This document presents Noise2Score, a unified framework for self-supervised image denoising without clean images. It discusses how previous approaches like Noise2Noise, SURE, and supervised learning are special cases of Tweedie's formula for the exponential family. Noise2Score estimates the score function using an amortized residual denoising autoencoder, allowing it to denoise images with different noise models like Gaussian, Poisson, and Gamma noise, using the same network training. The framework provides a novel unified approach for self-supervised image denoising without requiring paired clean-noisy images.