Introduction To Pharmacoeconomics, Objectives, Need of Pharmacoecomics, Four methods of Pharmaeconomics Evaluation, Basic Terminology, Importance of
Pharmacoeconomics.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
A concise overview of pharmacoeconomics, health economics, various costs, various pharmacoeconomic study designs and its application in the field of medicine and drug development
Pharmacoeconomics is a branch of health economics which compares the value of one drug or a drug therapy to another.
By understanding the principles, methods, and application of pharmacoeconomics, healthcare professionals will be prepared to make better decisions regarding the use of pharmaceutical products and services.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
A concise overview of pharmacoeconomics, health economics, various costs, various pharmacoeconomic study designs and its application in the field of medicine and drug development
Pharmacoeconomics is a branch of health economics which compares the value of one drug or a drug therapy to another.
By understanding the principles, methods, and application of pharmacoeconomics, healthcare professionals will be prepared to make better decisions regarding the use of pharmaceutical products and services.
Quality Use of Medicines means:
• Selecting management options wisely by:
Considering the place of medicines in treating illness and maintaining health, and
recognising that there may be better ways than medicine to manage many disorders.
• Choosing suitable medicines if a medicine is considered necessary so that the best available option is selected by taking into account:
- the individual
- the clinical condition
- risks and benefits
- dosage and length of treatment
- any co-existing conditions
- other therapies
- monitoring considerations
- costs for the individual, the community and the health system as a whole.
Definition and scope of Pharmacoepidemiology ABUBAKRANSARI2
In these slides I shared the information of definition and scope of pharmacoepidemiology. Types of studies - cohort studies, cross-sectional studies etc.
Genetic polymorphism in drug transport and drug targets.pavithra vinayak
Genetic polymorphism in drug transport and targets.--pharmacogenetics
DRUG TRANSPORTER
Two types of transporter :
•ATP binding Cassette (ABC) – Found in ABCB, ABCD and ABCG family. Associated with multidrug resistance (MDR) of tumor cells causing treatment failure in cancer.
•Solute Carrier (SLC) – Transport varieties of solute include both charged or uncharged
P-glycoprotein
• ATP binding cassette subfamily B member- 1 (ABCB 1)
• Multidrug resistance protein 1 (MDR1)
• Transport various molecules, including xenobiotic, across cell membrane
• Extensively distributed and expressed throughout the body
Mechanism of Pglycoprotein
Substrate bind to P-gp form the inner leaflet of the membrane
ATP binds at the inner side of the protein
ATP is hydrolyzed to produce ADP and energy
Patient medication adherence, Medication adherence, Causes of medication non-adherence, Problems linked with Medication Non-adherence, Factors affecting medication adherence, Patient related factors, Social and Economic factor, Disease related factor, Health care provider related factors, Therapy related factors, pharmacist role in the medication adherence, role of pharmacist in the medication adherence, monitoring of patient medication adherence, Direct method, Indirect method
Pharmacoeconomics is essential to reduce burden for patients in the terms of cost and improve the therapeutic effectiveness by selecting alternative treatments. Physician and pharmacist plays an important role in selecting drugs and treatment alternatives. So, proper selection helps to minimize the cost of therapy in patients. Research studies on pharmacoeconomics helps to know the burden of patients paying for their illness.
Quality Use of Medicines means:
• Selecting management options wisely by:
Considering the place of medicines in treating illness and maintaining health, and
recognising that there may be better ways than medicine to manage many disorders.
• Choosing suitable medicines if a medicine is considered necessary so that the best available option is selected by taking into account:
- the individual
- the clinical condition
- risks and benefits
- dosage and length of treatment
- any co-existing conditions
- other therapies
- monitoring considerations
- costs for the individual, the community and the health system as a whole.
Definition and scope of Pharmacoepidemiology ABUBAKRANSARI2
In these slides I shared the information of definition and scope of pharmacoepidemiology. Types of studies - cohort studies, cross-sectional studies etc.
Genetic polymorphism in drug transport and drug targets.pavithra vinayak
Genetic polymorphism in drug transport and targets.--pharmacogenetics
DRUG TRANSPORTER
Two types of transporter :
•ATP binding Cassette (ABC) – Found in ABCB, ABCD and ABCG family. Associated with multidrug resistance (MDR) of tumor cells causing treatment failure in cancer.
