Definition,Causes,Types,Symptoms and ManagementDr.Md.Monsur Rahman
Dr.Md.Monsur Rahman, Bachelor of Physiotherapy (BPT), Master of Physiotherapy (MPT) in Musculoskeletal Disorders, ABC-Spine in Osteopathic Approach,
Maharishi Markandeshwar (Deemed to be University), Ambala -Haryana.
Radial Nerve is very important topic for first year MBBS Students and as well as for day today clinical practice. This slide gives you full course & relations with clear diagrams as well as applied anatomy with clinical Co-relation.
Claw Hand,Definition,Causes,Types,Symptoms and ManagementDr.Md.Monsur Rahman
Dr.Md.Monsur Rahman, Bachelor of Physiotherapy (BPT), Master of Physiotherapy (MPT) in Musculoskeletal Disorders, ABC-Spine in Osteopathic Approach,
Maharishi Markandeshwar (Deemed to be University), Ambala -Haryana.
This lecture give us an understanding about the pathway of the peripheral nerves that emerges from the brachial and cervical plexus. I also discuss about the motor and cutaneous innervation from these nerves and also some condition relate to peripheral nerve injury.
The sciatic nerve is the longest and largest nerve in the human body. It runs from the lower back through the back of the leg, and down to the toes. Any type of pain and/or neurological symptoms that are felt along the sciatic nerve is referred to as sciatica.
This lecture give us an understanding about the pathway of the peripheral nerves that emerges from the brachial and cervical plexus. I also discuss about the motor and cutaneous innervation from these nerves and also some condition relate to peripheral nerve injury.
The sciatic nerve is the longest and largest nerve in the human body. It runs from the lower back through the back of the leg, and down to the toes. Any type of pain and/or neurological symptoms that are felt along the sciatic nerve is referred to as sciatica.
• Median nerve is the nerve of front of forearm.
• It supplies most of the long muscles of front of forearm and supplies muscles of thenar eminence.
• Median nerve controls coarse movements of hand.
• Origin- medial and lateral cord
• Root value- C5- T1
CONCEPT OF NODOPATHIES AND PARANODOPATHIES.pptxNeurologyKota
emergence of autoimmune neuropathies and role of nodal and paranodal regions in their pathophysiology.
Peripheral neuropathies are traditionally categorized into demyelinating or axonal.
dysfunction at nodal/paranodal region key for better understanding of patients with immune mediated neuropathies.
antibodies targeting node and paranode of myelinated nerves have been increasingly detected in patients with immune mediated neuropathies.
have clinical phenotype similar common inflammatory neuropathies like Guillain Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
they respond poorly to conventional first line immunotherapies like IVIG
This presentation briefs out the approach of dementia assessment in line with consideration of recent advances. Now the pattern of assessment has evolved towards examining each individual domain rather than lobar assessment.
This presentation contains information about Dementia in Young onset. Also it describes the etiologies, clinical feature of common YOD & their management.
Entrapment Syndromes of Lower Limb.pptxNeurologyKota
This presentation contains information about the various Entrapment syndromes of Lower limb in descending order of topography. It also contains information about etiology, clinical features and management of each of these entrapment syndromes with special emphasis on electrodiagnostic confirmation.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. ULNAR NERVE C 7, 8 &T1
• Origin:
• From the medial cord of the brachial plexus.
• It runs downward on the medial side of the brachial artery as far
as the middle of the arm.
• At the insertion of the coracobrachialis, it pierces the medial
intermuscular septum and, accompanied by the superior ulnar
collateral artery, to enter the posterior compartment of the arm.
• At the elbow, it passes behind the medial epicondyle.
• It has no branches in the arm.
3.
4. ULNAR NERVE
in the Forearm
• It continues downward to enter the forearm between the two
heads of the flexor carpi ulnaris.
• It runs down the forearm between FCU and FDP.
• In the lower half of the forearm it lies medial to the ulnar artery.
5. • Branches:
Muscular: Immediately distal to the elbow joint the
nerve gives off its first two muscular branches
Flexor carpi ulnaris- ulnar flexor of the wrist
Medial ½ of FDP- flexor of the terminal phalanges of the fourth
and fifth fingers
• Articular: To elbow joint.
