The document provides information on India's National Tuberculosis Control Program (RNTCP). It discusses the magnitude of TB in India, the evolution of control efforts from the initial National TB Control Program to the current Revised National TB Control Program (RNTCP) launched in 1997 based on WHO's DOTS strategy. The RNTCP aims to achieve 85% cure rates among new cases and detect 70% of cases. It utilizes strategies like standardized treatment regimens, involvement of communities/NGOs, and program innovations to achieve its goals.
A decentralized system of disease surveillance for timely and effective public health action with a focus on functional integration of surveillance components of various vertical programmes.
National leprosy eradication program CHNNehaNupur8
Leprosy is a chronic infectious disease caused by ‘Mycobacterium Leprae’ an acid fast , rod shaped bacillus.
The disease mainly affects the skin , the peripheral nerves , mucosa of the upper respiratory tract and also eyes.
Cardinal Features:-
° Hypopigmented patch
° Loss of cutaneous sensation
° Thickened Nerve
° Acid fast bacilli
Leprosy has been regarded by tbe community as a contagious , mutilating and incurable disease.
Leprosy is curable and treatment provided in the early stages averts disability.
Multidrug Therapy (MDT) treatment has been made available by WHO free of charge to all patients worldwide since 1995, and provides a simple yet highly effective cure for all typesof leprosy.
National Mental Health Programme was launched in 1982 keeping in view the heavy burden of mental illness in the community, and the absolute inadequacy of mental health care infrastructure in the country to deal with it.
A decentralized system of disease surveillance for timely and effective public health action with a focus on functional integration of surveillance components of various vertical programmes.
National leprosy eradication program CHNNehaNupur8
Leprosy is a chronic infectious disease caused by ‘Mycobacterium Leprae’ an acid fast , rod shaped bacillus.
The disease mainly affects the skin , the peripheral nerves , mucosa of the upper respiratory tract and also eyes.
Cardinal Features:-
° Hypopigmented patch
° Loss of cutaneous sensation
° Thickened Nerve
° Acid fast bacilli
Leprosy has been regarded by tbe community as a contagious , mutilating and incurable disease.
Leprosy is curable and treatment provided in the early stages averts disability.
Multidrug Therapy (MDT) treatment has been made available by WHO free of charge to all patients worldwide since 1995, and provides a simple yet highly effective cure for all typesof leprosy.
National Mental Health Programme was launched in 1982 keeping in view the heavy burden of mental illness in the community, and the absolute inadequacy of mental health care infrastructure in the country to deal with it.
Acquired immunodeficiency syndrome (AIDS) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight infection and disease.
The National AIDS Control Programme (NACP), launched in 1992, is being implemented as a comprehensive programme for prevention and control of HIV/AIDS in India. Over time, the focus has shifted from raising awareness to behavior change, from a national response to a more decentralized response and to increasing involvement of NGOs and networks of PLHIV.
National Leprosy Eradication Programme (NLEP)Kavya .
Chronic infectious disease caused by Mycobacterium leprae.
It usually affects the skin and peripheral nerves
Long incubation period generally 5-7 years.
Classified as paucibacillary or multibacillary
permanent disability
Timely diagnosis and treatment of cases
National mental health programme - Presented By Mohammed Haroon Rashid Haroon Rashid
Subject - Mental Helath Nursing topic - National Mental Health Programme, Presented By Mohammed Haroon Rashid, Basic B.Sc Nursing 3rd Year in Florence College Of Nursing
Acquired immunodeficiency syndrome (AIDS) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight infection and disease.
The National AIDS Control Programme (NACP), launched in 1992, is being implemented as a comprehensive programme for prevention and control of HIV/AIDS in India. Over time, the focus has shifted from raising awareness to behavior change, from a national response to a more decentralized response and to increasing involvement of NGOs and networks of PLHIV.
National Leprosy Eradication Programme (NLEP)Kavya .
Chronic infectious disease caused by Mycobacterium leprae.
It usually affects the skin and peripheral nerves
Long incubation period generally 5-7 years.
