This document discusses different types of powders used in pharmaceuticals. It describes powders as mixtures of finely divided drugs or chemicals in dry form that can be used internally or externally. The key types discussed are:
- Bulk powders for internal or external use which contain multiple doses and are less accurate.
- Simple and compound powders for internal use which contain a single ingredient or multiple ingredients divided into individual doses wrapped in paper.
- Powders enclosed in capsules or cachets to allow ingestion of unpleasant tasting powders.
- Compressed powders which are potent drugs mixed with diluents and compressed into tablet form using moulds.
This document provides information on various liquid dosage forms including their descriptions, advantages, disadvantages and examples. It discusses liquid forms such as otic preparations, nasal preparations, syrups, elixirs, tinctures, fluid extracts, douches, enemas, liniments, collodion, aromatic waters, spirits/essences, mouthwashes, gargles and astringents. For each type, it outlines what they are, how they are administered and common examples. The document is an informative reference for the different types of liquid dosage forms used in pharmaceutical preparations.
This document discusses different types of powders used in pharmacy. It describes bulk powders meant for external use which are supplied in containers designed for application. Common bulk powders include dusting powders, insufflations, snuffs, and dentifrices. Dusting powders are used on the skin and in body cavities, and contain ingredients like talc, starch, zinc oxide, and salicylic acid. Insufflations and snuffs are inhaled into body cavities and nostrils. Dentifrices contain abrasives like calcium carbonate and flavors to clean teeth. Simple and compound powders for internal use contain one or multiple ingredients wrapped in individual doses. Cachets enclose powders in shells
Elixirs are clear, sweetened liquids containing flavoring substances or active medicinal agents dissolved in water and alcohol. Their primary ingredients include alcohol, water, glycerin, preservatives, sorbital, and flavoring agents. There are two main types - non-medicated elixirs which contain no therapeutic agents, and medicated elixirs which contain active drug ingredients dissolved in the liquid. Elixirs are formulated to be stable, clear solutions and are quality controlled through tests such as measuring alcohol concentration and viscosity. They are commonly used to deliver and mask the taste of other drugs.
Semisolid dosage forms are neither solid nor liquid, however, they are a combination or mixture of both, and they used for both local and systemic effects. Pharmaceutical semisolid dosage forms such as creams, ointments, gels, suppositories, and paste are used for topical application. Semisolid dosage forms are intended used as drug carriers that are transported topically through the skin, buckle tissue, rectal tissue, outer ear lining nasal mucosa, urethral membrane, vagina, and cornea. The semisolid may adhere adequately before washing on the surface of the application; this helps to extend the supply of drugs on the application site.
This document discusses powders and granules used in pharmaceutical preparations. It begins by defining powders as mixtures of finely divided drugs or chemicals for internal or external use. The advantages of powders include stability, flexibility in dosing, and low cost of preparation. Challenges include unpleasant taste, instability of hygroscopic drugs, and difficulty dispensing small doses. Powders are generally prepared through comminution to reduce particle size and blending. The document then classifies and describes methods for different types of powders including bulk powders, simple/compound powders, powders in capsules/cachets, and those addressing special stability issues.
Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques
This document provides information on various liquid dosage forms including their descriptions, advantages, disadvantages and examples. It discusses liquid forms such as otic preparations, nasal preparations, syrups, elixirs, tinctures, fluid extracts, douches, enemas, liniments, collodion, aromatic waters, spirits/essences, mouthwashes, gargles and astringents. For each type, it outlines what they are, how they are administered and common examples. The document is an informative reference for the different types of liquid dosage forms used in pharmaceutical preparations.
This document discusses different types of powders used in pharmacy. It describes bulk powders meant for external use which are supplied in containers designed for application. Common bulk powders include dusting powders, insufflations, snuffs, and dentifrices. Dusting powders are used on the skin and in body cavities, and contain ingredients like talc, starch, zinc oxide, and salicylic acid. Insufflations and snuffs are inhaled into body cavities and nostrils. Dentifrices contain abrasives like calcium carbonate and flavors to clean teeth. Simple and compound powders for internal use contain one or multiple ingredients wrapped in individual doses. Cachets enclose powders in shells
Elixirs are clear, sweetened liquids containing flavoring substances or active medicinal agents dissolved in water and alcohol. Their primary ingredients include alcohol, water, glycerin, preservatives, sorbital, and flavoring agents. There are two main types - non-medicated elixirs which contain no therapeutic agents, and medicated elixirs which contain active drug ingredients dissolved in the liquid. Elixirs are formulated to be stable, clear solutions and are quality controlled through tests such as measuring alcohol concentration and viscosity. They are commonly used to deliver and mask the taste of other drugs.
Semisolid dosage forms are neither solid nor liquid, however, they are a combination or mixture of both, and they used for both local and systemic effects. Pharmaceutical semisolid dosage forms such as creams, ointments, gels, suppositories, and paste are used for topical application. Semisolid dosage forms are intended used as drug carriers that are transported topically through the skin, buckle tissue, rectal tissue, outer ear lining nasal mucosa, urethral membrane, vagina, and cornea. The semisolid may adhere adequately before washing on the surface of the application; this helps to extend the supply of drugs on the application site.
This document discusses powders and granules used in pharmaceutical preparations. It begins by defining powders as mixtures of finely divided drugs or chemicals for internal or external use. The advantages of powders include stability, flexibility in dosing, and low cost of preparation. Challenges include unpleasant taste, instability of hygroscopic drugs, and difficulty dispensing small doses. Powders are generally prepared through comminution to reduce particle size and blending. The document then classifies and describes methods for different types of powders including bulk powders, simple/compound powders, powders in capsules/cachets, and those addressing special stability issues.
Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques
This document discusses different types of powder dosage forms including their advantages and disadvantages. It describes bulk powders for internal and external use which contain multiple doses of powder in containers. Simple and compound powders for internal use contain individually dosed powders wrapped in paper. Powders can also be enclosed in cachets or capsules. Compressed powders refer to tablets which are made by compressing powder mixtures into flat discs. The document provides examples of different types of powders and details on their preparation and use.
This document discusses powders and granules used in pharmaceutical formulations. It defines powders and granules and discusses their advantages. Particle size and shape are described. Hard and soft gelatin capsules are summarized, including their manufacturing and filling methods. Sustained release and enteric coated capsules are briefly outlined. Microencapsulation techniques like coacervation and pan coating are introduced. Spray drying is also mentioned as a microencapsulation method.
1. The document discusses liquid dosage forms, which provide advantages over solid forms like faster absorption.
2. Liquid dosage forms are classified as monophasic containing one phase like syrups, or biphasic containing two phases like suspensions and emulsions.
3. Key liquid dosage forms are described including their composition, preparation, and uses both internally and externally. Advantages and disadvantages of liquid dosage forms are also outlined.
Pharmaceutical powders are solid dosage forms containing one or more drugs in finely divided form, with or without excipients. They have advantages like faster onset of action compared to other oral solid dosage forms. Powders are classified based on their intended use and formulation. They include bulk powders, simple/compound powders enclosed in papers or capsules, and compressed powders made into tablets. Proper mixing and packaging is important for powder formulations to ensure uniform drug content and stability.
Gels and jellies are semisolid dosage forms used to deliver drugs. Gels contain a gelling agent that is dispersed in water, producing a jelly-like consistency. Common gelling agents include polymers, natural gums, and cellulose derivatives. Gels are classified as single-phase or two-phase based on distribution of the gelling agent. Jellies are transparent and less greasy than gels. Common gelling agents for jellies include tragacanth, sodium alginate, pectin, and gelatin. Key evaluation tests for gels and jellies include pH, drug content, viscosity, and spreadability.
This document provides information about syrups and elixirs. It defines syrups as concentrated aqueous preparations containing sugar or sugar substitutes with or without flavoring agents and medicinal substances. Elixirs are sweetened, flavored, hydro-alcoholic solutions for oral use. The document discusses the types, components, preparation, and examples of both syrups and elixirs. It also provides a brief comparison of the key differences between syrups and elixirs.
A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.
Pharmaceutical powders are mixtures of finely divided drugs or chemicals meant for internal or external use. Powders have advantages like good chemical stability and ease of swallowing large doses. However, powders also have disadvantages such as the potential for misunderstanding correct usage and difficulty making uniform individually wrapped doses. Proper mixing and particle size reduction are important to ensure homogeneity and the desired properties of pharmaceutical powders.
This document provides information on suppositories, including their advantages and types. It discusses various suppository bases such as cocoa butter, emulsified cocoa butter, hydrogenated oils, and water soluble bases. The document describes the preparation of suppositories using the fusion method as well as evaluation methods for suppositories such as weight variation, melting range, and dissolution testing. Rectal, vaginal, and other types of suppositories are covered in detail in terms of their shape, weight and intended use.
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
This document discusses powder dosage forms, including their definition, advantages, disadvantages, classification, formulation, and characterization. Powders are intimate mixtures of dry, finely divided drugs and/or chemicals that can be used internally or externally. They have advantages like good stability, rapid onset of action, and ease of administration. However, they are not suitable for unstable, bitter, or hygroscopic drugs. The document outlines methods for obtaining powders, mixing them, and packaging different types including bulk powders, snuffs, dental powders, and insufflations. Characterization parameters like particle size and flow properties that influence formulation are also described.
The document discusses different types of drug incompatibilities, including physical, chemical, and therapeutic incompatibilities. Physical incompatibilities involve changes in a drug formulation's properties from mixing ingredients, like precipitation or color changes. Chemical incompatibilities can cause immediate reactions between ingredients like gas formation. Therapeutic incompatibilities modify a drug's intended effects, such as negative interactions between drugs. The document provides examples for each type of incompatibility to illustrate the concepts.
Throat paints are viscous solutions intended for application to the throat to treat conditions like pharyngitis and tonsillitis. Common active ingredients include iodine, crystal violet, phenol, and tannic acid. Mandl's throat paint contains potassium iodide, iodine, alcohol, water, peppermint oil and glycerin. Glycerin makes it viscous and sticky to prolong the effect. It is applied using a soft brush and food/water should be avoided for 1 hour after. It is stored in an amber bottle in a cool place and the bottle should be shaken before use.
Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
This document summarizes a seminar presentation on powder dosage forms for external use. It defines powders as intimate mixtures of drugs and chemicals that may be for internal or external use. Powders are classified as bulk powders, simple/compound powders, powders in capsules, or compressed powders (tablets). Bulk powders for external use include dusting powders, snuffs, and dental powders. Packaging depends on the intended use, with bulk powders in wide-mouth jars and divided powders in individual folded papers. Advantages include stability and convenient dosing, while disadvantages include instability in some conditions and dosing inaccuracies.
