Rheumatology Sheet from Rheumatology Department, Faculty of Medicine, Zagazig University, Egypt.
Disclaimer : not my slide. Just uploading for my personal use..
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues.
The extreme heterogeneity of the disease has led some investigators to propose that SLE represents a syndrome rather than a single disease.
Lupus was first recognised as a systemic disease with visceral manifestations by Moriz Kaposi (1837–1902).
Rheumatology Sheet from Rheumatology Department, Faculty of Medicine, Zagazig University, Egypt.
Disclaimer : not my slide. Just uploading for my personal use..
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues.
The extreme heterogeneity of the disease has led some investigators to propose that SLE represents a syndrome rather than a single disease.
Lupus was first recognised as a systemic disease with visceral manifestations by Moriz Kaposi (1837–1902).
L’innovation dans les petites et moyennes entreprises (PME) au CamerounUniversité de Dschang
M. Ndzana Eloundou Martin Jaurès a soutenu une thèse de Doctorat/Phd en Sciences Économiques ce 15 juin 2016 à l'Université de Dschang. Le jury présidé par le Prof. Désiré Avom lui a décerné la mention honorable.
L’innovation dans les petites et moyennes entreprises (PME) au CamerounUniversité de Dschang
M. Ndzana Eloundou Martin Jaurès a soutenu une thèse de Doctorat/Phd en Sciences Économiques ce 15 juin 2016 à l'Université de Dschang. Le jury présidé par le Prof. Désiré Avom lui a décerné la mention honorable.
Le 27 décembre, j’ai eu l’occasion d’animer avec le centre de recherche en numérique de Sfax un workshop sur le Design Thinking. CE workshop était destiné pour environ 50 personnes dont 40 sont des doctorants (en 2ème, 3ème et 4ème année de thèse) tous dans la discipline informatique (génie logiciel) et 10 sont des enseignants chercheurs aussi des informaticiens.
L’objectif de ce workshop est de développer l’esprit du « design Thinking » chez les participants. Il est était basé sur une approche pédagogique de « Learning by Doing » ou les participants ont essayé de développer des concepts innovants avec l’approche du design thinking.
a quick review of the articles issued by WHO, CDC and other medical experts...
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on its epidemiology, etiology, clinical manifestations, diagnosis, management and prevention.
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Rheumatology
1. ARTHRITIS Inflammation of the Joint (over 100 specific diseases) Rheumatoid Arthritis Gout Degenerative Joint Diseases Ankylosing spondylitis JRA Psoriatic Arthritis Bacterial Arthritis Systemic Lupus Erythematosus Scleroderma
2. ARTHRITIS: Inflammation of the Joint Pain Swelling Redness Warmth
3. IL-8 IL-6 GM-CSF IL-1 TNF- FGF Fibroblast/ type B synovial cells Metalloproteinases Prostaglandins Complement IL-6 IL-1 IL-6 IL-8 GM-CSF M-CSF Macrophage/ type A synovial cells IL-1 TNF- Adhesion molecule expression on blood vessels HLA-DR Complement metalloptoteinases CYTOKINE NETWORKS IN SYNOVITIS + FEEDBACK
4. IL-8 IL-6 GM-CSF IL-10 IL-1 TNF- FGF Fibroblast/ type B synovial cells Metalloproteinases Prostaglandins Complement IL-6 TGF- IL-4 IL-1 IL-6 IL-8 GM-CSF M-CSF Macrophage/ type A synovial cells IL-1 TNF- Adhesion molecule expression on blood vessels HLA-DR Complement metalloptoteinases CYTOKINE NETWORKS IN SYNOVITIS + FEEDBACK - FEEDBACK
5. Points to Remember Cells involved in Inflammation: - macrophage, fibroblast, T-cells Pro inflammatory cytokines: - IL-1, TNF alpha, IL-6 - IL-8, FGF, GM-CSF Anti inflammatory cytokine: - IL-10, TGF-B, IL-4
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12. Biochemical markers in Osteoarthritis Major tissue of origin Biochemical markers Synovium Hyaluran, type 2 collagen propeptide, proteases Subchondral bone Type 1 collagen crosslinks, osteocalcin, alk. phosphatase, Cart. oligomeric protein (COMP)
18. Mechanism of Action of NSAIDs – New hypothesis Arachidonic Acid Prostaglandins Prostaglandins Protection of gastric mucosa Homeostasis Mediates pain Inflammation and fever Conventional NSAIDs COX-1 COX-2 Coxibs
19. COX-1 COX-2 - produces PG from AA - produces PG from AA - constitutively expressed - inducible - governs PG production - governs PG production that mediate hemostatic that mediate inflammation function - essentially important in: gastric, bowel mucosa kidney, platelets
102. Wasnich RD: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 4th edition, 1999, p 257 Incidence Rates for Vertebral, Wrist and Hip Fractures in Women After Age 50 40 30 20 10 Slide Modified: Review: Reviewer Memo: Source: Memo: 50 60 70 80 Vertebrae Hip Wrist Age (Years) Annual incidence per 1000 women
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104. Unitary model for postmenopausal bone loss: role of oestrogen deficiency Indirect effects Directly increases osteoclast number and longevity Dietary calcium (decreased absorption) Secondary hyperparathyroidism Increased bone resorption Bone loss Decreased bone formation Remodelling imbalance ? Adapted from: Riggs BL, et al. J Bone Miner Res 1998;13:763–73 Oestrogen deficiency
105.