•Solute Carrier (SLC) – Transport varieties of solute include both charged or uncharged
P-glycoprotein
• ATP binding cassette subfamily B member- 1 (ABCB 1)
• Multidrug resistance protein 1 (MDR1)
• Transport various molecules, including xenobiotic, across cell membrane
• Extensively distributed and expressed throughout the body
Mechanism of Pglycoprotein
Substrate bind to P-gp form the inner leaflet of the membrane
ATP binds at the inner side of the protein
ATP is hydrolyzed to produce ADP and energy
Patient medication adherence, Medication adherence, Causes of medication non-adherence, Problems linked with Medication Non-adherence, Factors affecting medication adherence, Patient related factors, Social and Economic factor, Disease related factor, Health care provider related factors, Therapy related factors, pharmacist role in the medication adherence, role of pharmacist in the medication adherence, monitoring of patient medication adherence, Direct method, Indirect method
Pharmacoeconomics is essential to reduce burden for patients in the terms of cost and improve the therapeutic effectiveness by selecting alternative treatments. Physician and pharmacist plays an important role in selecting drugs and treatment alternatives. So, proper selection helps to minimize the cost of therapy in patients. Research studies on pharmacoeconomics helps to know the burden of patients paying for their illness.
Outcomes, health economics and pharmacoeconomicsDureshahwar khan
Pharmacoeconomics can be regarded as a branch of health economics which deals with identifying, measuring, and comparing the costs and consequences of pharmaceutical products and services. Some of the concepts involved in pharmacoeconomic analysis include cost minimization, cost effectiveness, cost benefit, and cost utility analysis.
Anthropod-Borne Infections Introduction,Causative agent, Epidemiology, Clinical Presentation, Diagnosis, Treatment and Role of Pharmacist of following infections, Malaria, Chikungunya and Filariasis.
Dengue ,
Introduction to Microbiology And Common Micro-Organisms, EpidemiologyMonika P. Maske
Introduction to Microbiology, Classification Of Micro-Organisms, Bacteria , Classification of Bacteria Depend on Shape and Characteristic Arrangement, Algae,Fungi, Moulds And Yeasts, Spores, Viruses, Protozoa, Rickettsia & Mycoplasma, Identification of Bacteria, Scope of Microbiology, Introduction to Epidemiology, Applications of Epidemiology,Definitions.
Introduction of National Health Programmes,Objectives, Main Activities, Ongoing National Health Programmes in India, National Iodine Deficiency Disorders Control Programme (NIDDCP), National Leprosy Eradication Programme (NLEP),National Mental Health Programme(NMHP), National Palliative Care (NPPC) , National Oral Health Programme (NOHP), National Organ Transplant Programme (NOTP), National Programme for Control of Blindness and Visual Impairment (NPCBVI), National Programme for Prevention and Control of Fluorosis (NPPCF),National Tobacco Control Programme (NTCP),Revised National TB Control Programme (RNTCP), National Programme on Health Care for Elderly (NPHCE), National Programme for Prevention and Control of Deafness (NPPCD), National Programme for Prevention & Control of Cancer, Diabetes, CVS Diseases & Stroke, b) Programme National Rabies Control (NRCP), c) National Viral Hepatitis Surveillance Programme (NVHSP), ) Six Vector – Borne DiseasesThey are chikn gunya, malaria, filariasis, kala azar, Japanese encephalitis and dengue, National Programme for Prevention & Mangement of trauma & Burn Injuries (NPPMTBI), National Pulse Polio Programme, Health Programmes Monitored by National Centre for Disease Control (NCDC)1. Antimicrobial Resistance (AMR) Containment, 2. National Programme on Climate Change & Human Health (NPCCHH), 3. Integrated Disease Surveillance Programme (IDSP), 4. Yaws Eradication Programme (YEP) there Objectives and Functions and Outcome, Additional National Health Programmes and Role of Pharmacist in National Health Programmes.
Introduction to Nutrition And Health, Introduction Of Balance Diet, Healthy Benefits of a Balanced Diet, WHO Recommendations For Balanced Diet, Nutrition Deficiency Diseases, Deficiency Diseases Induced Due To Deficiency Of Proteins, Symptoms, Treatments And Preventions of Kwashiorkor and Marasmus, Treatments And Preventions of Of
Vitamins, Treatments And Preventions of Minerals,Ill Effects Of Junk Foods, Types Of Junk Foods, Appealing nature of Junk Food, Adverse Effects of Junk Food, Nutritive And Calorific Values of Various Foods, Daily Calorific Requirements, Fortification of Food, Types of Fortification, Benefits of Fortification, Introduction To Food Adulteration, Safe Food Handling, Adulteration Of Foods, Adulterants And Their Harmful Effects, Artificial Ripening, Effects Of Artificial Ripening, Pesticides, Uses Of Pesticides, Effects Of Pesticides, Genetically Modified Foods, Advantages Of GM Crops, Potential Benefits (Long-Term Effects),Disadvantages Of GM Crops, Dietary Supplements, Types of Supplements, Benefits, Dietary Supplements And Their Roles, Indications, Nutraceuticals, Concept of Neutraceuticals, Nutraceuticals Benefits, Classification, Dietary Supplement Health And
Education Act (DSHEA), Medicinal Plants Used as
Neutracuticals, Drug – Food Interactions.
