Neuroblastoma diagnosis, treatment, complications, and further management. The main contents of this review have been accessed from MedScape. Please do not reprint or copy this material without permission from the copyright owner.
Presentation about the the second most common type of ovarian tumors which have a very unique property of being similar to the testicular germ cell tumors.
Presentation about the the second most common type of ovarian tumors which have a very unique property of being similar to the testicular germ cell tumors.
This presentation reviews the current neurosurgical management of patients with medulloblastoma, including the data on molecular subtyping; uses “medulloblastoma” as a springboard to discuss other topics / tumor cell biology in general; and formulates research questions to further advance neurosurgical basic science.
Dr Vandana, cranio spinal irradiation, radiotherapy, medulloblastoma, cancer, radiation, treatment, diagnosis, management, natural history of medulloblastoma, signs & symptoms of medulloblastoma,
current approach, future advancements
This presentation reviews the current neurosurgical management of patients with medulloblastoma, including the data on molecular subtyping; uses “medulloblastoma” as a springboard to discuss other topics / tumor cell biology in general; and formulates research questions to further advance neurosurgical basic science.
Dr Vandana, cranio spinal irradiation, radiotherapy, medulloblastoma, cancer, radiation, treatment, diagnosis, management, natural history of medulloblastoma, signs & symptoms of medulloblastoma,
current approach, future advancements
Audit of Appropriateness for Brain Scan Use for Paediatric Headache at the Em...Lyndon Woytuck
The purpose is to evaluate practice variation at the emergency department in comparison with best practice for brain imaging in children presenting with headache. The results of the study might be used to inform a clinical prediction rule in order to better stratify risk according to the American College of Radiology Appropriateness Criteria.
I created a poster for presentation and am currently working on a paper for publication in a scholarly journal.
Getting Compensation for a Personal Injuryanna barton
Personal Injury is the legal term for any kind of physiological, psychological or emotional injury that is caused to a person. If you have suffered any personal injury in recent times and were not in any way responsible for the accident, then you can file a personal injury claim to get compensation for all the losses you have suffered.
http://personalinjurycompensationhelp.weebly.com/
Lecture on DKA in pregnancy - presented at JGH Obstetrics & Gynaecology Teaching Jan 2020. Fictional details have been used to anonymise any resemblance to persons living or passed.
How is mental illness defined? Why is the philosophy of psychiatry the way it is today? Is there hope for improvement in the societal context of ill persons?
Poster: Audit of Appropriateness for Brain Scan Use for Paediatric Headache a...Lyndon Woytuck
The purpose is to evaluate practice variation at the emergency department in comparison with best practice for brain imaging in children presenting with headache. The results of the study might be used to inform a clinical prediction rule in order to better stratify risk according to the American College of Radiology Appropriateness Criteria.
I created a poster for presentation and am currently working on a paper for publication in a scholarly journal.
A review of mesenteric ischemia: investigations, treatment, surgical approach, medical therapy, and resolution. Flow charts are courtesy of UpToDate.com (all rights reserved 2017).
The aetiology, epidemiology, and investigative management of herpes zoster (shingles). The patient details have been changed and anonymised to protect the identity of the individual.
A review of the investigation and management of diabetic ketoacidosis in newly diagnosed type I diabetes. Patient details have been changed and anonymised to protect the identity of the individual.
Juvenile glaucoma: a case study and disease reviewLyndon Woytuck
A review of juvenile glaucoma including screening, diagnostic approach, and management. Patient details have been anonymised to protect the individual.
Case Study: Recurrent myoma with menorrhagiaLyndon Woytuck
A case study on a patient presenting with menorrhagia in a history of recurrent myomatous disease. The patient details have been changed to anonymize the individual.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. CELLULAR
• Neuroblasts are pluripotent stem
cells of the nervous system
• These cells migrate along the
neuraxis to populate various sites,
with tumours presenting in adrenal
medulla (40%), paraspinal ganglia
(25%), thoracic (15%), pelvic (5%),
cervical (3%), and miscellaneous
(12%)
• Neural crest tumours can be
classified as neuroblastoma,
ganglioneuroblastoma, and
ganglioneuroma, depending on the
degree of maturation and
differentiation of the tumour.
