Dr. Mohammad Mataro Hingorjo outlines a patient scenario of a 26-year-old female diagnosed with dengue fever who was advised to use papaya leaf juice by a relative to increase her platelet count. He then reviews the available literature on dengue fever, papaya, and the therapeutic uses and evidence regarding papaya's effects on dengue and platelets. While some studies found papaya leaf extracts increased platelets in animals and humans, the evidence is conflicting and more rigorous randomized controlled trials are needed to establish papaya's benefits and safety as a dengue treatment. Standard diagnosis and treatment should not be replaced by reliance on papaya leaf extracts alone.
Definition of drug interaction, potential of herb-drug interactions,significance of study of herb-drug interactions, reasons for their study, types according to ayurveda, effects & different ways of herb-drug interactions, their mechanism, hypericum, kava lava, ginkgo biloba, ginseng, garlic, pepper, ephedra.
Description on types of fungal organisms with differences between bacteria and fungi. A note on useful and harmful fungi. Brief insight on Antifungal classification, mechanism of actions and pharmacological profile with drug of choices for various fungal infections.
Hello friends. In this PPT I am talking about anti-fungal drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Definition of drug interaction, potential of herb-drug interactions,significance of study of herb-drug interactions, reasons for their study, types according to ayurveda, effects & different ways of herb-drug interactions, their mechanism, hypericum, kava lava, ginkgo biloba, ginseng, garlic, pepper, ephedra.
Description on types of fungal organisms with differences between bacteria and fungi. A note on useful and harmful fungi. Brief insight on Antifungal classification, mechanism of actions and pharmacological profile with drug of choices for various fungal infections.
Hello friends. In this PPT I am talking about anti-fungal drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
A Presentation on Medicinal Plants like Lavender and Alfalfa. We tell you the uses, advantages and more in this presentation.
Made by the students of Sharjah Indian School.
Pharmacological Classification, Mechanism of Action, Clinical Uses, Administration Routes, Dosing for Adults and Pediatrics, Pharmacokinetics, Dose Adjustments, Patient Counseling, Adverse Effects, Drug Interactions, Contraindications, Personal Experience with Ondansetron, Future Clinical Uses of Ondansetron
CONCEPT OF LOADING AND MAINTAINANCE DOSE.pptxNamrataSawant19
Most drugs for chronic condition are prescribed in a dosage regimen is based on the administration of a fixed constant dose(D) at fixed regular dosing intervals(T) for long period of time.
The D & T recommended by the manufacturer is based on the effective therapeutic concentration of drug in the plasma needed to treat the chronic condition.
Primary purpose of using loading dose in therapeutic treatment is to attain steady-state concentration of the drug as quickly as possible, usually right from the start of the dosage regimen for the treatment.
1. Pharmacognostic profile of Fenugreek
2. Macroscopy
3. General uses and Common names of fenugreek
4. Health benefits
5. Nutraceutical properties
6. Medicinal uses of fenugreek
7. Doses & Adverse effects
8. Formulations
9. Thank you
Pharmacology- anti-fungal drugs.Classification and details on polyenes, echinocandins, griseofulvin, azoles, terbinafine, and topical azoles.
Their uses, side effects, adverse effects are mentioned with the mechanism of action.
Esomeprazole works by binding irreversibly to the H+/K+ ATPase in the proton pump.
Inhibition dramatically decrease the secretion of hydrochloric acid into the stomach
Herb drug and herb food interaction ppt by nitesh kumarNITESH KUMAR
HERB DRUG AND HERB FOOD INTERACTION IS AN IMPORTANT CHAPTER IN HERBLA DRUG TECHNOLOGY IN THE SYLLABUS OF B.PHARMACY 6TH SEM. IT GIVES A BETTER UNDERTANDING OF HERB FOOD INTERACTION AND RELATED DRUGS.
A Presentation on Medicinal Plants like Lavender and Alfalfa. We tell you the uses, advantages and more in this presentation.
Made by the students of Sharjah Indian School.
Pharmacological Classification, Mechanism of Action, Clinical Uses, Administration Routes, Dosing for Adults and Pediatrics, Pharmacokinetics, Dose Adjustments, Patient Counseling, Adverse Effects, Drug Interactions, Contraindications, Personal Experience with Ondansetron, Future Clinical Uses of Ondansetron
CONCEPT OF LOADING AND MAINTAINANCE DOSE.pptxNamrataSawant19
Most drugs for chronic condition are prescribed in a dosage regimen is based on the administration of a fixed constant dose(D) at fixed regular dosing intervals(T) for long period of time.