Introduction to Nutrition And Health, Basics of nutrition, Objective of nutrition, Classification of food, macronutrients, Carbohydrates, Functions of carbohydrates, proteins, Functions of proteins, Protein Requirements for Different Age Groups
, fats, Functions of fats, Sources, Functions And Deficiency Of Fat-Soluble Vitamins, Sources, Functions And Deficiency Of Water-Soluble Vitamins, minerals, Daily Requirement, Functions And Sources Of Trace Elements, fibres, Importance of fibre in diet, Water, Importance of water in diet.
Introduction To Pollution, Types of pollution,Water Pollution & Sources of Water Supply, Source of water pollution, Effects on health of water pollution, Water Born Disease, Treatment of water pollution or Purification of water , Importance of safe drinking water,Introduction To Air Pollution,Functions & Composition of Air, Source of air pollution, Effects on health, Control of Air Pollution, Introduction To Noise Pollution,Source of noise pollution, Effects on health, Control of Noise Pollution,Sewage And Solid Waste Disposal, Sewage Treatment Plant, Occupational Illness, Precaution against occupational disease, Environmental pollution due to pharmaceuticals,
Overview on Vaccine, Immunity, Types of Immunity and ImmunisationMonika P. Maske
Overview of vaccines, types of immunity and immunization introduction, Response of Vaccine In Body, Antigen , Antibody, Composition Of Vaccines, History of Vaccine, Types of Vaccine, Live attenuated vaccine (LAV), Inactivated vaccine (Killed vaccine), Subunit vaccine (Purified antigen), Toxoid vaccine (Inactivated Toxoid), Ideal characteristics of vaccine, On the basis of components vaccine are also divided, Immunity, Types of Immunity, Non-specific,Specific Immunity, Difference between Active and Passive Immunity.
,
Demography introduction, IMPORTANCE OF DEMOGRAPHY,COMMON SOURCES & INDICATORS OF DEMOGRAPHY, Demography cycle,Family planning,objectives,Efforts made in the past,individuals and organisations took initiative to propagate the need for birth control,Contraceptive methods,Various birth control methods like Behavioural methods, Natural methods, Chemical methods, Mechanical methods, Hormonal methods, Terminal methods, Post-conceptional methods,Role Pharmacist of family planning.
Mother And Child Health Introduction, Paediatrics or Child Health, Maternal and Child Health Programme(MCH), Objectives, Importance,Breastfeeding introduction, Composition of Milk, Other Vital Components of Breast Milk, Importance of Breastfeeding for Baby, Importance of Breastfeeding for Mother, Infant Milk Substitutes & Bottle Feeding,Effects of Bottle Feeding, Illness And Hospitalisation Risk, Pharmacists Role in Mother And Child Health.
National Health Policy Introduction, NHP 1983, NHP 2000, NHP 2002, NHP 2017, Seven Priority areas, Sustainable Developmental (SDGs), Public and Private health system in India, National Health Mission (NHM),Sustainable Development Goals (SDGs), International Pharmaceutical Federation Development Goal (FIP),
Introduction to Social Pharmacy, Definition, Social Pharmacy as a Discipline, Scope of Social Pharmacy in Improving Public Health, Role of Pharmacist in Public Health, Concept of Health, Dimensions of Health, Determinants of Health, Health Indicators.
Introduction to Clinical Pharmacy Practice, Definitions and Aim, Objectives, Scopes or services of Clinical Pharmacy, Functions and Roles of Clinical Pharmacy, Qualities of Clinical Pharmacy.
Introduction of Water, Physical Properties of water, Chemical properties of water, Chemical properties of water, Hardness of Water, Type hardness of water, Difference between hard and soft water, Units of hardness, Methods of Softening of hard water and types of lime soda water, Zeolite softening process, Ion exchange process, Natural & Portable Water, Sterile Water for Injection, Water for Injection, Purified Water, Selection of Suitable Water for Use, Solubility of Pharmaceuticals, Methods of Expression of Solubility, Factors Affecting Solubility.
