Nano based polymers have applications in drug delivery. Nanoparticles can be covered by DNA or other polymers to create a "nano-vector" for targeted drug delivery. The nano-vector seeks out specific receptors on tumor cells to deliver its drug payload directly into cancer cells. This allows the drug to potentially destroy tumors without surgery by inhibiting tumor cell cycling and protein synthesis. The nano-vector aims to break down the tumor from within by a targeted, controlled release of drugs directly into cancer cells.

1. NANO BASED POLYMERS AND
APPLICATIONS
(DRUG DELIVERY)
Presented By:
Mr. Anil Kumar
M.Phil./ Ph.D. Nano-science (2012-13)
Centre for Nano-science
Central University of Gujarat

2. NANO POLYMERS FORMATION
Macro Micro Nano Å Å
Molecules
Monomers
Small Bulk Material units
or Micro Polymers Nano
Bulk Material Polymers

3. Techniques Applied formation To
Nano Polymers
Top Down Approaches Nano Bottom Up Approaches
Lysis of Bulky Materials:- Synthesis of
Materials (Nano
1. Chemolysis. (Use organic 1. Self Assembling. (Inter or
Composites):-
solvents ) Intra Molecular
Nano polymers
2. Thermolysis. (ΔG = ΔH – Interaction)
TΔS) 2. Crystallization. ( Solid
3. Radiation. (Break chemical and Liquid )
bonds, phenolic , 3. Precipitation. ( Liquid and
polystyrene) Liquid recovery of salt
4. Diffusion. (stirrer with high and metals)
speed) 4. Sol-Gel. (NM + Organic
5. Enzymolysis. (cellulase, Solvent + Gel)
pectinase, ribulase..etc.) 5. Molecular
6. Biodegradation. (bacteria, Interaction.(Ionic
fungi, algae ..etc.) Interaction)

4. Model of Surface-to-volume
Comparisons…
Single Box Ratio
6 m2 2 3
1m 3 = 6 m /m
Smaller Boxes Ratio
12 m2
3 = 12 m2/m3
1m
 Neglecting spaces between the smaller boxes, the
volumes of the box on the left and the boxes on the right
are the same but the surface area of the smaller boxes
added together is much greater than the single box.

5. PROPERTIES
Structural :- Platelets, Fibers, Spheroids, Linear, Branch, Network..etc.
Physical & Chemical:- Like as Stiffness, Strength, Stability, etc. (2D,3D).
Typical Structures are:
• Linear (end-to-end, flexible) .
• Branched(one end free, other
attached to stalk polymer).
• Network (similar to highly cross-
linked structures,termosetting
polymers).

6. Polymer has a Multidisciplinary
Field of Science & Technology

7. Nano Based Polymers Types
Chemical Synthetics
- Polyglycolic acid (PGA)
- Polylactic acid (PLA)
- PGA-PLA
- Polydioxanone (PDO)
- Polycaprolactone
- PGA-polycaprolactone
- PLA-polycaprolactone
- Polydioxanone-polycaprolactone
Natural
- Elastin
- Gelatin collagen
- Fibrillar collagen
- Collagen blends
- Fibrinogen
- Heamoglobine

8. NANO BASED SOME POLYMERS AND
APPLICATION
Broad Fields Nano Size Polymers Applications
Chemicals  PVC. (Poly vinyl chloride)  Raincoats, shower curtains, water pipes
 PMMA. (Poly methyl  Plastic base glasses
methacrylate)
 PE. (Polyethylene)  Grocery bags, shampoo, bottles, children’s toys,
bulletproof vests
 PS. (Polystyrene)  Comb, TVs body,. radio knobs. drinking cups foamy
 PP. (Polypropene)  packaging, textiles (e.g. ropes, thermal underwear,
carpets), stationery, plastic parts laboratory,
equipment, loudspeakers,
 PPS. (Poly phenylene  Resist chemical and thermal attacks
sulfide)
 ABS. (Poly acrylonitrile  Very strong and lightweight polymer. It is strong
butadiene styrene) enough to be used to make automobile body parts
 PNBR. (Polymer Nitrile  Cleaning of lab equipment, sophisticated,
Buna-N rubber) instruments and examination gloves.
Biological  Immunogenic  Immunoglobulin (IgA, IgD, IgE, IgG, IgM)
 Antigenic  Epitope, Motifs, TCR (CD4,CD8), MHC
Lipids  Emulsions  Mixture (HC+H2O)
 Liposomes  Micelle, Amphipathic
Metals  Nanoshell  Cover (Sphere) of NP
 Nanocomposites  NP + Polymer
Fibers  Nanosphere  Careers Nanoparticles(amino, carboxyl, surfaces)
 Nanocapsule  Fiber Coat (Medicine coat, cover)

9. Outline Process of Nano-Vector
Nano polymer mostly can be very effective to be Designing a
Drug as name “NANO VECTOR” by using of Nano Polymers and
Nano Materials in size nano range and also Applied for induced
tumor cells available in Critical Organs of Body such as Brain,
Lung, Heart...etc. These vector designed a typical types, who are
search to target site, that target site a specific receptor Presented
in outer cell membrane of the tumor cell receptor made be
become Biomolecules it bind by various ways and released to NP
into tumor cells. Where It are do The tumor Cells Remove or
Destroyed as may be possible without surgery Because Some
Tumor Cell have arises to another Tumor Cell by Cell Cycling,
here break Cell Cycling by This Nano Vector will as a processing
inhabit of protein synthesis of tumor cell.

10. Nano-Vector
DNA Strand in nm

11. Nano-Vector
DNA Strand
Nanoparticle
(Drugs)

12. Nano-Vector
DNA Strand
 Covering of NP by DNA Polymer
Nanoparticle
(Drugs)

13. Nano-Vector
DNA Strand
 Covering of NP by DNA Polymer
Nanoparticle
(Drugs)
DNA Strand
 Covered of NP by DNA Polymer
NP

14. vector with
Drugs

15. vector with Moieties Target
Drug (Receptors)

16. Nanovector Moieties Target
with Durg (Receptors)

17. vector with Moieties Target
Durg (Receptors)

18. vector with Moieties Target
Durg (Receptors)
Nano vector with various
moiety receptors

19. Assembled Nano Vector (Drug)
Thank You
for a kind Attention