The D & T recommended by the manufacturer is based on the effective therapeutic concentration of drug in the plasma needed to treat the chronic condition.
Primary purpose of using loading dose in therapeutic treatment is to attain steady-state concentration of the drug as quickly as possible, usually right from the start of the dosage regimen for the treatment.
1. Pharmacognostic profile of Fenugreek
2. Macroscopy
3. General uses and Common names of fenugreek
4. Health benefits
5. Nutraceutical properties
6. Medicinal uses of fenugreek
7. Doses & Adverse effects
8. Formulations
9. Thank you
Pharmacology- anti-fungal drugs.Classification and details on polyenes, echinocandins, griseofulvin, azoles, terbinafine, and topical azoles.
Their uses, side effects, adverse effects are mentioned with the mechanism of action.
Esomeprazole works by binding irreversibly to the H+/K+ ATPase in the proton pump.
Inhibition dramatically decrease the secretion of hydrochloric acid into the stomach
Herb drug and herb food interaction ppt by nitesh kumarNITESH KUMAR
HERB DRUG AND HERB FOOD INTERACTION IS AN IMPORTANT CHAPTER IN HERBLA DRUG TECHNOLOGY IN THE SYLLABUS OF B.PHARMACY 6TH SEM. IT GIVES A BETTER UNDERTANDING OF HERB FOOD INTERACTION AND RELATED DRUGS.
Papaya is a fruit which is highly helpful for your weight loss program which provides you only 39Kcal per 100gm. Papaya is the fruit of the Carica papaya plant, which can either be used as food, cooking aid or as medicine. Get more information about papaya and its benefits from here - http://www.bookmydoctor.com/health-article/10-reasons-to-include-papaya-in-your-diet-147/
Reducing Postharvest Softening of Papaya (Carica papaya cv. Maradol) by using...Agriculture Journal IJOEAR
Abstract— The shelf life of ‘Maradol’ papaya fruit (Carica papaya) harvested at one-quarter stage maturity (yellow-orange color in 25% of fruit surface) and treated with aqueous 1-methylcyclopropene (1-MCP) was evaluated. The effects of immersion time (30 or 60 seconds) and dose response (50 or 300 ng∙kg-1) on the quality of papaya fruit stored for 12 days at 20 ± 2 °C and 85 ± 5% RH were studied. After 3 days, the control and fruit treated with 50 ng∙kg-1 1-MCP for 30 seconds lost 82% and 72% of the initial firmness, respectively. A 1-MCP concentration of 300 ng∙kg-1 for 30 or 60 seconds inhibited softening and slowed skin color change for 12 days. The pH, titratable acidity, and soluble solids concentration ranged from 5.3-5.7, 0.06-0.12 % and 10-12 %, respectively. The shelf life of papaya was extended up to 3 days in fruit treated with 50 ng∙kg-1 1-MCP for either 30 or 60 seconds of immersion.
One of the best fruits one should add to the daily diet is papaya. It is also considered to be an ideal fruit for the woman to consume, as it’s benefits are enriching. The flesh of papaya has a high amount of proteins, iron, calcium and magnesium that helps to keep the body in excellent shape by cutting down excess fat and flushing out harmful toxins.
ABSTRACT Andrographis paniculata (A. paniculata) is an herbaceous plant has been effectively used in traditional Asian medicines for centuries. The demand for the herbal drug treatment of various ailments is increasing day by day and plant drugs from the Ayurvedic system are being explored more in India as well as globally. The aerial part of the plant is used. It contains a large number of chemical components like diterpene, diterpenoid, glycosides, flavonoids as well as flavonoid glycosides. Andrographolide has been reported to have a wide range of biological activities, such as Anti-inflammatory, anti-allergic, anti-platelet aggregations, hepatoprotective and anti-HIV. A. paniculata polysaccharides combined with andrographolide can be used in the recovery of diabetic nephropathy. In addition to these activities the ethanol and an aqueous extract of A. paniculata also decrease blood glucose levels in normal rats and streptozotocin diabetic rats. Andrographolide, reacts with several inter and intracellular constituents like a bipolar compound hence ensuing in many biological responses.
