This presentation focuses on different types of arthritis/joint disorders. It provides stepwise approach to evaluation and diagnoses and it's truly wonderful to have a broad overview of many joint conditions in one presentation - ranging from osteoarthritis, gout, rheumatoid arthritis, septic arthritis, to ankylosing spondilitis, and many others, including fibromyaligia.
This presentation focuses on different types of arthritis/joint disorders. It provides stepwise approach to evaluation and diagnoses and it's truly wonderful to have a broad overview of many joint conditions in one presentation - ranging from osteoarthritis, gout, rheumatoid arthritis, septic arthritis, to ankylosing spondilitis, and many others, including fibromyaligia.
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
http://curegoutpainnow.com
There are two different styles of treatment that you want to look at. The first is prevention and the other is taking care of it at the first sign so that it isn’t full blown and become painful.
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
http://curegoutpainnow.com
There are two different styles of treatment that you want to look at. The first is prevention and the other is taking care of it at the first sign so that it isn’t full blown and become painful.
JOINT DISEASE
A combination of pain and stiffness , leading to loss of function, is a classic feature of joint disease.Usually one component will predominates as stiffness in inflammation, and pain in mechanical joint problem.Therefore specific questions will establish whether symptoms are mechanical (e.g. degenerative joint disease & mechanical tear) or inflammatory(e.g. rheumatoid arthritis or gout).
Lupus update for rhem fellows wramc 2014 talkDonald Thomas
Update about the diagnosis and management of systemic lupus erythematosus (SLE) from the past several years. This includes the SLICC revision classification criteria for SLE, importance of using ANA by immunofluorescence instead of solid assays, appearance of autoantibodies many years before SLE diagnosis, the need for using Plaquenil along with immunosuppressant medications, importance of correcting vitamin D levels, avoiding lupus triggers (UV light, tobacco, sulfa), proper dosing of Plaquenil (hydroxychloroquine), the proper screening tests for anti-malarial retinopathy, including Gardasil and Prevnar PCV-13 at important vaccines, and the use of IM steroids for flares.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Evaluation of Patients With
Musculoskeletal Complaints
Goals
• Accurate diagnosis
• Timely provision of therapy
• Avoidance of unnecessary diagnostic testing
Approach
Anatomic localization of complaint (articular vs. nonarticular)
Determination of the nature of the pathologic process
(inflammatory vs. noninflammatory)
Determination of the extent of involvement (monoarticular,
polyarticular, focal, widespread)
Determination of chronology (acute vs. chronic)
Consider the most common disorders first
Formulation of a differential diagnosis
What is the impact of the condition on the patient’s life?
3. Articular Vs. Non-articular
Must discriminate the anatomic origin(s) & pt.s complaint
Requires a careful & detailed examination
Articular
Articular structures- the synovium,
synovial fluid, articular cartilage,
intra-articular lig., joint capsule and
juxta-articular bone.
Articular disorders may be
characterised by deep or diffuse
pain, pain or limited ROM on
active and passive movement,
and swelling( caused by synovial
proliferation, effusion, or bony
enlargement), crepitation,
instability, “locking” or deformity.
Non-articular
Non-articular( Peri-articular) structures-
supportive extra-articular lig.s,
tendons, bursae, muscles, fascia,
bone, nerve and overlying skin.
By contrast non-articular disorders
tend to be painful on active, but not
on passive(or assisted) ROM. Non-
articular joints seldom demonstrate
swelling, crepitation's, instability or
deformity of jt. itself.
Peri-articular conditions often
demonstrate joint or focal tenderness
in regions adjacent to articular
structures and have physical findings
remote from the joint capsule
4. Distinguishing Inflammatory vs
Noninflammatory Joint Disease by Features
Feature Inflammatory Noninflammatory
Systemic symptoms Prominent, including
fatigue
Unusual
Onset Insidious
Usually affecting multiple
joints
Gradual
1 joint or a few joints
Morning stiffness > 1 h < 30 min
Worst time of day Morning As day progresses
Effect of activity on
symptoms (joint pain and
stiffness)
Lessen with activity
Worse after periods of rest
May also have pain with
use
Worsen with activity
Lessen with rest
5.