• Dorsal or posterior cutaneous branch:
• To the dorsal surface medial 1/3rd of the hand and 1½ fingers.
• Palmar cutaneous branch : to supply skin of palm of hand.
6.
7. ULNAR NERVE in the Hand
Enters the palm superficial to the flexor retinaculum, passes between the pisiform
carpal bone medially and the hook of the hamate carpal bone laterally (ulnar tunnel
or canal of Guyon)
• Then it divides into superficial & deep branches.
Superficial branch:
• It supplies palmaris brevis & palmar aspect of the medial 1½ fingers(sensory
supply).
Deep branch
• Runs between abductor digiti minimi & flexor digiti minimi.
• It pierces opponens digiti minimi.
• Then passes laterally within the concavity of deep palmar arch.
• It lies deep to the flexor tendons.
• It supplies 14 muscles
8. Musclar supply on hand
• Palmaris brevis (C8–T1) :A cutaneous muscle
• Abductor digiti minimi (C8–Tl) :An abductor of the fifth finger
• Opponens digiti minimi (C8–T1): An opposer of the fifth finger
• Flexor digiti minimi (C8–T1) :Flexor of the fifth finger
• Lumbricals III and IV (C8–T1): Flexors of the
metacarpophalangeal joints and extensors of the proximal
interphalangeal joints of the fifth and fourth fingers
9. • Interosseous muscles (C8–Tl) :Flexors of the
metacarpophalangeal joints and extensors of the proximal
interphalangeal joints, four dorsal interossei are finger
abductors, whereas the three palmar interossei are finger
adductors
• Adductor pollicis (C8–T1) : An adductor of the metacarpal of
the thumb.
• Deep head of the flexor pollicis brevis (C8–Tl): Flexor of the
first phalanx of the thumb.
10.
11.
12. Localisation of nerve leison
• Lesions above the Elbow:
• lesion of the medial cord of the brachial plexus
• Abnormal appearance of the hand –hypothenar eminence
and interossei are atrophied and flattened
• Incomplete claw hand
13.
14. • Sensory findings: all three sensorybranches of the ulnar nerve
are affected (palmar,dorsal, and superficial terminal
cutaneous branches)
16. • Ulnar nerve is most commonly compressed at the elbow in
the cubital tunnel
• Ulnar neuropathy at the elbow often spares the flexor carpi
ulnaris muscle
• tardy ulnar nerve palsy
17.
18.
19. • Lesions in the Forearm:
• Lesions above the Elbow except that the flexor carpi ulnaris
and the flexor digitorum profundus I and II muscles are often
spared
• In a patient with surgical section of the distal ulnar nerve in
the forearm, ulnar sensation in the dorsal hand was spared in
relation to the superficial radial sensory innervation of the
ulnar hand dorsum
• (“paradoxical” preservation of ulnar sensory function)
20.
21. • Lesions at the Wrist and in the Hand-
• Distal deep palmar motor lesion:
• Affects all muscles supplied by the deep palmar motor branch
except the hypothenar muscles, superficial branch containing
the sensory fibers and motor innervation to the palmaris
brevis is not affected.
• Proximal deep palmar motor lesion:Affects all ulnar-
innervated hand muscles, including the hypothenar muscles,
with the exception of the palmaris brevis; the superficial
branch containing the sensory fibers and motor innervation to
the palmaris brevis is not affected.
22. • Proximal canal lesion: Affects all branches of the ulnar nerve,
including the proximal and distal deep palmar motor and the
superficial branches which contain the sensory fibers and
motor innervation to the palmaris brevis
• Superficial branch lesion: Affects only the superficial branch,
which is primarily sensory
23. • Pseudoulnar Nerve Palsy:Pseudoulnar nerve palsy refers to
isolated hand weakness apparently in an ulnar distribution
that is due to contralateral cerebral infarction in the white
matter of the angular gyrus of the inferior parietal lobe
• Palmaris brevis spasm syndrome:Prolonged use of a
computer mouse and keyboard Electrophysiologic studies
suggest a distal ulnar motor branch