The parietal lobe is involved in sensory processing, spatial awareness, and motor coordination. Unilateral lesions can cause sensory deficits, visual field cuts, and neglect of the opposite side of space. Bilateral lesions are associated with Balint's syndrome of simultanagnosia, optic ataxia, and ocular apraxia. Dominant parietal lesions may induce Gerstmann syndrome, alexia, or conduction aphasia, while nondominant lesions can result in anosognosia, topographic disorientation, and blepharospasm.
Intramedullary spinal cord tumor is the rare condition demanding high index of suspicion in diagnosis and high yield surgical expertise to produce good outcome.
I. The carotid system.
II. The vertebral system.
1) The ophthalmic artery.
2) The anterior choroidal artery.
3) The posterior communicating artery
II. The Vertebro-Basilar System VOS
brain stem syndromes
Intramedullary spinal cord tumor is the rare condition demanding high index of suspicion in diagnosis and high yield surgical expertise to produce good outcome.
I. The carotid system.
II. The vertebral system.
1) The ophthalmic artery.
2) The anterior choroidal artery.
3) The posterior communicating artery
II. The Vertebro-Basilar System VOS
brain stem syndromes
Due to damage of the CNS or PNS or both. There is some involvement of the basic motor processes used in speech and this results in a movement disorder...
8% of all bone tumors present in spine
25-30% of bone tumors are benign
Peak age: 2-3rd decade
Posterior element involved: osteoid osteoma, osteoblastoma, aneurysmal bone cyst
Anterior element involved: giant cell tumor, hemangioma, eosinophilic granuloma
Functional Independence Measure (FIM)
Is an 18-item, 7-level ordinal scale
Is designed to assess areas of dysfunction in activities that commonly occur
The scale has few cognitive, behavioral, and communication-related functional items
Is not specific for spinal cord injuries but is designed to assess neurological, musculoskeletal, and other disorders.
It Is essentialy diencephalon structure but anatomically situated at the diencephalo-mesencephalic junction at the level of the incisure of the cerebellar tentorium.
Axons of the peripheral nervous system have the potential for regeneration, after they are severed.
Axons of the peripheral nervous system have the potential for regeneration, after they are severed.
Delivery of electrical current to a specific subcortical grey matter target to stimulate a desired group of nerve cells which results in specific modulation the output of the involved neurocirciut.
Ephaptic transmission of impulses between neighbouring neurons (i.e. coupling of adjacent nerve fibres due to local exchange of ions or local electric fields) leading to excessive or abnormal firing.
An entrapment neuropathy is defined as a pressure or pressure-induced injury to a segment of a peripheral nerve secondary to anatomic or pathologic structures.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Anatomy
• Limits
• Anteriorly – Central Sulcus
• Posteriorly
• Parieto-occipital sulcus superiorly
• Preoccipital notch inferiorly
• Inferiorly – Sylvian fissure
• Parts
• Two sulci
• Post-central sulcus
• Interparietal sulcus
• Inferior Parietal Lobule
• Supramarginal Gyrus (Area 40)
• Angular Gyrus (Area 39)
• Superior Parietal Lobule
• Bound by the post central gyrus,
interparietal gyrus and extends
onto the medial surface (areas 5
and 7)
• Post central gyrus
• Brodmans areas 1, 2 and 3
3.
4. Brodman Areas In the Parietal Lobe
• Area 1, 2 and 3 – Postcentral Gyrus
• Primary sensory cortex
• Area 5 – Somatosensory association
cortex
• Area 7 – Somatosensory association
cortex
• Together form the superior parietal
lobule
• Area 39 – Wernicke’s area – Angular
Gyrus
• Area 40 – Supramarginal Gyrus
5.
6. Unilateral Parietal Lobe Disease
• On either side
• Cortical Sensory syndrome
• Sensory extinction
• Homonymous hemianopia with visual inattention
• Contralateral neglect
• Abolition of optokinetic nystagmus to one side
8. Cortical Sensory Syndrome
• Loss of position sense and passive movement sense
• Inability to localize touch, temperature or pain
• Astereognosis
• Agraphesthesia
• Loss of two-point discrimination
• Easy fatigability of sensory perceptions
• Difficulty in distinguishing simultaneous stimulations
• Hyperpathia
• Touch hallucinations
• Preservation sensations – Pain, Pressure, Touch, Temperature, Vibration
(when the postcentral gyrus is not involved in the lesions)
9. Exceptions
• Cortical lesion presenting as a thalamic syndrome
• Dejerine and Mouzon’s sensory syndrome
• touch, pressure, pain, thermal, vibratory, and position sense are lost on one
side of the body or in a limb
• Typically seen with thalamic lesions
• May occur with acute lesions involving the central and subcortical region of
the parietal lobe
• Cortical lesion presenting as radiculopathy or peripheral neuropathy
• May be cause by smaller lesions – glancing blows to the skull
• Pseudothalamic Pain Syndrome
• Pain on the side deprived of sensations
10. Character of Parietal Sensory Defects
• Easy fatigability
• Inconsistent response to stimuli
• Tactile extinction – disregard of stimuli on affected side when both
sides are stimulated simultaneously
• Hyperpathia
11. Anton Babinski Syndrome
• Anosognosia (anos- disease, agnosia – lack of knowledge)
• Apathy
• Allocheria
• Dressing apraxia
• Extinction
• Contralateral visual field inattention
12. • Anosognosia
• Lesion lies in the cortex and white matter of Superior Parietal lobule
• Rarely lesion of ventrolateral thalamus and adjacent parietal lobe white matter may
show similar symptoms
• Unilateral Astomatognosia is more often associated with Nondominant lesions than
with Dominant parietal lesions
• In respect to spatial attention, the right parietal lobe is truly dominant
• Unilateral Spatial Neglect
• Ask the patient to draw a clock, copy a flower
• Rejection Behaviour
• Loss of exploratory and orienting behaviour with the contralateral arm
• Tendency to avoid tactile stimuli
• Release of grasp reflex –
• Frontal – self grasp not present
• Parietal – self grasp present
13.
