Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a genetic disorder caused by
mutation in the Proteoglyacn PRG4 gene on chromosome 1. The syndrome is characterized by congenital or early onset camptodactyly and childhood-onset of non-inflammatory arthropathy, coxa vara deformity,or other dysplasia associated with progressive hip disease and non-inflammatory pericardial effusion. It has an autosomal recessive mode of inheritance and the causative gene is located on chromosome band 1q25-31.
Evidence Based Practice in Medical Imaging- Ankylosing SpondylitisNoor Farahuda
This presentation is about evidence-based practice in medical imaging for a particular disease, which is the Ankylosing Spondylitis. It is actually focusing on the imaging modalities that have been used for diagnose the disease and the appearances of the disease on the image of the modalities.
In the presentation, I discussed new concepts in OA pathogenesis and identified possible targets of treatment. This was followed by a review of new treatment options for osteoarthritis. Presented during the Joint RA OA SIG Symposium at the F1 Hotel last 28 November 2014.
Evidence Based Practice in Medical Imaging- Ankylosing SpondylitisNoor Farahuda
This presentation is about evidence-based practice in medical imaging for a particular disease, which is the Ankylosing Spondylitis. It is actually focusing on the imaging modalities that have been used for diagnose the disease and the appearances of the disease on the image of the modalities.
In the presentation, I discussed new concepts in OA pathogenesis and identified possible targets of treatment. This was followed by a review of new treatment options for osteoarthritis. Presented during the Joint RA OA SIG Symposium at the F1 Hotel last 28 November 2014.
Musculoskeletal disorders
includes the following disorders:
Bone infections: Osteomyelitis, and Septic arthritis; Disorders of foot:
Hallux valgus (bunions), Morton’s neuroma (plantar neuroma), and
Hammer toe; Muscular disorders:
Muscular dystrophy, and Rhabdomyolysis
Musculoskeletal manifestations of diabetes mellitusfathi neana
The complications of diabetes mellitus are numerous and multisystemic including the musculoskeletal system. The long term metabolic consequences of diabetes mellitus stay behind Several rheumatic conditions. Higher levels of diabetic complications is due to poor glycemic control. The incidence and prevalence of diabetes mellitus is rising. About 50% of people with diabetes mellitus are unaware of their condition.
Approximately 25% of all patients with diabetes undergoing surgery are undiagnosed on admission to hospital. Patients with diabetes have a higher risk of cardiovascular insult and a higher perioperative risk. Surgeons and anaesthetists should be familiar with the risks of the diabetes, surgery and anesthesia.
In emergency situations or non-elective cases insulin, glucose and potassium infusions (blood glucose control + rehydration) before surgery
Prone to post operative complications, infection, wound care and bone healing.
Pharmacotherapy, diet, regular exercises and sensible physiotherapy programmes should be the cornerstone of diabetes management.
Osteoartritis (OA) adalah salah satu jenis artritis yang paling sering dialami oleh sebagian orang. Penyakit ini merupakan penyakit sendi degeneratif yang mempengaruhi tulang rawan persendian. OA terjadi akibat rusaknya kartilago yang melindungi dan memberi bantalan bagi sendi.
Benefits of Mechanical Manipulation of the Sacroiliac Joint: A Transient Syno...CrimsonPublishersOPROJ
Benefits of Mechanical Manipulation of the Sacroiliac Joint: A Transient Synovitis Case Study by Brady Hauser* in Crimson Publishers: Orthopedic Research and Reviews Journal
Annals of Hematology & Oncology is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts covering various aspects in the field of medicine that includes early to late symptoms, diagnosis, staging, treatment, prognosis, and follow-up of two interrelated medical specialties namely hematology and oncology. This journal also focuses upon the study of blood, the blood-forming organs, and blood diseases, cancer etiology, diagnosis, staging, treatment, drugs, epidemiology, and awareness.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Annals of Hematology & Oncology accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of hematology and oncology.
