Non-aqueous titration allows for the titration of weak acids and bases that cannot be accurately measured in aqueous solution. It involves titrating the substance using a non-aqueous solvent and titrant. Various organic solvents like acetic acid, alcohols, and amines can be used that compete less than water for proton donation or acceptance. This allows for sharper endpoints compared to titration in water for very weak acids and bases. Selection of the appropriate non-aqueous solvent depends on factors like solubility of the sample and ability to produce a clear endpoint.