Definition of drug interaction, potential of herb-drug interactions,significance of study of herb-drug interactions, reasons for their study, types according to ayurveda, effects & different ways of herb-drug interactions, their mechanism, hypericum, kava lava, ginkgo biloba, ginseng, garlic, pepper, ephedra.
Herbs, Herbal Drugs
Present Scope of Herbal Drug Industry
Scope of Herbal Drug Medicine and Industry
Indian Herbal Industry
International Scope of Herbal Medicines
World Wide Herbal Trade
Overview on plant based industries and research institutions in India
List of few herbal drug industries in India
List of few herbal research institution/ centres in India
General Introduction to Herbal Industry
Herbal drugs industry: Present scope and future prospects.
A brief account of plant based industries and institutions involved in work on medicinal and
aromatic plants in India.
Regulations in India (ASU DTAB, ASU DCC), Regulation of
manufacture of ASU drugs - Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Introduction
Regulatory Requirements
Key function of regulatory agencies
Regulation in India
DRUG TECHNICAL ADVISORY BOARD
Drugs Consultative committee-DCC
Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Herbs, Herbal Drugs
Present Scope of Herbal Drug Industry
Scope of Herbal Drug Medicine and Industry
Indian Herbal Industry
International Scope of Herbal Medicines
World Wide Herbal Trade
Overview on plant based industries and research institutions in India
List of few herbal drug industries in India
List of few herbal research institution/ centres in India
General Introduction to Herbal Industry
Herbal drugs industry: Present scope and future prospects.
A brief account of plant based industries and institutions involved in work on medicinal and
aromatic plants in India.
Regulations in India (ASU DTAB, ASU DCC), Regulation of
manufacture of ASU drugs - Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Introduction
Regulatory Requirements
Key function of regulatory agencies
Regulation in India
DRUG TECHNICAL ADVISORY BOARD
Drugs Consultative committee-DCC
Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Herb drug and herb food interaction ppt by nitesh kumarNITESH KUMAR
HERB DRUG AND HERB FOOD INTERACTION IS AN IMPORTANT CHAPTER IN HERBLA DRUG TECHNOLOGY IN THE SYLLABUS OF B.PHARMACY 6TH SEM. IT GIVES A BETTER UNDERTANDING OF HERB FOOD INTERACTION AND RELATED DRUGS.
Schedule T – Good Manufacturing Practice of Indian systems of medicine
Components of GMP (Schedule – T) and its objectives
Infrastructural requirements, working space, storage area, machinery and equipments,
standard operating procedures, health and hygiene, documentation and records.
INTRODUCTION
Components of GMP
GMP Provisions: Under Schedule-T are grouped
Location and surroundings
Factory Premises
Buildings
Water supply
Containers cleaning
Disposal of Waste
Requirements for the sterile products
store
Working space:
Space requirement for manufacturing of Unani medicine
Health & Hygiene
Machinery and Equipments
Machinery and equipments for maufacturing of ayurveda and siddha medicine
Documentation and Records
Herbal Drug Technology (B.Pharm. 6th Semester)
Definition of herbs, herbal medicine, herbal medicinal product, herbal drug preparation
Source of herbs, Selection, identification and authentication of herbal materials,
Processing of herbal raw material
Herbal excipients which are easily available, lower cost and are noncarcinogenic, which can be used to replace synthetic excipients which are carcinogenic.
Natural colorants obtained from various insects and plants, which gives harmless dying agents which can be used in food industry as well as textile industry.
Biopharmaceutics: Mechanisms of Drug AbsorptionSURYAKANTVERMA2
Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimise the therapeutic efficacy of the drug products.
HERB DRUG & HERB FOOD INTERACTIONS.pptxSachinPadole5
Herbs have been used for centuries to promote health and treat various illnesses. However, they can also interact with drugs and foods, which can have significant consequences for your health. Here's a brief overview of herb-drug and herb-food interactions:
Herb-Drug Interactions:
Herbs can interact with prescription and over-the-counter medications, which can alter the way your body processes drugs. For instance, St. John's wort, a popular herb for treating depression, can interfere with the effectiveness of some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs).
