5. PHARMACOKINETICS
• Bioavailability: poorly absorbed from the GI
tract
• Half-life: approximately 20 minutes
• Distribution: into extracellular fluid, minimally
crosses the placenta
• Elimination Route: excreted principally in
urine and also in feces via biliary elimination
9. METABOLISM AND EXCRETION
Ester Hydrolysis
This action is catalyzed by nonspecific esterases
Hofmann Elimination
A spontaneous non-enzymatic chemical breakdown
occurs at physiological pH and temperature.
10. DOSAGE AND ADMINISTRATION
• A dose of 0.5 mg/kg is administered
intravenously for intubation
• incremental doses of 0.1 mg/kg every 10–20
min after administration of succinylcholine
• An infusion of 5–10 mcg/kg/min can
effectively replace intermittent boluses
13. CLINICAL SIDE EFFECTS
Hypotension and Tachycardia
Bronchospasm
Laudanosine Toxicity
Temperature and pH Sensitivity
Chemical Incompatibility
Allergic Reactions