This document discusses distillation, which is a process used to separate mixtures based on differences in their boiling points. It defines distillation and provides examples of its applications. It then classifies different types of distillation, including simple distillation, fractional distillation, vacuum distillation, and molecular distillation. For each type, it provides a brief overview of the principle, construction, working, and some applications. The document is presented by an assistant professor and provides detailed information on various distillation methods.
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Surface and Interfacial tension [Part-3(a)](Measurement of Surface and Inter...Ms. Pooja Bhandare
MEASUREMENT OF SURFACE AND INTERFACIAL TENSION
Capillary Rise Method, Drop Count and Weight Method.
Wilhelmy Plate Methods ,The DuNouy Ring Method.
Capillary Rise Method: Upward force due to surface tension: Drop count and Weight method Downward Force: Drop weight method: Drop count method
Distribution Law
What is Distribution law?
Immiscible liquids
Explanation
APPLICATION OF DISTRIBUTION LAW
Limitations of Distribution Law
Contrast and Comparison between separation through Separating funnel and Fractional Distillation
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Surface and Interfacial tension [Part-3(a)](Measurement of Surface and Inter...Ms. Pooja Bhandare
MEASUREMENT OF SURFACE AND INTERFACIAL TENSION
Capillary Rise Method, Drop Count and Weight Method.
Wilhelmy Plate Methods ,The DuNouy Ring Method.
Capillary Rise Method: Upward force due to surface tension: Drop count and Weight method Downward Force: Drop weight method: Drop count method
Distribution Law
What is Distribution law?
Immiscible liquids
Explanation
APPLICATION OF DISTRIBUTION LAW
Limitations of Distribution Law
Contrast and Comparison between separation through Separating funnel and Fractional Distillation
Suspension may be defined as preparations containing finally divided drug particles (the suspenoid) distributed somewhat uniformly throughout a vehicle in which the drug exhibits a minimum degree of solubility.
Some suspension are available in ready to use form i.e. already distributed through a liquid vehicle with or without stablizen and other additives.
Prepared suspension not requiring reconstitution at the time of dispensing are simply designated as “Oral Suspension”
Pharmacy College, Azamgarh
Distillation, distillation process for pharma students, simple distillation, ...RajkumarKumawat11
Distillation, distillation process for pharma students, simple distillation, fractional distillation, distillation under reduced pressure, steam distillation, destructive distillation, water for injection and sterile water
Basic Principles and methodology of distillationAkankshaPatel55
What is distillation?
Distillation is a physical separation process that utilizes the differences in boiling points of various components within a liquid mixture. It involves selectively boiling and condensing these components to achieve greater purity or isolate specific desired fractions. Imagine separating salt from saltwater: distillation boils the water away, leaving behind concentrated salt.
How does it work?
Heating: The mixture is heated in a container called a still. As the temperature rises, components with lower boiling points start to vaporize first.
Vaporization: These vapors rise and travel through a condenser, a cooled tube or chamber.
Condensation: When the vapors encounter the cool surfaces, they lose heat and condense back into a liquid form.
Collection: This collected liquid, called the distillate, is usually richer in the more volatile component(s).
Fractional distillation: This technique involves multiple condensers at different temperatures, collecting separate fractions based on their boiling points. For example, distilling crude oil separates gasoline, kerosene, and other fractions.
Applications of distillation:
Purification: Distillation is widely used to purify water, removing impurities and producing drinkable water. It also purifies alcohol, removing water and other impurities to get higher-proof spirits.
Separation: Distillation is essential in separating various chemicals and compounds, like essential oils from plants, fragrances from flowers, and specific chemicals from crude oil.
Desalination: Distillation can be used for desalination, converting saltwater into freshwater, although other methods are more common now.
Types of distillation:
Simple distillation: Used for mixtures with significant boiling point differences. The distillate is less pure than other methods.
Fractional distillation: Used for complex mixtures with closer boiling points, collecting different fractions based on their volatility.
Vacuum distillation: Used for heat-sensitive materials that decompose at normal boiling points. It lowers the boiling point by reducing pressure.
objectives, applications, mechanism of size separation, the official standard of powders, sieves, sieve shaker, cyclone separator, air separator, bag filter, elutriation tank
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. DEFINITION
○ “Distillation is an unit operation which involves separation of
a vaporizable component from a multi-component system
and subsequent condensation of vapours.”
○ “Distillation is a process of separating the component
substances from a liquid mixture by selective evaporation
and condensation.”
○ “Distillation is defined as the separation of the components
of a liquid mixture by a process involving vaporization and
subsequent condensation at another place.”
3. APPLICATIONS:
❑ Separation of volatile oils- cloves(Eugenol comprises 72-
90%, Vanilin, acetyl eugenol).