Similarly, Ginkgo biloba, a herb used to improve cognitive function and memory, can increase the risk of bleeding in people taking blood-thinning medications like warfarin or aspirin. This can lead to severe health consequences, including stroke.
Herb-Food Interactions:
Herbs can also interact with certain foods, affecting the absorption and metabolism of nutrients. For example, grapefruit can interact with a variety of medications, including statins, which are used to lower cholesterol levels. Grapefruit can inhibit the enzymes that break down these medications, leading to an increase in their concentration in the blood, which can cause side effects.
Additionally, some herbs can interact with nutrients found in food. For example, high doses of zinc supplements can inhibit the absorption of copper, leading to a deficiency. Herbs like St. John's wort can also decrease the absorption of iron, which can lead to anemia.
In summary, while herbs can have numerous health benefits, they can also interact with medications and foods, which can cause serious health consequences. Therefore, it's essential to consult your healthcare provider before taking any herbs, particularly if you are already taking medication or have underlying health conditions.
Herb drug and herb food interaction ppt by nitesh kumarNITESH KUMAR
HERB DRUG AND HERB FOOD INTERACTION IS AN IMPORTANT CHAPTER IN HERBLA DRUG TECHNOLOGY IN THE SYLLABUS OF B.PHARMACY 6TH SEM. IT GIVES A BETTER UNDERTANDING OF HERB FOOD INTERACTION AND RELATED DRUGS.
Schedule T – Good Manufacturing Practice of Indian systems of medicine
Components of GMP (Schedule – T) and its objectives
Infrastructural requirements, working space, storage area, machinery and equipments,
standard operating procedures, health and hygiene, documentation and records.
INTRODUCTION
Components of GMP
GMP Provisions: Under Schedule-T are grouped
Location and surroundings
Factory Premises
Buildings
Water supply
Containers cleaning
Disposal of Waste
Requirements for the sterile products
store
Working space:
Space requirement for manufacturing of Unani medicine
Health & Hygiene
Machinery and Equipments
Machinery and equipments for maufacturing of ayurveda and siddha medicine
Documentation and Records
Herbal Drug Technology (B.Pharm. 6th Semester)
Definition of herbs, herbal medicine, herbal medicinal product, herbal drug preparation
Source of herbs, Selection, identification and authentication of herbal materials,
Processing of herbal raw material
Herbal excipients which are easily available, lower cost and are noncarcinogenic, which can be used to replace synthetic excipients which are carcinogenic.
Natural colorants obtained from various insects and plants, which gives harmless dying agents which can be used in food industry as well as textile industry.
Biopharmaceutics: Mechanisms of Drug AbsorptionSURYAKANTVERMA2
Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimise the therapeutic efficacy of the drug products.
HERB DRUG & HERB FOOD INTERACTIONS.pptxSachinPadole5
Herbs have been used for centuries to promote health and treat various illnesses. However, they can also interact with drugs and foods, which can have significant consequences for your health. Here's a brief overview of herb-drug and herb-food interactions:
Herb-Drug Interactions:
Herbs can interact with prescription and over-the-counter medications, which can alter the way your body processes drugs. For instance, St. John's wort, a popular herb for treating depression, can interfere with the effectiveness of some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs).
Similarly, Ginkgo biloba, a herb used to improve cognitive function and memory, can increase the risk of bleeding in people taking blood-thinning medications like warfarin or aspirin. This can lead to severe health consequences, including stroke.
Herb-Food Interactions:
Herbs can also interact with certain foods, affecting the absorption and metabolism of nutrients. For example, grapefruit can interact with a variety of medications, including statins, which are used to lower cholesterol levels. Grapefruit can inhibit the enzymes that break down these medications, leading to an increase in their concentration in the blood, which can cause side effects.
Additionally, some herbs can interact with nutrients found in food. For example, high doses of zinc supplements can inhibit the absorption of copper, leading to a deficiency. Herbs like St. John's wort can also decrease the absorption of iron, which can lead to anemia.
In summary, while herbs can have numerous health benefits, they can also interact with medications and foods, which can cause serious health consequences. Therefore, it's essential to consult your healthcare provider before taking any herbs, particularly if you are already taking medication or have underlying health conditions.