Key-words: Andrographis paniculata, Andrographolide, Anti-inflammatory, Biological activities
Hematological and Liver Function of Plasmodium Berghei Positive Wister Treate...ijtsrd
Eradication of malaria in Africa continues to be one of the greatest challenges in the health sector. All the drugs developed thus far have their limitations and are generally expensive. In Africa and Nigeria the use of herbs in treating sicknesses dated as far back as the existence of man and is still in use today by many Nigerians in rural areas. Here we evaluated the therapeutic efficacy of ethanolic extract for three of these herbs lemon grass, lime and turmeric used singly and in combination on Plasmodium berghei infected rats. Results reveals that there was an 81.54 reduction in parasite level in groups treated with herbs and an 88.9 reduction in those treated with ACTs. The time frame of this study wasn’t enough to determine if there will be a resurgence in the parasitemia level. Results from the liver function test also reveals that the herbs also reduced the levels of liver enzymes in the serum but the results from the liver histology from the onset shows little or no damage to the liver This helps us to understand that the plasmodium parasites does not cause much damage to the liver cells or requires more time to do so. Hence the study concludes that potent herbs like turmeric, lemon grass and lime although not as effective as ACTs but if harnessed properly can be substituted for ACTs in treating malaria in low income rural areas of Nigeria. Nwaisaac Ikechukwu Samuel | Igbokwe Vincent Ugochukwu | Okonkwo Chukwudi Onyeka | Okpa Precious Nwaka | Nnyaha Anthonia Ekenedilichukwu | Ajeka Prisca "Hematological and Liver Function of Plasmodium Berghei Positive Wister Treated With Herbs and Acts" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46277.pdf Paper URL: https://www.ijtsrd.com/medicine/other/46277/hematological-and-liver-function-of-plasmodium-berghei-positive-wister-treated-with-herbs-and-acts/nwaisaac-ikechukwu-samuel
Here the reviewers tried to follow up differentiate implementation on raw herbal products for the treatment of Diabetic patient collected from home yard ground.
Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens A Clinical...ijtsrd
Background Homoeopathic medicines known for its utility in wider spectrum of pathological conditions. Homoeopathic Science adds new medicines in the system through drug proving and explores additional features of already existed medicines through clinical verification. Gaultheria Procumbens is among those medicines having broader application but lesser known due to limited Clinical Experience with the medicine. Clinical verification of this Medicine will explores many new insights in its healing power and ultimately its utility in day to day practice. Aims The Main Objective was to study to verify the Clinical Utility of Rare and Lesser Known Medicine Gaultheria Procumbens. Another important objective is to prepare a Remedy Profile of Gaultheria Procumbens from clinical verified Symptoms during study. With research question, Will the verification of rare and lesser known medicine Gaultheria Procumbens helpful in Homoeopathic Practice Setting and Design The study was Prospective Analytical and Interventional Clinical Verification study. A clinical study had been conducted in which total 30 experimental samples were Purposively selected from the 3 project sites, Smt. S. I. Patel Ipcowala Homoeopathic Hospital, Amul Dairy Road, Anand and Rural as well as O.P.D. centers situated at Dharmaj, Napad and Anand Agriculture university Health centre.Materials and Methods 30 samples were selected through Purposive Sampling method with fulfillment of inclusion and exclusion criteria. Data collection was done with the Personal Interview Method According to guidelines given in Organon of medicine, book by Dr. Hahnemann. Remedy Profile of Gaultheria Procumbens from available data during Review of Literature with specially Prepared Case Performa and Scoring systems were selected as tools for data collection. Potency Selection, Repetition and Follow ups were decided according to need of particular case. Statistical Analysis Paired t test was done in Microsoft Excel using Pre Treatment and Post Treatment Score from Subjective Scoring System MYMOP Measure Yourself Medical Outcome Profile .Result Most of the cases 11 36.67 were seen in the age group 51 60 that suggest this age group have more Prevalence of the diseases affect the Locomotor system during this era and Female sex having slightly more Predominance than Male sex. Most of cases in this study with Acute phase or Acute Excerbations of Chronic than the Chronic one. Other variables like potency and diagnosis were also observed.Conclusion This study helps to verify the medicine Gaultheria Procumbens and Explore its utility in Practical Homeopathy. Some characteristic symptoms as well as sphere of action were also found during this study which will be helpful in prescribing as well as studying the medicine Gaultheria Procumbens. This Primary research will be a good base for further research with Gaultheria Procumbens. Dr. Jalpa P. Atri "Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens: A Clinic
This was a double blind randomized clinical trial, conducted on adult patients during a 6-year period from 2003 to 2009. Included in this study were 84 adult participants that had
experienced PPC (persistent post-infectious coughs) longer than 3 weeks. All of them had the history of several referrals to different physicians and despite treatment, their cough had persisted.