Classified as paucibacillary or multibacillary
permanent disability
Timely diagnosis and treatment of cases
National mental health programme - Presented By Mohammed Haroon Rashid Haroon Rashid
Subject - Mental Helath Nursing topic - National Mental Health Programme, Presented By Mohammed Haroon Rashid, Basic B.Sc Nursing 3rd Year in Florence College Of Nursing
After the successful NSP 2017-2025,Goi is lauching NSP 2017-2025 for elimination of TB on 24th march( World TB day ) 2017. Module is on MOHFW site but i have try to keep it brief,hope its ll be useful specially for academic and administrative purposes.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
2. 20-Feb-16
Lesson Objectives
To know about the magnitude of TB
problem
To know about the evolution of TB
control in India
To learn about the goals, objectives
and strategies
To know about the achievements and
progress
3. 20-Feb-16
Magnitude of the Problem
Source: WHO Geneva; WHO Report 2008: Global Tuberculosis Control; Surveillance, Planning and Financing
Global annual incidence = 9.1 million
India annual incidence = 1.9 million
India is 17th among 22
High Burden
Countries (in terms of
TB incidence rate)
4. 20-Feb-16
Global Burden of Tuberculosis
TB is one of the leading causes of death
due to infectious disease in the world
Almost 2 billion people are infected with M.
tuberculosis
Each year about:
9 million people develop TB disease
2 million people die of TB
5. 20-Feb-16
The Beginning :National Tuberculosis
Control Program (1962)
Before the Revised National Tuberculosis
Program (NTCP) came into force the existing
Tuberculosis program had the following
objectives:
• To identify and treat as large a number of TB
patients as possible so that infectious cases are
rendered non- infectious.
• To reduce the magnitude of TB problem in the
country to a level where it ceases to be a public
health problem.
6. Y REVISED??
Was technically sound but suffered
from managerial weakness
Inadequate funding
Overall reliance on x ray for diagnosis
Frequent interrupted supplies of drugs
Low rates of treatment completion
20-Feb-16
7. 20-Feb-16
Revised National TB Control Program
(RNTCP)
Launched in 1997 based on WHO DOTS
Strategy
Entire country covered in March’06 through an
unprecedented rapid expansion of DOTS
Implemented as 100% centrally sponsored
program
Govt. of India is committed to continue the support till TB
ceases to be a public health problem in the country
All components of the STOP TB Strategy-
2006 are being implemented
8. 20-Feb-16
Objectives of RNTCP
To achieve and maintain a cure rate of at
least 85% among newly detected
infectious (new sputum smear positive)
cases
To achieve and maintain detection of at
least 70% of such cases in the population
9. 20-Feb-16
Strategy
1. Augmentation of organizational support at
the central and state level for meaningful
coordination
2. Increase in budgetary outlay
3. Use of Sputum microscopy as a primary
method of diagnosis among self reporting
patients
4. Standardized treatment regimens.
10. 20-Feb-16
contd.
7 Augmentation of the peripheral level
supervision through the creation of a sub
district supervisory unit
8. Ensuring a regular uninterrupted supply of
drugs up to the most peripheral level
9. Emphasis on training, IEC, operational
research and NGO involvement in the
program
11. 20-Feb-16
Program innovations
Creation of sub district level supervisory and monitoring
unit “TB Unit”
Patient-wise individual drug boxes for entire course of
treatment
Community involvement in DOTs – shopkeepers, teachers,
postmen, cured patients, etc
Continuous Internal Evaluation of districts
Monitoring strategy document with checklists
NGO & PP (Private Provider) schemes
Task Force mechanism for involvement of Medical colleges
Web based IEC resource centre
12. 20-Feb-16
Contd.
