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![Regulatory proteins
Genetic regulatory proteins bind to segments of DNA and bring about gene
regulation. Non-genetic classes of regulatory proteins include those
target, effector proteins that are involved in special cellular functions such
as signaling as receptor
proteins and pumps, adhesion,chemotaxis, cellular transport and active
transport, and metabolic regulation, includingenzymatic action and protein
degradation.
REPRESSOR and other regulatory proteins probably search for target
sequences by binding to DNA and scanning its major groove. Most regulatory
proteins recognize DNA because they can slide along it while searching for a
specific target sequence. Such a search would be much slower for a protein that
cannot bind DNA. [s]
most regulatory proteins are single proteins, often homodimers or
homotetramers, which bind to two ligands: a. a metabolic intermediate, and b.
a cis-acting gene regulation element](https://image.slidesharecdn.com/regulatoryproteins-120321134944-phpapp02/85/Regulatory-proteins-1-320.jpg)
Uploaded byShivani Gupta
Regulatory proteins
Regulatory proteins bind to segments of DNA and bring about gene regulation. There are genetic and non-genetic classes of regulatory proteins that are involved in various cellular functions such as signaling, adhesion, transport, and metabolic regulation. Most regulatory proteins recognize DNA sequences by binding to DNA and scanning its major groove. They can slide along DNA while searching for a specific target sequence. Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3.
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Regulatory proteins
- 1. Regulatory proteins Genetic regulatory proteins bind to segments of DNA and bring about gene regulation. Non-genetic classes of regulatory proteins include those target, effector proteins that are involved in special cellular functions such as signaling as receptor proteins and pumps, adhesion,chemotaxis, cellular transport and active transport, and metabolic regulation, includingenzymatic action and protein degradation. REPRESSOR and other regulatory proteins probably search for target sequences by binding to DNA and scanning its major groove. Most regulatory proteins recognize DNA because they can slide along it while searching for a specific target sequence. Such a search would be much slower for a protein that cannot bind DNA. [s] most regulatory proteins are single proteins, often homodimers or homotetramers, which bind to two ligands: a. a metabolic intermediate, and b. a cis-acting gene regulation element
- 2. Regulated stages ofgene expression Any step of gene expression may be modulated, from the DNA- RNA transcription step to post-translational modification of a protein. The following is a list of stages where gene expression is regulated, the most extensively utilised point is Transcription Initiation: Chromatin domains Transcription Post-transcriptional modification RNA transport Translation mRNA degradation Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3.
- 3. A cDNA ina positive yeast colony was found to encode cyclin D3, a cell cycle regulator of G1 phase. (ii) A purified chimeric protein consisting of glutathione S- transferase (GST) fused to cyclin D3 specifically formed complexes with ICP0 contained in HSV-1-infected cell lysate.