Musculoskeletal disorders
includes the following disorders:
Bone infections: Osteomyelitis, and Septic arthritis; Disorders of foot:
Hallux valgus (bunions), Morton’s neuroma (plantar neuroma), and
Hammer toe; Muscular disorders:
Muscular dystrophy, and Rhabdomyolysis
Musculoskeletal manifestations of diabetes mellitusfathi neana
The complications of diabetes mellitus are numerous and multisystemic including the musculoskeletal system. The long term metabolic consequences of diabetes mellitus stay behind Several rheumatic conditions. Higher levels of diabetic complications is due to poor glycemic control. The incidence and prevalence of diabetes mellitus is rising. About 50% of people with diabetes mellitus are unaware of their condition.
Approximately 25% of all patients with diabetes undergoing surgery are undiagnosed on admission to hospital. Patients with diabetes have a higher risk of cardiovascular insult and a higher perioperative risk. Surgeons and anaesthetists should be familiar with the risks of the diabetes, surgery and anesthesia.
In emergency situations or non-elective cases insulin, glucose and potassium infusions (blood glucose control + rehydration) before surgery
Prone to post operative complications, infection, wound care and bone healing.
Pharmacotherapy, diet, regular exercises and sensible physiotherapy programmes should be the cornerstone of diabetes management.
Osteoartritis (OA) adalah salah satu jenis artritis yang paling sering dialami oleh sebagian orang. Penyakit ini merupakan penyakit sendi degeneratif yang mempengaruhi tulang rawan persendian. OA terjadi akibat rusaknya kartilago yang melindungi dan memberi bantalan bagi sendi.
Benefits of Mechanical Manipulation of the Sacroiliac Joint: A Transient Syno...CrimsonPublishersOPROJ
Benefits of Mechanical Manipulation of the Sacroiliac Joint: A Transient Synovitis Case Study by Brady Hauser* in Crimson Publishers: Orthopedic Research and Reviews Journal
Annals of Hematology & Oncology is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts covering various aspects in the field of medicine that includes early to late symptoms, diagnosis, staging, treatment, prognosis, and follow-up of two interrelated medical specialties namely hematology and oncology. This journal also focuses upon the study of blood, the blood-forming organs, and blood diseases, cancer etiology, diagnosis, staging, treatment, drugs, epidemiology, and awareness.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Annals of Hematology & Oncology accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of hematology and oncology.
Presentazione a cura della Dottoressa Fulvia Ceccarelli - XII° Congresso Nazionale FIMeG 2018 - The Silver Tsunami: l'anziano fra appropriatezza e farmaeconomia
Tmj Ankylosis In Still’s Disease – A Case ReportQUESTJOURNAL
ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and destruction of synovial joints, leading to severe disability and premature mortality. TMJ complaints are present in about more than 50% of patients of RA. TMJ is usually among the last joint to be involved and is associated with many clinical signs and symptoms of which pain is a major problem later leading to inflammation, limited movements, swelling (joint stiffness) and muscle spasm. If it occurs in early age it may result in mandibular growth disturbance, facial deformity, and ankylosis and in adult these can vary from mild joint stiffness to total joint disruption with occlusal-facial deformity. The diagnosis and management of TMJ involvement in RA is exclusionary based on history, physical findings, radiographic study, and lab testing. Hence a multidisciplinary approach is necessary. The present paper reports a case of RA with bilateral TMJ involvement with its classical radiographic findings.
Introduction: Partial or complete aplasia of the posterior arches of the atlas is a well-documented anomaly but a relatively rare condition caused by a defect in their closure. This condition is usually asymptomatic so most are diagnosed incidentally.
Case report: We report the case of a patient who presents a defect of the posterior arch of atlas.
Conclusion: There is a variety of the congenital defects of the arch of the atlas. Further studies are required on these lesions in order to take possible protection measures against trauma, and the selection between conservative or surgical treatment.
Abstract
Objective: To assess the outcome of arthroscopic release in patients with cronicalchronic lateral epicondylitis. Materials and methods: Arthroscopic release in three patients with lateral epicondylitis was performed. The Mayo Elbow Performance Index (or Mayo Elbow Performance score) was used pre and post surgical treatment. Sample: Two females and one male. The patients were principal labourers and not athletes. Patients had significant pain and pain was the principal symptom that affected the score of the performance index.