❑ Separation of drugs obtained from plant and animal
sources- Vit. A from fish liver oil.
❑ Purification of organic solvents-absolute alcohol (100%).
❑ Purification of drugs obtained from chemical process.
❑ Manufacture of official preparations -sprit of nitrous ether, sprit
of ammonia, D.water and water for inj.
❑ Quality control methods- Alcohol content in elixir(4-40%).
❑ Refining of petroleum products- Petroleum ether 60,80.
❑ Recovery of solvents- synthesis.
4. CLASSIFICATION OF DISTILLATION METHODS
I. Simple Distillation (Differential distillation)
II. Flash Distillation (Equilibrium distillation)
III. Vacuum distillation (distillation under reduced pressure)
IV. Molecular Distillation (Evaporation distillation or short path
distillation.)
V. Fractional Distillation (Rectification)
VI. Steam Distillation
22
5. 1. SIMPLE DISTILLATION
○ Simple distillation is a process of converting a single
constituent from a liquid (or mixture) into its vapour,
transferring the vapour to another place and recovering
the liquid by condensing the vapour, usually by allowing it
to come in contact with a cold surface.
○ This process is known differential distillation, as
distillation is based on the differences in volatilities and
vapour pressures of the components in the mixture.
23
6. Principle:
○ Liquid boils when its vapour pressure is equal to atmospheric
pressure. Simple distillation is conducted at its boiling point.
○ The higher the relative volatility of a liquid, the better is the
separation by simple distillation. Heat is supplied to the liquid so
that it boils. The resulting vapour is transferred to a different place
and condensed.
CONSTRUCTION:
○ It consists of a distillation flask with a side arm sloping
downwards.
○ Condenser is fitted into the side arm by means of a cork.
○ The condenser is usually water condenser, i.e., jacketed for
circulation of water.
○ The condenser is connected to a receiver flask using an adapter
with ground glass joints.
○ On a laboratory scale, the whole apparatus is made of glass. 24
7.
8. WORKING:
○ The liquid to be distilled is filled into the flask to one-half to
two-third of its volume. Bumping is avoided by adding small
pieces of porcelain before distillation.
○ A thermometer is inserted into the cork and fixed to the flask.
The thermometer bulb must be just below the level of the
side arm.
○ Water is circulated through the jacket of the condenser.
The contents are heated gradually.
○ The liquid begins to boil after some time. The vapour
begins to rise up and passes down the side arm into the
condenser.
○ The temperature rises rapidly and reaches a constant
value.
○ The temperature of the distillate is noted down, which is
equal to the boiling point of the liquid. The vapour is
condensed and collected into the receiver.
26
9. ○ The flame is adjusted so that the distillate is collected at
the rate of one to two drops per second. Distillation should
be continued until a small volume of liquid remains in the
flask.
Applications:
○ For the preparation of distilled water and water for injection.
○ Volatile and aromatic waters are prepared.
○ Organic solvents are purified.
○ A few official compounds are prepared by distillation.
Examples are spirit of nitrous ether and aromatic spirit of
ammonia.
○ Non-volatile solids are separated from volatile liquids.
10. 2. FLASH DISTILLATION
○ Flash distillation is defined as a process in which the
entire liquid mixture is suddenly vaporized (flash) by
passing the feed from a high pressure zone to a low
pressure zone.
○ Flash distillation is also known as equilibrium distillation,
i.e., separation is attempted when the liquid and vapour
phases are in equilibrium. This method is frequently
carried out as a continuous process and does not involve
rectification.
11. Principle:
○ When a hot liquid mixture is allowed to enter from a high-
pressure zone into a low-pressure zone, the entire liquid
mixture is suddenly vaporised.
○ This process is known as flash vaporisation. During
this process the chamber gets cooled. The individual
vapour phase molecules of high boiling fraction get
condensed, while low boiling fraction remains as
vapour.
13. Working:
○ The feed is pumped through a heater at a certain pressure.
○ The liquid gets heated, which enters the vapour-liquid separator
through a pressure-reducing valve.
○ Due to the drop in pressure, the hot liquid flashes, which
further enhances the vaporisation process.
○ The sudden vaporisation induces cooling. The individual
vapour phase molecules of high boiling fraction get
condensed, while low boiling fraction remains as vapour.
14. ○ The mixture is allowed for a sufficient time, so that
vapour and liquid portions separate and achieve
equilibrium.
○ The vapour is separated through a pipe from above and
liquid is collected from the bottom of the separator.
○ By continuously feeding into the still, it is possible to obtain
continuous flash distillation.
○ The operating conditions can be adjusted in such a way
that the amount of feed exactly equals the amount of
material removed.