Comparing the effectiveness of all three treatment regimens, this study found "honey with coffee" as the most effective treatment modality for PPC (P<0.001). Combination of honey and coffee can successfully treat the PPC at a short time. Thus, it is recommended for the treatment of PPC.
Protective Effect of Musa paradisiaca Fruit.pdfgynomark
Abstract: Musa paradisiaca often refereed as Banana is an ancient herbaceous flowering plant and the most earlier crop to be cultivated. It is one the important component of diet for all classes of people worldwide. All the parts of the plant is believed to have beneficial effects in different ailments and an excellent nutritional element. The present study was aimed to find the protective effect of Musa paradisiacal fruit extract on acute pancreatitis in rats.
Male Sprague dawley rats were randomly divided in to 4 groups. Control group with normal saline; disease control group where acute pancreatitis was induced by using a single dose of L-arginine (2.5g/kg b.w); Musa paradisiacal fruit extract were prophylactically administered before the induction of acute pancreatitis at a dose of 200 and 400 mg/kg b.w orally in normal saline for 7 days. At the end of the study, blood samples and isolated pancreas were subjected to different pancreatic, antioxidant and inflammatory biomarker analysis. The remaining tissue was subjected to histopathological studies and DNA fragmentation assay for assessing the damage and protection of the tissues.
The results of the study revealed that prophylactic administration of the extracts reduced the amylase and lipase levels when compared to disease control group as well as improved the overall antioxidant status in a dose dependent manner. Further, the extracts also showed a protective effect against apoptosis.
In conclusion, the present study suggest that administration of Musa paradisiacal fruit extract exhibited a protective effect on acute pancreatitis and further investigation is required for its molecular based mechanisms.
Keywords: Musa paradisiacal, acute pancreatitis, free radicals, apoptosis.
Background: Dennentia tripetalla (Pepper Fruit) belongs to the Annonaceae family and is abundant in Nigeria. Its
fruit in folklore medicine is used for treatment of varying ailments. While ample research evidence exists on the
plants fruit and seed, no current study exists on the toxicological profile of the plant leaves.
Methods: qualitative and quantitative phytochemicals and In vitro antioxidant assays were carried out using
standard methods. The acute toxicity study indicates that the LD50 was higher than 2000 mg/Kg body weight. Subchronic
toxicity studies was carried out using five groups of rats. Group 1 served as control, 2–5 received 100 mg/
Kg, 200 mg/Kg, 500 mg/Kg and 1000 mg/Kg body weight orally for 28 days.
Results: Post-administration biochemical analysis indicates there was increased weight in rats administered 100
mg/kg and 200 mg/kg while it reduced in the 500 mg/kg group. Significant elevations of liver function markers
were reported for 200 mg/kg and 500 mg/kg respectively. Serum and hepatic protein profiles remained unaltered.
Renal function analysis revealed elevated serum urea and creatinine for 200 and 500 mg/kg groups, elevated serum
Na+ and Ca+ and reduced serum Cl− for the 500 mg/Kg group. Elevated Kidney K+ and Ca+ levels, reduced Cl−
were significantly observed in 500 mg/Kg group. Significant rise in hepatic and renal lipid peroxidation was
observed in 200 and 500 mg/Kg groups. There were observed disarmament of the antioxidant defense systems
occasioned by rise and drop in tissue (hepatic, renal, testes, heart) Superoxide dismutase (SOD), Catalase (Cat),
Glutathione-s-transferase (GST), Glutathione peroxidase (GPx) activities in the test groups relative to control.
Histopathological examination indicated architectural aberrations at 500 and 1000 mg/kg.