Results: Scores on the performance index improved after surgery. No neurological complications were reported and early return to normal daily activities was noted.
Conclusion: Arthroscopic treatment was an alternative safe and effective method for treating chronic lateral epicondiyitis in three cases. This method makes it possible to simultaneously scan the articulation to diagnostic and treatment associated diseases. It is necessary most wide assays and comparative studies for establish sure treatment protocols.
Traditionally, obtaining tissue diagnosis from the Temporomandibular Joint (TMJ) has required invasive open techniques. In this case-series, the authors demonstrate a minimally invasive technique using arthroscopy to diagnose and treat Pigmented Villonodular Synovitis (PVNS) and pseudogout of the TMJ, followed by a review of the literature.
Primary hydatidosis of the tibia is a rare disease. In an endemic area, it should be considered in the differential diagnosis of a
hypolucent osteolytic lesion on x-ray. If not properly managed, anaphylactic shock may occur intraoperatively, as well as increased recurrence of the disease. This is a case report of a primary tibial hydatid cyst, treated fi rst with curettage and phenolizaton, and then after recurrence, with total knee arthroplasty. We will review the literature of the diagnosis and the treatment of a tibial hydatid cyst.
Cauda Equina Neuroendocrine Tumor: Report of Two Cases and Review of Literaturesemualkaira
Cauda equina Neuroendocrine Tumor (NET), previous known as
cauda equina paragangliomas, is uncommon neoplasm in adults.
In this study, we retrospectively reviewed two cases of cauda equina NET patients who had underwent surgical treatment in our department. We reviewed patient age, gender, presenting symptom,
tumor radiological feature, surgical procedure, pathologic data
and postoperative complications. Two cases were all clinically
non-functional cauda equina NETs without sympathetic symptom.
While image-based differential diagnosis of cauda equina tumors
is still difficult and definite diagnosis depends on pathology and
immunohistochemical staining, resecting the tumor with minimally invasive technique has good curative effect.
Similar to Open Journal of Orthopedics and Rheumatology (20)
Recent Advancement and Patents of the Lipid Polymer Hybrid Nanoparticlespeertechzpublication
In recent years, robustness and surface engineering of dosage form made improvement in
pharmacokinetics with decrease in dose of drug. Specifi city with adherence of ligands has now become
the reality as surface modifi cation can easily deceive phagocytic system. Lipid molecules ensures the
release of drug at lymphatic system, entrapment of polymeric nanoparticles in lipoidal core led to the
avoidance of disadvantage of low entrapment effi ciency if use of hydrophobic drug with hydrophobic
polymer becomes essential. Various studies have been published and the best formulations with optimal
In vitro and In vivo results are highlighted in this paper. In this review most advanced researches and
accepted patents were discussed so to act as a medium for getting everything regarding lipid polymer
hybrid particles under one umbrella.
Vibrational Characterization and Antioxidant Activity of Newly Synthesized Ga...peertechzpublication
The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined
by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA
(NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the
suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex
were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand
binding mode.
Synthesis and Antimicrobial Evaluation of Some Nitro-Mannich Bases Derived fr...peertechzpublication
The present work focused on exploring the reactivity of β-nitrostyrene towards Mannich reaction
with different approaches. The synthesized nitro-Mannich bases were tested as antimicrobial agents
that showed high activity against both gram positive and gram negative bacteria.
Recent Structure Activity Relationship Studies of 1,4-Benzodiazepinespeertechzpublication
Structure activity relationship studies of 1,4-benzodiazepines have been discussed especially
with their effects as antianxiety and anticonvulsants. The currently available benzodiazepines are
associated with various side effects. Nowadays the purpose of these studies is to minimize side effects
with these drugs. A very little alteration is possible on the benzene ring while the modification can be
done on the diazepine ring. It can adopt the different conformations and in some cases some aromatic
and heterocyclic rings have been fused with this part in order to see the effect of these conformation
blockers on the pharmacological activity. The structure activity studies are also linked to molecular
modeling studies. This is important in adding some information for the interaction of these drugs with
the receptors and how this interaction can be improved.
