1) The document discusses signs associated with lesions in the frontal and parietal lobes. Tests are described to assess functions localized to these regions like motor skills, memory, attention, and language abilities.
2) Parietal lobe signs include sensory deficits, agnosias like finger agnosia, and apraxias involving how to complete tasks. Tests evaluate two-point discrimination, graphesthesia, and stereognosis.
3) Both lobes are involved in executive functions and attention. Tests mentioned include the Wisconsin Card Sorting Test, Trail Making Test, and Stroop Test.
این ارائه در کارگاه تخصصی تقلید و آپراکسی سرنخ هایی برای مداخلات مبتنی بر شواهد توسط دکتر هاشم فرهنگ دوست تدریس شده است.
برای مطالعه مطالب بیشتر در این زمینه به وب سایت فروردین مراجعه کنید.
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Surgical approach to thalamus explained in details their surgical anatomy and lesion, Preop post op results with different surgical approach for thalamic lesions
Preoperative assessment of epilepsy clinical & radiological, eeg, megDr Fakir Mohan Sahu
Preoperative Assessment of Epilepsy and their localization, clinical semiology and Radiological evaluation MRI imaging, Video EEG MEG SPECT PET and patient management conference explained in simplified way
General Basic knowledge of Brain tumour explained in brief of classification, pathogenesis, clinical features, CT, MRI, management, Radiotherapy. Best for MBBS and PG preparation student.
Facial and Hearing Preservation in Acoustic Neuroma SurgeryDr Fakir Mohan Sahu
Vestibular Schwannoma Most common CPA (Cerebellopontine angle) tumor changed from prolongation of life to nerve preservation explained in brief with all pre- operative work up.
Details of Cerebrospinal Fluid special reference to cell count and alteration of CSF Hydrodynamics explained in brief and Different Diagnostic parameters to Hydrocephalus
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. Functional region of the frontal lobe
• I Primary motor area
• II. Premotor area
• III. Frontal eye fields
• IV. Dorsolateral prefrontal cortex
• V. Orbital and basal areas
• VI. Supplementary motor area and anterior cingulated gyrus area
4. Clinical Assessment of frontal lobe sign
• History, Examination and formal tests :
Abnormal behavior, speech disorder, urinary incontinence, Frontal
gait(magnetic gait) , weakness of limbs
• Test sense of smell.
• Frontal release reflexes
Grasp reflex
Sucking reflex (pout, snout, rooting)
Palmo-mental reflex
Glabellar tap reflex
5. Emotional make-up and personality is best assessed by
history from family / friends & observation.
•Abstraction and judgment are assessed by proverb
interpretation and similarities.
•E.g explain in your own words the meaning of
•Don’t cry over spilled milk
•Similarity between mango and orange, car and airplane.
6. Attentionand memory
• Alternative sequence (e.g. copying MNMN)- Attention
• Motor Luria’s ‘fist-edge-palm’ test
• Go/no-go
• Digit span test: Measure of short term memory
9. To assess perseveration and abstract thinking.
Measure of executive function.
Consists of four key cards and 128 response cards.
Wisconsin Card Sorting Test(WCST)
10. Trail Making Test
• Test for visual attention and task switching.
.
• In Part A, the circles are numbered 1 – 25
• In Part B, the circles include both numbers (1 –
13) and letters (A – L); (i.e., 1-A-2-B-3-C, etc.).
15. Tests for cortical sensations
A. Two point discrimination
: Calipers or compass
used.
Sites – Palms (8-15 mm)
Dorsum (2-3cm)
Back (3-4 cm).
16. B. Graphesthesia :
Done with pencil or swab stick.
sites – palms, fingers and face.
C. Stereognosis :
• No preliminary visual demo given.
• ex: key, pen or coin
17. ASOMATAGNOSIAS
• Inability to feel, recognize, or be conscious
of one’s own specific body parts or bodily
conditions.
ANOSAGNOSIA
• Denial of illness
HEMI NEGLECT
• Neglect on one side of body in dressing and
grooming.
19. Tests for finger agnosia
• Inability to name , point or recognize
fingers on oneself or others.
1. Non verbal finger recognition
2. Verbal finger recognition
20. Tests for right – left confusion
Identification on self
.
Crossed commands on self
Identification on examiner
Crossed commands on examiner
.
21. Tests for calculations
Components – Rote tables (add, multiply,
etc) Recognition of signs (+ , - , * )
Basic arithmetic(carrying, borrowing)
Spatial alignment of written
calculations
• Verbal rote examples : what is 4 plus 6 ?
• Verbal complex examples : what is 21 / 5 ?
22. • Written complex examples :
• Pt with rt.
hemisphere lesion
& left neglect.
• Pt with rt. parietal
hematoma –
showing poor
alignment and
calculation errors.