Powders are drug formulations meant for internal or external use. They have advantages like stability, easy swallowing, and rapid dissolution/onset of action. However, powders also have disadvantages such as hygroscopicity, unpleasant taste, difficult handling and compounding, and potential to carry microorganisms. Particle size affects properties like dissolution rate and suspendability. Powders are prepared by processes like spatulation, trituration, sifting, and tumbling. They are packaged in individual doses or in bulk containers.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
This document discusses different types of aqueous solutions used for therapeutic purposes. It describes gargles which are concentrated solutions used to treat the throat and nasal passages. It also mentions mouthwashes, eye washes, and nasal washes which are diluted aqueous solutions often used for their refreshing and antiseptic effects. Finally, it outlines different types of douches and enemas used to irrigate or cleanse parts of the body including the eyes, nose, throat, vagina, and rectum.
Elixirs are clear, sweetened alcoholic solutions intended for oral use. They contain 10-12% alcohol which helps dissolve ingredients. Elixirs differ from syrups in that alcohol is always present in elixirs and they remain clear while syrups can contain dyes. Common types of elixirs include simple non-medicated elixirs and medicated elixirs containing active ingredients. Elixirs are prepared by separately dissolving water and alcohol soluble components before combining the solutions and adding excipients like sweeteners, flavors, and preservatives.
This document discusses semisolid dosage forms including ointments, creams, and gels. It defines these forms, describes common ingredients used in their preparation such as bases, preservatives, and gelling agents. Methods of preparation including fusion and emulsification are outlined. The document also discusses ideal properties and how these forms are evaluated based on parameters like penetration, release of active ingredients, and irritation potential.
Powders are solid dosage forms consisting of finely divided drugs or chemicals. They can be administered internally or externally. Powders have advantages over other dosage forms like stability, rapid onset, and ability to administer large doses. However, they are not suitable for drugs with unpleasant tastes or those that are hygroscopic. Powders are prepared using methods like spatulation, trituration, and sifting. They can be dispensed in bulk powder, wrapped individually, or enclosed in cachets or capsules.
This document discusses different types of powder dosage forms including their advantages and disadvantages. It describes bulk powders for internal and external use which contain multiple doses of powder in containers. Simple and compound powders for internal use contain individually dosed powders wrapped in paper. Powders can also be enclosed in cachets or capsules. Compressed powders refer to tablets which are made by compressing powder mixtures into flat discs. The document provides examples of different types of powders and details on their preparation and use.
This document discusses powders and granules used in pharmaceutical formulations. It defines powders and granules and discusses their advantages. Particle size and shape are described. Hard and soft gelatin capsules are summarized, including their manufacturing and filling methods. Sustained release and enteric coated capsules are briefly outlined. Microencapsulation techniques like coacervation and pan coating are introduced. Spray drying is also mentioned as a microencapsulation method.
1. The document discusses liquid dosage forms, which provide advantages over solid forms like faster absorption.
2. Liquid dosage forms are classified as monophasic containing one phase like syrups, or biphasic containing two phases like suspensions and emulsions.
3. Key liquid dosage forms are described including their composition, preparation, and uses both internally and externally. Advantages and disadvantages of liquid dosage forms are also outlined.
Pharmaceutical powders are solid dosage forms containing one or more drugs in finely divided form, with or without excipients. They have advantages like faster onset of action compared to other oral solid dosage forms. Powders are classified based on their intended use and formulation. They include bulk powders, simple/compound powders enclosed in papers or capsules, and compressed powders made into tablets. Proper mixing and packaging is important for powder formulations to ensure uniform drug content and stability.
Gels and jellies are semisolid dosage forms used to deliver drugs. Gels contain a gelling agent that is dispersed in water, producing a jelly-like consistency. Common gelling agents include polymers, natural gums, and cellulose derivatives. Gels are classified as single-phase or two-phase based on distribution of the gelling agent. Jellies are transparent and less greasy than gels. Common gelling agents for jellies include tragacanth, sodium alginate, pectin, and gelatin. Key evaluation tests for gels and jellies include pH, drug content, viscosity, and spreadability.
This document provides information about syrups and elixirs. It defines syrups as concentrated aqueous preparations containing sugar or sugar substitutes with or without flavoring agents and medicinal substances. Elixirs are sweetened, flavored, hydro-alcoholic solutions for oral use. The document discusses the types, components, preparation, and examples of both syrups and elixirs. It also provides a brief comparison of the key differences between syrups and elixirs.
A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.
Pharmaceutical powders are mixtures of finely divided drugs or chemicals meant for internal or external use. Powders have advantages like good chemical stability and ease of swallowing large doses. However, powders also have disadvantages such as the potential for misunderstanding correct usage and difficulty making uniform individually wrapped doses. Proper mixing and particle size reduction are important to ensure homogeneity and the desired properties of pharmaceutical powders.
This document provides information on suppositories, including their advantages and types. It discusses various suppository bases such as cocoa butter, emulsified cocoa butter, hydrogenated oils, and water soluble bases. The document describes the preparation of suppositories using the fusion method as well as evaluation methods for suppositories such as weight variation, melting range, and dissolution testing. Rectal, vaginal, and other types of suppositories are covered in detail in terms of their shape, weight and intended use.
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
This document discusses powder dosage forms, including their definition, advantages, disadvantages, classification, formulation, and characterization. Powders are intimate mixtures of dry, finely divided drugs and/or chemicals that can be used internally or externally. They have advantages like good stability, rapid onset of action, and ease of administration. However, they are not suitable for unstable, bitter, or hygroscopic drugs. The document outlines methods for obtaining powders, mixing them, and packaging different types including bulk powders, snuffs, dental powders, and insufflations. Characterization parameters like particle size and flow properties that influence formulation are also described.
The document discusses different types of drug incompatibilities, including physical, chemical, and therapeutic incompatibilities. Physical incompatibilities involve changes in a drug formulation's properties from mixing ingredients, like precipitation or color changes. Chemical incompatibilities can cause immediate reactions between ingredients like gas formation. Therapeutic incompatibilities modify a drug's intended effects, such as negative interactions between drugs. The document provides examples for each type of incompatibility to illustrate the concepts.
