The Apgar score is a test given to newborns soon after birth. This test checks a baby's heart rate, muscle tone, and other signs to see if extra medical care or emergency care is needed. The test is usually given twice: once at 1 minute after birth, and again at 5 minutes after birth
Every year more than 10 million children die in developing countries due to acute respiratory infections (mostly pneumonia), diarrhea, measles, malaria, or malnutrition - and often to a combination of these illnesses. In 1990s, the WHO, in collaboration with UNICEF and many other agencies, institutions and individuals, responded to this challenge by developing a strategy known as the Integrated Management of Childhood Illness (IMNCI).This strategy adopted in India as Integrated Management of Neonatal and Childhood Illness (IMNCI). IMNCI caters to two groups of children
• 0-2 months, referred to as young infants.
• 2 months to 5 years, referred to as children.
This slides contain description about breast feeding, anatomy of breast, types of human milk, good position for latching, holding for the baby, advantages of breast feeding, contraindication of breast feeding, barriers and problems associated with breast feeding with their management
The Apgar score is a test given to newborns soon after birth. This test checks a baby's heart rate, muscle tone, and other signs to see if extra medical care or emergency care is needed. The test is usually given twice: once at 1 minute after birth, and again at 5 minutes after birth
Every year more than 10 million children die in developing countries due to acute respiratory infections (mostly pneumonia), diarrhea, measles, malaria, or malnutrition - and often to a combination of these illnesses. In 1990s, the WHO, in collaboration with UNICEF and many other agencies, institutions and individuals, responded to this challenge by developing a strategy known as the Integrated Management of Childhood Illness (IMNCI).This strategy adopted in India as Integrated Management of Neonatal and Childhood Illness (IMNCI). IMNCI caters to two groups of children
• 0-2 months, referred to as young infants.
• 2 months to 5 years, referred to as children.
This slides contain description about breast feeding, anatomy of breast, types of human milk, good position for latching, holding for the baby, advantages of breast feeding, contraindication of breast feeding, barriers and problems associated with breast feeding with their management
A reflexes is an involuntary or automatic action that your body does in response to something without even to think about it.
Normally developing newborn should respond to certain stimuli with these reflexes.
MENDELE'S EXPERIMNENT AND TERMINOLOGY, BY MR. DINABANDHU BARAD, MSC TUTOR, DEPARTMENT OF PEDIATRIC, SUM NURSING COLLEGE, SIKSHA 'O' ANUSANDHAN DEEMED TO BE UNIVERSITY
INBORN ERRORS OF METABOLISM, PKU, PHENYLKETONURIA, BY: MR. DINABANDHU BARAD, MSC TUTOR, SUM NURSING COLLEGE, SIKSHA O ANUSANDHAN DEEMED TO BE UNIVERSITY, BHUBANESWAR, ODISHA
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. WHAT IS A REFLEX ?
• A reflex is an involuntary, or automatic, action that the body does in
response to stimulation, without awareness.
• Neonatal reflexes or primitive reflexes are the inborn behavioral
patterns that develop during uterinelife.
• They should be fully present at birth and are gradually inhibited by
higher centers in the brain during postnatallife.
8. MORO REFLEX
Begins at 28weeks of gestation
Initiated by any sudden movementof the neck
Elicited by -- pulling the baby halfway to sitting
position from supine & suddenly let the head fall back
Consists of rapid abduction & extension of arms with
the opening of hands, tensing of the back muscles,
flexion of the legs and crying
9. Clinical significance
Its nature gives an indication of muscle tone
Failure of the arms to move freely or the hands toopen fully indicates
hypotonia.
It fades rapidly and is not normally elicited after 6 months of age.
MORO REFLEX
10. PALMAR/GRASP REFLEX
Begins at 32weeks ofgestation
Light touch of the palmproduces reflex flexion of the
fingers
Most effective way -- slide the stimulating object, such as
afinger or pencil, across the palm fromthe lateral border
Disappears at 3-4months
Replaced by voluntary grasp at45 months
11. Clinical significance
Exceptionally strong grasp reflex -- spastic form of cerebral palsy &
Kernicterus
May be asymmetrical in hemiplagia & in cases of cerebral damage
Persistence beyond 3-4 months indicate spastic form of palsy
PALMAR/GRASP REFLEX
12. PLANTAR/GRASP REFLEX
Placing object or finger beneath the
toes causes curling of toes around the
object
Present at 32weeks ofgestation
Disappears at 9-12 months
• Clinical significance :
This reflex is referred to as the
"readiness tester".
Integrates at the same time that
independent gait first becomes
possible.
13. WALKING/STEPPING REFLEX
When sole of foot is pressed against the
couch, baby tries to walk
Legs prance up & down as if baby
is walking or dancing
Present at birth, disappearsat approx 2-4
months
With daily practice of reflex, infants
may walk alone at 10 months
CLINICAL SIGNIFICANCE
Premature infants will tend to walk in a
toe-heel fashion while more mature
infants will walk in a heel-toe pattern.
14. ASYMMETRIC TONIC NECK REFLEX
Most evident between 2-3months ofage
• Clinical significance
The reflex fades rapidly and is not normally
seen after 6 months of age.
