This document provides information about the anesthetic drug Propofol, including its brand name, generic name, strength, description, pharmacology, mechanism of action, indications, dosage and administration, contraindications, advantages, and competitors. Propofol is an injectable emulsion containing 10 mg/ml of propofol that is formulated for intravenous administration. It acts as a sedative-hypnotic agent and induces hypnosis within 40 seconds of IV injection through activating GABAA receptors. Propofol is indicated for induction and maintenance of general anesthesia as well as sedation of ventilated ICU patients and monitored anesthesia care.

1. Techno Drugs Ltd.
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2. Short –acting IV anesthetic
agent.
Propofol
Propofol BP

3. Product Profile:
• Brand Name: Propofol
• Generic Name: Propofol
• Therapeutic Class : Anesthesia
• Strength : 20 ml IV injection (10 mg/ml )

4. Description:
• Propofol® Injectable Emulsion is a sterile, non
pyrogenic emulsion containing 10 mg/ml of
propofol suitable for intravenous administration.
Propofol is slightly soluble in water and, thus, is
formulated in a white to light yellow, oil-in-water
emulsion. In addition to the active component,
Propofol®, the formulation also contains soybean
oil (100 mg/ml), glycerol (22.5 mg/ml), egg
lecithin (12 mg/ml) and disodium edetate (0.005%)
with sodium hydroxide to adjust pH.

5. Pharmacology:
Propofol® Injectable Emulsion is an IV sedative-
hypnotic agent for use in the induction and
maintenance of anesthesia or sedation.
IV injection of a therapeutic dose of propofol
induces hypnosis, with minimal excitation, usually
within 40 seconds from the start of injection (the
time for one arm-brain circulation). As with other
rapidly acting IV anesthetic agents, the half-time
of the blood-brain equilibration is approximately 1
to 3 minutes, accounting for the rate of induction
of anesthesia.

6. Mechanism of action:

7. When GABAA receptors are activated, trans membrane chloride
conductance increases, resulting in hyperpolarization of the
postsynaptic cell membrane and functional inhibition of the
postsynaptic neuron.

8. Indications:
Propofol® is a short-acting intravenous anesthetic
agent suitable for
• Induction and maintenance of general anesthesia.
• Sedation of ventilated patients receiving intensive
care.
• Monitored anesthesia care sedation for surgical
and diagnostic procedures.

9. Dosage & Administration:
Induction of General Anesthesia
Healthy Adults Less Than 55 Years of Age:
40 mg every 10 seconds until induction onset (2-2.5 mg/kg).
Elderly, Debilitated, or ASA III/IV Patients:
20 mg every 10 seconds until induction onset (1-1.5 mg/kg).
Cardiac Anesthesia:
20 mg every 10 seconds until induction onset (0.5-1.5 mg/kg).
Neurosurgical Patients:
20 mg every 10 seconds until induction onset (1-2 mg/kg).
Pediatric Patients - healthy, from 3-16 years of age:
2.5-3.5 mg/kg administered over 20-30 seconds.

10. Maintenance of General
Anesthesia
Healthy Adults Less Than 55 Years of Age:
100-200 μg/kg/min (6-12 mg/kg/h).
Elderly, Debilitated, ASA III/IV Patients:
50-100 μg/kg/min (3-6 mg/kg/h).
Pediatric Patients - healthy, 3 years to 16 years of age: 125-
300 μg/kg/min (7.5-18 mg/kg/h)
Cardiac Anesthesia, Most Patients Require:
Primary propofol injectable emulsion with secondary opioid:
100-150 μg/kg/min. Low-dose propofol injectable emulsion
with primary opioid: 50-100 μg/kg/min.
Neurosurgical Patients: 100-200 μg/kg/min (6-12 mg/kg/h).

11. Contraindication:
• Absolute contraindications: Patients with a known
hypersensitivity to propofol or any of its components;
allergies to eggs, egg products, soybeans or soy
products; disorders of fat metabolism.
• Relative contraindications: Patients undergoing
stereotactic neurosurgery such as pallidotomy, as it
temporary abolishes tremors in patients with
Parkinsonism; Known case of Epilepsy; Untreated
hypertensive, compromised Left ventricle function;
Hepatic or Renal impairment; Pregnant and lactating
mother; Paediatric patients age < 3 years.

12. Advantages of propofol:
1. Rapid & smooth Recovery.
2. Completed eliminated from body in 4 hours so
patient is ambulatory early.
3. Anti-Emetic.
4. Anti-Pruritic.
5. Bronchodilator.

13. Competitors:
Brand Name Contains
Dosage
Form
Manufactur
er
Price(Tk.)
FRESOFOL
Propofol
10mg/ml
Injection
Fresenius
Kabi/Hye
Impex
20ml amp x
5s pack:
1758.00
MRP; 50ml
bot x 1s
pack: 779.00
MRP
POFOL I.V
Propofol
10mg/ml
i.v Injection
Popular
Pharmaceut
icals Ltd.
20ml amp x
1s pack:
200.00 MRP
RECOFOL
Propofol
10mg/ml
Injection
Bayer
Schering
Oy/ Tajarat
20ml amp x
1s pack:
MRP; 50ml
vial x 1s
pack:

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