Introduction To Pharmacoeconomics, Objectives, Need of Pharmacoecomics, Four methods of Pharmaeconomics Evaluation, Basic Terminology, Importance of
Pharmacoeconomics.
A concise overview of pharmacoeconomics, health economics, various costs, various pharmacoeconomic study designs and its application in the field of medicine and drug development
clinical and preclinical approaches to drug discovery.Here we mainly deals with preclinical approaches, ie. Pharmacological approach and toxicological approach
Introduction To Pharmacoeconomics, Objectives, Need of Pharmacoecomics, Four methods of Pharmaeconomics Evaluation, Basic Terminology, Importance of
Pharmacoeconomics.
A concise overview of pharmacoeconomics, health economics, various costs, various pharmacoeconomic study designs and its application in the field of medicine and drug development
clinical and preclinical approaches to drug discovery.Here we mainly deals with preclinical approaches, ie. Pharmacological approach and toxicological approach
Pharmacoeconomics is a branch of health economics which compares the value of one drug or a drug therapy to another.
By understanding the principles, methods, and application of pharmacoeconomics, healthcare professionals will be prepared to make better decisions regarding the use of pharmaceutical products and services.
Definition and scope of Pharmacoepidemiology ABUBAKRANSARI2
In these slides I shared the information of definition and scope of pharmacoepidemiology. Types of studies - cohort studies, cross-sectional studies etc.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
Pharmacovigilance AND ADVERSE DRUG REACTIONS.
MONITORING REPORTING ROLE OF PHARMACIST.
CLASSIFICATION OF ADR. MECHANISM OF ADR
ROLE OF PHARMACIST IN MANAGING ADR. AUGMENTED, BIZZARE, CONTINOUS, DELAYED, END OF TREATMENT, ABCD, ABCDE.
In this presentation i have tried to explain in detail about the measurements of the outcomes which are used in epidemiology such as prevalence, incidence, fatality rate, crude death rate etc.
Pharmacoeconomics is a branch of health economics which compares the value of one drug or a drug therapy to another.
By understanding the principles, methods, and application of pharmacoeconomics, healthcare professionals will be prepared to make better decisions regarding the use of pharmaceutical products and services.
Definition and scope of Pharmacoepidemiology ABUBAKRANSARI2
In these slides I shared the information of definition and scope of pharmacoepidemiology. Types of studies - cohort studies, cross-sectional studies etc.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
Pharmacovigilance AND ADVERSE DRUG REACTIONS.
MONITORING REPORTING ROLE OF PHARMACIST.
CLASSIFICATION OF ADR. MECHANISM OF ADR
ROLE OF PHARMACIST IN MANAGING ADR. AUGMENTED, BIZZARE, CONTINOUS, DELAYED, END OF TREATMENT, ABCD, ABCDE.
In this presentation i have tried to explain in detail about the measurements of the outcomes which are used in epidemiology such as prevalence, incidence, fatality rate, crude death rate etc.
Pharmacoeconomics is essential to reduce burden for patients in the terms of cost and improve the therapeutic effectiveness by selecting alternative treatments. Physician and pharmacist plays an important role in selecting drugs and treatment alternatives. So, proper selection helps to minimize the cost of therapy in patients. Research studies on pharmacoeconomics helps to know the burden of patients paying for their illness.
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outcomes of healthcare interventions. An economic evaluation is concerned
with identifying the differences in costs and outcomes between options. It can
be defined as a study that compares the costs and benefits of two or more
alternative interventions; so, the main components are costs and benefits
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The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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2. Introduction
Definition:
Health economics is the science of
assessing cost and benefits of
healthcare
Pharmacoeconomics is a branch
of health economics which
compares the value of one drug or
a drug therapy to another.
3. Pharmacoeconomics identifies,
measures, and compares the costs
and consequences of drug therapy to
healthcare systems and society.
Pharmacoeconomics is the process of
identifying, measuring, and comparing the costs,
risks, and benefits of programs, services, or
therapies and determining which alternative
produces the best health outcome for the
resource invested
5. Perspectives of Evaluation
Common perspectives include:
Patient perspective – Cost of drug
Provider perspective – eg. Hospitals- Direct
costs
Payer perspective – eg. Insurance
companies, employers, or the government.
Society perspective - All direct and indirect
costs.
6. Costs
The value of the resources consumed by a
program or drug therapy, is defined as Cost.