Microwave Irradated Synthesis, Characterization and Evaluation for their Antibacterial and Larvicidal Activities of some Novel Chalcone and Isoxazole Substituted 9-Anilino Acridines
drug delivery and formulation sciences in the most intelligent
way. This should be attained to fulfi l the ultimate goal for all
scientists to leave their experimental results all over the years
as footsteps for followers to walk on.
Mycobacterium Tuberculosis cause severe disease of lungs known as Tuberculosis. It is a major cause
of morbidity and mortality even in the emerging countries also. However, to prepare an antibiotics drug against Mycobacterium tuberculosis is a major challenge
Mini tablets are solid dosage forms with a diameter ≤ 3 mm and separated into subunits of conventional
tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple
punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment.
Drug-Drug interactions (DDI) is a serious clinical issue. An important mechanism underlying of DDI, is
induction or inhibition of drug metabolizing enzymes (DMEs) and transporters that mediate metabolism, cellular uptake and efflux of xenobiotics. DDI cannot be avoided in many cases, as they belong to routine medical practice.
In recent years, robustness and surface engineering of dosage form made improvement in pharmacokinetics with decrease in dose of drug. Specificity with adherence of ligands has now become the reality as surface modifi cation can easily deceive phagocytic system. Lipid molecules ensures the
release of drug at lymphatic system, entrapment of polymeric nanoparticles in lipoidal core led to the
avoidance of disadvantage of low entrapment effi ciency if use of hydrophobic drug with hydrophobic polymer becomes essential. Various studies have been published and the best formulations with optimal In vitro and In vivo results are highlighted in this paper. In this review most advanced researches and accepted patents were discussed so to act as a medium for getting everything regarding lipid polymer hybrid particles under one umbrella.
Few species are standardized and have been used as test organisms around the world in
ecotoxicological assays. In the case of sediment assessment, there are only two amphipod species
(Tiburonella viscana and Grandidierella bonnieroides) standardized protocols for toxicity test in South
Atlantic region
Gigantic submarine landslides are among the most energetic events on the Earth surface. During the
Late Pleistocene the Mediterranean Sea was the scenario of a 9 number of such events, some of whose
geological fi ngerprints are the 500 km3 mass transport deposit SL2 at the Nile delta fan (dated at ca. 110
ka BP) and the Herodotus Basing Megaturbidite (HBM, a 400 km3 deposit dated at ca. 27.1 ka BP).
Natural frequency of structure mainly depends on mass and stiffness. Stiffness is bound to change
after structural damage. Hence, natural frequency starts to decline.
In this study, the green-lipped mussels Perna viridis were collected from a high activity sampling at
Senibong in the Straits of Johore and two relatively clean sites with fi sh aquacultural activity at Bagan
Tiang (Perak) and Sg. Semerak (Kelantan). The mussels were dissected by gender into byssus, crystalline
style, foot, gill, gonad, mantle and muscle.
The current study examines the generation and propagation of a Third order solitary water wave along
the channel. Surface displacement and wave profi le prediction challenges are interesting subjects in the
fi eld of marine engineering and many researchers have tried to investigate these parameters. To study the
wave propagation problem, here, fi rstly the meshless Incompressible Smoothed Particle Hydrodynamics
(ISPH) numerical method is described. Secondly,
The growth of data and its effi cient handling is becoming more popular trend in recent years bringing
new challenges to explore new avenues. Data analytics can be done more effi ciently with the availability of
distributed architecture of “Not Only SQL” NoSQL databases.
In modern mechanical engineering and steelwork the use of cold-rolled steel sections is a
standard method. These sections should be mechanically stable on the one hand and cost efficient on
the other hand. To decide what profile suits for a certain case is a constrained optimization problem which is in general non convex, i.e. several local optima exist.
Few species are standardized and have been used as test organisms around the world in
ecotoxicological assays. In the case of sediment assessment, there are only two amphipod species
(Tiburonella viscana and Grandidierella bonnieroides) standardized protocols for toxicity test in South
Atlantic region.