6.
7. Impact of the condition on the patient
Understanding the impact of the disease on the patient is crucial to
negotiating a suitable management plan.
Ask open questions about functional problems and difficulty in doing
things.
It may be easiest to get the patient to describe a typical day, from
getting out of bed to washing, dressing, toileting etc.
Potentially sensitive areas, such as hygiene or sexual activity, should
be approached with simple, direct, open questions.
The impact of the disease on the patient’s employment will be
important.
A patient’s needs and aspirations are an important part of the
equation and will influence their ability to adapt to the condition.
10. Clinical history
Aspects of the pt.s profile( Age, sex, race considerations)
Complaints chronology
Extent of joint involvement
Precipitating factors
Age groups( Age prevalence of different conditions)
Sex
Racial
Young Middle age Elderly
SLE
Reactive arthritis
Fibromyalgia
RA
OA
Polymyalgia
rheumatica
Male Female
Gout
Spondyloarthropathies(e.g. AS)
RA
Fibromyalgia
Lupus
11. Familial aggregation- as in AS, gout,Heberden’s nodule of OA
Chronology of the Complains- imp. Diagnostic feature
- divided into onset, evolution, duration
Onset:
Evolution
Duration
Abrupt Indolent
Septic arthritis
Gout
OA
RA
Fibromyalgia
Chronic Intermittent Migratory Additive
OA Crystal or Lyme’s
disease
Rheumatic fever
Gonnococcal or
Viral Arthritis
RA
Psoriatic
arthritis
Acute ( < 6 wk ) Chronic ( > 6 wk )
Infectious
Crystal induced
-non-inflammatory or immunologic arthrides (
e.g. OA, RA ) & non-articular disorders ( e.g.
fibrmyalgia)
14. Pain
Localize pain anatomically.
Ask the pt. to point to the area of pain with one finger
Pain in the jt.- most probably articular disorder
Pain between jt.s- bone or muscle disorders or referred pain
Diffuse pain, variable, poorly described or unrelated to
anatomic structures- Fibromyalgia, malingering or
psychogenic problems.
Severity of pain- 1 t 10
Jt. Pain at rest and mov.- inflammatory process.
Pain primarily during activity- Mechanical
15. Stiffness
Discomfort perceived when the pt. attempts to move jt.s after a
period of inactivity.
When it occurs stiffness or gelling, usually develops after several
hours of inactivity.
Morning stiffness- RA
Morning stiffness a/w non-inflammatory jt. Dis. Is
always of short duration( usually less than 30 min) & of less severity than
the stiffness of the inflammatory jt. Dis.
Absence of morning stiffness though does not exclude systemic
inflammatory diseases, it’s absence is uncommon.
16. Limitation of Motion
It must be differentiated from stiffness because stiffness is usually
transient but true limitation of motion is fixed & not variable from hour
to hour.
Determination of the extent of disability resulting from lack of motion is
imp.
Ascertain- the length of time of limitation of ROM,
whether both active & passive ROM are restricted,
whether it began abruptly( may suggest mechanical
derangement e.g. a tendon rupture) or gradually suggesting
inflammatory jt. Dis.
17. Swelling
True joint swelling narrows the D.D.
Ask where & when the swelling occurs
A description of the exact location of the swelling
Onset, persistence & factors that influence the joint are also imp.
Discomfort with use of swollen part may indicate synovitis or bursitis
18. Weakness
o when it is present, a loss of motor power or muscle strength is nearly
always objectively demonstrable on physical examination
o Examiner must determine whether there is “true weakness” or “give
way” weakness.