Conclusions: It concluded that the plant had significant phytochemical and antioxidant properties of medical
interest and possessed toxic properties in rats when administered at a dose above 200 mg/Kg over a prolonged
period of time.
Phytochemical, Antioxidant and Antibacterial Studies on Bambusa arundinacea a...SUS GROUP OF INSTITUTIONS
This study was formulated to check the phytochemical, antioxidant, antibacterial potential of
Bambusa arundinacea (Bamboo) and Mangifera indica (Mango) trees. Aqueous, ethanolic and
methanolic extracts were prepared from leaves of former and stem bark of later. The phytochemical
screening of the extracts showed the presence of various bioactive compounds such as
carbohydrates, flavonoids, saponins and proteins in B. arundinacea, alkaloids, flavonoids, tannins,
saponins, steroids and cardiac glycosides in M. indica. Total phenolic concentration and
percentage of free radical scavenging activity was more in ethanolic extracts of B. arundinacea and
M. indica followed by methanolic extracts and aqueous extracts. Highest percentage of ferric
reducing antioxidant power was found in ethanolic extracts and lowest in aqueous extracts indicates
that ethanolic extracts has more antioxidant potential than the other two extracts. Ethanolic extracts
of both plants had higher inhibition on the tested Gram positive (B. subtilis & S. aureus) as well as
Gram negative (E.coli & P. aeruginosa) bacteria evidenced from the zones of inhibition. M. indica
showed more therapeutic potential as compared to B. arundinacea and ethanolic as well as
methanolic extracts of both the tested plants were more effective than aqueous extracts due to better
extraction power of organic solvents. Overall study indicates that B. arundinacea and M. indica are
potential source of natural antioxidants, phytochemicals and antibacterials that can be used for the
development of novel drugs and may represent new source of antimicrobials with stable, biologically
active components that can establish a scientific base for further use in modern medicines.
Effects of Aqueous and Methanolic Leaf Extracts of Vitex doniana on Lipid Pro...IOSR Journals
The effect of aqueous and methanolic extracts of Vitex doniana leaves in serum lipid profile and liver enzymes in normal and alloxan-induced diabetic rats were investigated using standard analytical protocols. A total of 35 albino rats divided into seven groups of five rats each comprising one normal untreated group as animal control, one diabetic untreated group as diabetic control, one normal treated with 750mg/kg body weight as reference group, three diabetic groups treated with 250, 500 and 750mg/kg body weight respectively and one diabetic group treated with 5mg/kg Glibenclamide as standard. The result of acute toxicity test obtained indicated lethal dose (LD50) of greater than 5000mg/kg extract. The results showed that induction of diabetes caused significant (P<0.05)><0.05)><0.05)><0.05) increase in high density lipoprotein in the reference and diabetic groups when compared to normal and diabetic control groups respectively after oral administration of Vitex doniana leaf extracts. It could therefore be concluded that Vitex doniana leaf extract is safe, medicinal and have anti-lipidemia properties and hepato-protective effects.
Design of Experiments (DoE) manipulation in the formulation and optimization ...RAHUL PAL
Introduction: In India, the regulatory body for catechu is the Food Safety and Standards Authority of
India (FSSAI). The FSSAI is responsible for regulating the manufacture, sale, and distribution of food in
India, including catechu. The FSSAI has set standards for the purity and quality of catechu, and it also
monitors the market for adulterated catechu. The FDA (The Food and Drug Administration) is
responsible for regulating the safety and efficacy of drugs and dietary supplements in the United States
(US). The FDA has not approved catechu as a drug or dietary supplement, but it does regulate catechu as
a food additive. The FDA has set limits on the amount of catechu that can be added to food
Objective: The primary objective of this research was to involvement of design of experiments (DoE)
manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried
extract of Senegalia catechu enhanced through statistical analysis.
Methodology: The dried extract of Senegalia catechu was collected and identified at the botanical
herbarium garden. Subsequently, it underwent a drying process and was ground into a powder.
This was my Home Health/Home based Palliative Care Rotation Feedback; It is major part is concerned about how to take spiritual history and how to address spiritual concerns/Cues of our patients
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Outlines
Patient Scenario
Questions(?)