Histology: Top right - neuroblastoma: A
monotonous population of hyperchromatic
cells with scant cytoplasm. Bottom left -
ganglioneuroblastoma: Increased schwannian
stroma. Bottom right - ganglioneuroma:
Mature ganglion cell with schwannian stroma.
3. GENETIC
• MYCN oncogene is overexpressed via amplification of the distal arm
of chromosome 2 in approximately 25% of de novo cases and is more
common in patients with advanced-stage disease, with rapid tumor
progression and poor prognosis
• Short arm deletions of chromosome 1 are the most common
chromosomal abnormality present in neuroblastoma and confer a
poor prognosis. The 1p chromosome region likely harbours tumor
suppressor genes or genes that control neuroblast differentiation
• hyperdiploidy (DNA index >1) has a good therapeutic response to
cyclophosphamide and doxorubicin, with better prognosis
4. PROGNOSIS AT PRESENTATION
• Infants more commonly present with thoracic and cervical tumors, whereas older children
more frequently have abdominal tumors.
• ~70-80% of patients >18 months present with metastatic disease
• lymph nodes, liver, bone, and bone marrow
• Patients with localized tumours have an 80-90% 3-year event-free survival [EFS] rate
• <50% with metastasis are cured, even with the use of high-dose therapy followed by
autologous bone marrow or stem cell rescue.
• Generally, >50% of patients present with metastatic disease at the time of diagnosis, 20-
25% have localized disease, 15% have regional extension, and approximately 7% present
during infancy with disseminated disease limited to the skin, liver, and bone marrow
(stage 4S).
• The 3-year EFS for high-risk patients, those with disseminated disease, treated with
conventional chemotherapy, radiation therapy, and surgery is less than 20%.
• Differentiating agents and dose intensification of active drugs, followed by autologous bone marrow
transplant, have been reported to improve the outcome for these patients, contributing to an EFS of
38%. A single-arm study of tandem stem cell transplantation: 3-year EFS of 58%, with other ongoing
randomized studies
5. EPIDEMIOLOGY
• 7.8% of childhood cancers in the United States
• Incidence ~9.5 cases per million children (highest among high income countries)
• Incidence white>black children
• Sex: male-to-female ratio 1.2:1.
• Age: Incidence decreases every consecutive year up to age 10 years, after which
the disease is rare
• The survival rate 5 years from diagnosis is approximately 83% for infants, 55%
for children aged 1-5 years, and 40% for children older than 5 years
• 40% of patients are at <1year, 35% at 1-2 years, and 25% >2 years old when
diagnosed.
6. PRESENTATION
• Pain or palpable mass
• May present with abdominal distension
• Other symptoms dependent on local mass effect
• emesis, weight loss, anorexia, fatigue, and bone pain. Hypertension is an uncommon sign of the disease and is
generally caused by renal artery compression, not catecholamine excess. Chronic diarrhea is a rare presenting
symptom secondary to tumor secretion of vasoactive intestinal peptide secretion. bone pain and a limp. However,
patients may also present with unexplained fever, weight loss, irritability, and periorbital ecchymosis secondary to
metastatic disease to the orbits. The presence of bone metastases can lead to pathologic fractures. neurologic
symptoms, including weakness, limping, paralysis, and even bladder and bowel dysfunction. mild airway obstruction
or chronic cough Horner syndrome metastatic disease confined to the liver, skin, and bone marrow (stage 4S). If this
type of tumor develops in neonates, skin lesions may be confused with congenital rubella, and, if the patient has
severe skin involvement, the term "blueberry muffin baby" may be used.
• Approximately 2% of patients present with opsoclonus and myoclonus a paraneoplastic syndrome characterized by
the presence of myoclonic jerking and random eye movements. These patients often have localized disease and a
good long-term prognosis. Unfortunately, the neurologic abnormalities can persist or progress and can be
devastating.
• Finally, intractable diarrhea is a rare paraneoplastic symptom and is associated with more differentiated tumors and a
good prognosis.
7. EXAMINATION
• Children are usually referred to a pediatric oncologist by primary care providers who have
identified a persistent unexplained symptom or sign, either upon physical examination or
based on screening test findings.
