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OLFACTORY NEUROBLASTOMA ESTHESIONEUROBLASTOMA  16 yr old male with                                                                         recurrent  nasal bleeding. Plain MR study of the brain / nasal region reveals ....................... ,[object Object]
Macrocyst along the periphery of the   intracranial component of the lesion.
Interspread  haemorrhage , microcysts in the core of the lesion.
Epicentre along the left nasal fossa  with more of the longitudinal than horizontal  extension. MERCURY IMAGING INSTITUTE  SCO 172-173 SEC 9C  CHANDIGARH MERCURY IMAGING CENTRE  SCO 16-17 SEC 20D CHANDIGARH
Esthesioblastoma a brief.............. Esthesioneuroblastomas are histologically similar to adrenal or sympathetic ganglionicneuroblastomas and retinoblastomas. Originally descried by Bergen et al. in 1924 as esthesioneuroepitheliomaolfactif .  Incidence peaks once in 11-20 years of age group and again in 50-60 years age group :However, age of these patients ranges from 3-88 years. It occurs equally in men and women.  Synonyms include olfactory esthesioneuroma, neuroesthesioma and olfactory neurocystoma.
EPICENTRE OF THE LESION IS MORE ANTERIORLY LOCATED AND  HELPS TO DISTINGUISH OLFACTORY NEUROBLATOMA FROM OTHER PATHOLOGIES LIKE ,[object Object]
 Nasopharyngeal carcinoma.
Pitutarymacroadenoma
 Juvenile angiofibromaEXTENSION OF THE LESION  IS  CRANIAL AND HELPS TO DISTINGUISH OLFACTORY NEUROBLASTOMA FROM   ,[object Object],PERITUMORAL CYSTS ARE APRPECIATED ALONG THE PERIPHERAL PART OF THE  INTRACRANIAL EXTENT OF THE OLFACTORY NEURO BLASTOMA  : Not appreciated in rest of the lesions  Like : Rabdomyosarcoma . An olfactory neuroblastoma (also known as an esthesioneuroblastoma) is a tumour arising from the basal layer of the olfactory epithelium in the superior recess of the nasal cavity.
T2w SEQUENCE – large macrocyst with  intermediate signal core contents in the intracranial  part of the  Mass . Multicompartmentinvolvement extending from the nasal cavity to sinuses to intracranial compartment.  ESTHESIONEUROBLASTOMAIS  ALMOST  ALWAYS UNILATERAL . ONLY NEGLECTED CASES MAY PRESENT AS BILATERAL NASAL FOSSA MASSES.

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Olfactory neuroblastoma

  • 1.
  • 2. Macrocyst along the periphery of the intracranial component of the lesion.
  • 3. Interspread haemorrhage , microcysts in the core of the lesion.
  • 4. Epicentre along the left nasal fossa with more of the longitudinal than horizontal extension. MERCURY IMAGING INSTITUTE SCO 172-173 SEC 9C CHANDIGARH MERCURY IMAGING CENTRE SCO 16-17 SEC 20D CHANDIGARH
  • 5. Esthesioblastoma a brief.............. Esthesioneuroblastomas are histologically similar to adrenal or sympathetic ganglionicneuroblastomas and retinoblastomas. Originally descried by Bergen et al. in 1924 as esthesioneuroepitheliomaolfactif . Incidence peaks once in 11-20 years of age group and again in 50-60 years age group :However, age of these patients ranges from 3-88 years. It occurs equally in men and women. Synonyms include olfactory esthesioneuroma, neuroesthesioma and olfactory neurocystoma.
  • 6.
  • 9.
  • 10. T2w SEQUENCE – large macrocyst with intermediate signal core contents in the intracranial part of the Mass . Multicompartmentinvolvement extending from the nasal cavity to sinuses to intracranial compartment. ESTHESIONEUROBLASTOMAIS ALMOST ALWAYS UNILATERAL . ONLY NEGLECTED CASES MAY PRESENT AS BILATERAL NASAL FOSSA MASSES.
  • 11. T2w sequence – Macrocyst with variegated intermediate signal core contents . Appreciate the buckling of the adjacent brain parenchyma
  • 12. No inversion of the cystic component of the mass lesion on FLAIR sequence.
  • 14. INTERMEDIATE TO HYPERINTENSE SIGNAL ON t1w SEQUENCE No inversion of the core contents on the fat sat sequence.
  • 15. No pathological restriction of diffusion . Interspread bloom on GRE sequence suggestive of haemorrhage / calcification
  • 16. Points of interest.................. Multicompartment involvement. Usually unilateral lesion. Longitudinal pattern of extension. Macro/ microcysts along the periphery of the intracranial part of the lesion.