In these slides I shared the information of definition and scope of pharmacoepidemiology. Types of studies - cohort studies, cross-sectional studies etc.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
conversion from INTRAVENOUS TO ORAL DOSING----- design of dosage regimenpavithra vinayak
conversion from INTRAVENOUS TO ORAL DOSING----- TYPES OF IV TO PO THERAPY CONVERSIONS: MEDICATIONS INCLUDED IN AN IV TO PO CONVERSION PROGRAM: SELECTION OF PATIENTS FOR IV TO PO THERAPY CONVERSION: design of dosage regimen--clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Genetic polymorphism in drug transport and drug targets.pavithra vinayak
Genetic polymorphism in drug transport and targets.--pharmacogenetics
DRUG TRANSPORTER
Two types of transporter :
•ATP binding Cassette (ABC) – Found in ABCB, ABCD and ABCG family. Associated with multidrug resistance (MDR) of tumor cells causing treatment failure in cancer.
•Solute Carrier (SLC) – Transport varieties of solute include both charged or uncharged
P-glycoprotein
• ATP binding cassette subfamily B member- 1 (ABCB 1)
• Multidrug resistance protein 1 (MDR1)
• Transport various molecules, including xenobiotic, across cell membrane
• Extensively distributed and expressed throughout the body
Mechanism of Pglycoprotein
Substrate bind to P-gp form the inner leaflet of the membrane
ATP binds at the inner side of the protein
ATP is hydrolyzed to produce ADP and energy
adaptive methods are doing with feedback in population pharmacokinetics---- clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Population pharmacokinetics is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest
conversion from INTRAVENOUS TO ORAL DOSING----- design of dosage regimenpavithra vinayak
conversion from INTRAVENOUS TO ORAL DOSING----- TYPES OF IV TO PO THERAPY CONVERSIONS: MEDICATIONS INCLUDED IN AN IV TO PO CONVERSION PROGRAM: SELECTION OF PATIENTS FOR IV TO PO THERAPY CONVERSION: design of dosage regimen--clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Genetic polymorphism in drug transport and drug targets.pavithra vinayak
Genetic polymorphism in drug transport and targets.--pharmacogenetics
DRUG TRANSPORTER
Two types of transporter :
•ATP binding Cassette (ABC) – Found in ABCB, ABCD and ABCG family. Associated with multidrug resistance (MDR) of tumor cells causing treatment failure in cancer.
•Solute Carrier (SLC) – Transport varieties of solute include both charged or uncharged
P-glycoprotein
• ATP binding cassette subfamily B member- 1 (ABCB 1)
• Multidrug resistance protein 1 (MDR1)
• Transport various molecules, including xenobiotic, across cell membrane
• Extensively distributed and expressed throughout the body
Mechanism of Pglycoprotein
Substrate bind to P-gp form the inner leaflet of the membrane
ATP binds at the inner side of the protein
ATP is hydrolyzed to produce ADP and energy
adaptive methods are doing with feedback in population pharmacokinetics---- clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Population pharmacokinetics is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest
Pharmacoepidemiology is the study of effects of drugs in large numbers of people.
Epidemiologic Study Designs, Reasons to perform Pharmacoepidemiology studies, Users of pharmacoepidemiology and Role of Pharmacists & other Public Health Practitioners in Pharmacoepidemiology are discussed in this presentation.
Epidemiology is the study of occurrence, distribution and determinants of health and
diseases or disorders in man and its application in controlling health problems.
Epidemiology has by tradition two major areas.
First is the study of infectious diseases that spread to large populations, i.e., epidemics.
The second is the study of chronic diseases.
Epidemiological studies help to solve such health problems and provide a basis for
improving living conditions of the people.
During its progress and development, epidemiology has made available precise and
strict methodologies for the study of diseases.
Pharmacology is the study of the effects of drugs.
Clinical Pharmacology is the study of the effects of drugs in humans, It is traditionally
divided into two basic areas namely:
1. Pharmacokinetics
2. Pharmacodynamics.
Pharmacokinetics is the study of the relationship between dose administered of a drug
and the serum or blood level achieved, it deals with absorption, distribution, metabolism
and excretion.
Epidemiology is the study of the distribution and determinants of diseases in
populations.
Epidemics is the study of chronic/ infectious diseases in large populations.
Pharmacoepidemiology is the study of the use of and the effects of drugs in large
number of people.
It involves the examination of a single individual or large groups of people followed for
many years.
It involves gathering & analysis of information in order to identify possible causation &
related factors, that can be applied in clinical practice to group of people & also to
individuals undergoing treatment.
The pharma aspirants can read the important information provided in this presentation about Pharmacovigilance which is necessary to qualify the interviews of the same field
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Definition and scope of Pharmacoepidemiology
1. Definition and
scope ofPharmacoepidemiology
Submitted By :
Abu Bakr Ansari
Pharm. D 5th Year
Roll No. 1601096001
Enroll No. 1600100627
Submitted To :
Dr. Mohd Khustar Sir
Associate Professor
Integral University, Lucknow
Faculty of Pharmacy
PRY – 502 Pharmacoepidemiology
and Pharmacoeconomics
2. Definition and Introduction
Pharmacoepidemiology is derived from the words
‘pharmacology’ and ‘epidemiology’; the study of
population or diseases in a population. The
pharmacoepidemiology is applying of principles of
epidemiology into pharmacology. It is a specialized
branch of epidemiology that looks into the effects of
drugs approved in the market. Pharmacoepidemiology
can be applied in drug utilization studies (prospective or
retrospective), outcomes studies and data analytics.