Healthcare costs are categorized as…
Direct Medical Costs - Drugs, medical
supplies, and equipment, laboratory and
diagnostic tests, hospitalizations, and
physician visits.
7. Direct Nonmedical Costs - Transportation to and from
healthcare facilities, extra trips to the emergency
department, child or family care expenses, special diets,
and various other out-of-pocket expenses
Indirect Nonmedical Costs - Morbidity cost – Loss
of productivity. Mortality – Loss of years of service
due to premature death.
Intangible Costs - Nonfinancial outcomes of
disease and medical care such as pain, suffering,
inconvenience, and grief.
8. Opportunity Costs – Value (economic
benefit) of the alternative therapy that
was forgone.
Incremental Costs - The extra costs
required to purchase an additional unit of
effect.
9. Pharmacoeconomic Methodologies
Economic evaluations
Partial economic evaluations
o Cost consequence analysis (CCA) or Cost outcome analysis (COA)
o Cost-of-illness (COI) evaluation
Full economic evaluations
o Cost Minimization Analysis (CMA)
o Cost Benefit Analysis (CBA)
o Cost Effectiveness Analysis (CEA)
o Cost Utility Analysis (CUA)
Humanistic evaluation
Health Regulated Quality of Life (HRQOL)
Patient preferences
Patient satisfaction
10. Quality patient care must not be compromised
while attempting to contain costs. The
products and services delivered by today's
healthcare professionals should
demonstrate pharmacoeconomic value—that
is, a balance of economic, humanistic, and
clinical outcomes.
11. Economic Evaluation Methods
The basic task of economic evaluation is to
identify, measure, value, and compare the
costs and consequences of the alternatives
being considered.
The two distinguishing characteristics of
economic evaluation are as follows:
(1) Is there a comparison of two or more
alternatives?
(2) Are both costs and consequences of the
alternatives examined?
12. A full economic evaluation encompasses both
characteristics, whereas a partial economic
evaluation addresses only one.
Pharmacoeconomic evaluations conducted in
today's healthcare settings can be either
partial or full economic evaluations.
13. Partial economic evaluations
Partial economic evaluations can include
simple descriptive tabulations of outcomes or
resources consumed
thus require a minimum of time and effort.
14. Partial economic evaluations
(cont…)
A cost-outcome or cost-consequence
analysis (CCA):
o describes the costs and consequences of an
alternative
o does not provide a comparison with other
treatment options
15. Partial economic evaluations
(cont…)
Cost of Illness (COI) evaluation:
COI identifies and estimates the overall cost of a
particular disease for a defined population.
COI evaluation method is also known as burden
of illness.
It involves measuring the direct and indirect costs
attributable to a specific disease such as diabetes,
mental disorders, or cancer.
COI evaluation is not used to compare competing
treatment alternatives but to provide an estimation
of the financial burden of a disease.
16. Partial economic evaluations
(cont…)
For example, by determining the cost of a
particular disease to society, the cost of a
prevention strategy could be subtracted from
this to yield the benefit of implementing this
strategy nationwide.
17. FULL ECONOMIC EVALUATION
Cost-Minimization Analysis
Cost-minimization analysis (CMA) involves the
determination of the least costly alternative when
comparing two or more treatment alternatives.
With CMA, the alternatives must have an
assumed or demonstrated equivalency in safety
and efficacy (i.e., the two alternatives must be
equivalent therapeutically).
Once this equivalency in outcome is confirmed,
the costs can be identified, measured, and
compared in monetary units (dollars).
18. FULL ECONOMIC
EVALUATION(cont…)
For example, if drugs A and B are antiulcer
agents and have been documented as
equivalent in efficacy and incidence of ADRs,
then the costs of using these drugs could be
compared using CMA.
Another example would be prescribing a
generic preparation instead of the brand
leader.
19. FULL ECONOMIC
EVALUATION(cont…)
Cost Benefit Analysis (CBA):
Cost-benefit analysis (CBA) is a method that allows
for the identification, measurement, and comparison
of the benefits and costs of a program or treatment
alternative.
Measures costs and benefits in monetary terms.
Estimates the strengths and weaknesses of
alternatives.
Both the costs and the benefits are measured and
converted into equivalent dollars in the year in
which they will occur.
20. FULL ECONOMIC
EVALUATION(cont…)
The costs and benefits are expressed as a ratio
(a benefit-to-cost (B:C) ratio).
