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Nodular Patternitie
By
Gamal Rabie Agmy , MD , FCCP
Professor of Chest Diseases ,Assiut University
Nodular Pattern
Nodular pattern
 A nodular pattern consists of multiple round opacities,
generally ranging in diameter from 1 mm to 1 cm
 Nodular opacities may be described as miliary (1 to 2 mm,
the size of millet seeds), small, medium, or large, as the
diameter of the opacities increases
 A nodular pattern, especially with predominant distribution,
suggests a specific differential diagnosis
Perilymphatic distribution
Centrilobular distribution
Random distribution
ARE NODULES IN CONTACT
WITH PLEURA
NO
CENTRILOBULAR
YES
PERILYMPHATIC RANDOM
TO SUM UP..
• Random
– touch pleura
– scattered in lung
• Centrilobular
–away from pleura
• Perilymphatic
– around vessels, bronchi
– touch pleura or fissure
Size, Distribution, Appearance
Nodules and Nodular Opacities
Size
Small Nodules:<10 mm Miliary - <3 mm
Large Nodules: >10 mm Masses - >3 cms
Appearance
Interstitial opacity:
 Well-defined, homogenous,
Soft-tissue density
Obscures the edges of vessels or adjacent structure
Air space:
Ill-defined, inhomogeneous.
Less dense than adjacent vessel – GGO
small nodule is difficult to identify
Interstitial
nodules
Air space opacity
Miliary tuberculosis
sarcoidosis
in a lung transplant patient
with bronchopneumonia
RANDOM: no consistent relationship to any structures
PERILYMPHATIC: corresponds to distribution of lymphatic
CENTRILOBULAR: related to centrilobular structuresDistribution
13
Angiocentric
Bronchocentric, ill Defined
Bronchocentric, well Defined
Lymphocentric
Disseminated histoplasmosis and nodular ILD.
CT scan shows multiple bilateral round circumscribed
pulmonary nodules.
Notice the nodules along the fissures indicating a
perilymphatic distribution (red arrows).
The majority of nodules located along the bronchovascular
bundle (yellow arrow).
Sarcoidosis
The majority of nodules located
along the bronchovascular bundle
(yellow arrow).
PERILYMPHATIC NODULES
Perilymphatic and Random distribution of
nodules , seen in sarcoidosis.
Centrilobular distribution
Hypersensitivity pneumonitis
Respiratory bronchiolitis in
smokers
infectious airways diseases
(endobronchial spread of
tuberculosis or
nontuberculous
mycobacteria,
bronchopneumonia)
Uncommon in
bronchioloalveolar
carcinoma, pulmonary
edema, vasculitis
Random distribution
Small random nodules
are seen in:
 Hematogenous
metastases
 Miliary tuberculosis
 Miliary fungal infections
 Sarcoidosis may mimick
this pattern, when very
extensive
 Langerhans cell
histiocytosis (early
nodular stage)
Langerhans cell histiocytosis: early nodular stage before the typical
cysts appear.
Differential diagnosis of a nodular
pattern of interstitial lung disease
SHRIMP
Sarcoidosis
Histiocytosis (Langerhan cell
histiocytosis)
Hypersensitivity pneumonitis
Rheumatoid nodules
Infection (mycobacterial, fungal, viral)
Metastases, Miliary TB
Microlithiasis, alveolar
Pneumoconioses (silicosis, coal
worker's, berylliosis)
Reticulonodular pattern
A reticulonodular pattern results from a
combination of reticular and nodular opacities.
This pattern is often difficult to distinguish from
a purely reticular or nodular pattern, and in
such a case a differential diagnosis should be
developed based on the predominant pattern.
If there is no predominant pattern, causes of both
nodular and reticular patterns should be
considered.
Nodular pattern

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Nodular pattern

  • 1.
  • 2. Nodular Patternitie By Gamal Rabie Agmy , MD , FCCP Professor of Chest Diseases ,Assiut University
  • 4. Nodular pattern  A nodular pattern consists of multiple round opacities, generally ranging in diameter from 1 mm to 1 cm  Nodular opacities may be described as miliary (1 to 2 mm, the size of millet seeds), small, medium, or large, as the diameter of the opacities increases  A nodular pattern, especially with predominant distribution, suggests a specific differential diagnosis
  • 6. ARE NODULES IN CONTACT WITH PLEURA NO CENTRILOBULAR YES PERILYMPHATIC RANDOM
  • 7.
  • 8.
  • 9. TO SUM UP.. • Random – touch pleura – scattered in lung • Centrilobular –away from pleura • Perilymphatic – around vessels, bronchi – touch pleura or fissure
  • 10.
  • 11. Size, Distribution, Appearance Nodules and Nodular Opacities Size Small Nodules:<10 mm Miliary - <3 mm Large Nodules: >10 mm Masses - >3 cms Appearance Interstitial opacity:  Well-defined, homogenous, Soft-tissue density Obscures the edges of vessels or adjacent structure Air space: Ill-defined, inhomogeneous. Less dense than adjacent vessel – GGO small nodule is difficult to identify
  • 12. Interstitial nodules Air space opacity Miliary tuberculosis sarcoidosis in a lung transplant patient with bronchopneumonia
  • 13. RANDOM: no consistent relationship to any structures PERILYMPHATIC: corresponds to distribution of lymphatic CENTRILOBULAR: related to centrilobular structuresDistribution 13
  • 18. Disseminated histoplasmosis and nodular ILD. CT scan shows multiple bilateral round circumscribed pulmonary nodules.
  • 19. Notice the nodules along the fissures indicating a perilymphatic distribution (red arrows). The majority of nodules located along the bronchovascular bundle (yellow arrow).
  • 20. Sarcoidosis The majority of nodules located along the bronchovascular bundle (yellow arrow).
  • 21. PERILYMPHATIC NODULES Perilymphatic and Random distribution of nodules , seen in sarcoidosis.
  • 22. Centrilobular distribution Hypersensitivity pneumonitis Respiratory bronchiolitis in smokers infectious airways diseases (endobronchial spread of tuberculosis or nontuberculous mycobacteria, bronchopneumonia) Uncommon in bronchioloalveolar carcinoma, pulmonary edema, vasculitis
  • 23. Random distribution Small random nodules are seen in:  Hematogenous metastases  Miliary tuberculosis  Miliary fungal infections  Sarcoidosis may mimick this pattern, when very extensive  Langerhans cell histiocytosis (early nodular stage)
  • 24. Langerhans cell histiocytosis: early nodular stage before the typical cysts appear.
  • 25. Differential diagnosis of a nodular pattern of interstitial lung disease SHRIMP Sarcoidosis Histiocytosis (Langerhan cell histiocytosis) Hypersensitivity pneumonitis Rheumatoid nodules Infection (mycobacterial, fungal, viral) Metastases, Miliary TB Microlithiasis, alveolar Pneumoconioses (silicosis, coal worker's, berylliosis)
  • 26. Reticulonodular pattern A reticulonodular pattern results from a combination of reticular and nodular opacities. This pattern is often difficult to distinguish from a purely reticular or nodular pattern, and in such a case a differential diagnosis should be developed based on the predominant pattern. If there is no predominant pattern, causes of both nodular and reticular patterns should be considered.