Brief introduction of Dengue Fever
Brief Introduction of Papaya
Therapeutic Uses of Papaya
Papaya and Dengue
Possible Mechanism of Action of Papaya
Evidence
Critical Analysis
Conclusion
Acknowledgments
2
3. Scenario
26 years female, @ CHC
◦ Dengue Fever one week back, here with Dengue
IgM report
◦ Currently recovering
◦ Platelet count: 110
She is advised to use Papaya leaves’ Juice by
one of her relative from Bangladesh
◦ Saying that it increases platelets!
She asked for expert advice regarding
papaya use in dengue fever
3
4. Questions?
Background Question
◦ What is the role of Papaya in Dengue fever?
Foreground Question:
◦ Role of Papaya
Juice/extract/leaves/fruit/seeds in
increasing platelets in patients having
Dengue fever/Dengue hemorrhagic fever
4
5. Introduction to Dengue Fever
Major international public health problem
Mild febrile illness to a life-threatening shock
syndrome
Early diagnosis and proper handling reduces
complication
50 million dengue infections worldwide every year
Endemic in more than 123 countries
Pakistan first reported an epidemic of dengue fever
in 1994
Endemic in Pakistan, a peak incidence in the post
monsoon period
5
Papaya extract to treat dengue: A novel therapeutic
option? Annals of medicine 2014
6. Introduction Continued
Platelet count drops in dengue patients
after the first three days
Gradually increases after the 7th day
OR
Drop further with derangement of other
clotting factors to develop into dengue
hemorrhagic state
Papaya extract to treat dengue: A novel therapeutic
option? Annals of medicine 2014
6
7. Introduction to Papaya
Scientific Name Carica Papaya
Has been used since ancient times for the
treatment of a number of disease conditions
Ayurvedic literature reveals that papaya
(Carica papaya) leaf extract has hemostatic
and other medicinal properties
Internet communications revealed the
beneficial effects of papaya leaf extract in
Asian patients
Papaya extract to treat dengue: A novel therapeutic
option? Annals of medicine 2014
7
8. Therapeutic Uses of Papaya
The chymopapain and papain extracts of
the leaves are useful in the treatment of
digestive disorders
The extracts from fruits and seeds have
bactericidal properties
The fruit juice and leaf extract have been
demonstrated to have anticancer,
antioxidative, anti-inflammatory,
anti-bacterial, nephroprotective,
hepatoprotective, hypoglycemic and
hypolipidemic effects
Anti-sickling effect in sickle cell disease
Papaya extract to treat dengue: A novel therapeutic
option? Annals of medicine 2014
8
9. Therapeutic Uses of Papaya
The ripe fruit and seeds have been used against
ringworm
The green fruit has been used to lower blood
pressure
Green fruits are also used for causing abortions
It is also used in the treatment of chronic skin
ulcers
The oral administration of C. papaya seed
extract can induce reversible male infertility,
hence can be used as contraceptive
The leaf extract has also been shown to have
larvi-cidal properties against the Aedes aegypti
mosquito
Papaya extract to treat dengue: A novel therapeutic option?
Annals of medicine 2014
9
10. Papaya Use in Dengue
Recently, crude formulations of papaya leaf
have been successfully employed in folk
medicine in Malaysia, Indonesia, Nepal,
India and Pakistan for the treatment of
dengue infections with hemorrhagic
manifestations
10
Papaya leaves extract capsules on platelets count and hematocrit level in dengue fever
patients, International Journal of Medicinal and Aromatic Plants, Vol. 2, No.4, pp. 573-
578, December 2012
11. Possible Mechanism
C. papaya L. leaf extracts inhibit
heat-induced and hypo tonicity-induced
hemolysis of erythrocytes
The extracts are likely to possess
membrane-stabilizing properties and
protect blood cells against
stress-induced destruction
Papaya extract to treat dengue: A novel
therapeutic option? Annals of medicine 2014
11
15. Journal/year
of
publication
Study design
and
population
Methods/
Intervention
Results
Journal: Wien Klin
Wochenschr (2009)
121 [Suppl 3]: 19–
22
Topic: Thrombocyte
counts in mice after
the administration
of papaya leaf
suspension
Objective: to
investigate the
effect of C.papaya
crude leaf material
on the thrombocyte
count in an animal
model
Study Design:
Animal study
Study site: Malaysia
Sample size:
15 white male mice
0.405–0.555 ml of
the CPL suspension
in Palm oil, (15
mg/kg) given to five
mice.