Following file comprises of information about interactions taking place between herbs-drug, herbs-herbs, it also highlights some of the cases of clinical laboratory test interactions taking place due to use of herbal medicines.
Herbal-Drug and Herb-Food Interactions, Herbal Drug Technology-6th semester.pptxRahul Dev
General introduction to interaction and classification.
Study of following drugs and their possible side effects and interaction: Hypericum, Kava - Kava, Ginkgo biloba, Ginseng, Garlic, Pepper, and Ephedra.
It is science of medicine from plants. It is far different from homeopathy and have various advantages over conventional medicine. Various traditional medicine system existed in past.
Similar to Herb drug & herb-food interactions (20)
Objective
Definition
Animal welfare board of India
Experimentation on animals
Committee for experimentation on animals
Power of entry and inspection
Power to prohibit experiments on animals
penalties
Objectives of the Drugs and Cosmetics Act
Definitions
DRUGS TECHNICAL ADVISORY BOARD (DTAB)
GOVERNMENT ANALYST
Drug Inspectors
Regulatory provisions relating to import of cosmetics
Offences & penalties
Loan license
Requirements pertaining to labeling of cosmetics
References
A glycogen storage disease (GSD, also glycogenosis and dextrinosis) is a metabolic disorder caused by an enzyme deficiency affecting glycogen synthesis, glycogen breakdown, or glucose breakdown, typically in muscles and/or liver cells.
PREPARATION AND IN-VITRO EVALUATION OF ITRACONAZOLE LOADED NANOSPONGES FOR T...Mahewash Sana Pathan
Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infections. It is a BCS Class II drug having very low solubility in water i.e. 1-4ng/ml. The oral use of Itraconazole is not much recommended as it has many side effects. The present research has been undertaken with the aim to develop a topical hydrogel formulation of Itraconazole loaded nanosponges to increase the solubility, permeability and stability of itraconazole. Itraconazole loaded nanosponge was prepared by emulsion solvent diffusion method by using different concentrations of ethyl cellulose as a polymer, Polyvinyl alcohol as surfactant and dichloromethane as cross linking agent. Physical characteristics of the nanosponges as well as the drug entrapment efficiency, percentage drug content, Percent yield, drug polymer compatibility, solubility studies of the nanosponges were investigated. Particle size analysis and surface morphology of nanosponges were performed. The scanning electron microscopy of nanosponges showed that they were spherical in shape and spongy in nature. Drug entrapment efficiency was found to be in the range of 42.75 % to 73.10 %. The optimized nanosponge formulation was loaded into hydrogel using carbopol 940 and studied for pH, viscosity, in vitro drug release. Of the nanosponge formulations prepared, F4 was found to show drug release of 70.62%. It was concluded that Itraconazole nanosponge hydrogel may have increased solubility and drug release
The safe use of medicines is perhaps the single most important criteria that any regulatory authority within a given country has to ensure in order both to protect the public health and the integrity of its health care system. For the same purpose pharmacovigilance was established. According to WHO, Pharmacovigilance is the science and activities related to the collection, detection, and assessment of ADR’s. It promotes the systematic, rational use and assures the confidence for the safety of drugs. It improves patient care and safety. Significance of pharmacovigilance is growing as the patients or consumers have become more responsive about the advantage and hazard of medicines. Pharmacovigilance is a complex process and a robust system is essential to undertake the activity. A good pharmacovigilance system will identify the hazard aspects in the short period of time. This review article tries to explain the some basic principles, history and developments, methods and some scope of this developing field i.e. Pharmacovigilance in India.
Presentation include chapter solubility of drugs from second yr B-Pharm
Solubility, solubility expression, solute solvent interactions, solubility parameters, solvation and dissolution, factors affecting solubility, solubility of gases in liquids, liquids in liquids, fractional distillation, azeotropes, dissolution and drug release and diffusion.
Cosmetics regulatory: includes Regulatory provision relating to manufacture of cosmetics, Schedule M (II) of D & C rule 1945 deals with requirements for the factory premises for the manufacture of cosmetic, requirement of plant & equipment, conditions of licencing, regulatory provision on sale of cosmetics, loan licence, Regulatory provision relating to import of cosmetics, offences & penalties, List of amending Act and adaptation orders.