Throat paints are viscous solutions intended for application to the throat to treat conditions like pharyngitis and tonsillitis. Common active ingredients include iodine, crystal violet, phenol, and tannic acid. Mandl's throat paint contains potassium iodide, iodine, alcohol, water, peppermint oil and glycerin. Glycerin makes it viscous and sticky to prolong the effect. It is applied using a soft brush and food/water should be avoided for 1 hour after. It is stored in an amber bottle in a cool place and the bottle should be shaken before use.
Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
This document summarizes a seminar presentation on powder dosage forms for external use. It defines powders as intimate mixtures of drugs and chemicals that may be for internal or external use. Powders are classified as bulk powders, simple/compound powders, powders in capsules, or compressed powders (tablets). Bulk powders for external use include dusting powders, snuffs, and dental powders. Packaging depends on the intended use, with bulk powders in wide-mouth jars and divided powders in individual folded papers. Advantages include stability and convenient dosing, while disadvantages include instability in some conditions and dosing inaccuracies.
Powders are drug formulations meant for internal or external use. They have advantages like stability, easy swallowing, and rapid dissolution/onset of action. However, powders also have disadvantages such as hygroscopicity, unpleasant taste, difficult handling and compounding, and potential to carry microorganisms. Particle size affects properties like dissolution rate and suspendability. Powders are prepared by processes like spatulation, trituration, sifting, and tumbling. They are packaged in individual doses or in bulk containers.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
This document discusses different types of aqueous solutions used for therapeutic purposes. It describes gargles which are concentrated solutions used to treat the throat and nasal passages. It also mentions mouthwashes, eye washes, and nasal washes which are diluted aqueous solutions often used for their refreshing and antiseptic effects. Finally, it outlines different types of douches and enemas used to irrigate or cleanse parts of the body including the eyes, nose, throat, vagina, and rectum.
Elixirs are clear, sweetened alcoholic solutions intended for oral use. They contain 10-12% alcohol which helps dissolve ingredients. Elixirs differ from syrups in that alcohol is always present in elixirs and they remain clear while syrups can contain dyes. Common types of elixirs include simple non-medicated elixirs and medicated elixirs containing active ingredients. Elixirs are prepared by separately dissolving water and alcohol soluble components before combining the solutions and adding excipients like sweeteners, flavors, and preservatives.
This document discusses semisolid dosage forms including ointments, creams, and gels. It defines these forms, describes common ingredients used in their preparation such as bases, preservatives, and gelling agents. Methods of preparation including fusion and emulsification are outlined. The document also discusses ideal properties and how these forms are evaluated based on parameters like penetration, release of active ingredients, and irritation potential.
Powders are solid dosage forms consisting of finely divided drugs or chemicals. They can be administered internally or externally. Powders have advantages over other dosage forms like stability, rapid onset, and ability to administer large doses. However, they are not suitable for drugs with unpleasant tastes or those that are hygroscopic. Powders are prepared using methods like spatulation, trituration, and sifting. They can be dispensed in bulk powder, wrapped individually, or enclosed in cachets or capsules.
This document discusses powders as a dosage form for drugs and chemicals. Powders can be administered internally or externally and exist in crystalline or amorphous forms. They have advantages like stability, rapid onset of action, and lower cost compared to other dosage forms. However, powders with unpleasant tastes or that are hygroscopic cannot be used. Powders are classified based on their use and include bulk powders, simple/compound powders enclosed in packets, and compressed powders in tablets/capsules. Special care needs to be taken with volatile, hygroscopic, or efflorescent powders.
This document discusses classical dosage forms, which include pills, lozenges, mixtures, inhalations, powders, glycerites, throat paints, elixirs, draughts, granules, solutions, pessaries, tinctures, and syrups. It provides details on the composition, preparation, uses, and examples of each type of classical dosage form. Classical dosage forms were commonly used in ancient times but have been replaced by more advanced forms in modern times due to various disadvantages like poor stability or ease of administration.
The document discusses various types of solid, liquid, and semi-solid dosage forms used to deliver drugs to the body. Solid dosage forms include tablets, capsules, powders, and granules which provide accurate dosing and protection of drugs. Liquid forms like syrups provide quick absorption but stability can be an issue. Semi-solids like ointments and creams are used for external application. Dosage forms aim to deliver drugs safely and effectively based on factors like taste-masking, sustained release, and site of action within the body.
Powders are solid dosage forms consisting of finely divided drugs and chemicals meant for both internal and external use. They are classified as bulk powders, divided powders, granules, and those contained in capsules. Bulk powders are less accurate but more stable than other forms. Divided powders allow accurate dosing. Granules can mask unpleasant tastes and are easier to swallow than powders. Other solid dosage forms discussed include tablets, capsules, lozenges, pills, and pastilles, each having advantages and disadvantages for drug delivery and patient acceptance.
This document discusses solid dosage forms, specifically powders. It defines powder as a solid dosage form containing finely divided drugs or chemicals that can be administered internally or externally. Powders are classified based on their intended use and form, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders (tablets). Preparation methods like mixing, packing, and labeling are also outlined. Common bulk powders for external use include dusting powders, snuffs, and dentifrices. Powders provide advantages like stability and ease of administration but also have disadvantages like unpleasant taste and instability of some drugs.