In musculoskeletal disorders- weakness is persistent rather than
intermittent
Initially good strength with subsequent weakness- clue to
neuromuscular disorders
Inflammatory myopathies- proximal weakness
Distal weakness- neurologic disorders or inclusion body myositis
19. Fatigue
Defined as inclination to rest even though pain & weakness are not
limiting factors
It is a normal phenomena after various degrees of activity but should
resolve after rest.
In rheumatic disease fatigue may be prominent even after rest.
Malaise commonly occurs with fatigue.
Malaise is an indefinite feeling of lack of health.
Stiffness is a discomfort during movement & weakness is an inability to
move normally, esp. against resistance.
20. Important physical signs of arthritis
• Swelling
• Tenderness
• Limitation of motion
• Crepitation
• Deformity
• Instability
21. Swelling
Swelling around a joint may be caused by intra-articular effusion, synovial
thickening, periarticular soft tissue inflammation( such as tendinitis or bursitis),
bony enlargements or extra-articular fat pads.
A joint effusion is often visible, compare jt. Of one side with the opp. Side for
symmetry or asymmetry
Palpable fluid in a jt. Without recent trauma suggests synovitis.
Thickened synovial membrane- chr. Inflammatory arthrides such as RA, may have
a “doughy” or “ boggy” consistency.
22. Tenderness
Is an unusual sensitivity to touch or pressure
Localization of tenderness by palpation helps to determine whether
the pathologic site is intra- or peri-articular, such as fat pad, tendon
attachment, ligament, bursa or muscle or in the skin.
Also palpate the non-involved str.s to help asses the significance of
tenderness.
23. Limitation of Motion
Normal type & ROM of each jt. Must be kept in
mind
Comparison with an unaffected jt. Of opp.
Extremity should be done
Limitations in ROM may be d/t limitation in the jt.
Itself or in the periarticular strs.
In pt. with jt. Dis. Passive ROM is often greater
than the active type, possibly because of pain,
weakness or the state of articular or peri-
articular stress.
The pt. must be relaxed.
24. Crepitation
It is a palpable grating or crunching sensation produced by motion.
May or may not be accompanied by pain.
Fine creps on palpation over jt.s- Chronic inflammatory arthritis
Coarse creps- Inflammatory or non-inflammatory
Bone-on-bone creps- a palpable or audible “squeak” of higher frequency.
25. Deformity
Is the mal-alignment of the joints
Manifested by a bony enlargement, articular sublaxation,
contracture or ankyloses in non-anatomical positions.
Deformed joints:-
1) Do not function normally
2) Frequently restrict activities
3) May give rise to pain esp. hen put to stressful use
4) May be of cosmetic concern
26. Instability
Is present when the joint has greater than normal movement in any
plane
Subluxation
Dislocation
Again pt. must be relaxed.
27. Rheumatic review of systems
Systemic features:-
o Fever
o Rash
o Nail abnormalities
o Myalgias
o Weakness
Involvement of organs
Eyes ( Behcet’s disease, Sarcoidosis, Spondyloarthritis)
GIT ( Scleroderma, IBD)
GUT ( Reactive arthritis, gonococcemia)
Nervous system( Lyme’s disease, vasculitis)
28. Red flags:
These red flags should always prompt consideration of serious pathology and
can be indicative of any inflammatory, infective or neoplastic process
Erythema, warmth, effusion, and decreased range of motion
Fever with acute joint pain
Acute joint pain in a sexually active young adult
Skin breaks with signs of cellulitis adjacent to the affected joint
Underlying bleeding disorder or use of anticoagulants
Systemic or extra-articular symptoms
Weight loss
Night pain
Single joint involvement
Neurological symptoms and signs
29. Recording of joint Examinations
The “S-T-L “ system records:-
Degree of Swelling (S)
Tenderness (T)
Limitation of movement (M)
on a basis of a quantitative estimation of gradation.
grade ranges from 0(normal) to 4(highly abnormal)
In limitation of motion:
Grade 1= 25% loss of motion
2= 50% loss of motion
3= 75% loss of motion
4= Ankylosis
30. Performing a regional examination of the musculoskeletal system
(‘REMS’) -
Regional examination of the musculoskeletal system refers to the
more detailed examination that should be carried out once an
abnormality has been detected either through the history or
through the screening examination.