• In patients with suspected neuroblastoma, performing a thorough examination with
careful attention to vital signs (eg, blood pressure), neck, chest, abdomen, skin, and
nervous system is essential.
• Metastatic lesions of the skin are common in infants younger than 6 months and may
represent stage 4S disease.
• Examination of the abdomen may reveal an abdominal mass, leading to the appropriate
workup.
• Neurologic examination may reveal Horner syndrome. In the case of dumbbell tumors,
compression of the spinal cord may produce lower extremity weakness or paraplegia.
Patients with neurologic involvement by tumor should be treated emergently, secondary
to the risk of permanent neurologic sequelae.
8. DIFFERENTIAL
• For an intra-thoracic neuroblastoma consider:
• intrathoracic lymphoma
• extra lobar pulmonary sequestration
• round pneumonia
• ganglioneuroma
• ganglioneuroblastoma
• For an intra-abdominal neuroblastoma consider:
• ganglioneuroma
• ganglioneuroblastoma
• rhabdomyosarcoma
• Wilms tumour
9. INVESTIGATION
• CBC count and differential (Anemia or other cytopenias suggest bone marrow involvement.)
• Urine collection for catecholamines (VMA/HVA) and UAA single sample or collected urine test for
VMA/HVA is highly accurate in CLIA approved laboratories. Centers usually send samples to a
specialty laboratory and/or perform a timed collection of urine.
• A urinary catecholamine level is considered to be elevated if it is 3 standard deviations higher than
the age-related reference range levels.
• Serum creatinine
• Liver function tests
• Electrolytes
• Calcium, Magnesium, Phosphorus, Uric acid;
• Serum lactate dehydrogenase (LDH); Ferritin; Thyroid-stimulating hormone (TSH), T4;
Immunoglobulin (Ig)G levels
10. INVESTIGATION
• Xray: typically demonstrating an intrathoracic or intraabdominal soft-tissue mass. Pressure on
adjacent bones may cause remodelling of ribs, vertebral bodies or pedicle thinning. Up to 30% may
have evidence of calcification on the plain film. Skeletal metastases usually ill-defined and lucent,
with periosteal reaction or metaphyseal lucency.
• Ultrasound: Neuroblastoma on ultrasound demonstrates a heterogeneous mass with internal
vascularity. Often there are areas of necrosis that appear as regions of low echogenicity. Calcification
may or may not be evident on ultrasound
• CT:tumour typically is heterogeneous with calcifications seen in 80-90% of cases2. Areas of necrosis
are of low attenuation. May usually displace tissues or invade. Commonly lymph node enlargement
• MRI: superior to all other modalities in assessing the organ of origin, intracranial or intraspinal
disease and bone marrow disease
• MIBG (metaiodobenzylguanidine labeled to Iodine123) 95% of neuroblastomas secrete catecholamines,
however, 30% of neuroblastomas are negative on MIBG: sensitivity: 88%, specificity: 99% (for
sympathetic tissue)
11. MANAGEMENT
• Medical: Cooperative Group Treatment Strategies – Low, intermediate and high risk stratification: Vincristine, cyclophosphamide, and
doxorubicin
• Carboplatin and etoposide
• Cisplatin and etoposide
• Ifosfamide and etoposide
• Cyclophosphamide and topotecan
• Consolidation regimens used in neuroblastoma include the following:
• Carboplatin and etoposide with melphalan or cyclophosphamide
• Thiotepa and cyclophosphamide
• Melphalan and total body irradiation
• In Europe, several studies have used busulfan with melphalan or cyclophosphamide. One commonly used salvage or relapse therapy
regimen is the combination of topotecan and cyclophosphamide. The use or retinoids have been incorporated in maintenance regimens in
the posttransplant setting. Irinotecan is also under investigation.
• Surgical: Surgical resection plays an important role in the treatment of patients with neuroblastoma. For patients with localized disease,
surgical resection is curative. For patients with regional or metastatic disease, surgery to establish a diagnosis and obtain adequate
samples for biologic studies is essential. Typically, second-look surgery postchemotherapy is used to attempt a complete resection. The
emphasis in the second-look procedure is as complete a debulking as possible without sacrificing major organ function. Patients with
residual disease postchemotherapy and surgery may benefit from the use of radiotherapy.