Pharmacovigilance is defined as, The pharmacological science and activities concerned with the detection, assessment, understanding and prevention of adverse reactions to medicines or Pharmacovigilance is the name given to the mechanisms and controls that together map and ensure the safety of a medicine throughout its life span – from test tube to patient.
Challenges in herbal formulation
Steps in herbal drug formulation
Types of conventional herbal formulations
Liquid herbal dosage forms
Solid herbal dosage forms
Other herbal dosage forms
Novel dosage form
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Drug interactions
Potential for herb-drug interactions
Significance to study herbal-drug interactions
Reasons for herbal drug interactions.
Types of drug interactions as per Ayurveda.
Different Ways Of Herbal Preparations Toxicity
Effects Of Herb-drug Interactions On Various Systems Of
Body
Mechanism Of Herb-drug Interactions
Study of drugs & their possible side effects and interactions:
Hypericum, Kava-kava, Ginkgo biloba, Ginseng, Garlic,
Pepper, Ephedra
2
3. Drug interaction is defined as “ alteration in the
pharmacological activity of one drug by the
concomitant use of another drug or other
substances. The concurrent use of herbs may
increase, decrease or mimic the effect of other
drugs.”
3
4. There is no chemical reaction between herb & drug
but components of herb can enhance or diminish
the amount of drug present in bloodstream.
Herbal drugs may be toxic intrinsically or when
these are taken with combination of other
preparations, toxic effects can be observed.
Herbal drugs contain contaminants (incorrect
species, pollen grains, insects, allergens, heavy
metals & poisonous drugs, etc) may cause toxic
reactions.
4
5. Herbal drug interactions can affect health &
efficiency of treatments as some herbal therapies
might:
a. Increase the side effects of drugs, leading to
toxicity.
b. Leads to treatment failure due to decrease in
effect of drug.
c. Unexpected complications may occur due to
modification of drug action.
d. Enhance therapeutic effect of drug.
e. Prescription & non prescription drugs can alter
reaction of body to herbal therapies.
5
6. 1. Proper information is not available regarding the
contents of herbal product.
2. Product information may be incomplete or
inaccurate.
3. Herbal product contain many phytoconstituents
which are not characterized properly.
4. Lack of adequate knowledge of combinations.
6
7. HERB
INTERACTIONS
Herb-herb
interaction Eg.
Piper betal should
not be
administered with
Garcinia morella
Herb-Food
interactions eg.
Sesame seed
with blak cumin
cause
diarrhoea.
Herb & drug of
animal origin eg.
Meat is
contraindicated
with Brassica alba
Interactions
related to
diseases eg.
Haritaki cannot
be administered
in pregnancy.
7
8. •Some herbs contain toxic ingredient. E.g.
Mentha pulegium oil contain a potent
abortifacient compound.
1. Toxic ingredients
•Herbal weight reduction e.g. Aristolochia
fangchi causes kidney damage & cancer.
2. Unintentional
addition of toxic
species
•This is done to potentiate the effect of
herbs. Adulteration with steroids etc.
3. Intentional
addition of drugs
•E.g. Heavy metal poisoning
4. Contamination due to
envionmental factors
•Toxicity due to metabolic & physiologic
effects of modern medicines.
5. Toxicity due to
combination with
modern medicines
8
9. 1. GIT: Horse chestnut acts as irritant to GIT & can affect
efficacy of anti ulcer drugs. Activity of laxatives may be
enhanced by use of senna.
2. CVS: Antihypersensitive drugs may be adversely
affected by use of ginseng & dandelion. Alfalfa
enhances effect of hypolipidaemic drrugs.
3. CNS: Sedatve herbs react with hypnotic & anxiolytic
drugs. Evening primerose oil can react with
epileptogenic drugs.
4. Endocrine system: Ginseng & red clover can interfere
with activity of sex hormonal treatment & oral
contraceptives.
9
11. Synonym: St. John’s wort, Amber, Demon chaser,
Amber touch-and-heal, Millepertuis, Goat weed,
Bassant.