14. Motor disturbances with parietal lobe lesions
• Mild hemiparesis – significant contribution to the corticospinal tract
• May simulate a hemiplegia because of inability to move the limb
• Reduced movements of opposite side – Parietal lesions have been
reported to cause contralateral muscular atrophy and trophic skin
changes
• Optic ataxia – inability to grasp an object under visual guidance
• Pseudocerebellar syndrome – intention tremor and incoordination
• Pseudoathetosis – random finger movements in an outstretched
hand
• Apraxias
15. Apraxia
• Loss of the ability to execute previously learned activities in the
absence of weakness, ataxia, sensory loss, or extrapyramidal
derangement that would be adequate to explain the deficit.
• Planned or commanded action is normally first conceptualized in the
parietal lobe of the language-dominant hemisphere, where visual,
auditory, and somesthetic information is integrated – The space-time
plan
16. Apraxia
• Ideational apraxia – What to do?
• The failure to conceive or formulate an action to command
• Areas 5 and 7 in dominant parietal lobe + supplementary and premotor cortex of bilateral
frontal lobe
• Ideomotor apraxia – How to do?
• Impaired performance of skilled motor acts despite intact sensory, motor, and language
function.
• Patient may know how to do a task but is unable to execute it.
• Oral-buccal-lingual apraxia
• Inability to carry out facial movements on command
• May be able to imitate them
• Left supramarginal gyrus or the left motor association cortex
• Limb-kinetic apraxia
• Clumsiness due to inability to fluidly connect the various movements of the hand or limbs.
17. Apraxia
• The exact lesion - Variable
• Supramarginal gyrus
• Superior parietal lobe (areas 5 and 7)
• Subcortical or cortical
• Majority of lesions – Left hemisphere
18. Testing for Apraxia
1. Observe the actions of a patient while he engages in simulated
tasks
2. Ask he patient to carry out symbolic acts
• Wave goodbye
• Salute
• Blow a kiss
3. Ask the patient to imitate such acts if he cannot perform them on
command
4. Ask him to do more complex tasks – simulate taking out comb from
pocket and comb hair, brush teeth, hammer a nail…
19. Gerstmann Syndrome
• Left-Right Confusion
• Dysgraphia
• Finger agnosia
• Acalculia
• Lesion in inferior parietal lobule – angular gyrus and subjacent white
matter
• Spatial knowledge mediated by the language has been proposed as a
basic underlying deficit
20. • The right angular gyrus clearly participates in visuospatial processing,
and damage to it results in severe hemi-spatial neglect.
• The left angular gyrus participate in calculation abilities, reading/
writing, naming, and some type of body-knowledge (somatognosis).
21. Visual Disorders in Parietal Lobe Lesion
• Visual Field Defects
• Homonymous hemianopia
• Homonymous inferior quadrantanopia
• Visual neglect
• Posterior parietal lesions
• More prominent on the right side
• Loss of optokinetic nystagmus
• Abolished when following objects towards the lesion side
22. • Posterior Parietal Lesions
• Deficits in localization of visual stimuli
• Inability to compare the sizes of objects
• Failure to avoid objects when walking
• Inability to count objects
• Disturbances in smooth-pursuit eye movements
• Loss of stereoscopic vision
• Blepharospasm
• Disinclination to open eyelids when addressed
• Intense blepharospasm precluding ocular examination
• Topographagnosia
• Patients are unable to orient themselves to abstract space
• Loss of topographical memory
23. Auditory Neglect
• Less apparent than is visual neglect
• Displacement of the direction of the perceived origin of sounds
toward the opposite side
• Lesion in right superior lobule.
24. Balint Syndrome
• Visual-spatial Imperception – Simultagnosia
• Unable to percieve more than a single object at a time
• Optic Apraxia
• Difficulty in directing gaze to an object
• Optic Ataxia
• Difficulty in reaching out to an object under vision
25. Aphasias seen with Parietal Lobe Lesions
• Wernicke’s Aphasia
• Temporal, supramarginal and angular gyri
• Fluent aphasia – neologism, lacks meaning
• No repetition
• Greatly impaired comprehension
• Transcortical Sensory Aphasia
• Similar to Wernicke’s but repetition is preserved
• Lesion is near the Wernicke’s area
• Conduction Aphasia
• Lesion in supramarginal gyrus or insula
• Fluent aphasia where comprehension and is preserved but repetition is lost
26. Summary
• Unilateral Parietal Lobe Syndrome
• Sensory disturbances
• Homonymous hemianopia
• Abolition of optokinetic nystagmus with target moving toward side of the
lesion
• Contralateral Hemineglect
• Dominant Parietal Lobe Lesion
• Language dysfunction (Alexia)
• Gerstmann syndrome
• Bilateral astereognosis
• Bilateral apraxia