Introduction, Classification of Vitamins, Fat –Soluble Vitamins-) Vitamin A ,Biochemical Function of Vitamin A, Deficiency of Vitamin A, Vitamin D ,Vitamin E, Deficiency and Role of Vit.E , Vitamin K, Water-Soluble Vitamins, Thiamine, ) Riboflavin , Nicotinic Acid, Pantothenic acid , Pyridoxine , Biotin, Deficiency of folic acid, Cyanocobalamin, structure and deficiency of co-enzyme B12 , Lipoic acid, Non B-Complex, Ascorbic acid , benifites of vit. C, CO-ENZYMES,
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
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Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Introduction To
Pharmacoeconomics
o Pharmacoeconomics is the branch of economics that
uses cost-benefit, cost-effectiveness, cost minimization,
cost of illness and cost utility analyses for comparing
pharmaceutical products and treatment strategies.
o It’s a part of health economics focusing on economic
estimation of drugs.
2
3. o Cost can be measured in following ways cost/unit,
cost/treatment, cost/person, cost/person/year, etc.
o Pharmacoeconomics coined by Townsend in 1986.
3
5. Objectives
o Outline the issues and theory.
o To show its application to make decision about drug
therapy.
o To show application in decreasing financial burden on
the consumers for effective managing of healthcare
system.
o The limited resources more effective for expansion of
healthcare benefit at lower cost.
5
6. Need of
Pharmacoecomics
o To find out the optimal therapy at lowest cost.
o In industry to develop specific research and development
alternatives.
o In public to design health insurance benefits.
o In government the determine programmer benefits and
prices.
6
7. Four methods of
Pharmaeconomics Evaluation
1. Cost-Minimization Analysis (CMA)
It involves measuring only costs, of health services
ex. Prescribing generic medicine instead of brand
leader.
2. Cost-Effectiveness Analysis (CEA)
It refers to the whole of economic evaluation but
specifically a particular type of evaluation in which the
health benefit can be defined and measured in natural
units. Ex. Years of life saved, etc.
7
8. 3. Cost-Utility Analysis (CUA)
Its similar to cost effectiveness but the outcome is
a unit of utility. Ex. Quality adjusted life years (QALY) is
coronary artery bypass versus cost for erythropoietin in renal
diseases.
4. Cost-Benefit Analysis (CBA)
The benefit is measured as the associated
economic benefit of an intervention. Ex. Monitor value of
returning a worker to employment earlier.
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9. Basic Terminology
o Pharmacoeconomic – It’s the branch of health
economics that deals with the evaluation of the
costs and consequences of therapeutic decision
making.
o Cost of Drugs – It’s the total resources spent in
making the drug or drug preparation.
o Price – It’s the amount a customer pays for a
product or service.
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10. o QOL (Quality of Life) – An individual’s preparation of their
position in life in the context of the culture and value system
in which they live and in relation to their goals, expectations,
standards and concerns.
o Time Trade Off (TTO) – It’s a tool to help determine QOL of
patient.
o QALY – Quality Adjusted Life Years.
o Discounting – It’s a method for time adjustment for costs
where the future costs are brought to the present.
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11. Direct Cost
o These are the resources consumed in the prevention,
detection or treatment of a disease or illness.
o It involve transfer of money.
A) Direct Medical Cost : Represents costs that are
incurred during provision of care.
Ex. Cost of drugs, lab tests, salaries of health care
professionals.
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12. B) Direct Non-Medical Costs : Arising due to illness
but do not involve purchasing medical services.
Ex. Cost of transportation, cost of special clothing's, etc.
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13. Indirect Cost
o It’s the external cost or indirect cost.
o These are costs of reduced productivity.
o It is the one borne by the patient and family.
o Ex. Wages and salaries lost due to mortality and
morbidity.
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14. Intangible Costs
o These are costs incurred, which represent non -financial
outcomes of disease and medical care, which cannot
be expressed in money value.
o Its related to the patients pain, worry and suffering the
patients family.
o Ex. Quality of life for patients of cancer, arthritis.
o Its difficult to measure and presently included in indirect
costs.
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15. Utility Unity & Quality of Life
o Utility Unity :- It evaluates the changes in a patients
satisfaction or sense of safety as an effort to calculate the
approved result from moving from one state to other for
the use of drug therapy.
o Quality of Life :- It involves physical and psycho-social
dimensions of life. physical dimensions include presence
or absence of ache and immobility; while psycho-social
dimensions include level of anxiety, depression and
reduced ability of patient to deal with issues.
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16. Importance of
Pharmacoeconomics
o Pharmacoeconomic analysis helps to achieve
maximum benefit in limited cost.
o Clinicals want their patients to receive best care
and outcome available.
o The payers want to manage rising costs.
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17. o Pharmacoecomics combines the objectives of both
clinics and payers by estimating the value of patient
outcomes for the expenditure spent on medications
and other healthcare services.
o In todys healthcare settings, Pharmacoecomics
methods can be applied for effective formulary
management, individual patient treatment,
medication policy determinations and resource
allocation.
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