Biological source: Dried aerial plant parts of
Hypericum perforatum L.
Family: Hypericaceae.
Geographical source: England, Europe, Australia,
western himalayas.
11
12. MACROSCOPIC
CHARACTERS:
Colour- leaves are green
with black spots
Odour- distinct, balsamic
Taste- astringent & bitter
Shape- leaves are oblong,
entire
Flowers- yellow corolla,
small five petaled.
Capsules- ovoid
Seeds- very small
Stem- 2 edged.
12
14. STANDARDS:
i. FOM: > 3.0 %
ii. Alcohol soluble extractive: < 13.0 %
iii. Water soluble extractive: <24%
iv. LOD: >10%
v. Total ash: >7%
vi. Acid insoluble ash: >0.8%
14
15. 1. Anti depressant
2. In treatment of anxiety, seasonal affective disorders.
3. In the treatment of symptoms of menopause, mental
disorders, premenstrual syndrome.
4. In treatment of fibromyalgia (chronic rheumatic condition),
chronic fatigue syndrome(CFS), burning feelings in the
mouth, maigraine, pain, irritable bowel syndrome,skin
diseases.
5. Food flavour
6. Hypericin reported to have antiviral potential against HIV &
hepatitis C virus.
15
16. Hypericum when taken orally upto 12 weeks, it is
considered as safe. Possible side effects are:
Trouble sleeping
Vivid dreams
Restlessness
anxiety
Irritability
Stomach upset
Fatigue
Diarrhoea
Skin rash
Dizziness
Dry mouth
16
17. Hypericum interacts with certain antidepressant drugs
leads to serious conditions resulting excess of
serotonin. Symptoms of this interaction are confusion,
fever, hallucinations, nausea, imbalance in muscle
coordination, sweating, & shakiness.
Decreases metabolism of anti-anxiety drug alprazolam,
hence decrease its effectiveness.
Decreases efficacy of birth control pills.
Decreases effect of cardiotonic drug digoxin.
Decreases effect of anti HIV drugs like imatinib,
irinotecan, ketamine, etc.
Hypericum with cyclosporin decreases drug
concentration & rejection of transplanted organ by
induction of Cyt P3A4.
17
18. Synonym: Ava pepper, Ava root, Awa.
B/S: dried roots of plant Piper methysticum, family-
Piperaceae.
G/S: Melanesia, Micronesia, polynesia.
M/C: it is shrub & has heart shaped leaves & woody
stem. Stem are green with swollen nodes. The fruits are
berries with one seed.
18
19. Root consist of 12% water, 43% starch, 20% fibers,
sugars & minerals.
Main phytoconstituents are kavalactones, chalcones,
kawain, 7,8-dihydrokawain, methysticin, yangonin,
demethoxy yanonin.
Minor constituents are three chalcones flavokavain A,
B & C.
19
20. Kava decreases anxiety, stress, insomnia & post
menopausal symptoms.
It may used in treatment of cancer, ADHD, epilepsy,
psychosis, depression, CFS & headaches.
In treatment of common cold, respiratory tract
infection, tuberculosis, muscle pain, UTI, skin diseases
& wounds.
Possible side effects of Kava:
When taken orally, may cause liver damage.
Aggregates the symptoms of depression & parkinson’s
disease.
Not safe during pregnancy & lactation.
It may cause visual disturbances, GI discomfort,
urinary retention, etc.
20
21. Kava when taken together with alprazolam cause
drowsiness.
Kava interact with CNS depressants & cause
drowsiness.
Decrease liver metabolism of some drugs.
Kava enhances absorption of medications such as
etoposide, paclitaxel, vinblastine, vincristine,
indinavir, nelfinavir, cimetidine, corticosteroids.
Kava when administered with medicines such as
acetaminophen, amiodarone, isoniazid, methyldopa,
itraconazole, etc can cause hepatotoxicity.
21
22. SYNONYM: Maiden hair tree,
kew tree
Biological source: Dried leaves
of Ginkgo biloba L.
Family: Ginkgoaceae.
Geographical source: China,
USA, Japan, Europe, Australia.
Macroscopic characters:
Colour: bright yellow flowers.
