This document discusses several protein databases and bioinformatics tools. It describes Protein Data Bank (PDB) as a repository for 3D structural data of proteins and nucleic acids overseen by wwPDB. National Center for Biotechnology Information (NCBI) provides access to biomedical and genomic databases. BLAST is a tool that compares sequences to databases to find similar regions and calculate statistical significance of matches. Swiss-Prot, PIR, and UniProt are comprehensive protein sequence databases that include functional information derived from literature. ExPASy is a bioinformatics resource portal offering databases and tools in areas like proteomics, genomics, and systems biology.

1. PRESENTED
BY :MALVIKA

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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
ExPASy
SWISS-PROT
PIR
PDB

3. 1. PROTEIN STRUCTURE
2.NCBI

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2. NCBI

8. 1. PROTEIN STRUCTURE
2. NCBI
3. DATABASES

11. Protein Database
is a
collection of sequences
from several sources,
including translations from
annotated coding regions in
Gen Bank, Ref Seq as well
as records from SWISSPROT, PIR & PDB.

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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
SWISS-PROT
PIR
PDB

14.  Finds
regions of local similarity
between sequences .
 Compares nucleotide or
protein sequences to sequence
databases.
 Calculates statistical
significance from matches.

15. Can be used to infer
functional and evolutionary
relationships between
sequences.
 It can also help in
identifying members of the
gene family .

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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
ExPASy
SWISS-PROT
PIR
PDB

17. Ex pert P rotein A nalysis
Sy stemis a bioinformatics
ExPASy
resource portal operated by the
Swiss Institute of Bioinformatics
(SIB).
The portal is aimed for both
expert users and for people that
are not familiar with a specific
domain in life sciences.

18. Ex pert P rotein A nalysis
Sy stem
It provides access to scientific
databases and software tools
(i.e., resources) in different
areas of life sciences
including proteomics,
genomics, phylogeny, systems
biology, population genetics,
transcriptomics etc.
etc

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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
PUB-MED
SWISS-PROT
PIR
PDB

20. •SWISS-PROT also called UniProt is;
a comprehensive, high-quality and
freely accessible database of protein
sequence and functional
information.
•Many entries are derived from
genome sequencing projects.

21. SWISS-PROT
• Contains a large amount of information
about the biological function of proteins
derived from the research literature.
• The mission of UniProt is to provide the
scientific community with a comprehensive,
high-quality and freely accessible resource
of protein sequence and functional
information.

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PROTEIN STRUCTURE
NCBI
DATABASES
BLAST
EXPASY
PUB-MED
SWISS-PROT
PIR
PDB

23.  PIR was established in 1984 by the National
Biomedical Research Foundation (NBRF) as a
resource to assist researchers in the
identification and interpretation of protein
sequence information.
 PIR has provided many protein databases
and analysis tools freely accessible to the
scientific community, including the Protein
Sequence Database (PSD).

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PROTEIN STRUCTURE
NCBI
DATABASES
SWISS-PROT
PUB-MED
EXPASY
BLAST
PIR
PDB

26.  Protein Data Bank (PDB) is a repository for the 3D structural data of large biological molecules, such
as proteins and nucleic acids.
 PDB is overseen by an organization called the
Worldwide Protein Data Bank, wwPDB.
 PDB is a key resource in areas of structural
biology, such as structural genomics.