23. APRAXIA AND PARIETAL LOBE
• An inability to carry out a commanded task
despite the retention of motor and sensory
function
25. IDEOMOTOR APRAXIA (“how to do”)
• Most common type of apraxia
i. Buccofacial apraxia
ii. Limb apraxia
iii. Whole body apraxia
26. IDEATIONAL APRAXIA (“what todo”)
• Able to do individual tasks, but
cann't integrate them as a
whole.
• ‘Conceptual apraxia’ - inability to
recognise the use of objects.
(object agnosia)
27. CONSTRUCTIONAL APRAXIA
• Constructional ability/praxis
(visuoconstructive ability)
• Non dominant parietal lobe
• Area
17
IPL (kinesthetic analysis of visual
patterns done here)
Premotor
area
28. DRESSING APRAXIA
• Not a true apraxia.
• Combination of spatial disorientation
and visuospatial inattention.
29. VISUAL DISORDERS
• Optic radiation passes through Inferior part of
the parietal lobe – incongruous homonymous
hemianopia or an inferior quadrantanopia.
• Rt. angular gyrus - Left sided visual neglect.
30. AUDITORY NEGLECT
• In right parietal lesions are initially unresponsive to
voices or noises on the left side.
• Main lesion - right superior lobule.
The dorsolateral frontal cortex is concerned with planning, strategy formation, and executive function.
The frontal operculum contains the centre for expression of language.
The orbitofrontal cortex is concerned with response inhibition
Broca's area: expressive language, i.e. language production.
Frontal eye field area :Voluntary eye movements
The primitive reflexes are present in normal babies. As the CNS matures, frontal lobe cells develop and begin to inhibit these reflexes. They may reappear with brain damage or disease
Attention is the patient’s ability to attend to a specific stimulus without being distracted by external, internal or environmental stimuli.
An example is to ask the patient to tap the knee when the examiner says "Stop" and not to tap when the examiner says "Go"
“repeat 3-5; 7-5-8; 3-9-4-8..” N: >5 increasing sequence of no
A two year child has a digit span of 2, 3yr- 3, 4yr- 4, 5yr- 5, 6yr-6 and 7yr to adult- 7
Using A F S normal individual more than 10 also check for repitation no less than 8 abnrmal
Trail Making Test consist of 25 circles distIn
Part A, the circles are numbered 1 – 25, and the patient should draw lines to connect the numbers in ascending order.
ributed over a sheet of paper
In Part B, the circles include both numbers (1 – 13) and letters (A – L); as in Part A, the patient draws lines to connect the circles in an ascending pattern, but with the added task of alternating between the numbers and letters (i.e., 1-A-2-B-3-C, etc.).
Test of inhibition response
Patients are asked to state the color in which words are printed rather than the words themselves
failed inhibition
PRIMARY SOMASTHETIC AREA Body image representation
SOMASTHETIC ASSOCIATION AREA Body in space and Tactile discrimination
SUPERIOR PARIETAL LOBULE connections with all lobes) Visual spatial properties Visual attention, 3 D analysis of body space interactions
cingulate gyrus and prefrontal cortex . Therefore they mediate influence of emotion, attention and motivation
INFERIOR PARIETAL LOBULE reading , calculations
Angular gyrus & Supra marginal gyrus- they have interconnections with visual, auditory, somasthetic, supr. colliculus, LGB and other lobes
Cortical defect is essentially to one of sensory discrimination i.e impaired ability to integrate and localize stimuli.
Inability to recognize part of one’s body.
Ask pt. to close both eyes – respond as ‘one’ or ‘two’.
Single and double points to be differentiated
Compare with other side
Tongue 1mm
Lips-4 mm
Digits like 1-9 , or shapes/symbols used.
abnormal side done first and then normal side.
(perception of one’s body and the relations of bodily parts to one another)
Even when patients are told that the body part belongs to them, many will deny the reality and remain firm in their belief that it is not a part of them.
It’s the lack of awarence or insight in pt to understand that suffered from any disease, refuse medication and trt.
Shave only one side or use only one sleeve of shirt.
Fail to use one side of body, even though paralysis is not present
Denial and neglect - non-dominant parietal lesions.
Parietal lobe is – “ Lobe of hand ”.
Hand is extensively represented
Parietal lobe gathers information regarding various objects through hand
An example of bilateral asomatognosia and is due to lesion in left dominant. inferior parietal lobule (angular gyrus).
with pt eyes closed, touch one of his fingers. Ask him to touch the same finger of examiner, with eyes open.
Examiner places hand in some irregular position and asks pt – “ point to my middle finger”
ex : show your left foot
ex : with your right hand touch your left ear
ex : point my right elbow
ex : with your left hand point my right foot
Lt parietal lesions – inability to understand and carry out numericals.
Severe acalculia = Anarithmetria.
Rt parietal lesions – inability to align numbers and to do complex computations (borrowing, carrying, etc).
But, pt can do problems in his head.
Defect - unable to show, but uses the object. –
unable to do whole task, but does individual tasks.