This lecture discusses pharmaceutical powders. It begins by defining a pharmaceutical powder as a solid dosage form containing finely divided drugs or chemicals meant for internal or external use. Powders permit drugs to be reduced to a very fine state, enhancing dissolution rate, absorption, and masking unpleasant tastes. The lecture then covers various types of powders including divided powders for internal use (simple, compound, cachet-enclosed), bulk powders (antacids, laxatives), and powders for external use. Methods for reducing particle size like trituration, pulverization, and levigation are also summarized.
Dosage forms refer to pharmaceutical preparations that contain one or more active drug substances along with inactive excipients. Solid dosage forms include tablets, capsules, powders, and granules while liquid forms include syrups, suspensions, and emulsions. Powders are a bulk solid dosage form that can be used internally or externally and include dusting powders, snuffs, and insufflations, with properties like hygroscopic, deliquescent, efflorescent, and effervescent substances affecting their use and stability.
1. Dosage forms can be classified in several ways including by route of administration, physical form, sterility, and dose accuracy.
2. Common solid dosage forms include tablets, capsules, powders, and granules while common liquid forms include solutions, suspensions, emulsions, and elixirs.
3. Semi-solid dosage forms for external use include ointments, creams, gels, and suppositories which are administered via different routes such as oral, topical, rectal, etc.
PHARMACEUTICAL DOSAGE FORMS : an overall introduction .pptxAdinathSangale2
Dosage forms are the mechanism by which drug molecules / APIs are administered to areas of action inside the body to generate maximum intended benefits and the lowest unwanted effects.
OR The Dosage form is the combination of Active Pharmaceutical Ingredients (API) and Excipients in the formulation.
Pharmaceutical . powders . pdf . Pharmacyzuluzulaika4
Pharmaceutical powders are solid dosage forms of medicines that are finely divided and meant for internal or external use. They have advantages like stability, convenience, and rapid onset of action compared to other dosage forms. Powders are mixed using various techniques like spatulation, trituration, geometric dilution, and tumbling. They are classified based on method of dispensing and include bulk powders, simple/compound powders, and compressed powders. Common examples are dusting powders, snuffs, and dentifrices which are used externally in various forms.
Powders are solid dosage forms where drugs are dispensed in a finely divided state, with or without excipients. They have advantages like faster onset of action compared to other forms but also disadvantages like bitter drugs not being suitable. Powders are prepared through processes like size reduction, weighing ingredients, mixing through methods like spatulation or geometric dilution, and packaging. They are classified based on use and include bulk powders, simple/compound powders, and compressed powders.
The document defines drugs and dosage forms. It explains that dosage forms transform pure drug compounds into predetermined forms mixed with non-drug components to aid drug delivery. Dosage forms provide accurate dosing, protection, masking of taste/odor, and controlled release. There are various types of dosage forms classified by route of administration and physical form including solids, liquids, semi-solids, and gases. Common solid dosage forms are tablets, capsules, powders, and granules while liquids include solutions, emulsions, suspensions, elixirs and linctuses. Semi-solid forms for external use are ointments, creams, pastes and jellies.
This document provides an introduction to different dosage forms. It defines dosage forms as combinations of drugs and excipients that deliver drug molecules to sites of action in the body. Dosage forms come in solid, liquid, and semi-solid forms and are classified based on their route of administration and drug release properties. The document discusses various types of solid dosage forms like tablets, capsules, and powders as well as liquid forms like solutions, suspensions, and emulsions. It provides examples of how dosage forms are tailored to meet specific drug delivery needs like sustained release or targeted delivery to tissues.
Powders are mixtures of finely divided drugs and chemicals that may be intended for internal or external use. They offer advantages like rapid onset of action and ease of administration to infants. However, they can be difficult to formulate when drugs are hygroscopic, deliquescent, or efflorescent. Powder production involves size reduction, mixing, and packaging. Size reduction methods include cutting, compression, impact, and attrition. Mixing ensures uniform drug distribution and appearance. Hygroscopic powders require formulations like granules or packets to reduce moisture absorption.
This document discusses various size reduction equipment, including hammer mills, ball mills, and disintegrators. It provides advantages and disadvantages of hammer mills, such as their ability to control particle size but potential for heat buildup. Ball mills are described as using impact between rapidly moving balls and material to reduce size. Key advantages are their ability to produce fine powder and handle wet or dry materials. Disintegrators work via impact of fast-spinning beaters inside a drum and are useful for reducing very hard drugs to a fine powder.
Niosomes are a novel drug delivery system composed of a bilayer vesicle encapsulating medication. They are similar to liposomes in using a vesicle structure to carry hydrophilic, amphiphilic, and lipophilic drugs. Niosomes are very small, on the nanoscale. Their bilayer vesicle structure forms from certain non-ionic surfactants immersed in water. Niosomes can be unilamellar, containing one bilayer, or multilamellar, containing multiple bilayers. They diffuse drugs across the skin's stratum corneum and can enhance skin penetration and oral bioavailability of medications. Niosomes have advantages over liposomes such as being cheaper, more stable
This document discusses monoclonal antibodies, including their preparation and applications. It begins with an introduction to antibodies and monoclonal antibodies. It then describes the preparation process, which involves immunizing an animal, isolating B cells, fusing them with myeloma cells to form hybridomas, screening clones, and growing selected clones to produce monoclonal antibodies. The document outlines major applications of monoclonal antibodies in diagnosis using techniques like immunoassays and imaging, as well as their use as therapeutic agents and in protein purification.
This document provides an overview of aerosols, including their advantages and disadvantages for drug delivery. It describes the key components of aerosol systems, including propellants, containers, valves, and actuators. It also discusses the different types of aerosol systems and the manufacturing process for pharmaceutical aerosols. The document serves as a comprehensive reference on the topic.