Persistence is the most frequently observed
abnormality of the infantile reflexes in
infants with neurological lesions
Greatly disrupts development
15. SYMMETRIC TONIC NECK REFLEX
Extension of the head causes
extension of the fore limbs and
flexion of the hind limbs
Evident between 2-3months ofage
Clinical significance
Not normally easily seen or elicitedin
normal infants
May be seen in an exaggerated form
in many children with cerebral palsy.
16. BABINSKI’S REFLEX
Stimulus consists of a firm painful stroke
along the lateral border of the sole from
heel to toe
Response consists of movement (flexion
or extension) of the big toe and
sometimes movement (fanning) of the
othertoes
Present at birth, disappears at approx9-
10 months
Presence of reflex later may indicate
disease
17. BABKIN REFLEX
Deep pressure applied simultaneously
to the palms of both hands while the
infant is in supine position
Stimulus is followed by flexion or
forward bowing of the head, opening of
the mouth and closing of the eyes
Fades rapidly and normally cannot be
elicited after 4 months of age.
18. • Clinical significance
Reflex can be demonstrated in the newborn, thus showing a hand-
mouth neurological link, even at that early stage
BABKIN REFLEX
19. PARACHUTE REFLEX
Reflex appears at about 6-9 months &
persists thereafter
Elicited by holding the child in ventral
suspension & suddenly lowering him to
the couch
Arms extend as a defensivereaction
• Clinical significance
Absent or abnormal in childrenwith
cerebral palsy
Would be asymmetrical in spastic
hemiplagia
20. GALLANT’S REFLEX
Firm sharp stimulation along sides of
the spine with the fingernails or a pin
produces contraction of the underlying
muscles and curving of the back.
Response is easily seen when the infant
is held upright and the trunk movement
is unrestricted
Best seen in the neonatal period and
thereafter gradually fades.
22. BLINK REFLEX
A bright light suddenly shown into the eyes, a puff ofair upon the
sensitive cornea or a sudden loud noise will produce immediate
blinking of the eyes
Purpose – to protect the eyes from foreign bodies &bright light
May be associated tensing of the neck muscles, turning of the head
away from the stimulus, frowning and crying
Reflexes are easily seen in the neonate and continue to be
present throughout life
23. CLINICAL SIGNIFICANCE
Examination is a part of some neurological exams, particularly
when evaluatingcoma
Satisfactory demonstration of these reflexes indicate–
No cerebral depression
Contraction of appropriate muscles in response
BLINK REFLEX
24. DOLL’S EYE REFLEX
(OCULOCEPHALIC REFLEX)
Passive turning of the head of the
newborn leaves the eye “behind”
A distinct time lag occurs before the
eyes move to a new position in
keeping with the head position
Disappears at within a weekor two
of birth
Failure of this reflex to appear
indicates a cerebral lesion
25. AUDITORY ORIENTING REFLEX
A sudden loud and unpleasant noise :
May produce the blink reflex
Infant may remain still and show increased alertness
Quieter sounds usually cause reflex eye and head turning tothe side of
the sound, as if to locate it
Seen first at about 4 months of age
Thereafter, head turning towards sound stimuli occurs and the
accuracy of localization increases rapidly by 9-10 months
26. CLINICAL SIGNIFICANCE
Reflex responses are made use of in tests of infants for
hearing loss
Pattern of the localization responses indicates the level of neurological maturity
AUDITORY ORIENTING REFLEX
28. Baby’s cheek is stroked :
They respond by turning their head
towards the stimulus
They start sucking, thus allowing
for breast feeding
When corner of mouth is touched,
lower lip is lowered, tongue moves
towards the point stimulated
When finger slides away, head turns to
follow it
When center of lip is stimulated,
lip elevates
ROOTING REFLEX
29. Onset -- 28weeks IU
Well established – 32-34weeks IU
Disappears – 3-4 months
Clinical significance
Persistence can interfere with sucking
Absence of this is seen in neurologically impaired
infants.
ROOTING REFLEX
30. SUCKING / SWALLOWING REFLEX
Touching lips or placing something in
baby’s mouth causes baby to draw
liquid into mouth by creating vacuum
with lips, cheeks & tongue
Onset – 28weeks IU
Well established – 32-34weeks IU
Disappears around 12 months
31. GAG REFLEX
(PHARYNGEAL REFLEX)
Seen in 19weeks of IU life
Reflex contraction of the back of
the throat
Evoked by touching the roof of the
mouth, the back of the tongue,
the area around the tonsils
and the back of the throat
32. Functional significance
It, along with reflexive pharyngeal swallowing, prevents
something from entering the throat except as part of normal
swallowing and helps prevent choking
Clinical significance
Absence of the gag reflex -- symptom of a number of severe
medical conditions :
Damage to the glossopharyngeal nerve, the vagus nerve,
Brain death.
GAG REFLEX
(PHARYNGEAL REFLEX)
33. CRY REFLEX
Non conditioned reflex which
accounts for its lack of its individual
character
Sporadic in nature
Starts as early as 21-29weeks of IU life