106. Glucocorticoid dose Dependent Effect on Fracture Risk 0.99 1.77 5.18 1.55 2.59 2.27 0 1 2 3 4 5 6 Hip Vertebral Type of Fracture Relative Risk of Fracture <2.5 mg 2.5 mg-7.5 mg >7.5 mg Dose* Van Staa TP, et al. J Bone Miner Res. 2000. *Prednisolone equivalent N = 488 470
107. Most rapid bone loss occurs in the first 6-12 months of Steroid therapy
115. Osteoporosis prevention T-score >–2.5 Osteopenia treatment with or without previous fracture Osteoporosis treatment with multiple fractures and at risk for hip fracture 50 55 60 65 70 75 80 85 Raloxifine Age (years) HRT Therapeutic Management of Postmenopausal Osteoporosis Teriparatide Bisphosphonates Adapted from Seeman & Eisman, MJA Vol 180 15 March 2004, p298-303
116. Optimal Daily Calcium Requirements 1300 mg 1000 mg 1200 mg Recommended Calcium Intake (Daily) Age 1997 Recommended Dietary Intakes 9-18 years 19-50 years 51 years or older National Academy Press. Available at: http://books.nap.edu/catalog/5776.html. 1999.
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118. Widespread Prevalence of Vitamin D Inadequacy* Regardless of Geographic Location *Vitamin D inadequacy was defined as serum 25(OH)D <30 ng/ml; **Interim results of ongoing study Study Design: Observational, cross-sectional study of 1285 community-dwelling women with osteoporosis from 18 countries to evaluate serum 25(OH)D distribution. Adapted from Lim S-K et al. Poster presented at ISCD, February 16–19, 2005, New Orleans, Louisiana,USA; Heaney RP Osteoporos Int 2000;11:553–555. Prevalence (%) 0 10 30 40 60 80 90 Latin America 51% 63% Asia All 59% Australia 59% Europe 52% Regions N=1285 81% Middle East 50 70 20 In a cross-sectional observational international study in 1285 postmenopausal women with osteoporosis**
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120. Vitamin D Inadequacy* Has Important Consequences Appropriate neuromuscular function *Vitamin D inadequacy is defined as serum 25(OH)D <30 ng/ml. Adapted from Parfitt AM et al Am J Clin Nutr 1982;36:1014–1031; Allain TJ, Dhesi J Gerontology 2003;49:273–278; Holick MF Osteoporos Int 1998;8(suppl 2):S24–S29; DeLuca HF Metabolism 1990;39(suppl 1):3–9; Pfeifer M et al Trends Endocrinol Metab 1999;10:417 – 420; Lips P. In: Draper HH, ed. Advances in Nutritional Research . New York, Plenum Press, 1994:151–165. Bone mineral density Parathyroid hormone Calcium absorption Risk of fracture Artistic rendition
121. Bisphosphonate mechanism of action Adapted from: Bone H, et al. Clin Ther 2000;22:15–25 RESTING RESORPTION Osteoclast FORMATION Osteoblasts BISPHOSPHONATES INHIBIT OSTEOCLAST -MEDIATED BONE RESORPTION
122. PTH - Mechanism of Action PTH binds to cell surface G protein-coupled receptor Stimulates differentiation of bone lining cells and preosteoblasts to osteoblasts Decreases apoptosis of osteoblasts Net increase in number and action of bone forming osteoblasts
123. Osteoporosis has been thought of as a silent epidemic….this is not true anymore. At present, there is much noise in the field of research for its prevention, diagnosis and treatment. Ego Seeman ARCOS meeting, Feb 2002
124. One of the Many Faces of Osteoporosis “ You could have floored me when they told me. It’s very frightening, very frightening… I don’t want to end up in a nursing home incapacitated.”
125. Thank You ! Please visit: http://crisbertcualteros.page.tl