This document discusses phytosomes, which are herbal extracts bound to phospholipids. They have improved absorption over traditional herbal extracts due to better bioavailability. Phytosomes are prepared through a reaction between phospholipids and active plant constituents. They have various advantages over liposomes and traditional extracts, including stronger effects, lower dosing needs, and protection of actives. Common phytosomes discussed are made from milk thistle, grape seed, green tea, and curcumin. Phytosomes show promise for delivering herbal medicines due to their improved properties.
Active transporters use energy to move molecules across cell membranes against a concentration gradient. They include pumps that use ATP to pump ions out of cells like the sodium-potassium pump, as well as transport proteins that couple the transport of one substance to the energy released from transporting another. These transporters play an important role in maintaining electrochemical gradients across cell membranes.
This document summarizes information about the Datura plant, including its scientific classification, names, geographical sources, physical description, traditional medicinal uses, toxic alkaloid composition, and effects of its main alkaloids like atropine, scopolamine, and hyoscyamine. Datura is known by names like jimson weed and thorn apple. It contains toxic tropane alkaloids that have anticholinergic effects and can cause hallucinations. The plant has a long history of traditional uses but is now banned as an over-the-counter drug due to its toxicity.
This document summarizes tobacco herb. It is made from the dried leaves of Nicotiana Tobaccum, which belongs to the Solanaceae family. Tobacco is cultivated annually by germinating seeds in cold frames then transplanting to rich, well-drained soil in warm climates. Over 7 million tons were produced worldwide on 4.2 million hectares in 2000. Dried tobacco leaves are green or brown in color, with a bitter taste and characteristic odor, measuring 60-80cm in length and having an ovate shape. Microscopically, tobacco leaves have an upper and lower epidermis, stomata, spongy and palisade mesophyll layers, vascular bundles, and trichomes
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
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2. Introduction
POWDER
- Powders are the mixture of finely divided drug or
chemicals in dryform.
- They are used for internally &externally.
- Theyareavailable in crystallineoramorphous form.
- There is a relationship between particle size of powder &
dissolution, absorption & therapeutic effectof drug.
3. Advantages of Powders
Powders are more stable than liquid dosageform.
The chance of incompatibility are less as compared to liquid
dosage form.
The onset of action of powdered drug is rapid as compared to
other solid dosage form e.g. tablet, capsules. Due to smaller
particlesizeof powder, itget dissolved easily in body fluids.
Larger quty. of powdered drugs can be administered to the
patient orally by dissolving or mixing the powder in the
suitable liquid.
Small children or elderly patient can easily take the powdered
drug as such ordispersed in wateroranyother liquid.
Powders are more economical as compared with other dosage
form because not required any special machinery or
technique.
Powders are more easy tocarry than the liquid dosage form.
4. Disadvantages of Powders
Drugs having bitter, nauseous & unpleasant taste cannot
be dispensed in powderedform.
Deliquescent & hygroscopic drugs cannot be dispensed in
powder form.
Drugs which get affected by atmospheric conditions are
notsuitable fordispensing in powder forms.
The dispensing of powder is a timeconsuming.
5. Classification of Powders
1. Bulk powder for internaluse.
2. Bulk powder for externaluse.
3. Simple & Compound powder for internaluse.
4. Powders enclosed in cachets &capsules.
5. Compressed powders (Tablets)
6. Bulk Powder for Internal Use
When accuracy of dosage form is not required or is not
important at that time powders are dispensed in bulk
form.
Bulk powdercontains several dosesof powder.
They are supplied in wide-mouthed containers that
permitseasy removal of a spoonful powder.
The non potent substances which are supplied in bulk are
antacid & laxativeetc.
E.g. rhubarb powder
7. Bulk Powder for External Use
Bulk powder forexternal useare non potentsubstance.
These powders are supplied in cardboard, glass or plastic
containers, which are often designed for the specific
method of application.
The dusting powders are supplied in perforated or sifter
topcontainers.
The bulk powders which are commonly used for external
applications arefollows:
- Dusting Powders
- Insufflations
- Snuffs
- Dentifrices
8. Dusting Powders:
- These are used for external application on the skin &
generallyapplied in very fine state toavoid local irritation.
- Therefore, dusting powder should be passed through sieve
no. 80 or 120 toenhance theireffectiveness.
- Dusting powders are 2 types: i. Medical ii.Surgical
- Medical & surgical dusting powders are free from
pathogenic microorganism.
- Medical & Surgical dusting powders before use must be
sterilised by dry heat method at 1600 C for 2hrs.
- Surgical dusting powders are used in body cavities & also
used on burn case & umbilical cord ofinfants.
- Whereas, medical dusting powders are generally use on
superficial skincondition.
Bulk Powder for External Use
9. Cont..
- In the preparation of dusting powder the talc or kaolin,
starch are used commonly because these are chemically
inert.
- But, such ingredients are readily contaminated with
pathogenic bacteria so, these must be sterilised before their
use by dry heat sterilisationmethod.
- The dusting powders are dispensed in sifter or aerosol
containers.
- Dusting powders are generally non- toxic but inhalation of its
fine powdered ingredients by infants may lead to pulmonary
inflammation. So proper care should be taken while
handling.
- Use : Antiseptic, Astringent, Absorbent,Antiperspirant
Bulk Powder for External Use
10. E.g of Dusting powder
Rx,
Purified talc, sterilised 50 gm
Starch powder 25 gm
Zinc oxide powder 20 gm
Salicylic acid powder 5gm
Procedure: weigh accurately all the powders & mix them
ascending order of their weight. Pass the mixed powder
through sieve no 85 or 120. after sieving mix them lightly &
Transfer into sifter top container & protect it from
atmosphericcontamination.