3. • It is the bridging between clinical pharmacology
and epidemiology.
Pharmacoepidemiology
Pharmakon-
Drug
Epi – uponor
among
Demos –People
or district
Logos -Study
4. Aim
• WHO targets its pharmacoepidemiological efforts to ensure the
quality, safety and efficacy of drugs.
• The studies focus on
• Global trends in prescribing
• Appropriateness of drug use
• Medication adherence
• Lifestyle effects on drug therapy
• Special population (Elderly, Pediatric, etc.) drug therapy
• Drug Interactions
• Predictable ADRs
• Uncommon and unpredictable ADRs
5. Sources of Data
• The sources of drug data includes:
- Institutionalized medical records and databases from
hospital and pharmacy claims
- System wide databases from health insurance
claims or pharmaceutical organization.
- National databases like Medical Expenditure
Panel Survey, National Ambulatory Medical Care
Survey.
- Field data like records from dispensers,
sellers or distributers or from small groups.
- Experimental clinical trial data.
8. Cross Sectional Study
These studies are examinations of the use of drugs at
one specific point in time.
They are usually done through surveys, chart
reviews and data base analyses.
They provide a view of the state of affairs at that time
and an estimate of the prevalence of utilization and of
outcomes.
Such information can be used for
formulary management and policy development.
Used to compare drug use between countries or
regions within in a country.
9. Eg: cross-sectional studies was published by Dua and
colleagues, who examined inappropriate sale of antibiotic use
in pharmacies in Nagpur.
Such studies can identify problem areas and suggest where
remedial action should be directed.
10. Case Control Study
These studies compare cases with disease to controls without
disease.
11. Advantages
• Useful to study multiple possible
causes of a single disease.
• Useful to study uncommon diseases.
• Relatively easy to carry out.
• Rapid and inexpensive.
• Requires comparatively few subjects.
• Does not need an ethical clearance.
• There is no risk to the subject .
Disadvantages
• It introduces bias.
• To select an appropriate
control could be difficult .
• It may be difficult to
distinguish between the
cause of a disease and an
associated factor.
12. Cohort Study
Cohort studies identify subsets of a defined population and
follows them over time, looking for differences in their
outcome.
They are useful to compare exposed patients to unexposed
patients.
13. Advantages
There is no bias.
It is effective for studying rare
exposures.
It allows the study of the natural
history of the disease.
It assists in determining the temporal
relationship between the etiological
factor & the disease.
Can study multiple outcomes.
Disadvantages
• It takes a long time.
• It is expensive.
• Large no of subjects are
needed.
• There could be changes in
the standard methods
or diagnostic criteria .
14. Need of
Pharmacoepidemiology
There are 3 main reasons why there is a strong need for PE.
1. Source of supplementation of information available from pre-marketing
studies: It is useful for the better quantification of the incidence of
known adverse and beneficial effects.Advantages of being a source of
supplemental information are: higher precision in results, provides
information of patients not studied in pre-marketing studies (for eg;
elderly, pregnant population etc), provides understanding of how a
drug is modified by other drugs and illnesses and helps to compare
with other drugs for the same indication in terms of safety and efficacy.
2. Source of new information not available from pre-marketing studies:
These PE studies provide information on (a) undetected adverse
events and beneficial effects (b) pattern of drug utilization (c) effects of
drug over doses (d) economic implications.
15. 3. General contributions of PE: PE studies can reassure drug
safety and also fulfill certain ethical and legal obligations.Aims
of PE: The aim of PE is to describe, explain, control and
predict the uses and effects of drugs in a defined time, space
and population.
16. Applications of PE
• Government agencies & Health care plans:
Pharmacoepidemiology research is important for the government
agencies like the Agency for Healthcare Research and Quality
(AHRQ) and the Centers for Medicare and Medicaid Services
(CMS) and Healthcare plans.
• Practitioners:
Pharmacoepidemiological studies can help Pharmacists,
Physicians, Nurses and other Public health care practitioners to
make informed decisions about treatment for patients.
17. Pharmaceutical industries:
The pharmaceutical industry want to understand how a drug is
prescribed, used and what are all the positive and negative
outcomes.
Academicians:
Academicians often conduct pharmacoepidemiological studies to
find answers to practice related questions.
Attorneys:
Findings from pharmacoepidemiological studies can be used as can
be used as evidence that a drug product did or didn’t cause an event.
Consumers and Patients:
To learn about safetyand effectiveness of drug products,
patients and consumers rely on pharmacoepidemiological
studies.
18. Reference
1. Textbook of clinical pharmacy practice,
pharmacoepidemiology, by Jayashri
Sankaranararyanan and Thomas R Einarson; page
no: 467- 483.
2. https://en.wikipedia.org/wiki/Pharmacoepidemiolo
gy
3. https://www.slideshare.net/DivjyotKaur/pharmacoe
pidemiology