A control group (n =
5) was given the
vehicle(palm oil)
alone.
Another five mice
received
physiological saline
at the same dose
volume
blood were drawn at
0 hr. and thereafter
at 1,
2, 4, 8, 10, 12, 24, 48,
and 72 hours after
dosing in all
animals.
Saline Group: no
Significant
improvement
Palm oil group: Same
progress as saline
CPLJ group:
statistically
significant rise in PLT
with a peak at 4 hours
Conclusion: Results
are significant in
comparison reaching p
values as low as
0.000002, indicating a
potential of papaya
leaf formulations in the
treatment of
Dengue/ITP
15
16. Journal/year of
publication
Study design
and population
Methods/
Intervention
Results
Journal:Ann Med
Health Sci Res.
2014 May-Jun;
Topic: Papaya
Extract to Treat
Dengue: A Novel
Therapeutic
Option?
Objective:
There is conflicting
reports on the
effectiveness of this
extract in the
treatment of
dengue. A brief
review of available
literature
regarding the use
of the papaya leaf
extract is presented
here
Study Design:
Systemic Review
Study site:
Department of
Pharmacology, Sri
Devaraj Urs
Medical College and
Academy of Higher
Education and
Research, Tamaka,
Kolar, Karnataka,
India
Sample Size:
352
The search was
done independently
by the two authors
using PubMed,
Google and the
library database
and included
relevant articles of
the last 10 years. A
total of 7 studies
were included in
this review, which
were one animal
study, one case
report, three case
series and two
randomized
controlled trials
Papaya extract no
doubt offers a cheap
and possibly effective
treatment for dengue.
However, currently, it
is also necessary
not to rely entirely on
the leaf extract and
ignore standard
treatment for dengue
until the benefits are
established
16
17. Journal/year of
publication
Study design
and population
Methods/
Intervention
Results
Journal: Evidence-
Based
Complementary and
AlternativeMedicine
Volume 2013
Topic: Carica
papaya Leaves Juice
Significantly
Accelerates the Rate
of Increase in
Platelet Count
among Patients
with DF & DHF
Objective: to
investigate the
platelet
increasing
property of CPLJ
in patients with
dengue fever
Study Design:
Randomized
controlled trial
Sample size: 228
Setting: Infectious
Disease Research
Center, Institute
for Medical
Research, Jalan
Pahang, 50588
Kuala Lumpur,
Malaysia
Half the
inpatients
received juice,
for 3 consecutive
days .
Controls received
the standard
management.
FBC ,monitored
Q8H for 48
hours.
The mean
increase in
platelet counts
were compared
in both groups
Significant increase in
mean platelet count
observed in the
intervention group (𝑃
< 0.001) but not in
the control group 40
hours since the first
dose of CPLJ.
Mean platelet count in
intervention group was
significantly higher
than control group
after 40 and 48 hours of
admission (𝑃 < 0.01).
Conclusion: It was
concluded that CPLJ
does significantly
increase the platelet
count in patients with
DF and DHF.
17
18. Journal/year of
publication
Study design
and population
Methods/
Intervention
Results
Journal:
International Journal
of Medicinal and
Aromatic Plants,
Vol. 2, No.4, pp.
573-578, December
2012
Topic:
The effect of Carica
papaya leaves
extract capsules on
platelets count and
hematocrit level in
dengue fever
patients
Objective: to
determine the effect
of C-pappaya
leaves extract
capsules in dengue
fever patients.
Study Design:
Randomized
controlled trial
Study site:
Indonesia
Duration: From
November 2011 to
April 2012
Sample size: 80
Subjects
randomized in two
groups
Intervention
Group: 40
Controls:40
550mg CPC,
containing 70%
ethanol extract of
CP leaves.