Direction: Applied on the affected part two or three times a
day.
Use: Zinc oxide use for astringent & antiseptic & salicylic acid
used for antiseptic &fungicidal.
Bulk Powder for External Use
11. Insufflations:
- These are medicated dustingpowder.
- they are introduced into body cavities such as, nose, throat,
ears & vagina with the helpof an apparatus “Insufflator”.
- Nowadays, the insufflations are available in the form of
pressureaerosols & theseaerosols used forpotentdrugs.
- Insufflations are used to produce a local effect in the
treatment of ear, nose, throat infection with antibiotics or to
produce a systemic effect from a drug that is destroyed in the
gut.
Bulk Powder for External Use
12. Snuffs:
- These are finely divided solid dosage
form of medicament.
- Which are inhaled into nostrils for
antiseptic, bronchodilator &
decongestion action.
- Snuffs are dispensed in flat metal
boxes or glass container with hinged
lid.
Bulk Powder for External Use
13. Dentifrices:
- Theseareapplied on tooth surface with helpof brush.
- In thatcontains suitabledetergentor soap, some abrasive
substance & suitable flavoring agents areinvolved.
- Abrasiveagents such ascalcium sulphate, calciumcarbonate,
sodium carbonate & sodium chlorideare use in fine powder.
- E.g.
Rx,
Hard soap powder 50 gm
Calcium carbonate powder 935 gm
Saccharin sodium 2 gm
Peppermintoil 4 ml
Cinnamon oil 2 ml
Methyl salicylate 8 ml
Bulk Powder for External Use
14. Simple & Compound Powders for Internal
Use
In this form of powder, each individual dose is enclosed in
paper.
The numberof ingredient is one i.e. simple powderwhile
more than one i.e. compoundpowder.
The minimum quty of each powder should not be less then
100 mg for it can be handled conveniently by patient & can
be weighedaccurately.
15. Simple & Compound Powders for Internal Use
SIMPLE POWDER:
- In simple powder contains only one ingredient either in
crystalline form or amorphousform.
- If powder present in crystalline form then it is reduced to fine
powder, weighed the powder & divided into number of doses
& wrapped as individualdose.
- E.g. Dispensed six powders of Aspirin each powder contains
300 mg of aspirin
- Rx,
Aspirin 300 mg
Procedure: powder the aspirin & weigh the required quty of
aspirin. Weigh 300 mg of aspirin for each powder & wrap
each powder in individual powderpaper.
Direction: One powderto be takenaftereveryeight hours.
16. COMPOUND POWDERS:
- Compound powders contains two or more than two substances
which are mixed together.
- Then divided into desired number of individualdoses.
- Then dispensed into each powderpaper.
- E.g Dispense eight powder of A.P.C each powder contains 500mg
of A.P.C
- Rx,
Aspirin
Paracetamol
Caffeine
300 mg
150 mg
50 mg
Procedure: weigh accurately of each powder & mix them as per
ascending order of their weight. Weigh 500 mg of the mixed
powder for each powder & wrap each dose individual in powder
paper.
Simple & Compound Powders for Internal Use
17. Powders enclosed in cachets &
capsules
Cachets are solid dosage form of drug & cachets are also
called as wafercapsules.
These are molded from riceflour.
Rice paper prepared from mixture of rice f lour with water
enclosed in between two hot, polished,cylinders.
Then waterwasevaporates & wafer is formed.
In the cachets 0.2 to 1.5 gm nauseous or disagreeable drugs in
powder form areenclosed.
18. Cachets are quite hard so, before swallowing they dipped in
water for seconds & then placed on the tongue & swallowed
with draught ofwater.
After swallowing the cachets gets disintegrate & drug is
released.
ADVANTAGES OF CACHETS:
- Madeeasily..
- Disintegrate quickly instomach
- Drug can be easilydispensed
- Large doseof drug can be swallowed by using cachets.
Powders enclosed in cachets &
capsules
19. DISADVANTAGES OF CACHETS:
- Required soften before use orswallowing.
- Easilydamaged.
- Cannot be protect the enclosed drug from light& moisture.
- Shell of cachets are fragile so, drug contents cannot be
compressed.
- Theyare not suitable for filling thedrug in large scale.
- They occurs more space compae with tablets & capsules solid
dosage form.
Powders enclosed in cachets & capsules
20. Cachets are twotypes:
- Wet seal cachets
- Dry sealcachets
- WET SEAL CACHETS:
- A wet seal cachets is made up of two similar convex halves
having flat edges.
- The weighed of powder drug is placed in one half, the edge of
other half are moistened with water & placed exactly over the
first half containing thedrug.
- The flat edges of both the halves are pressed together in
order to seal itperfectly.
Powders enclosed in cachets & capsules
22. DRY SEAL CACHETS:
- Dry seal cachetsconsistsof two halves, the upper half &
lower half.
- The diameterof upper half is slightly larger than lower half.
- The powdered drug is filled in lower half & upper halfis
fitted overit.
- The filled cachetsare then sealed in a machine by pressing
the two halves, removed & packed inboxes.
- B.P.C includes twocachets sodiumaminosalicylate & sodium
aminosalicylate with isoniazid.
Powders enclosed in cachets & capsules
23. In that powders moulded intotablets.
Theyare flat, circulardisc & usuallycontains potentdrug.
In that potentdrugsare mixed with lactose, dextroseorsome
otherdiluents.
The used apparatus is made upof stainlesssteel orplastic.
Itconsistof upper & lowerperforated plates & having the
same numbers of halves.