Gigantic submarine landslides are among the most energetic events on the Earth surface. During the
Late Pleistocene the Mediterranean Sea was the scenario of a 9 number of such events, some of whose
geological fi ngerprints are the 500 km3 mass transport deposit SL2 at the Nile delta fan (dated at ca. 110
ka BP) and the Herodotus Basing Megaturbidite (HBM, a 400 km3 deposit dated at ca. 27.1 ka BP). This
paper presents an exploratory study on the tsunamigenic potential of these slides by using a numerical
model based on the 2D depth-averaged non-linear barotropic shallow water equations.
Introduction: The aim of this study is to evaluate, within the scope of an experimental design, to
what extent the assessment of two different settings of prepared cavities, based on video sequences,
containing digital analysis tools of the prepCheck software, as well as to what extent they deviate from one another and are reliable. Materials and Methods: For
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Evaluation of antidepressant activity of clitoris ternatea in animals
Open Journal of Orthopedics and Rheumatology
1. Open Journal of Orthopedics and Rheumatology
012
Citation: Maher SE, Mahgoob MHM, El Ameen N (2017) Camptodactyly Arthropathy CoxaVara Pericarditis Syndrome: Early diagnosis prevents unnecessary and
harmful treatment. Open J Orthop Rheumatol 2(1): 012-014. DOI: http://dx.doi.org/10.17352/ojor.000008
Clinical Group
CC Byhttp://dx.doi.org/10.17352/ojor.000008DOI
Abstract
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a genetic disorder caused by
mutation in the Proteoglyacn PRG4 gene on chromosome 1. The syndrome is characterized by congenital
or early onset camptodactyly and childhood-onset of non-inflammatory arthropathy, coxa vara deformity,
or other dysplasia associated with progressive hip disease and non-inflammatory pericardial effusion. It
has an autosomal recessive mode of inheritance and the causative gene is located on chromosome band
1q25-31.
Case Report
Camptodactyly Arthropathy CoxaVara
Pericarditis Syndrome: Early diagnosis
prevents unnecessary and harmful
treatment
Sheren Esam Maher1
*, Mohamed
Hashem M Mahgoob1
and Nadia El
Ameen2
1
Assistant Professor of Pediatrics-Minia University
Hospital -Egypt
2
Assistant Professor of Radiology -Minia University
Hospital -Egypt
Dates: Received: 04 April, 2017; Accepted: 26 May,
2017; Published: 29 May, 2017
*Corresponding author: Sheren Esam Maher, As-
sistant Professor of Pediatrics, Minia University
Hospital, Egypt, Tel: 00201001097818; E-mail:
Keywords: Camptodactyly-Arthropathy-Coxa; Vara-
Pericarditis Syndrome; Juvenile idiopathic arthritis;
Non-erosive arthropathy
https://www.peertechz.com
Introduction
Juvenile idiopathic arthritis is the most common
inflammatory joint disease. No single clinical sign or symptom
or test result distinguishes it from other joint diseases, nor are
the pathological features of synovitis [1]. Rather it diagnosed
by a combination of clinical findings and laboratory tests.
There are a number of disease entities affecting the joints that
may present in a similar way. Treatment of juvenile idiopathic
arthritis now based on more aggressive management including
the use of traditional disease-modifying antirheumatic drugs
upon disease onset and the early use of biologics [2].
We present a case of a male child who presented with early
onset camptodactyly, non-inflammatory arthropathy, with
specific features magnetic resonance imaging (MRI).
Case Report
A 3-year 5-month-old boy presented with a one year history
of swelling of both knees and wrists. The mother complained
from swelling that progress to joint pain and limitation of
movement. She also noticed bending deformity of three fingers
of his hands. There was no systemic symptoms as fever, rash,
abdominal pain or swelling.
Laboratory Investigation of our patient at the onset of the
disease: Routine blood work-up revealed normal hemogram,
Erythrocyte Sedimentation Rate (ESR) and C-reactive
protein (CRP) with negative Antinuclear Antibody (ANA) and
Rheumatoid factor (RF).