24 capsules were
given BID to
intervention group
PLT and HCT
were checked twice
daily
Results: There was
accelerated platelet
growth and shortened
hospital stay noted in
intervention group (p
value <0.005)
Conclusion:
CPC could be used as
an additional or
complementary drug in
the management of
Dengue fever
18
19. Journal/yea
r of
publication
Study
design and
population
Methods/
Intervention
Results
Journal: Kala,
Med Aromat
Plants 2012, 1:6
Topic: Leaf Juice
of Carica papaya
Leaves: A Remedy
of Dengue Fever
Objective: To
investigate the role
of CPLJ in
potentiating
platelet growth in
Dengue fever
patients
Study Design:
Case Series
Setting: Faculty
of Public Health
Sciences ,
University of
Indonesia
Sample size: 05
Home made CPLJ
given two tablespoons
three times a day to 05
patients
Samples before and
after ingestion of juice
taken
The increase in number
of platelets varied from
patients to patients that
ranged from 8000 to
11000. The
dengue patients had
reiterated that there
was a significant
improvement
in their health within
24 hrs. of taking
papaya leaf juice
Conclusion: The juice
of papaya leaves is an
effective herbal therapy
for curing the dengue
fever
19
20. Journal/year of
publication
Study design
and
population
Methods/
Intervention
Results
Journal: Sri Lankan
Family Physician,
2008, 29, 17-19
Topic: Salutary
effects of Carica
papaya leaf
extract in dengue
fever patients
– a pilot study
Objective:
Find out whether
carica papaya leaf
extract had any
effect on increasing
the lowered platelet
count.
Study Design:
Case Series
Setting:
Family
Physician’s Clinic,
Maharagama Siri
Lanka
Sample size:12
Study included patients
with clinically or
biochemically proven
dengue fever who were
managed as outpatients
They were given a
drink of papaya leaf
extract 5ml doses at an
8 hour interval for
adults and 2.5 ml doses
at an 8 hour interval for
children
<10 years.
PLT, WBC,PCV,ALT
were checked before
and after the intake of
CPLJ ,Samples
repeated second day
too, Patients were
monitored for two
weeks for adverse
effects
12 patients’ platelet and
WBC count improved
Clinical condition
improved. 08 patients
did not have significant
improvement in PCV
and SGPT, 04 patients
had 1/3 reduction in
SGPT, 05 patients with
PLT < 100000 had
itching hemorrhagic
skin rash which
disappeared within two
days of treatment with,
papaya leaf juice
Conclusion:
This pilot study has
shown the effects of
papaya leaf
juice in dengue patients
of elevating the total
white cell counts,
platelet counts and
recovery without
hospital admission. 20
21. Journal/year of
publication
Study design and
population
Methods/
Intervention
Results
Journal: Asian
Pacific Journal of
Tropical
Biomedicine 2011
Topic: Dengue
fever treatment
with Carica
papaya leaves
extracts
Objectives: to
investigate the
potential of Carica
papaya leaves
againist Dengue
fever in 45 year old
patient bitten by
carrier mosquitoes
Study Design:
Case Report
Setting: Lady
Reading Hospital,
Peshawar Pakistan
Sample size: 01
Age: 45 years
Intervention:
25ml of aqueous
extract Q12H, for
five days
Blood samples
before and after
the extract
administration
taken and
compared
(WBC,PLT)
PLTs increased
from 55 to 168
WBC from 3.7 to 7.7
(After 72 hours)
Conclusion: From
patient feeling and
lab reports it is
appeared that
Carica Papaya
leaves extract
exhibited potential
activity against
dengue fever
21
22. Critical Analysis
Scientific literature reveals that C. papaya
L. leaf extract does have beneficial
properties in dengue
Rapid rise in platelets could be attributed
to presumed membrane stabilizing
properity of Papaya leaves’ extract
One study found that the leaves of papaya
plant are rich in several minerals may
balance the mineral deficiency caused by
the virus and strengthen the immune cells
against it
22
23. Critical Analysis continued:
Picture is not entirely cleared
In most of studies dengue fever is diagnosed
on the basis of thrombocytopenia only
Proper diagnosis is mandatory for more
convincing evidence
Most of the patients were given crude leave
extracts and amount given also differs
The active principle needs to be identified and
the dosage standardized to conduct clinical
studies on it to prove its efficacy in dengue
beyond doubt
23
24. Critical Analysis Continued
Pharmacokinetic studies need to be
conducted
Cheap and possibly effective treatment for
dengue
It is necessary not to rely entirely on the
leaf extract and ignore standard treatment
Large scale randomized clinical trials in
dengue-confirmed patients is necessary to
establish their usefulness and safety
Papaya plant also appears to be effective
against the Aedes mosquito, so could be
used for “Prevention” also
24