Ophthalmia neonatorum is inflammation of the conjunctiva in infants less than 30 days old, usually caused by infections transmitted during or after birth. Common causes include gonorrhea, chlamydia, staph, and strep bacteria. Left untreated, gonorrheal ophthalmia can lead to corneal ulceration and blindness. Prophylactic treatment with antibiotics like tetracycline or erythromycin ointment immediately after birth can prevent most cases. For diagnosed infections, treatment involves topical antibiotics, antivirals, or antiseptics as well as systemic antibiotics depending on the causative agent. Prompt and complete treatment is important to resolve symptoms and prevent complications.
Ophthalmia Neonatorum or Neonatal ConjunctivitisAakanksha Bajpai
This presentation describe the condition of eye which is very common among neonates i.e. ophthalmia neonatorum which is otherwise also known as neonatal conjunctivitis. the major causes,diagnostic tests and manqgement is described here. Also ways to prevent it are explained.
Ophthalmia Neonatorum or Neonatal ConjunctivitisAakanksha Bajpai
This presentation describe the condition of eye which is very common among neonates i.e. ophthalmia neonatorum which is otherwise also known as neonatal conjunctivitis. the major causes,diagnostic tests and manqgement is described here. Also ways to prevent it are explained.
A congenital opacity of the crystalline lens. Cloudiness in the lens of the eye that is present at, or develops shortly after birth. Congenital cataracts are also the most frequent cause of leukocoria (white pupil) in children.
BLEPHARITIS BY RAIN HEALTH CARE
RAIN HEALTH CARE
http://www.rainhealthcare.ml/
BLEPHARITIS BY INDRAJIT BISWAS
causes of blepharitis
complications of blepharitis,
home remedies for blepharitis,
indrajit biswas,
rain health care,
sign of blepharitis, symptoms of blepharitis,
treatment of blepharitis,
what is blepharitis
The corneal diseases are one of the leading causes of blindness in the world. in most cases, these infections are preventable or treatable.
This seminar provides an overview of the anatomy and physiology of the cornea, as well as an overview of common conditions.
A congenital opacity of the crystalline lens. Cloudiness in the lens of the eye that is present at, or develops shortly after birth. Congenital cataracts are also the most frequent cause of leukocoria (white pupil) in children.
BLEPHARITIS BY RAIN HEALTH CARE
RAIN HEALTH CARE
http://www.rainhealthcare.ml/
BLEPHARITIS BY INDRAJIT BISWAS
causes of blepharitis
complications of blepharitis,
home remedies for blepharitis,
indrajit biswas,
rain health care,
sign of blepharitis, symptoms of blepharitis,
treatment of blepharitis,
what is blepharitis
The corneal diseases are one of the leading causes of blindness in the world. in most cases, these infections are preventable or treatable.
This seminar provides an overview of the anatomy and physiology of the cornea, as well as an overview of common conditions.
Conjunctivitis is the inflammation of conjunctiva & is also called as "pink eye"
Some forms of conjunctivitis are contagious while other forms caused by trauma are non contagious. Neglected cases can loose their eyesight.
conjunctivitis is an eye disorder .this is all so known as pink eye .in the India south side people it is called as madras eye ..in this slide mentioned about .definition, review anatomy and physiology, types including causes , pathophysiology, signs and symptoms, treatment, nursing management, and prevention are there. the client who is affected with this use separate towels, wash your hands daily, eat eye healthy foods like vitamin a , e,omega 3 fatty acid, this will help the eyes verywell.eye exercise very helpful for eye health.if eye sensitive is there use sun glass that is very help full for the eye , eye staraning should be avioded.if the school student is affected means student should not go to the school for one week.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Ophthalmia neonatorum.docx
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Compiled by: Dr. Iddi Ndyabawe
OPHTHALMIA NEONATORUM
Ophthalmia neonatorum is the name given to bilateral inflammation of the conjunctiva occurring
in an infant, less than 30 days old.
It is a preventable disease usually occurring as a result of carelessness at the time of birth.
As a matter of fact any discharge or even watering from the eyes in the first week of life should
arouse suspicion of ophthalmia neonatorum, as tears are not formed till then.
Etiology
Source and mode of infection
Infection may occur in three ways: before birth, during birth or after birth.
1. Before birth infection is very rare through infected liquor amnii in mothers with ruptured
membrances.
2. During birth. It is the most common mode of infection from the infected birth canal especially
when the child is born with face presentation or with forceps.
3. After birth. Infection may occur during first bath of newborn or from soiled clothes or fingers
with infected lochia.