The lowerplatealso have two large pegs which ensurecorrect
fitting of theplates.
Theyareavailable in several sizes having a capacity ranging
from 30 to 250 mg.
Generally 50 to 250 tablet trituratescan be prepared ata time
from a tablet trituratemould.
Compressed powders (Tablets) or Tablet Triturates
or Moulded Tablets
24. The powder with diluents are mixed
together & madea stiff pastewith the
help of alcohol 60%.
Then, paste is introduced on upper
platewith the helpof spatula & fill all
the holes & removesexcess.
This plate is placed overthe lowerplate.
Then littlepressure is applied overthe
top plate which will force the plate
move downward, leaving the mould
tablet on the projectedpegs.
Then, prepared tablets dried in hotair
oven or by keeping in warmplace.
Compressed powders (Tablets) or Tablet Triturates
or Moulded Tablets
25. Dispensing of Powders Involving Special
Problems
Volatile Substances:
- Certainvegetablepowdercontainsvolatileoil.
- Toprevent the loss of volatileoils, thesevegetabledrugs must
be powdered lightly in amortar.
- Also, menthol, camphor & essential oils takes place
incorporation in powder.
- Final productpack with doublewrapping.
26. Hygroscopic & deliquescentpowders:
- Absorb the moisture from atmosphere are called hygroscopic
powders.
- Absorb the moisture from atmosphere & convert into solution are
called deliquescent powders.
- E.g. ammonium chloride, ammonium citrate, pepsin,
phenobarbitone, sodium iodideetc.
- Such substance are usually provide in granular form in order to
exposé less surface area to atmosphere & avoid convert into fine
powder.
- Such powder should be doublewrapped.
Dispensing of Powders Involving Special
Problems
27. Efflorescent powders:
- Some crystalline substance liberates water of crystallisation
whollyorpartlyon exposure to humid atmosphere.
- e.g. citricacid, caffeine, ferrous sulphateetc.
- So, this problem overcome by mixing or incorporate with
inert substanceorusing anhydrous slat.
Dispensing of Powders Involving Special
Problems
28. Eutectic mixture:
Liquids:
- In some prescription the liquid medicaments are also
incorporated with powders.
- In that case, if liquid quty is small, it may be triturated with
equal amount of powder, then the reset of the ingredients are
incorporated in small proportions with continuousstirring.
Dispensing of Powders Involving Special
Problems
29. Potentdrugs:
- The substance having a max. dose of less than 60 mg & poisonous
substances are called potentdrugs.
- Itshould be difficult toweigh on dispensing balance.
- For that, firstly potent drugs incorporated with diluents such as
lactose beforeweigh.
- e.g. Dispense following powder in 5 powderpackets
- Rx,
Codeine phosphate 10 mg
In that case, weigh 100 mg of codeine phosphate & 900 mg oflactose
mixed with ascending orderwith helpof spatula.
Out of 1 gm of triturate, weigh 100 mg of each powder contains 10
mg of codeine phosphate & pack in powder paper.
Dispensing of Powders Involving Special
Problems
30. Granularpowders:
- Some solid medicaments required to administered in orally in
large dose & its not possible to convert into tablet or capsule bec. a
large numberof themwill be required to takesingledose.
- And these medicaments are difficult to dispense in powder form
bec. Its bitter, nauseous & unpleasanttaste.
- In this case, solid medicaments mix with sweetening, flavoring &
coloring agent with suitable granulating agent to moisten the
powder to make coherentmass.
- Then, pass through sieve no. 10 to make granules & dry in hot air
oven at 600C & after drying pass through sieve no. 20 & pack into
wide mouthcontainers.
- E.g. Nowadays, antibiotics like erythromycin, ampicillin etc are
available in granularpowder bec. Theyare unstable in liquid form.
Dispensing of Powders Involving Special
Problems
31. Effervescentgranules:
- These type of medicament granules are prepared for internal
use.
- In that, medicaments mixed with citric acid, tartaric acid &
sodium bicarbonate with sweetening agents alsopresent.
- When contact with water they release of carbon dioxide to
mask the bitter & saline tasteof drug.
- Also, carbon dioxide stimulates the flow of gastric juice &
helps in the absorption ofmedicaments.
OF PREPARATION OF EFFERVESCENT- METHODS
GRANULES:
- Heat Method
- WetMethod
32. Heat Method:
- Firstly, porcelain dish make hot on water bath before transferring
the powder.
- Then, transfer the medicament with citric acid & other
ingredients.
- In that stagecitricacid liberates thewater & producedump mass.
- Heating stage takes 1 to 5mint.
- Then damp mass pass through sieve & dry in hot airoven at 600 C.
- Then finally packed in air tightcontainer.
33. Wet Method
- In this method, the ingredients are mixed with alcohol to
produce coherentmass.
- Produced mass pass through sieve no 10 or 8 & dry in hot air
oven at 600 C.
- Then dried granules are again passed through sieve to break
the lumpswhich may be formed during drying.
- Finally, the prepared granules are packed in air tight
containers.
35. Cont..
Spatulation: mixing the powders with help of spatula on a
paper orsheet.
Trituration: it is used for reduce of size & for mixing of
powders.
Geometric dilution: for potentdrugs..
Sifting: the powdersare mixed by passing through sifters.
Tumbling: tumbling is the process of mixing powders in a
large container rotated by an electric motor. These type of
blenders are widely used in industry as large volume of
powder mixers.
36. Packing of Powder
Doublewrapping:
- In that, wrap the powders by using twodifferent types
of paper.
- Outerpaper is plain paperwhile innerwrapping is of
gelatin paper.