○ Therefore, vapour and liquid concentrations at any
point remain constant in the unit.
15. Uses:
✓ Flash distillation is used for separating components, which boil
at widely different temperatures. It is widely used in petroleum
industry for refining crude oil.
Advantages:
✓ Flash distillation is a continuous process.
Disadvantages:
✓ It is not effective in separating components of comparable
volatility.
✓ It is not an efficient distillation when nearly pure components
are required, because the condensed vapour and residual liquid
are far from pure.
16. 3. VACUUM DISTILLATION
• The distillation process in which the liquid is distilled at a
temperature lower than its boiling point by the application
of vacuum. Vacuum pumps, suction pumps, etc. are
used to reduce the pressure on the liquid surface.
Distillation under the reduced pressure is based on the
principle of the simple distillation with some
modifications.
17.
18. vapour.
Principle:
• Liquid boils when vapour pressure is equal to the atmospheric
pressure, i.e., pressure on its surface. If the external pressure is
reduced by applying vacuum, the boiling point of liquid is
lowered.
• Therefore, the liquid boils at a lower temperature. This principle is
illustrated using an example of water.
• Water boils at an 100°C at an atmospheric pressure is 101.3I kPa
(760 mm Hg). At 40°C, the vapour pressure of water is
approximately 9.33 kPa (70 mm Hg). Hence, the external
pressure is reduced to 9.33 kPa (70 mm Hg) where water boils at
40°C. The net result is the increase in rate of mass transfer into
19. Assembling of apparatus:
○ It consists of a double-neck distillation flask known as Claisen flask .
○ Thick walled glass apparatus with interchangeable standard glass joints are
used for vacuum distillation.
○ In one of the necks of the Claisen flask, a thermometer is fitted. The second
neck prevents splashing of the violently agitated liquid.
○ Bumping occurs readily during vacuum distillation. Placing a fine capillary
tube in the second neck of the flask can prevent bumping.
○ The capillary tube is dipped in the boiling liquid, so that a stream of air
bubbles is drawn out.
○ Water bath or oil bath is used for heating.
○ The Claisen flask is connected to a receiver through a condenser.
○ Vacuum pump is attached through an adapter to the receiver. A small
pressure gau3g8e (manometer) should be inserted between the pump and
the receiver.
20. • Applications:
• Preventing degradation of active constituents (≈ 55◦C)
• Enzymes - malt extract, pancreatin
• Vitamins - thiamine, ascorbic acid
Glycosides - anthraquinones
Alkaloids - hyocyamine to atropine
• Disadvantages:
• In vacuum distillation, persistent foaming occurs. This may be
overcome by adding capryl alcohol to the liquid or by inserting
a fine air capillary tube in the second neck of the Claisen
flask.
• The stream of air is drawn in and breaks the rising foam. The
above method is not suitable for the preparation of semisolid
or solid extracts by distillation under vacuum. 39
21. 4. MOLECULAR DISTILLATION
○ It is defined as a distillation process in which each
molecule in the vapour phase travels mean free path
intermolecular
and gets condensed
collisions on
individually without
application of vacuum.
Molecular distillation is based on the principle of the
simple distillation with some modifications. This is
also called Evaporation distillation or Short path
distillation.
40
22. Principle:
○ The substances to be distilled have very low vapour pressures.
examples are viscous liquids, oils, greases, waxy materials and high
molecular weight substances.
○ These boil at very high temperature. In order to decrease the boiling
point of the liquids, high vacuum must be applied.
○ The pressure exerted by vapors above the liquid is much lower.
At very low pressure, the distance between the evaporating surface
and the condenser is approximately equal to the mean free path of the
vapour molecules.
○ Molecules leaving the surface of the liquid are more likely hit the
condenser surface nearby. each molecule is condensed individually.
the distillate is subsequently collected.
41
23. Applications:
Molecular distillation is used for the purification and separation of chemicals of
low vapour pressure.
1. Purification of chemicals such as tricresyl phosphate, dibutyl phthalate and
dimethyl phthalate.
2. More frequently used in the refining of fixed oils.
3. Vitamin A is separated from fish liver oil. Vitamin's is concentrated bythis
method from fish liver oils and other vegetable oils.
4. Free fatty acids are distilled at 100°C.
5. Steroids can be obtained between 100°C and 200°C,
6. Triglycerides can be obtained from 200°C onwards.
Proteins and gums will remain as nonvolatile residues. Thus, the above
mixture can be separated by molecular distillation. 42
24.
25. Principle:
➢ In this method, liquid feed is introduced into a vessel, which is
rotated at very high speed (centrifugal action).
➢ On account of heating, vaporisation occurs from a film of liquid
on the sides of the vessel.
