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Ocular Surface
Disease
ETIOLOGY AND MANAGEMENT DR. DWIGHT THIBODEAUX
OSD/Dry eye
 25 million in US
 Most common eye disease seen
 $3.8 billion spent yearly
 Ocular discomfort and vision problems
 CL intolerance
 New diagnostic techniques and treatment
options
Main Causes
Age > 50
Climate
Genetics, gender
Work environment
Smartphone use
Medications, systemic disease
LASIK
Secondary OSD
 Sjogren’s syndrome
 RA, Lupus, etc.
 Reactive arthritis (triad of classic signs)
 Thyroid dysfunction
 Diabetes
 Rosacea
 Obstructive sleep apnea
 Oxygen use for pulmonary dysfunction
 Meds, CL wear, Lasik, fatigue, insomnia
Diagnosis - established techniques
 Symptoms vs. signs – not always consistent
 Questionnaire, medical and rx hx.
 Lacrimal river, lid margins, digital exp.
 NaFl, Lissamine Green
 Conjunctival chalasis, floppy eyelids test
 Pingueculum and pterigium formation
 Shirmer’s tests - phenol red thread test
 Apposition of lids, blink freq. and quality
Diagnosis – new options
 MG expression -Tearscience MGE
 MMP levels - Inflammadry
 Osmolarity - TearLab
 Meibography - Tearscience Lipoview, Oculus
 Interferometry – Oculus Keratograph, Lipoview
 Immunoassay (lactoferrin) – TearScan
 Sjogrens - Sjo
Diagnosis – common but effective
 Questionnaire
 Dyes and stains
 Meibomian gland expression
Treatment – historical, generic
 Lubrication - gtts and hs ung
 Steroids/Restasis/doxy
 Punctal Plugs
 Surgical canalicular closure
 Removal of offending agent/preservatives
 Antihistamines
 Moisture chambers, humidifiers
Current OSD management varies
based on type of dry eye
 Dx: lipid vs aqueous deficiency
 85% is MGD – lipid deficiency, Demodex
 Most aqueous deficiency is found in
females, immune disorders or with the use
of opiods, Accutane, diuretics, beta
blockers, anti-depressives, anti-anxiety
meds and antihistamines
Aqueous deficiency treatments
 Steroids followed by Restasis
 Lubrication – viscous
 Blink training
 Plugs, canalicular closure
 Moisture chamber glasses
 Workplace changes
 Scleral lenses
 Autogolous serum drops, Prokera
MGD/evaporative dry eye therapy
 Lid/gland heat, MG expression, hygiene
 PF oil based lubricants, Omega 3 FA
 Blink training
 Z pack po +/-Azasite or Tobradex gtts
 Avenova and/or Cliradex
 Moisture chamber glasses and workplace
changes
 Plugs, Restasis, Maskin procedure
Meibomian Gland Dysfunction
 LIPOFLOW - $1300 to $2000
 MiBO - $500, three treatments over 6-8 wks
 IPL – Intense Pulsed Light
 Home therapy – Bruder hot mask/ massage/
hygiene
Keys to success in a dry eye
practice
 Manage expectations/patient education
 Long term therapy for a chronic progressive
disease
 Minimize worsening, maximize comfort and
vision
 Start with least expensive therapy not already
tried
 Give patients hope and options for advanced
care if needed

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Ocular surface disease

  • 1. Ocular Surface Disease ETIOLOGY AND MANAGEMENT DR. DWIGHT THIBODEAUX
  • 2. OSD/Dry eye  25 million in US  Most common eye disease seen  $3.8 billion spent yearly  Ocular discomfort and vision problems  CL intolerance  New diagnostic techniques and treatment options
  • 3. Main Causes Age > 50 Climate Genetics, gender Work environment Smartphone use Medications, systemic disease LASIK
  • 4. Secondary OSD  Sjogren’s syndrome  RA, Lupus, etc.  Reactive arthritis (triad of classic signs)  Thyroid dysfunction  Diabetes  Rosacea  Obstructive sleep apnea  Oxygen use for pulmonary dysfunction  Meds, CL wear, Lasik, fatigue, insomnia
  • 5. Diagnosis - established techniques  Symptoms vs. signs – not always consistent  Questionnaire, medical and rx hx.  Lacrimal river, lid margins, digital exp.  NaFl, Lissamine Green  Conjunctival chalasis, floppy eyelids test  Pingueculum and pterigium formation  Shirmer’s tests - phenol red thread test  Apposition of lids, blink freq. and quality
  • 6. Diagnosis – new options  MG expression -Tearscience MGE  MMP levels - Inflammadry  Osmolarity - TearLab  Meibography - Tearscience Lipoview, Oculus  Interferometry – Oculus Keratograph, Lipoview  Immunoassay (lactoferrin) – TearScan  Sjogrens - Sjo
  • 7. Diagnosis – common but effective  Questionnaire  Dyes and stains  Meibomian gland expression
  • 8. Treatment – historical, generic  Lubrication - gtts and hs ung  Steroids/Restasis/doxy  Punctal Plugs  Surgical canalicular closure  Removal of offending agent/preservatives  Antihistamines  Moisture chambers, humidifiers
  • 9. Current OSD management varies based on type of dry eye  Dx: lipid vs aqueous deficiency  85% is MGD – lipid deficiency, Demodex  Most aqueous deficiency is found in females, immune disorders or with the use of opiods, Accutane, diuretics, beta blockers, anti-depressives, anti-anxiety meds and antihistamines
  • 10. Aqueous deficiency treatments  Steroids followed by Restasis  Lubrication – viscous  Blink training  Plugs, canalicular closure  Moisture chamber glasses  Workplace changes  Scleral lenses  Autogolous serum drops, Prokera
  • 11. MGD/evaporative dry eye therapy  Lid/gland heat, MG expression, hygiene  PF oil based lubricants, Omega 3 FA  Blink training  Z pack po +/-Azasite or Tobradex gtts  Avenova and/or Cliradex  Moisture chamber glasses and workplace changes  Plugs, Restasis, Maskin procedure
  • 12. Meibomian Gland Dysfunction  LIPOFLOW - $1300 to $2000  MiBO - $500, three treatments over 6-8 wks  IPL – Intense Pulsed Light  Home therapy – Bruder hot mask/ massage/ hygiene
  • 13. Keys to success in a dry eye practice  Manage expectations/patient education  Long term therapy for a chronic progressive disease  Minimize worsening, maximize comfort and vision  Start with least expensive therapy not already tried  Give patients hope and options for advanced care if needed