District TB Control Society
Modular training
Patient wise boxes
Sub-district level supervisory staff (STS,
STLS) for
Treatment & microscopy
Robust reporting and recording system
13. 20-Feb-16
RNTCP Organization structure: State
level
Health Minister
Health Secretary
MD NRHM Director Health
Services
Additional / Deputy / Joint
Director
(State TB Officer)
State TB Cell
Deputy STO, MO, Accountant,
IEC Officer, SA,
DEO, TB HIV Coordinator etc.,
State Training and Demonstration
Center (TB)
Director, IRL Microbiologist, MO,
Epidemiologist/statistician, IRL LTs etc.,
14. 20-Feb-16
Core elements of Phase I
The core element of RNTCP in Phase I (1997-
2006)was to ensure high quality DOTS expansion in
the country, addressing the five primary components
of the DOTS strategy
Political and administrative commitment
Good Quality Diagnosis through sputum
Microscopy
Directly observed treatment
Systematic Monitoring and Accountability
Addressing stop TB strategy under RNTCP
15. 20-Feb-16
RNTCP Phase II( 2006-11)
The RNTCP phase II is envisaged to:
Consolidate the achievements of phase I
Maintain its progressive trend and effect
further improvement in its functioning
Achieve TB related MDG goals while
retaining DOTS as its core strategy
17. 20-Feb-16
Classification of Patients in Categories
for Standardized Treatment Regimen
Category Type of Patient Regimen Duration in
months
Category I
Color of
box: RED
New Sputum Positive
Seriously ill sputum negative,
Seriously ill extra pulmonary,
2 (HRZE)3,
4 (HR)3
6
Category II
Color of
box: BLUE
Sputum Positive relapse
Sputum Positive failure
Sputum Positive treatment
after default
2 HRZES)3,
1 (HRZE)3
5 (HRE)3
8
18. 20-Feb-16
Contd.
Category Type of Patient Regimen Duration
in
months
Category
III
Color of
box:
GREEN
Sputum Negative,
extra pulmonary not Seriously
ill
2
(HRZ)3,
4 (HR)3
6
19. Pediatric TB
20-Feb-16
•For diagnosis and treatment of pediatric cases
revision was made in guidelines in 2003 in RNTCP
•The pediatric drugs has to be supplied in boxes
(PWB) similar to adults
•Treatment on bases of child body wt
•2 PWB – 6-10 kg
11-17kg
•Were available from 2006
•This was first in world
20. 20-Feb-16
Types of Drug-Resistant TB
Mono-resistant Resistant to any one TB treatment
drug
Poly-resistant Resistant to at least any two TB
drugs (but not both isoniazid and rifampicin)
Multidrug- resistant
(MDR TB) Resistant to at least isoniazid and
rifampicin, the two best first-line TB treatment drugs
Extensively drug-resistant
(XDR TB)
Resistant to isoniazid and rifampicin, PLUS resistant to
any fluoroquinolone AND at least 1 of the 3 injectable
second-line drugs (e.g., amikacin, kanamycin, or
capreomycin)
21. 20-Feb-16
By 2010 DOTS-Plus services available in all states
By 2012, universal access under RNTCP to
laboratory based quality assured MDR-TB
diagnosis for all retreatment TB cases and new
cases who have failed treatment
By 2012, free and quality assured treatment to all
MDR-TB cases diagnosed under RNTCP (~30,000
annually)
By 2015, universal access to MDR diagnosis and
treatment for all smear positive TB cases under
RNTCP
RNTCP- DOTS-Plus Vision
22. 20-Feb-16
TB-HIV: Accomplishments
Developed and implemented mechanism for TB & HIV
program collaboration at all levels (National, State,
District)
Conducted surveillance and determined national burden
of HIV in TB patients
Mainstreamed TB-HIV activities as core responsibility of
both programs (training & monitoring)
23. 20-Feb-16
TB-HIV: Current Policies (2008)
TB/HIV activities in all States
Coordination & Training on TB/HIV
Intensified Case Finding (ICF)
Referral of all HIV- TB patients for HIV care and
support (CPT & ART)
Involve NGOs
Activities in high-HIV states
Provider-initiated HIV counseling and testing for all
TB patients
Decentralized provision of Co-trimoxazole
Expanded TB-HIV monitoring
24. 20-Feb-16
Quality Diagnostic and Treatment
Services
~12,500 decentralized designated microscopy
centers established
External Quality Assurance (EQA) system for
sputum microscopy as per international
guidelines
Quality assured anti-TB drugs
Patient friendly DOT services
25. 20-Feb-16
412766
Achievements in line with
the global targets
Achievements Under RNTCP
Since implementation
> 40 million TB suspects examined
> 9 million patients placed on treatment
> 1.6 million lives saved (deaths averted)
26. 20-Feb-16
Progress Towards Millennium
Development Goals
Indicator 23: between 1990 and 2015 to halve
prevalence of TB disease and deaths due to TB
Indicator 24: to detect 70% of new infectious cases
and to successfully treat 85% of detected sputum
positive patients
The global NSP case detection rate is 61% (2006) and
treatment success rate is 85%
RNTCP consistently achieving global bench mark of
85% treatment success rate for NSP; and case
detection rate 70% (2007)