Leaves: bilobate
22
23. Chemical constituents of Ginkgo:
Ginkgo leaves possess variety of glycosides,
predominantly flavonol, mono, di & tri glycosides of
isorhamnetin, kaempferol & quercetin.
Bio-flavones present are gingketin, gingkolic acid &
bilobetin.
Leaves also possess diterpene lactones, mainly
ginkgolides A, B, C, & J.
Total ash should be 11%.
23
24. Anti-inflammatory & hepatoprotective agent.
Plant has antilipedemic, antidiabetic & antioxidant
activity.
It reduces anxiety & treats dementia.
Also act as anti-allergic, anti viral, anti proliferative, anti
tumorigenic & anti carcinogenic agent.
Adverse effects:
Stomach upset, headache, dizziness, constipation,
increase in force of heartbeat, allergic skin reactions,
etc.
High dose of leaf extract may increase risk of liver &
thyroid cancers.
Ginkgo seeds may cause seizures & death.
It is not safe in pregnancy & lactation.
24
25. When ginkgo is administered with ibuprofen, it increase
chances of bruising & bleeding.
Can decrease effect of alprazolam, efavirenz,
carisoprodol, citalopram, diazepam, omeprazole,
haloperidol, olanzepinepropranolol, etc.
When administered with fluoxetine, may cause
hypomania.
Ginkgo may slow down the metabolism of certain drugs.
Decrease the effect of anti diabetic drugs such as
glimeperide, insulin, rosiglitazone, etc.
Trazodone when taken with ginkgo, may cause serious
side effects.
Hydrochlorothiazide when administered with ginkgo
cause increase in BP.
25
26. Synonym: Panax ginseng, red berry,
renshen, hong shen.
B/S: dried roots of Panax Ginseng,
Family- Araliaceae.
G/S: Manchuria, Chinese tartary,
eastern asia, Korea & Japan.
Description: it is smooth perennial
herb. Has large, fleshy, spindle
shaped very slow growing root.
Colour- Pale yellow to brownish
Odour- odourless
Taste- mucilagenous with slight
bitterness.
26
27. Steroid like saponin- Ginsenosides. Ginsenosides
Rb1, Rb2, Rc, Rd, R, etc comprise 90% of total
ginsenosides.
27
28. Treat depression, anxiety, general fatigue, chronic
fatigue syndrome, multiple sclerosi, anemia, chronic
bronchitis, swine flu, pre diabetes & diabetes, gastritis,
COPD, fertility problems.
It has wide applications in treating bleeding disorders,
loss of appetite, vomiting, intestinal problems,
gallstones, bad breath, insomnia, nerve pain, joint pain,
headache, convulasions, disorders of pregnancy, heart
failure, high BP, & as antiaging agent.
Side effects:
Skin reactions, diarrhoea, insomnia, headache, rapid
heartbeat, increased or decreased BP, loss of appetite,
itching, vaginal bleeding.
28
29. When taken with caffeine, can cause serious
reactions such as increased heart rate & high BP.
Decreases the effect of estrogen pills, furosemide,
midazolam, nifidipine.
Decreases metabolism of imatinib, amitriptylene,
clozapine, donepezil, fentanyl, fluoxetine,
methadone, etc.
Might decrrase the effectiveness of
immunosuppressant drugs.
Panax slows down blood clotting.
Ginseng when used with HIV drug like Raltegravir,
can increase chances of liver toxicity.
29
30. Synonym: Allium, Lasun
B/S: dried bulbs of Allium sativum L,
Family- Liliaceae.
G/S: Central Asia, Africa, United
states, India & Europe.
Description: It is a bulbous perennial
plant having height of 4ft. It consist of
several cloves covered with white or
pink membrane. It is hermaphrodite
flowers. Pollinated by bees & insects.
30
32. It acts as aphrodiasiac, carminative, expectorant,
stimulant.
Used to treat fever, hyperlipidemia, bronchial asthma,
tuberculosis, GIT disorders, diabetes, infections &
arteriosclerosis.
Possible side effects:
Allergic reactions such as difficulty in breathing,
swelling of face, lips, tongue or throat, etc.