Guidelines for the interpretation of this ratio are
indicated:
If the B:C ratio is greater than 1, the program or
treatment is of value. The benefits realized by
the program or treatment alternative outweigh
the cost of providing it.
21. If the B:C ratio equals 1, the benefits equal
the cost. The benefits realized by the
program or treatment alternative are
equivalent to the cost of providing it.
If the B:C ratio is less than 1, the program or
treatment is not economically beneficial. The
cost of providing the program or treatment
alternative outweighs the benefits realized by
it.
22. Many CBAs measure and quantify direct
costs and direct benefits only due to
difficulties in measuring indirect and
intangible benefits.
This approach is not widely used in health
economics
23. Cost-Effectiveness Analysis:
Cost-effectiveness analysis (CEA) is a way of
summarizing the health benefits and resources
used by competing healthcare programs so
that policymakers can choose among them.
CEA involves comparing programs or
treatment alternatives with different safety
and efficacy profiles.
24. Cost is measured in dollars, and outcomes are
measured in terms of obtaining a specific
therapeutic outcome. These outcomes are
often expressed in physical units, natural units,
or nondollar units (e.g., lives saved, cases
cured, life expectancy, or drop in blood
pressure)
25. The results of CEA are expressed as a
ratio either as an average cost-
effectiveness ratio (ACER) or as an
incremental cost effectiveness ratio
(ICER).
Average cost effectiveness (ACER) = Net
Cost / Net Health Benefit
26. The key measure of CEA is the incremental cost
effectiveness ratio (ICER).
Incremental Cost Effectiveness Ratio = (Cost of drug A -
Cost of drug B) / (Benefits of drug A - Benefits of drug B)
ICER = Difference in costs (A-B) / Difference in
benefits (A-B)
27. Cost Utility Analysis (CUA):
Pharmacoeconomists sometimes want to
include a measure of patient preference or
quality of life when comparing competing
treatment alternatives.
Cost-utility analysis (CUA) is a method for
comparing treatment alternatives that
integrates patient preferences and Health
Regulated Quality of Life (HRQOL).
28. CUA can compare cost, quality, and the
quantity of patient-years.
Cost is measured in dollars, and therapeutic
outcome is measured in patient-weighted
utilities rather than in physical units.
Often the utility measurement used is a
quality-adjusted life year (QALY) gained. QALY
is a common measure of health status used in
CUA, combining morbidity and mortality data
29. Results of CUA are expressed in a ratio, a
cost-utility ratio (C:U ratio).
CUA is complex, and thus CUA can be
limited in scope of application from a hospital
perspective.
CUA is employed less frequently than other
economic evaluation methods because of a
lack of agreement on measuring utilities,
difficulty comparing QALYs across patients
and populations, and difficulty quantifying
patient preferences.
30. Humanistic Evaluation Methods
Methods for evaluating the impact of disease and
treatment of disease on a patient’s HRQOL, patient
preferences, and patient satisfaction are all growing in
popularity and application to pharmacotherapy
decisions.
HRQOL has been defined as the assessment of the
functional effects of illness and its consequent therapy
as perceived by the patient.
These effects often are displayed as physical,
emotional, and social effects on the patient.
Measurement of HRQOL usually is achieved through
the use of patient-completed questionnaires.
31. Importance of
Pharmacoeconomics
Pharmacoeconomic analysis helps to achieve
maximum benefit in limited cost.
Clinicians want their patients to receive best
care and outcome available.
The payers want to manage rising costs.
Pharmacoeconomics combines the objectives
of both clinician and payers by estimating the
value of patient outcomes for the expenditure
spent on medications and other healthcare
services.
32. In today’s healthcare settings,
pharmacoeconomic methods can be applied
for effective formulary management, individual
patient treatment, medication policy
determination, and resource allocation.
33. Limits of Pharmacoeconomic
Evaluation
Health economics and pharmacoeconomics is a
young science and is slowly developing and testing its
methodologies.
Many problems limit the use of health economics in
practice.
The whole process may be open to bias, in the choice
of comparator drug, the assumptions made, or in the
selective reporting of results.
Most studies are conducted or funded by
pharmaceutical companies who obviously are
interested in the results, and there is a publication
bias towards those studies favourable to sponsoring
companies.
34. Health economics is therefore sometimes
misused as a marketing ploy.
Clinical pharmacologists should welcome
pharmacoeconomic evaluation as a means to
promote efficiency and effectiveness of
prescribing.