The document summarizes three eras of Renaissance art:
1) The Early Renaissance in Florence saw advances like Giotto's more realistic frescoes, Ghiberti's depth-illusion doors, and Brunelleschi's dome innovation. Donatello created the first large nude sculpture since antiquity.
2) The High Renaissance was centered in Rome, where Michelangelo painted the Sistine Chapel and Raphael became a favorite painter of the pope. Leonardo created the famous Last Supper fresco and Mona Lisa.
3) The Northern Renaissance spread ideas to Germany and Flanders through artists like Durer, Holbein, and van Eyck, blending Renaissance techniques