Ocular surface disease (OSD), commonly known as dry eye, affects 25 million people in the US and costs $3.8 billion annually. It causes ocular discomfort and vision problems. The main causes include aging, climate, genetics, medications, LASIK, and work environment. Secondary OSD can be caused by conditions like Sjogren's syndrome, rheumatoid arthritis, thyroid dysfunction, and diabetes. Diagnosis involves questionnaires, dye tests, meibomian gland expression, and newer tests of tear osmolarity, meibography, and biomarkers. Treatment depends on whether the dry eye is aqueous deficient or due to meibomian gland dysfunction (MGD). For MGD, treatments focus on lid