This document contains a series of pathology case studies and questions related to musculoskeletal disorders including different types of arthritis like osteoarthritis, rheumatoid arthritis, and gout. It also discusses other conditions affecting bones and joints like ankylosing spondylitis, osteosarcoma, and back pain. The case studies are presented along with clinical photos, x-rays, and MRIs to aid in diagnosis.

1. “Look at the sky. We are not alone. The whole universe is friendly to us and conspires only to give the best to those who dream and work.” - Wings of Fire: An Autobiography of Dr. APJ Abdul Kalam.

2. Quick Pathology ReviewPathology of ArthritisSystem : MuskuloskeletalClass : Disorders of joints - ArthritisTopic : Osteo & Rheumatoid Arthritis.Shashidhar Venkatesh MurthyA/Prof.& Head of PathologySchool of Medicine & Dentistry James Cook University Australia.

3. CPC 37-MSS-Arthritis: Core Learning Issues(CLI)Major CLI:Arthritis: Overview, classification & Diagnosis*Osteo, Rheum & Gout arthritis (OA, RA, GA)Minor CLI:Secondary arthritis (infective, trauma) Specific types: AnkylosingSpondylitis, Enteropathic arthritis, WebCPC: (self study)Connective tissue tumors. - Osteosarcoma*.Pathology of ageing* Osteoporosis*

4. A 86 year man, recurrent attacks of knee pain lasting 3 days to over week since several months usually improves with ibuprofen. Image shows knee x-ray. What is the most likely diagnosis?Osteoarthritis.Septic arthritis.Rheumatoid arthritis.Traumatic Meniscal tear.Pseudogout.Briefly discuss pathogenesis of this condition?List 2 gross and Microscopic feature of this disease?List other clinical features & how do you differentiate from Gout/RA/OA?

5. A 67 year woman, 1 day history of severe painful left big toe. No history of trauma, Enjoyed a sumptuous party last nite with her friends. His mild hypertension is well controlled by daily bendroflumethiazidetablet, otherwise well. Examination shows left toe hot, red and tender. Right toe has no pain but slight tenderness on movement. Image shows clinical photo & X-ray. What is the most likely diagnosis?Osteoarthritis.Septic arthritis.Rheumatoid arthritis.Gout.Pseudogout.Briefly discuss pathogenesis of this condition?What condition has precipitated this attack? List more conditions?Briefly describe 3 microscopic features of this condition?

6. A 38 year old man swelling and pain in his hands, worse in the morning. P/E Fingers show tender sausage like swelling. His nails show pitting and destruction (apparently not improved by antifungal cream he is applying for 6 months). Image shows clinical photo & X-ray. What is the most likely diagnosis?Fungal infection-Arthritis.Rheumatoid arthritis.Septic arthritis.Enteropathic arthritis.Psoariatic arthritis.Briefly discuss Enteropathic arthritis?List 3 Microscopic features? List 3 complications of this condition? (RA)List types of Immune arthritis? What is sero ‘+ve’ & sero ‘-ve’ arthritis?

7. A 29 year old woman with SLE & photosensitivity. Presents with fourth miscarriage in the last 8 years. Past history reveals two episodes of DVT one during her third pregnancy and second during flight to USA. Image shows clinical photo. What is the most likely auto antibody causing her miscarriage?Anti-Ro.Anti-RNP.Anti-La.Anti-Jo-1.Anti-cardiolipin.SLE, SjogrenSy.

8. SLE, MCTD

9. SLE, SjogrenSy.

10. SLE, Myopathy

11. SLE, Behcet, Syphilis, etc.Briefly discuss pathogenesis of her miscarriage?List 3 Microscopic features? List 3 complications of this condition? (RA)

12. A. Image shows clinical photo & X-ray. What is the most likely auto antibody causing her miscarriage?Pseudo-Gout.Osteoarthritis.Rheumatoid Arthritis.Psoariatic Arthritis.Gout.Briefly discuss pathogenesis of this disorder?List 3 Gross & 3 Microscopic features? List 3 complications of this condition?

13. A. 18 year old boy with 4 month history of right knee pain apparently following fall during a footy match. Image shows x-ray appearance and following detailed work up resulting in major surgical resection. What is the most likely diangosis? Ostesarcoma.Osteomyelitis.Metastases.Excess osteoid formation.Ewing’s sarcomaList 3 Gross & 3 Microscopic features? What is the most common site of metastases ? Gene mutation?What is the common risk factor if it occurs in elderly?

14. A 48 year old man, 10 month history of backpain & shooting pain radiating to his left leg. It is worse on prolonged sitting, forward bending and lifting weight. P/E loss of light touch over the posterolateral thigh, extending on to posterolateral calf and lateral side of foot. Image shows his MRI. What is the most likely diagnosis?Osteophyteformation (OA).Bony ankylosis (RA).Ankylosingspondylitis.Spondylolistheis.Disc prolapse.Briefly discuss risk factors & pathogenesis of this condition?Write a paragraph about pathology of ankylosingspondylitis? Write a paragraph about overview of pathology of “backpain” ?

15. “Those who cannot work with their hearts achieve but a hollow, half-hearted success that breeds bitterness all around.” - Wings of Fire: An Autobiography of Dr. APJ Abdul Kalam.