REMS involves the examination of a group of joints which are linked
by function, and may require a detailed neurological and vascular
examination.
five key stages:-
Introduce yourself.
Look at the joint(s).
Feel the joint(s).
Move the joint(s).
Assess the function of the joint(s).
31. Introduction
It is important to introduce yourself, explain to the patient what you
are going to do, gain verbal consent to examine, and ask the
patient to let you know if you cause them any pain or discomfort at
any time.
In all cases it is important to make the patient feel comfortable
about being examined. A good musculoskeletal examination relies
on patient cooperation, in order for them to relax their muscles, if
important clinical signs are not to be missed.
32. Look
The examination should always start with a visual inspection of the
exposed area at rest.
Compare one side with the other, checking for symmetry. You
should look specifically for skin changes, muscle bulk, and swelling in
and around the joint.
Look also for deformity in terms of alignment and posture of the joint.
33. Feel
Using the back of your hand, feel for skin temperature across the
joint line and at relevant neighbouring sites.
Any swellings should be assessed for fluctuance and mobility. The
hard bony swellings of osteoarthritis should be distinguished from the
soft, rubbery swellings of inflammatory joint disease.
Tenderness is an important clinical sign to elicit – both in and around
the joint.
Identifying inflammation of a joint (synovitis) relies on detecting the
triad of warmth, swelling and tenderness.
34. Move
The full range of movement of the joint should be assessed.
Compare one side with the other. As a general rule both active movements
(where the patient moves the joint themselves) and passive movements (where
the examiner moves the joint) should be performed.
If there is a loss of active movement, but passive movement is unaffected, this
may suggest a problem with the muscles, tendons or nerves rather than in the
joints, or it may be an effect of pain in the joints.
In certain instances joints may move further than expected – this is called
hypermobility. It is important to elicit a loss of full flexion or a loss of full extension
as either may affect function.
A loss of movement should be recorded as mild, moderate or severe. The quality
of movement should be recorded, with reference to abnormalities such as
increased muscle tone or the presence of crepitus.
35. Function
It is important to make a functional assessment of the joint – for
example, in the case of limited elbow flexion, does this make it
difficult for the patient to bring their hands to their mouth? In the
case of the lower limbs, function mainly involves gait and the
patient’s ability to get out of a chair.
one group of joints may need to be examined in conjunction with
another group (e.g. the shoulder and cervical spine).
36. RECORDING OF FINDINGS FROM THE REGIONAL
EXAMINATION
The positive and significant negative
findings of the REMS examination are
usually documented longhand in the
notes.
If no abnormality is found then ‘REMS
normal’ is sufficient.
You may find it helpful to document joint
involvement on a homunculus such as
the one shown in fig.
The total number of tender and swollen
joints can be used for calculating disease
activity scores – these are useful in
monitoring disease severity and response
to treatment over time.
37.
38. LAB. INVESTIGATIONS
Majority of musculoskeletal disorders can be easily diagnosed by a complete
history & physical examination.
An additional objective of the initial counter is to determine whether additional
investigations or immediate therapy is required.
Indications for additional evaluation:-
Monoarticular conditions
Conditions accompanied by neurologic changes or systemic manifestations of
serious disease
In individual with Chronic symptoms(>6 wk.), esp. when there’s lack of response
to symptomatic measures.
39. Investigations
CBC
ESR
CRP
Serum Uric acid
RF
Anti-CCP
ANA
Complement levels
ASO titre
Lymes and ANCA
Only if there is clinical evidence to
suggestion
of associated diagnosis.