Unpleasant breath or body odour, heartburn, burning
in mouth or throat, nausea, vomiting, gas or
diarrhoea, etc.
32
33. Garlic may increase bleeding times with
anticoagulants.
Garlic may induce hepatic CyP3A4 metabolism of
protease inhibitors like ritonavir, indinavir etc.
During & after surgery, garlic causes spontaneous
bleeding.
When co-administered with chlorpropamide,
produces antihyperglycemic effect.
Minor interactions include changes in paracetamol
pharmacokinetics & hypoglycaemia.
Decreases effect of anti HIV drugs.
Decreases effect of calcium channel blockers due to
increase in liver breakdown of such medications.
33
34. Synonym: Black pepper, kali miri,
Pippali
B/S: dried ripe fruits of Piper
nigrum, Family- Piperaceae.
G/S: Brazil, Indonesia & India.
Description: plant grows well in
shade & need support.
Leaves-heart shaped, alternate with
palmate veins.
Fruits- drupe with single seed & red
in color when matured.
Seeds- brown or black, with aromatic
odor & pungent taste.
34
35. 1-2.5% volatile oils. Pharmacologically active principle
is pungent alkaloid piperine.
Other phytoconstituents are Brachyamide B, dihydro-
pipericide, N- formylpiperidine, guineensine,
isobutyl-eicosadienamide, tricholein, piperamide,
piperettine, pipericide, samantine, limonene,
camphene, cinnamic acid, etc.
35
36. Antihypertensive, antiplatelet, antioxidant,
anticancer, antiasthmatic, anti-inflamatory, analgesic,
anti-diarrhoeal, antispasmodic, immunomodulatory,
anticonvulsant, anti-thyroid, hepatoprotective,
antifungal, insecticidal & larvicidal activities.
It act as a bioenhancers & increase absorption of
many drugs & nutrients.
Adverse effects:
It is generally safe when given in small doses.
If get into eyes cause redness & burning.
In large doses it may cause miscarriage in
pregnancy.
36
37. As pepper has diuretic effect, it decreases clearance
of lithium & increases its concentration in the body
hence cause serious side effects.
Enhances absorption of various drugs such as
lovastatin, ketoconazole, ITZ by altering their liver
metabolism.
Enhances the effects & side effects of phenytoin.
Carbamazepine absorption increases & metabolism
decreases when administered with pepper.
Piperine increases bioavailability of fexofenadine.
Piperine slows down blood clotting. Hence with
anticoagulant medications it may increase chances of
bruising & bleeding.
Can increase sedative side effects of pentobarbital.
37
38. Synonym: Ma-huang, yellow horse,
yellow astringent, pinellia.
B/S: dried young stem of Ephedra
gerardiana, E. nebrodensis, E. sinica,
E. equisetina, family- Ephedraceae.
G/S: northern china, mongolia,
southern europe, North Africa, Asia.
It typically grow in dry & desert
regions.
Description: it is an evergreen shrub
2-3 ft height & no leaves. Stem-
green, jointed, smooth, woody,
branching.
38
39. 1% of amino alkaloids such as ephedrine,
pseudoephedrine, norpseudoephedrine,
methylephedrine, including quinoline & 6-
hydroxykynurenic acid & tannis.
39
40. It is used in asthma, bronchitis, bronchospasm,
allergies, nasal congestion, colds, flu, fever & other
breathing problems.
Side Effects:
Dizziness, restlessness, anxiety, irritability, headache,
loss of appetite, nausea, vomiting, etc.
It also cause arrythmia & sudden death, myocardial
infarction, stroke, autonomic hyperactivity, seizures,
gastric mucosal injury, etc.
40
41. Ephedra when administered with medications like
amiodarone, disopyramide, dofetilide, ibutilide,
quinidine etc can cause serious side effects like heart
attack.
Ephedra when taken with methylxanthines might
cause nervousness, fast heartbeats, high BP &
anxiety.
Effectiveness of dexamethasone may decrease due to
ephedra.
Decreases efficacy of antidiabetic drugs.
Can decrease the efficacy of anticonvulsant drugs
such as phenobarbital, primiidone, valproic acid,
gabapentin, phenytoin.
41