Causative agents
1. Chemical conjunctivitis It is caused by silver nitrate or antibiotics used for prophylaxis.
2. Gonococcal infection was considered a serious disease in the past, as it used to be responsible
for 50 per cent of blindness in children. But, recently the decline in the incidence of gonorrhoea
as well as effective methods of prophylaxis and treatment have almost eliminated it in developed
countries. However, in many developing countries it still continues to be a problem.
3. Other bacterial infections, responsible for ophthalmia neonatorum are Staphylococcus
aureus, Streptococcus haemolyticus, and Streptococcus pneumoniae.
4. Neonatal inclusion conjunctivitis caused by serotypes D to K of Chlamydia trachomatis is
the commonest cause of ophthalmia neonatorum in developed countries.
5. Herpes simplex ophthalmia neonatorum is a rare condition caused by herpes simplex-II
virus.
2. 2
Clinical features
Incubation period
It varies depending on the type of the causative agent as shown below:
Symptoms and signs
1. Pain and tenderness in the eyeball.
2. Conjunctival discharge. It is purulent in gonococcal ophthalmia neonatorum and mucoid or
mucopurulent in other bacterial cases and neonatal inclusion conjunctivitis.
3. Lids are usually swollen.
4. Conjunctiva may show hyperaemia and chemosis.
There might be mild papillary response in neonatal inclusion conjunctivitis and herpes simplex
ophthalmia neonatorum.
5. Corneal involvement, though rare, may occur in the form of superficial punctate keratitis
especially in herpes simplex ophthalmia neonatorum.
Complications
Untreated cases, especially of gonococcal ophthalmia neonatorum, may develop corneal
ulceration, which may perforate rapidly resulting in corneal opacification or staphyloma
formation.
Treatment
Prophylactic treatment is always better than curative.
A. Prophylaxis needs antenatal, natal and postnatal care.
1. Antenatal measures include thorough care of mother and treatment of genital infections when
3. 3
suspected.
2. Natal measures are of utmost importance, as mostly infection occurs during childbirth.
Deliveries should be conducted under hygienic conditions taking all aseptic measures.
The newborn baby's closed lids should be thoroughly cleansed and dried.
3. Postnatal measures include:
Use of either 1 percent tetracycline ointment or 0.5 percent erythromycin ointment or 1
percent silver nitrate solution (Crede's method) into the eyes of the babies immediately after
birth.
Single injection of ceftriaxone 50 mg/kg IM or IV (not to exceed 125 mg) should be given to
infants born to mothers with untreated gonococcal infection.
B. Curative treatment. As a rule, conjunctival cytology samples and culture sensitivity swabs
should be taken before starting the treatment.
1. Chemical ophthalmia neonatorum is a self-limiting condition, and does not require any
treatment.
2. Gonococcal ophthalmia neonatorum needs prompt treatment to prevent complications.
i. Topical therapy should include:
-Saline lavage hourly till the discharge is eliminated.
-Bacitracin eye ointment 4 times/day. Because of resistant strains topical penicillin therapy is not
reliable. However in cases with proved penicillin susceptibility, penicillin drops 5000 to 10000
units per ml should be instilled every minute for half an hour, every five minutes for next half an
hour and then half hourly till the infection is controlled.
If cornea is involved then atropine sulphate ointment should be applied.
ii. Systemic therapy.
Neonates with gonococcal ophthalmia should be treated for 7 days with one of the following
regimes:
-Ceftriaxone 75-100 mg/kg/day IV or IM, QID.
-Cefotaxime 100-150 mg/kg/day IV or IM, 12 hourly.
-Ciprofloxacin 10-20 mg/kg/day or Norfloxacin 10 mg/kg/day.
If the gonococcal isolate is proved to be susceptible to penicillin, crystalline benzyl penicillin G
50,000 units to full term, normal weight babies and 20,000 units to premature or low weight
babies should be given intramuscularly twice daily for 3 days.
3. Other bacterial ophthalmia neonatorum should be treated by broad spectrum antibiotic drops
and ointments for 2 weeks.
4. 4
4. Neonatal inclusion conjunctivitis responds well to topical tetracycline 1 per cent or
erythromycin 0.5 per cent eye ointment QID for 3 weeks. However, systemic erythromycin
(125mg orally, QID for 3 weeks should also be given since the presence of chlamydia agents in
the conjunctiva implies colonization of upper respiratory tract as well. Both parents should also
be treated with systemic erythromycin.
5. Herpes simplex conjunctivitis is usually a self-limiting disease. However, topical antiviral
drugs control the infection more effectively and may prevent the recurrence.