41. S. Uric acid
end product of purine metabolism, excreted in urine
Useful in diagnosis of gout & in monitoring the response
to urate-lowering therapy
level is a/w gout, nephrolithiasis, but levels may not
correlate with severity of the disease.
level ( hence risk of gout)
Inborn errors of metabolism
Disease states( renal insufficiency, myeloproliferative disease,
psoriasis)
Drugs( Alcohol, cytotoxic therapy, thiazides)
42. IgM RF
Autoantibodies against the Fc portion of IgG
Found in 80% of pt.s with RA
Sensitivity= 70% & specificity= 80%
Also seen in low titres in pt.s with
Chronic infections( tuberculosis, leprosy, hepatitis)
Other auto-immune diseases( SLE, Sjogren’s syndrome)
Chronic pulmonary, hepatic and renal diseases
When considering RA, both Serum RF and Anti-CCP
antibodies should be obtained as these are
complementary.
43. Anti-CCP
Now Anti-CCP-3
Method of estimation- ELISA
Arbitary unit
Higher value- higher specificity
Specificity
In healthy controls= 99%
In diseased population= 95%
In RA presence of both anti-CCP & RF antibodies may indicate a
greater risk for more severe, erosive polyarthritis.
44. ANAs
Found in all pt.s ith SLE
Also seen in pt.s with other auto-immune diseases(
polymyositis, scleroderma, anti-phospholipid syndrome,
Sjogren’s syndrome), drug induced lupus(d/t
Hydralazine, procainamide, quinidine, tetracyclines, TNF
inhibitors), Chronic liver or renal disorders and advanced
age.
The interpretation of a positive ANA test may depend on
the magnitude of the titre & the pattern of IF
microscopy.
Indirect IF is the Gold standard.
46. Crystals
Crystals In polarised microscopy
In Gout • Long, needle-shaped,
negatively birefringent
• (Monosodium urate
crystals), usually intra-
cellular
In Calcium Pyrophosphate
Deposition (CPPD) (formerly
called Pseudogout)
& Chondrocalcinosis
• Short, rhomboid shaped
and positively birefringent
• Calcium pyrophosphate
dehydrate crystals
The negatively birefringent crystals appear
yellow when they lie parallel to the optical
axis of the compensator and blue when
perpendicular to it.
47. Diagnostic Imaging in Joint diseases
Conventional radiograph
Plain x-rays are most appropriate when there is a history
of trauma, suspected chronic infection, progressive
disability, or monoarticular involvement; when
therapeutic alterations are considered; or when a
baseline assessment is desired for what appears to be a
chronic process.
However, in acute inflammatory arthritis, early
radiography is rarely helpful in establishing a diagnosis
and may only reveal soft tissue swelling or juxtaarticular
demineralization
48. Diagnostic Imaging Techniques for Musculoskeletal Disorders
Method Imaging Time, h Costa Current Indications
Ultrasoundb <1 ++ Synovial cysts, Rotator cuff tears, Tendon injury
Radionuclide
scintigraphy
99mTc 1–4 ++ Metastatic bone survey
Evaluation of Paget's disease
Acute and chronic osteomyelitis
111In-WBC 24 +++ Acute infection, Prosthetic infection, Acute
osteomyelitis
67Ga 24–48 ++++ Acute and chronic infection, Acute osteomyelitis
Computed
tomography
<1 +++ Herniated intervertebral disk, Sacroiliitis ,Spinal
stenosis, Spinal trauma, Osteoid osteoma, Stress
fracture
Magnetic resonance
imaging
1/2–2 ++++ Avascular necrosis, Osteomyelitis, Intraarticular
derangement and soft tissue injury, Derangements of
axial skeleton and spinal cord, Herniated
intervertebral disk, Pigmented villonodular synovitis,
Inflammatory and metabolic muscle pathology
49. Summary
Clinical history is by far the most important diagnostic tool together
with the power of physical examination.
Appropriate Lab. & radiological inv.s should only be ordered based
on the strong clinical findings and in difficult & doubtful cases.
Recognising the Red Flag signs.