➢ The vapour (molecules) travels a short distance and gets
condensed on the adjacent condenser.
➢ Each molecule is condensed individually. The
subsequently collected.
distillate is
46
26. Construction:
❖ It consists of a bucket-shaped vessel having a diameter of about 1
to 1.5 m.
❖ It is rotated at high speed using a motor.
❖ Radiant heaters are provided externally to heat the fluid in the
bucket.
❖ Condensers are arranged very close to the evaporating surface.
❖ Vacuum pump is connected to the entire vessel at the top.
❖ Provisions are made for introducing the feed into the centre of the
bucket, for receiving the product and residue for re-circulation.
47
27. through the feed port for further distillation.
Working:
❖ Vacuum is applied at the centre of the vessel.
❖ The bucket shaped vessel is allowed to rotate at high speed.
❖ The feed is introduced from the centre of the vessel.
❖ Due to centrifugal action of the rotating bucket, liquid moves outward over the
surface of the vessel and forms a film.
❖ Since, the radiant heaters heat the surface, the liquid evaporates directly from
the film.
❖ The vapour (molecules) travels its mean tree path and strikes the condenser.
❖ The condensate is collected into another vessel.
❖ The residue is collected from the bottom of the vessel and is recirculated
48
28. 5. STEAM DISTILLATION
○ Steam distillation is method of distillation carried out with
aid of steam.
○ It is used to separate
• -High boiling substances from non-volatile impurities
• -Separate immiscible liquids
29. Principle:
A mixture of immiscible liquids begins to boil when
sum of their vapour pressure is equal to atmospheric
pressure.
In case of mixture of water and turpentine, mixture boils
below the boiling point of pure water, though the turpentine boils
at a much higher temperature than that of water.
30. Application:
➢ Used to separate immiscible liquids. Ex- Water + Toluene
Extraction at much lower temperature to protect from
decomposition without loss of aroma
➢ To extract volatile oils like clove, anise and eucalyptus oils.
➢ Purification of essential oils like almond oil.
➢ Camphor is distilled by this method.
➢ Aromatic water are prepared.
Limitation:
Not suitable when two immiscible liquids reacts with each other.
31. ➢ Provision are made to heat both steam can and flask separately.
Construction of assembly:
➢ Metallic steam can fitted with cork having two holes.
➢ Safety tube inserted up to bottom through one hole to maintain pressure
in side stem can, more over when steam comes out from safety tube
indicates that can is empty.
➢ Through other hole band tube is passed and other end of this tube is
connected to flask containing non-aqueous liquid in which tube is dipped.
➢ Flask and condenser is connected with delivery tube.
➢ Condenser is connected to receiver with help of adopter.
32.
33. ➢ Provision are made to heat both steam can and flask separately.
Working:
➢ Metallic steam can fitted with cork having two holes.
➢ Safety tube inserted up to bottom through one hole to maintain pressure
in side stem can, more over when steam comes out from safety tube
indicates that can is empty.
➢ Through other hole band tube is passed and other end of this tube is
connected to flask containing non-aqueous liquid in which tube is dipped.
➢ Flask and condenser is connected with delivery tube.
➢ Condenser is connected to receiver with help of adopter.
34. FRACTIONAL DISTILLATION
➢ This method is also known as rectification, because a part of
the vapour is condensed and returned as a liquid.
➢This method is used to separate miscible volatile liquids, whose
boiling points are close, by means of a fractionating column.
➢Fractional distillation is a process in which vaporisation of liquid
mixture gives rise to a mixture of constituents from which the
desired one is separated in pure form.
64
36. ➢In simple distillation,
vapour is directly passed
through the condenser.
➢Condensate is collected
directly into the receiver,
➢ In fractional distillation the vapour
must pass through a fractionating
column in which partial condensation
of vapour is allowed to occur.
➢Condensation takes place in the
fractionating column, so that a part of
the condensing vapour returns to the
still.
Simple Distillation Vs Fractional Distillation
37. Principle:
➢ When a liquid mixture is distilled, the partial condensation of the
vapour is allowed to occur in a fractionating column.
➢In the column, ascending vapour from the still is allowed to come
in contact with the condensing vapour returning to the still.
➢This results is enrichment of the vapour with the more volatile
component.
➢By condensing the vapour and reheating the liquid repeatedly,
equilibrium between liquid and vapour is set up at each stage, which
ultimately results in the separation of a more volatile component.
38. Applications:
Fractional distillation is used for the separation of volatile miscible liquids with
near boiling point such as
•Acetone and water
•Chloroform and benzene
Disadvantage:
Fractional distillation cannot be used to separate miscible liquids, which form
PURE azeotropic mixtures.
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