Knee US report showed joint effusion and synovial
membrane hypertrophy.
So, patient started Non-steroidal anti-inflammatory drugs
(NSAID) on 2mg/kg for 6 weeks. On follow up visit there
was slight significant Improvement .Our patient diagnosed
as oligoarthritis class of Juvenile Idiopathic Arthritis after
exclusion of other conditions associated with or mimicking
arthritis.
Follow up of our patient revealed no improvement of joint
state so new line started in the form of intra articular steroid
injection and biological therapy. Course of the disease remain
stationery without any improvement.
More investigations as -Gal An enzyme activity assay in
leucocytes for Fabry disease which came normal.
Our patient came to our pediatric Rheumatology clinic –
Minia University where he was reevaluated. On examination,
the patient had camptodactyly of the fingers with swelling of
both knees and wrists without restricted motion or signs of
inflammation like erythema or tenderness. There was also,
a waddling gait the parents also stated that they had noticed
bent fingers for nearly one and a half years.
Systemic examination showed no evidence of fever,
lymphadenopathy, skin rash, or other systemic features but
cardiac auscultation there was pan systolic murmur on mitral
area grad III (MR). Echocardiography showed mild mitral
regurge with normal systolic function.
2. 013
Citation: Maher SE, Mahgoob MHM, El Ameen N (2017) Camptodactyly Arthropathy CoxaVara Pericarditis Syndrome: Early diagnosis prevents unnecessary and
harmful treatment. Open J Orthop Rheumatol 2(1): 012-014. DOI: http://dx.doi.org/10.17352/ojor.000008
Anteroposterior (AP) radiograph of pelvis revealed a broad
left coxa vara (Figure 1). The articular surfaces were smooth
with no erosions.
MRI of the hip showed a moderate bilateral hip joint
effusion. The synovium was mildly thickened and showed
enhancement (Figure 2) conspicuously, there was absence of
cartilage destruction. Knee MRI Axial T2WI showed marked
bilateral knee joint effusion more at the left side (Figure 3).
Also, Sagittal T2WI showed the marked knee joint effusion
(Figure 4).
Discussion
Camptodactyly-arthropathy-coxa vara-pericarditissyn-
drome is a rare genetic condition due to a mutation in the
gene proteoglycan 4 (PRG4) - a chondroitin sulfateproteogly-
can that acts as a lubricant for the cartilage surfaces. This gene
is also known as lubricin. This condition is inherited as an au-
tosomal recessive.
The gene responsible for this condition is located on
the long arm of chromosome 1 (1q). The encoded protein
is a glycoprotein of ~345 kDa [3], specifically synthesized
bychondrocytes located at the surface of articular cartilage,
and also by some synovial lining cells. The cDNA encodes
a protein of 1,404 amino acids (human a isoform) with
asomatomedin B homology domain, heparin-binding domains,
multiple mucin-like repeats, a hemopexin domain, and an
aggregation domain. There are 3 consensus sequences for
N-glycosylation and 1 chondroitin sulfate substitution site.
This condition was first described in 1986 [4] and
is a syndrome of camptodactyly, arthropathy, coxa
vara and pericarditis [5]. It may also include congenital cataracts
[6]. The cause of this syndrome was discovered in 1999 [7].
Children with this syndrome often present with a joint
effusion that is cool and resistant to anti-inflammatory
therapy. The arthropathy principally involves large joints such
as elbows, hips, knees, and ankles [6]. Pericarditis may be
a presenting feature or may occur later in the course of the
disease but in our case we found Mitral regurge with normal
systolic function. Coxa vara occurs in 50–90% of cases and non-
inflammatory pericarditis in 30%.The main line of treatment is
physiotherapy and supportive analgesics like paracetamol [7].
Figure 1: Plain x ray pelvis showed left coxa vara.
Figure 2: Coronal T2WI of both hips showed moderate bilateral hip joint effusion
note the left coxa vara.
Figure 3: Axial T2WI showed marked bilateral knee joint effusion more at the left
side.
Figure 4: Sagittal T2WI showed the marked knee joint effusion.